SG10202005315SA - Agent for treating and/or preventing diseases associated with immune abnormalities by combining biguanide antidiabetic drug with immunosuppressive factor blocking agent or costimulatory receptor agonist - Google Patents
Agent for treating and/or preventing diseases associated with immune abnormalities by combining biguanide antidiabetic drug with immunosuppressive factor blocking agent or costimulatory receptor agonistInfo
- Publication number
- SG10202005315SA SG10202005315SA SG10202005315SA SG10202005315SA SG10202005315SA SG 10202005315S A SG10202005315S A SG 10202005315SA SG 10202005315S A SG10202005315S A SG 10202005315SA SG 10202005315S A SG10202005315S A SG 10202005315SA SG 10202005315S A SG10202005315S A SG 10202005315SA
- Authority
- SG
- Singapore
- Prior art keywords
- agent
- combining
- treating
- receptor agonist
- diseases associated
- Prior art date
Links
- XNCOSPRUTUOJCJ-UHFFFAOYSA-N Biguanide Chemical compound NC(N)=NC(N)=N XNCOSPRUTUOJCJ-UHFFFAOYSA-N 0.000 title 1
- 229940123208 Biguanide Drugs 0.000 title 1
- 229940127003 anti-diabetic drug Drugs 0.000 title 1
- 239000003472 antidiabetic agent Substances 0.000 title 1
- 239000002981 blocking agent Substances 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 title 1
- 108091008034 costimulatory receptors Proteins 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 230000009390 immune abnormality Effects 0.000 title 1
- 230000001506 immunosuppresive effect Effects 0.000 title 1
- 239000000018 receptor agonist Substances 0.000 title 1
- 229940044601 receptor agonist Drugs 0.000 title 1
Classifications
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
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- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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- A61K35/14—Blood; Artificial blood
- A61K35/15—Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
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- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Developmental Biology & Embryology (AREA)
- Endocrinology (AREA)
- Communicable Diseases (AREA)
- Rehabilitation Therapy (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2014166593 | 2014-08-19 | ||
JP2015085556 | 2015-04-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10202005315SA true SG10202005315SA (en) | 2020-07-29 |
Family
ID=55350709
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10202005315SA SG10202005315SA (en) | 2014-08-19 | 2015-08-17 | Agent for treating and/or preventing diseases associated with immune abnormalities by combining biguanide antidiabetic drug with immunosuppressive factor blocking agent or costimulatory receptor agonist |
SG11201700978SA SG11201700978SA (en) | 2014-08-19 | 2015-08-17 | Method for enhancing immune cell function and method for assessing immune cell multifunctionality |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201700978SA SG11201700978SA (en) | 2014-08-19 | 2015-08-17 | Method for enhancing immune cell function and method for assessing immune cell multifunctionality |
Country Status (15)
Country | Link |
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US (2) | US20170231929A1 (de) |
EP (2) | EP3192517A4 (de) |
JP (3) | JP6629211B2 (de) |
KR (1) | KR20170042778A (de) |
CN (1) | CN107148274A (de) |
AU (1) | AU2015304448B2 (de) |
BR (1) | BR112017002807A2 (de) |
CA (1) | CA2958573A1 (de) |
ES (1) | ES2915849T3 (de) |
IL (1) | IL250639B (de) |
MX (1) | MX2017002134A (de) |
PH (1) | PH12017500224A1 (de) |
RU (2) | RU2020127099A (de) |
SG (2) | SG10202005315SA (de) |
WO (1) | WO2016027764A1 (de) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2161336B2 (de) * | 2005-05-09 | 2017-03-29 | ONO Pharmaceutical Co., Ltd. | Humane monoklonale Antikörper für den programmierten Tod 1 (PD-1) und Verfahren zur Behandlung von Krebs mit PD-1-Antikörpern allein oder in Kombination mit anderen Immunotherapeutika |
JP6502959B2 (ja) | 2013-12-12 | 2019-04-17 | 上海恒瑞医薬有限公司 | Pd−1抗体、その抗原結合性断片及びそれらの医学的使用 |
MX2019003683A (es) | 2016-10-11 | 2019-08-22 | Agenus Inc | Anticuerpos anti gen 3 de activación linfocítica (lag 3 ) y métodos para usarlos. |
CN107082812B (zh) * | 2017-03-29 | 2018-11-13 | 上海科医联创生物科技有限公司 | 一种恢复衰竭性免疫细胞功能的融合蛋白及其应用 |
EP3630112B9 (de) * | 2017-06-02 | 2024-06-26 | Bayer HealthCare LLC | Kombination aus regorafenib und nivolumab zur behandlung von krebs |
JPWO2019069449A1 (ja) * | 2017-10-06 | 2019-11-14 | 純児 赤木 | 測定方法 |
WO2019124423A1 (ja) * | 2017-12-19 | 2019-06-27 | 国立大学法人 岡山大学 | がんの進行抑制、治療、予防及び/又は再発予防剤 |
JP2019112353A (ja) * | 2017-12-25 | 2019-07-11 | 合同会社チューモス | 自家腫瘍ワクチン及び免疫誘導方法 |
JP7329840B2 (ja) * | 2017-12-26 | 2023-08-21 | 民男 山内 | 免疫動態に関する情報を提供する方法、システムおよびプログラム |
AU2019200033B2 (en) * | 2018-01-05 | 2020-09-10 | Gnt Biotech & Medicals Corporation | A pharmaceutical combination and method for regulation of tumor microenvironment and immunotherapy |
WO2019202473A1 (en) * | 2018-04-16 | 2019-10-24 | Université de Lausanne | Ucp2 inducing agents for the treatment of cancer resistant to immune checkpoint blockade |
US20220017969A1 (en) * | 2018-12-07 | 2022-01-20 | Arizona Board Of Regents On Behalf Of The University Of Arizona | A method of determining risk for skin cancer development and skin cancer therapeutic prevention by measuring pd-1/pd-l1 signaling pathway members |
KR102510381B1 (ko) * | 2019-10-16 | 2023-03-15 | 한국과학기술원 | 메트포민을 유효성분으로 포함하는 뇌암의 예방 또는 치료용 면역치료제 조성물 |
WO2022072745A1 (en) * | 2020-10-01 | 2022-04-07 | The Regents Of The University Of California | Methods and compositions to treat and prevent viral infections and acute respiratory distress syndrome |
CN112791182A (zh) * | 2020-12-31 | 2021-05-14 | 中山大学 | 二甲双胍和抗pd-1抗体药物组合物在制备肝癌药物中的应用 |
CN113421627B (zh) * | 2021-05-11 | 2023-04-07 | 深圳市罗湖区人民医院 | 体外评估药物对nk细胞抗衰作用的系统 |
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US4938949A (en) * | 1988-09-12 | 1990-07-03 | University Of New York | Treatment of damaged bone marrow and dosage units therefor |
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US5620889A (en) * | 1993-10-14 | 1997-04-15 | Immunex Corporation | Human anti-Fas IgG1 monoclonal antibodies |
EP1387675A2 (de) * | 2000-08-07 | 2004-02-11 | Ranbaxy Signature LLC | Flüssige metforminformulierung |
DK2206517T3 (da) * | 2002-07-03 | 2023-11-06 | Ono Pharmaceutical Co | Immunpotentierende sammensætninger omfattende af anti-PD-L1-antistoffer |
EP2161336B2 (de) | 2005-05-09 | 2017-03-29 | ONO Pharmaceutical Co., Ltd. | Humane monoklonale Antikörper für den programmierten Tod 1 (PD-1) und Verfahren zur Behandlung von Krebs mit PD-1-Antikörpern allein oder in Kombination mit anderen Immunotherapeutika |
WO2009030257A1 (en) * | 2007-09-05 | 2009-03-12 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Methods and compounds for treating diseases caused by reactive oxygen species |
CA2772120A1 (en) | 2009-08-25 | 2011-03-17 | President And Fellows Of Harvard College | Use of metformin in cancer treatment and prevention |
US20130059916A1 (en) * | 2010-05-26 | 2013-03-07 | Stephane Rocchi | Biguanide compounds and its use for treating cancer |
WO2012095379A1 (en) * | 2011-01-11 | 2012-07-19 | Universität Basel | Combination of syrosingopine and mitochondrial inhibitors for the treatment of cancer and immunosuppression |
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CN103371991A (zh) * | 2012-04-18 | 2013-10-30 | 中国人民解放军第二军医大学 | 二甲双胍在制备预防或治疗肝细胞癌药物中的应用 |
WO2014009535A2 (en) * | 2012-07-12 | 2014-01-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting the survival time and treatment responsiveness of a patient suffering from a solid cancer with a signature of at least 7 genes |
JP6559566B2 (ja) * | 2012-08-06 | 2019-08-14 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 癌患者をスクリーニングするための方法及びキット |
DK2904011T3 (en) * | 2012-10-02 | 2017-12-04 | Bristol Myers Squibb Co | COMBINATION OF ANTI-KIR ANTIBODIES AND ANTI-PD-1 ANTIBODIES FOR TREATMENT OF CANCER |
WO2014083095A1 (en) * | 2012-11-29 | 2014-06-05 | Universitaet Basel | Combinations of metformin with other compounds for the treatment of cancer and for immunosuppression |
KR102214794B1 (ko) * | 2013-01-02 | 2021-02-10 | 디코이 바이오시스템즈 인코퍼레이티드 | 박테리아를 사용하는 암 치료용 조성물 및 방법 |
JP6242071B2 (ja) * | 2013-04-23 | 2017-12-06 | 国立大学法人 岡山大学 | 免疫疲弊cd8+t細胞の機能改善薬、がん治療薬及びメタボリック症候群の予防または治療薬 |
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AU2015304448B2 (en) | 2020-04-30 |
US20170281569A1 (en) | 2017-10-05 |
EP3232199B1 (de) | 2022-05-04 |
EP3232199A2 (de) | 2017-10-18 |
RU2731098C2 (ru) | 2020-08-28 |
JP6629211B2 (ja) | 2020-01-15 |
EP3232199A8 (de) | 2017-12-13 |
EP3192517A4 (de) | 2018-04-25 |
BR112017002807A2 (pt) | 2017-12-19 |
RU2017108754A3 (de) | 2019-03-29 |
RU2020127099A (ru) | 2020-09-02 |
JP2020109098A (ja) | 2020-07-16 |
RU2017108754A (ru) | 2018-09-20 |
JPWO2016027764A1 (ja) | 2017-06-01 |
JP2017165752A (ja) | 2017-09-21 |
EP3232199A3 (de) | 2018-02-14 |
IL250639A0 (en) | 2017-04-30 |
KR20170042778A (ko) | 2017-04-19 |
WO2016027764A1 (ja) | 2016-02-25 |
US20170231929A1 (en) | 2017-08-17 |
ES2915849T3 (es) | 2022-06-27 |
SG11201700978SA (en) | 2017-03-30 |
AU2015304448A1 (en) | 2017-03-09 |
CN107148274A (zh) | 2017-09-08 |
MX2017002134A (es) | 2017-09-13 |
CA2958573A1 (en) | 2016-02-25 |
EP3192517A1 (de) | 2017-07-19 |
PH12017500224B1 (en) | 2017-07-10 |
JP6672217B2 (ja) | 2020-03-25 |
PH12017500224A1 (en) | 2017-07-10 |
IL250639B (en) | 2020-02-27 |
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