SG10201405107YA - Compositions and methods useful for culturing differentiable cells - Google Patents

Compositions and methods useful for culturing differentiable cells

Info

Publication number
SG10201405107YA
SG10201405107YA SG10201405107YA SG10201405107YA SG10201405107YA SG 10201405107Y A SG10201405107Y A SG 10201405107YA SG 10201405107Y A SG10201405107Y A SG 10201405107YA SG 10201405107Y A SG10201405107Y A SG 10201405107YA SG 10201405107Y A SG10201405107Y A SG 10201405107YA
Authority
SG
Singapore
Prior art keywords
compositions
methods useful
differentiable cells
culturing differentiable
culturing
Prior art date
Application number
SG10201405107YA
Other languages
English (en)
Inventor
Allan Robins
Thomas Schulz
Original Assignee
Viacyte Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38459762&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG10201405107Y(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Viacyte Inc filed Critical Viacyte Inc
Publication of SG10201405107YA publication Critical patent/SG10201405107YA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0603Embryonic cells ; Embryoid bodies
    • C12N5/0606Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10Cells modified by introduction of foreign genetic material
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5073Stem cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/90Serum-free medium, which may still contain naturally-sourced components
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10Growth factors
    • C12N2501/105Insulin-like growth factors [IGF]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10Growth factors
    • C12N2501/115Basic fibroblast growth factor (bFGF, FGF-2)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10Growth factors
    • C12N2501/117Keratinocyte growth factors (KGF-1, i.e. FGF-7; KGF-2, i.e. FGF-12)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10Growth factors
    • C12N2501/119Other fibroblast growth factors, e.g. FGF-4, FGF-8, FGF-10
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10Growth factors
    • C12N2501/15Transforming growth factor beta (TGF-β)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10Growth factors
    • C12N2501/155Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10Growth factors
    • C12N2501/16Activin; Inhibin; Mullerian inhibiting substance
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10Growth factors
    • C12N2501/195Heregulin, neu differentiation factor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20Cytokines; Chemokines
    • C12N2501/23Interleukins [IL]
    • C12N2501/235Leukemia inhibitory factor [LIF]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00Coculture with; Conditioned medium produced by
    • C12N2502/13Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2509/00Methods for the dissociation of cells, e.g. specific use of enzymes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Microbiology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
SG10201405107YA 2006-02-23 2007-02-23 Compositions and methods useful for culturing differentiable cells SG10201405107YA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US77611306P 2006-02-23 2006-02-23

Publications (1)

Publication Number Publication Date
SG10201405107YA true SG10201405107YA (en) 2014-10-30

Family

ID=38459762

Family Applications (3)

Application Number Title Priority Date Filing Date
SG10202109176RA SG10202109176RA (en) 2006-02-23 2007-02-23 Compositions and methods useful for culturing differentiable cells
SG201101267-1A SG170021A1 (en) 2006-02-23 2007-02-23 Compositions and methods useful for culturing differentiable cells
SG10201405107YA SG10201405107YA (en) 2006-02-23 2007-02-23 Compositions and methods useful for culturing differentiable cells

Family Applications Before (2)

Application Number Title Priority Date Filing Date
SG10202109176RA SG10202109176RA (en) 2006-02-23 2007-02-23 Compositions and methods useful for culturing differentiable cells
SG201101267-1A SG170021A1 (en) 2006-02-23 2007-02-23 Compositions and methods useful for culturing differentiable cells

Country Status (10)

Country Link
US (6) US8153429B2 (fr)
EP (2) EP1994141B1 (fr)
JP (3) JP5830217B2 (fr)
KR (1) KR20080109775A (fr)
CN (3) CN105802904B (fr)
AU (1) AU2007220759A1 (fr)
CA (1) CA2643478C (fr)
DK (2) DK1994141T3 (fr)
SG (3) SG10202109176RA (fr)
WO (1) WO2007101130A2 (fr)

Families Citing this family (102)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7097840B2 (en) 2000-03-16 2006-08-29 Genentech, Inc. Methods of treatment using anti-ErbB antibody-maytansinoid conjugates
US7432104B2 (en) * 2001-08-06 2008-10-07 Bresgen Inc. Methods for the culture of human embryonic stem cells on human feeder cells
WO2006020919A2 (fr) 2004-08-13 2006-02-23 University Of Georgia Research Foundation, Inc. Compositions et procedes d'auto-renouvellement et de differentiation dans des cellules souches embryonnaires humaines
US8017395B2 (en) 2004-12-17 2011-09-13 Lifescan, Inc. Seeding cells on porous supports
AU2006255183B2 (en) 2005-06-08 2012-02-02 Centocor, Inc. A cellular therapy for ocular degeneration
CA2643478C (fr) 2006-02-23 2019-06-18 Novocell, Inc. Compositions et procedes utiles pour la culture de cellules differenciables
US8741643B2 (en) 2006-04-28 2014-06-03 Lifescan, Inc. Differentiation of pluripotent stem cells to definitive endoderm lineage
US7964402B2 (en) 2006-05-25 2011-06-21 Sanford-Burnham Medical Research Institute Methods for culture and production of single cell populations of human embryonic stem cells
JP2008099662A (ja) 2006-09-22 2008-05-01 Institute Of Physical & Chemical Research 幹細胞の培養方法
MX2010000348A (es) * 2007-07-01 2010-04-12 Lifescan Inc Cultivo de celulas madre pluripotentes individuales.
US9080145B2 (en) 2007-07-01 2015-07-14 Lifescan Corporation Single pluripotent stem cell culture
US9096832B2 (en) 2007-07-31 2015-08-04 Lifescan, Inc. Differentiation of human embryonic stem cells
US8623650B2 (en) 2007-10-19 2014-01-07 Viacyte, Inc. Methods and compositions for feeder-free pluripotent stem cell media containing human serum
MX2010005805A (es) 2007-11-27 2010-06-09 Lifescan Inc Diferenciacion de celulas madre embrionarias humanas.
JP5733986B2 (ja) 2008-02-21 2015-06-10 ヤンセン バイオテツク,インコーポレーテツド 細胞の付着、培養、及び剥離のための方法、表面改質されたプレート、並びに組成物
US8338170B2 (en) 2008-04-21 2012-12-25 Viacyte, Inc. Methods for purifying endoderm and pancreatic endoderm cells derived from human embryonic stem cells
US8623648B2 (en) 2008-04-24 2014-01-07 Janssen Biotech, Inc. Treatment of pluripotent cells
EP2128245A1 (fr) * 2008-05-27 2009-12-02 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Génération de cellules souches pluripotentes induites (iPS)
KR101829310B1 (ko) 2008-06-30 2018-02-14 얀센 바이오테크 인코포레이티드 만능 줄기 세포의 분화
EP2318516A1 (fr) * 2008-06-30 2011-05-11 Centocor Ortho Biotech Inc. Différenciation de cellules souches pluripotentes
US9498515B2 (en) * 2008-08-15 2016-11-22 Acorda Therapeutics, Inc. Compositions and methods for treatment during non-acute periods following CNS neurological injury
CN107904201B (zh) * 2008-10-31 2021-11-16 詹森生物科技公司 人胚胎干细胞向胰腺内分泌谱系的分化
RU2528861C2 (ru) 2008-10-31 2014-09-20 Сентокор Орто Байотек Инк. Дифференцирование человеческих эмбриональных стволовых клеток в линию панкреатических эндокринных клеток
NZ592622A (en) * 2008-11-04 2012-10-26 Viacyte Inc Stem cell aggregate suspension compositions and methods for differentiation thereof
US8895300B2 (en) 2008-11-04 2014-11-25 Viacyte, Inc. Scalable primate pluripotent stem cell aggregate suspension culture and differentiation thereof
US8008075B2 (en) * 2008-11-04 2011-08-30 Viacyte, Inc. Stem cell aggregate suspension compositions and methods of differentiation thereof
ES2932850T3 (es) 2008-11-14 2023-01-27 Viacyte Inc Encapsulación de células pancreáticas derivadas de células madre pluripotentes humanas
ES2584053T3 (es) 2008-11-20 2016-09-23 Janssen Biotech, Inc. Métodos y composiciones para la unión de células y cultivo en sustratos planos
WO2010059775A1 (fr) 2008-11-20 2010-05-27 Centocor Ortho Biotech Inc. Culture de cellules souches pluripotentes sur des micro-supports
ES2948761T3 (es) * 2009-02-03 2023-09-18 Koninklijke Nederlandse Akademie Van Wetenschappen Combinaciones de inhibidores de la replicación del virus de la influenza
EP2412800A1 (fr) 2010-07-29 2012-02-01 Koninklijke Nederlandse Akademie van Wetenschappen Organoïde du foie, ses utilisations et son procédé de culture pour l'obtenir
US9752124B2 (en) 2009-02-03 2017-09-05 Koninklijke Nederlandse Akademie Van Wetenschappen Culture medium for epithelial stem cells and organoids comprising the stem cells
US9109245B2 (en) 2009-04-22 2015-08-18 Viacyte, Inc. Cell compositions derived from dedifferentiated reprogrammed cells
CN107603943B (zh) * 2009-04-27 2019-10-11 威盛细胞有限公司 支持多能细胞生长的小分子和其方法
RU2540021C2 (ru) 2009-07-20 2015-01-27 Янссен Байотек, Инк. Дифференцировка эмбриональных стволовых клеток человека
CN102482643B (zh) 2009-07-20 2016-06-29 詹森生物科技公司 人胚胎干细胞的分化
RU2540016C2 (ru) 2009-07-20 2015-01-27 Янссен Байотек, Инк. Дифференцировка эмбриональных стволовых клеток человека
AU2010315712B2 (en) 2009-10-19 2014-04-17 FUJIFILM Cellular Dynamics, Inc. Cardiomyocyte production
KR101135636B1 (ko) * 2009-10-27 2012-04-17 서울대학교산학협력단 인간 만능줄기세포로부터 중배엽 줄기세포를 생산하는 방법 및 이에 의해 생성된 중배엽 줄기세포
ES2932664T3 (es) * 2009-11-12 2023-01-23 Technion Res & Dev Foundation Medios de cultivo, cultivos celulares y métodos de cultivo de células madre pluripotentes en estado no diferenciado
DK2516625T3 (da) 2009-12-23 2024-09-09 Janssen Biotech Inc Differentiering af humane embryonale stamceller
CA2784425A1 (fr) 2009-12-23 2011-06-30 Centocor Ortho Biotech Inc. Differenciation de cellules souches embryonnaires humaines
KR101928299B1 (ko) 2010-03-01 2018-12-12 얀센 바이오테크 인코포레이티드 만능 줄기 세포로부터 유래된 세포의 정제 방법
CN102884176B (zh) 2010-05-12 2017-09-05 詹森生物科技公司 人胚胎干细胞的分化
AU2011296381B2 (en) 2010-08-31 2016-03-31 Janssen Biotech, Inc. Differentiation of human embryonic stem cells
PL2611910T3 (pl) 2010-08-31 2018-06-29 Janssen Biotech, Inc Różnicowanie ludzkich embrionalnych komórek macierzystych
RU2599420C2 (ru) 2010-08-31 2016-10-10 Янссен Байотек, Инк. Дифференцирование плюрипотентных стволовых клеток
US9181529B2 (en) 2010-10-19 2015-11-10 Cellular Dynamics International, Inc. Titration of differentiation medium components
CN103384680B (zh) * 2010-12-17 2015-08-26 拜奥拉米那公司 细胞培养基
JP5890100B2 (ja) * 2011-02-09 2016-03-22 雪印メグミルク株式会社 皮膚コラーゲン産生促進剤
WO2012115619A1 (fr) 2011-02-21 2012-08-30 Viacyte, Inc. Système de chargement pour un dispositif d'encapsulation
DK2694644T3 (en) 2011-03-30 2018-04-16 Cellular Dynamics Int Inc Priming of pluripotent stem cells for neural differentiation
CN102294053B (zh) * 2011-07-24 2014-10-29 陕西省眼科研究所 去细胞异种角膜基质载体及其制备方法和应用
AU2012291281B2 (en) * 2011-08-03 2015-07-02 Fuso Pharmaceutical Industries, Ltd. Composition for embryo culture
US20130130373A1 (en) 2011-11-11 2013-05-23 Essential Pharmaceuticals, Llc Kit Comprising Serum Replacement and Labile Factors
KR102203056B1 (ko) 2011-12-22 2021-01-14 얀센 바이오테크 인코포레이티드 인간 배아 줄기 세포의 단일 인슐린 호르몬 양성 세포로의 분화
KR20140131999A (ko) 2012-03-07 2014-11-14 얀센 바이오테크 인코포레이티드 만능 줄기 세포의 증폭 및 유지를 위한 한정 배지
SG10201610313WA (en) 2012-06-08 2017-02-27 Janssen Biotech Inc Differentiation of human embryonic stem cells into pancreatic endocrine cells
AU2013248265B2 (en) 2012-11-08 2018-11-01 Viacyte, Inc. Scalable primate pluripotent stem cell aggregate suspension culture and differentiation thereof
CN105705634A (zh) 2012-12-31 2016-06-22 詹森生物科技公司 用于分化成胰腺内分泌细胞的人多能细胞的悬浮和群集
US10370644B2 (en) 2012-12-31 2019-08-06 Janssen Biotech, Inc. Method for making human pluripotent suspension cultures and cells derived therefrom
KR102084561B1 (ko) 2012-12-31 2020-03-04 얀센 바이오테크 인코포레이티드 췌장 내분비 세포로의 분화를 위한 공기-액체 계면에서의 인간 배아 줄기세포의 배양
DK2938723T3 (da) 2012-12-31 2023-02-20 Janssen Biotech Inc Differentiering af humane embryonale stamceller til pancreatiske endokrine celler under anvendelse af hb9-regulatorer
JP6234485B2 (ja) 2013-03-07 2017-11-22 ヴィアサイト インコーポレイテッド 3次元大収容力細胞封入デバイスアセンブリー
USD720469S1 (en) 2013-03-07 2014-12-30 Viacyte, Inc. Cell encapsulation device
US8859286B2 (en) 2013-03-14 2014-10-14 Viacyte, Inc. In vitro differentiation of pluripotent stem cells to pancreatic endoderm cells (PEC) and endocrine cells
CN105283541B (zh) * 2013-05-30 2019-02-19 味之素株式会社 干细胞培养用培养基
CN110551678B (zh) 2013-06-11 2024-02-20 哈佛学院校长同事会 SC-β细胞以及用于产生其的组合物和方法
US9527401B2 (en) * 2014-01-23 2016-12-27 Johnson Controls Technology Company Semi-active architectures for batteries having two different chemistries
JP2014036660A (ja) * 2013-10-09 2014-02-27 Viacyte Inc 幹細胞集合体懸濁液組成物、その分化方法
TW201527534A (zh) 2013-12-20 2015-07-16 Essential Pharmaceticals Llc 細胞培養基
USD734483S1 (en) * 2013-12-31 2015-07-14 Alamak Biosciences Incorporation Company Limited Tissue cell block for cancer detection
KR20160142340A (ko) * 2014-03-31 2016-12-12 아지노모토 가부시키가이샤 간세포용 배지
US11051900B2 (en) 2014-04-16 2021-07-06 Viacyte, Inc. Tools and instruments for use with implantable encapsulation devices
WO2015173425A1 (fr) 2014-05-16 2015-11-19 Koninklijke Nederlandse Akademie Van Wetenschappen Procédé de culture amélioré pour organoïdes
DK3143127T3 (da) 2014-05-16 2021-09-13 Janssen Biotech Inc Anvendelse af små molekyler til at forstærke mafa-ekspression i endokrine pankreasceller
GB201421094D0 (en) 2014-11-27 2015-01-14 Koninklijke Nederlandse Akademie Van Wetenschappen Culture medium
GB201421092D0 (en) 2014-11-27 2015-01-14 Koninklijke Nederlandse Akademie Van Wetenschappen Culture medium
EP3234110B1 (fr) 2014-12-18 2024-02-28 President and Fellows of Harvard College PROCÉDÉS DE GÉNÉRATION DE CELLULES ß DÉRIVÉES DE CELLULES SOUCHES ET LEURS UTILISATIONS
US10443042B2 (en) 2014-12-18 2019-10-15 President And Fellows Of Harvard College Serum-free in vitro directed differentiation protocol for generating stem cell-derived beta cells and uses thereof
US10253298B2 (en) 2014-12-18 2019-04-09 President And Fellows Of Harvard College Methods for generating stem cell-derived beta cells and methods of use thereof
GB201603569D0 (en) 2016-03-01 2016-04-13 Koninklijke Nederlandse Akademie Van Wetenschappen Improved differentiation method
MA45479A (fr) 2016-04-14 2019-02-20 Janssen Biotech Inc Différenciation de cellules souches pluripotentes en cellules de l'endoderme de l'intestin moyen
CN110167455B (zh) 2016-11-10 2022-10-11 韦尔赛特公司 含有pdx1胰腺内胚层细胞的细胞递送装置及其方法
GB201700504D0 (en) * 2017-01-11 2017-02-22 Francis Crick Inst Ltd Composition
DK3436568T3 (da) 2017-05-31 2023-09-18 Promocell Gmbh Kulturmedium til pluripotente stamceller
WO2018232180A1 (fr) 2017-06-14 2018-12-20 Semma Therapeutics, Inc. Dispositifs et méthodes d'administration de substances thérapeutiques
US10391156B2 (en) 2017-07-12 2019-08-27 Viacyte, Inc. University donor cells and related methods
WO2019099725A1 (fr) 2017-11-15 2019-05-23 Semma Therapeutics, Inc. Compositions pour la fabrication de cellules d'ilôts et procédés d'utilisation
CA3108275A1 (fr) 2018-08-10 2020-02-13 Vertex Pharmaceuticals Incorporated Differenciation d'ilot derive de cellules souches
US10724052B2 (en) 2018-09-07 2020-07-28 Crispr Therapeutics Ag Universal donor cells
WO2020243663A1 (fr) 2019-05-31 2020-12-03 W. L. Gore & Associates, Inc. Composite à membrane biocompatible
WO2020243666A1 (fr) 2019-05-31 2020-12-03 W. L. Gore & Associates, Inc. Composite à membrane biocompatible
EP3975925A1 (fr) 2019-05-31 2022-04-06 W.L. Gore & Associates, Inc. Composite à membrane biocompatible
EP3976237A1 (fr) 2019-05-31 2022-04-06 W.L. Gore & Associates Inc. Dispositifs d'encapsulation de cellules présentant des distances de diffusion d'oxygène régulées
CN114364791A (zh) 2019-09-05 2022-04-15 克里斯珀医疗股份公司 通用供体细胞
CN114375300A (zh) 2019-09-05 2022-04-19 克里斯珀医疗股份公司 通用供体细胞
CN112779209B (zh) * 2019-11-08 2023-01-24 合肥中科普瑞昇生物医药科技有限公司 原代乳腺上皮细胞培养基、培养方法及其应用
KR102268242B1 (ko) * 2020-01-06 2021-06-23 에스씨엠생명과학 주식회사 줄기세포의 기능강화용 조성물
CN111492979B (zh) * 2020-05-25 2022-03-22 四川天艺生态园林集团股份有限公司 一种小报春体细胞胚诱导方法
EP4271795A1 (fr) 2020-12-31 2023-11-08 CRISPR Therapeutics AG Cellules donneuses universelles
US11735303B2 (en) 2021-06-22 2023-08-22 David Haase Apparatus and method for determining a composition of a replacement therapy treatment

Family Cites Families (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0505148A1 (fr) 1991-03-17 1992-09-23 Yeda Research And Development Company Limited Facteur stimulateur du neu-recepteur
KR950701379A (ko) 1992-04-29 1995-03-23 예다 리서치 앤드 디벨럽먼트 캄파니 리미티드 neu 수용체의 재조합 자극인자(RECOMBINANT STIMULATING FACTOR OF THE neu RECEPTOR)
US5453357A (en) 1992-10-08 1995-09-26 Vanderbilt University Pluripotential embryonic stem cells and methods of making same
WO1994028133A1 (fr) 1993-05-21 1994-12-08 Amgen Inc. FACTEURS DE DIFFERENCIATION RECOMBINES DE $i(NEU)
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
US6225282B1 (en) 1996-01-05 2001-05-01 Genentech, Inc. Treatment of hearing impairments
EP0885308A4 (fr) 1996-02-28 2002-02-27 Univ Vanderbilt Compositions et procedes de production de cellules souches embryonnaires
CA2258721C (fr) * 1996-07-12 2014-09-09 Genentech, Inc. Adhesines heteromultimeres chimeriques
JP2001508302A (ja) * 1997-01-10 2001-06-26 ライフ テクノロジーズ,インコーポレイテッド 胚性幹細胞血清置換
US6136558A (en) 1997-02-10 2000-10-24 Genentech, Inc. Heregulin variants
EP0970207B1 (fr) 1997-02-10 2009-04-01 Genentech, Inc. Variants d'hereguline
US6331406B1 (en) 1997-03-31 2001-12-18 The John Hopkins University School Of Medicine Human enbryonic germ cell and methods of use
AU7984498A (en) * 1997-06-25 1999-01-04 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Serum-free cell growth medium
ATE438720T1 (de) * 1998-02-04 2009-08-15 Genentech Inc Verwendung des heregulins als epithelzellenwachstumsfaktor
JP2002517982A (ja) 1998-04-09 2002-06-25 ブレサゲン リミテッド 細胞の分化/増殖および維持因子ならびにそれらの使用
US6667176B1 (en) 2000-01-11 2003-12-23 Geron Corporation cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells
US6875607B1 (en) 1998-11-09 2005-04-05 Es Cell International Pte Ltd Embryonic stem cells
ES2307505T3 (es) * 1999-04-06 2008-12-01 Genentech, Inc. Utilizacion de ligandos receptores de erbb en el tratamiento de la diabetes.
WO2001005940A2 (fr) * 1999-07-16 2001-01-25 Neurotrophic Bioscience, Inc. Methodes de production et de preparation de cellules pour une therapie cellulaire
US7439064B2 (en) * 2000-03-09 2008-10-21 Wicell Research Institute, Inc. Cultivation of human embryonic stem cells in the absence of feeder cells or without conditioned medium
EP1272647B1 (fr) * 2000-04-11 2014-11-12 Genentech, Inc. Anticorps multivalents et leurs utilisations
US20030096414A1 (en) * 2001-03-27 2003-05-22 Invitrogen Corporation Culture medium for cell growth and transfection
US7432104B2 (en) 2001-08-06 2008-10-07 Bresgen Inc. Methods for the culture of human embryonic stem cells on human feeder cells
AU2002360424A1 (en) * 2001-11-26 2003-06-10 Advanced Cell Technology, Inc. Methods for making and using reprogrammed human somatic cell nuclei and autologous and isogenic human stem cells
CA2475356A1 (fr) * 2002-02-12 2003-08-21 Raven Biotechnologies, Inc. Cellules epitheliales derivees d'une vessie foetale humaine
AU2003228225B2 (en) * 2002-03-01 2010-05-13 Roger Williams Hospital SHC protein-related methods and compositions for the prognosis of breast, prostate and ovarian cancer
US20060121607A1 (en) 2002-08-08 2006-06-08 Thomas Schulz Compositions and methods for neural differentiation of embryonic stem cells
EP1539928A4 (fr) * 2002-09-06 2006-09-06 Amcyte Inc Cellules progenitrices endocrines pancreatiques positives cd56 chez l'etre humain adulte
AU2003276924A1 (en) 2002-09-25 2004-04-19 Bresagen, Inc. Compositions and methods for enrichment of neural stem cells using ceramide analogs
US20040121464A1 (en) * 2002-09-30 2004-06-24 Rathjen Peter David Method for the preparation of cells of mesodermal lineage
US20050031598A1 (en) * 2002-12-10 2005-02-10 Shulamit Levenberg Engineering three-dimensional tissue structures using differentiating embryonic stem cells
WO2004076624A2 (fr) 2002-12-18 2004-09-10 Bresagen, Inc. Compositions et methodes pour une production et pour une stabilisation de cellules nerveuses
WO2004090110A2 (fr) 2003-03-31 2004-10-21 Bresagen Inc. Compositions et procedes pour la regulation, la differenciation et/ou la manipulation de cellules multipotentes par l'intermediaire d'une voie de signalisation de gamma-secretase
EP1613661B1 (fr) * 2003-04-04 2011-06-29 Université de Lausanne Peptabody pour le traitement du cancer
US7820439B2 (en) * 2003-09-03 2010-10-26 Reliance Life Sciences Pvt Ltd. In vitro generation of GABAergic neurons from pluripotent stem cells
US20060030042A1 (en) 2003-12-19 2006-02-09 Ali Brivanlou Maintenance of embryonic stem cells by the GSK-3 inhibitor 6-bromoindirubin-3'-oxime
US8586357B2 (en) 2003-12-23 2013-11-19 Viacyte, Inc. Markers of definitive endoderm
EP2722387B1 (fr) * 2003-12-23 2019-12-11 Viacyte, Inc. Endoderme définitif
US7541185B2 (en) 2003-12-23 2009-06-02 Cythera, Inc. Methods for identifying factors for differentiating definitive endoderm
US7985585B2 (en) 2004-07-09 2011-07-26 Viacyte, Inc. Preprimitive streak and mesendoderm cells
US20050266554A1 (en) 2004-04-27 2005-12-01 D Amour Kevin A PDX1 expressing endoderm
US8647873B2 (en) 2004-04-27 2014-02-11 Viacyte, Inc. PDX1 expressing endoderm
DE602004026917D1 (de) * 2003-12-26 2010-06-10 Makoto Asashima Basalmedium zur kultivierung von es-zellen
WO2005065354A2 (fr) 2003-12-31 2005-07-21 The Burnham Institute Milieu défini pour culture de cellules souches pluripotentes
WO2005071063A1 (fr) * 2004-01-27 2005-08-04 The Hospital For Sick Children Methodes de fabrication et d'utilisation de cellules souches derivees de la peau
WO2005080598A1 (fr) * 2004-02-19 2005-09-01 Dainippon Sumitomo Pharma Co., Ltd. Methode de criblage d'amorceurs de noyaux de cellules somatiques
EP1740612B1 (fr) 2004-04-27 2019-08-07 Viacyte, Inc. Endoderme exprimant pdx1
WO2006004149A1 (fr) * 2004-07-06 2006-01-12 Kyowa Hakko Kogyo Co., Ltd. Procédé de fabrication de cellules nerveuses
EP1786896B1 (fr) 2004-07-09 2018-01-10 Viacyte, Inc. Methodes d'identification de facteurs pour differencier l'endoderme definitif
DK2341147T3 (da) 2004-07-09 2019-11-11 Viacyte Inc Præprimitive stribe- og mesendodermceller
JP2006042663A (ja) * 2004-08-03 2006-02-16 Reprocell Inc Es細胞の識別マーカー
WO2006020919A2 (fr) 2004-08-13 2006-02-23 University Of Georgia Research Foundation, Inc. Compositions et procedes d'auto-renouvellement et de differentiation dans des cellules souches embryonnaires humaines
WO2007002210A2 (fr) 2005-06-20 2007-01-04 Bresagen, Inc. Compositions de culture de cellules souches embryonnaires et methodes d’utilisation de celles-ci
ES2743202T3 (es) 2005-10-27 2020-02-18 Viacyte Inc Endodermo de intestino proximal dorsal y ventral que expresa PDX1
US8278104B2 (en) 2005-12-13 2012-10-02 Kyoto University Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2
CA2643478C (fr) 2006-02-23 2019-06-18 Novocell, Inc. Compositions et procedes utiles pour la culture de cellules differenciables
WO2007103282A2 (fr) 2006-03-02 2007-09-13 Cythera, Inc. Cellules precurseurs endocrines, cellules exprimant des hormones pancreatiques et procedes de productions associes
WO2007147165A2 (fr) 2006-06-16 2007-12-21 Bresagen, Inc. Compositions de culture de cellules souches cancéreuses humaines comprenant des variants d'erbb2 et leurs procédés d'utilisation
JP2010518459A (ja) 2007-02-14 2010-05-27 ミューズアミ, インコーポレイテッド 配布オーディオファイル編集用ウェブポータル
US7695963B2 (en) 2007-09-24 2010-04-13 Cythera, Inc. Methods for increasing definitive endoderm production
US8623650B2 (en) 2007-10-19 2014-01-07 Viacyte, Inc. Methods and compositions for feeder-free pluripotent stem cell media containing human serum
US20090298178A1 (en) 2008-06-03 2009-12-03 D Amour Kevin Allen Growth factors for production of definitive endoderm

Also Published As

Publication number Publication date
DK2420565T3 (en) 2017-12-04
SG170021A1 (en) 2011-04-29
CN105802904A (zh) 2016-07-27
JP5830217B2 (ja) 2015-12-09
US8153429B2 (en) 2012-04-10
CN101410509B (zh) 2016-05-18
KR20080109775A (ko) 2008-12-17
AU2007220759A1 (en) 2007-09-07
WO2007101130A3 (fr) 2007-12-27
EP1994141A2 (fr) 2008-11-26
US8415158B2 (en) 2013-04-09
US8211699B2 (en) 2012-07-03
EP1994141A4 (fr) 2009-04-22
EP2420565B1 (fr) 2017-08-30
CN105802904B (zh) 2021-04-20
SG10202109176RA (en) 2021-09-29
CA2643478A1 (fr) 2007-09-07
CA2643478C (fr) 2019-06-18
CN101410509A (zh) 2009-04-15
JP2016005462A (ja) 2016-01-14
US20080113433A1 (en) 2008-05-15
US20130309708A1 (en) 2013-11-21
JP2014097063A (ja) 2014-05-29
DK1994141T3 (en) 2018-02-12
US8658352B2 (en) 2014-02-25
JP5719919B2 (ja) 2015-05-20
CN113088483A (zh) 2021-07-09
US20140154802A1 (en) 2014-06-05
US20080268534A1 (en) 2008-10-30
EP2420565A1 (fr) 2012-02-22
EP1994141B1 (fr) 2017-11-15
WO2007101130A2 (fr) 2007-09-07
US20120214237A1 (en) 2012-08-23
JP2009528034A (ja) 2009-08-06
US20160145569A1 (en) 2016-05-26

Similar Documents

Publication Publication Date Title
SG10201405107YA (en) Compositions and methods useful for culturing differentiable cells
EP2148569A4 (fr) Procédés et compositions pour auto-renouvellement de cellules souches
EP2064324A4 (fr) Substrats utiles pour une culture de cellules, et leurs procédés de fabrication et d'utilisation
EP2089507A4 (fr) Dispositifs et procédés particulièrement efficaces dans la culture de cellules
EP2012806A4 (fr) Procédés et compositions permettant de modifier la fonction cellulaire
HK1177950A1 (en) Oligopeptide-free cell culture media
SG10201510384UA (en) Cell culture improvements
IL201225A0 (en) Method for evaluating the composition of a cell culture and cell phenotype
GB0613756D0 (en) Cell culture medium
IL196322A0 (en) Improved process for the culturing of cells
IL195619A0 (en) Compositions and methods for joininig non-conjoined iumens
EP1997877A4 (fr) Substrat de culture de cellules
IL194894A0 (en) Substrate for the growth of cultured cells in three dimensions
ZA200908481B (en) Compositions and methods for altering gene expression
EP2235201A4 (fr) Procédés et compositions pour le dosage de l'homocystéine
EP2162531A4 (fr) Procédé et moyens pour cultiver des ostéoblastes
EP2235033A4 (fr) Procédés et compositions destinés à augmenter l'expression génique
EP2054501A4 (fr) Procedes et kits pour l'isolement de cellules
EP2344625A4 (fr) Methodes et compositions de microstructuration a haute resolution pour la culture de cellules
IL205248A0 (en) Compositions and methods for making androstenediones
ZA200806434B (en) Calcium-enrichment compositions and methods for production thereof
GB0606671D0 (en) Cell Culture
GB0608403D0 (en) Substrate for the routine growth of cultured cells in three dimensions
EP2115127A4 (fr) Procédés et compositions pour améliorer la santé de cellules en culture
GB0606430D0 (en) Method for cell based assays