SE9703376D0 - A new combination - Google Patents
A new combinationInfo
- Publication number
- SE9703376D0 SE9703376D0 SE9703376A SE9703376A SE9703376D0 SE 9703376 D0 SE9703376 D0 SE 9703376D0 SE 9703376 A SE9703376 A SE 9703376A SE 9703376 A SE9703376 A SE 9703376A SE 9703376 D0 SE9703376 D0 SE 9703376D0
- Authority
- SE
- Sweden
- Prior art keywords
- combination
- pct
- alkyl
- enantiomer
- sec
- Prior art date
Links
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 229940123685 Monoamine oxidase inhibitor Drugs 0.000 abstract 1
- 208000019022 Mood disease Diseases 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 abstract 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000002899 monoamine oxidase inhibitor Substances 0.000 abstract 1
- 239000004031 partial agonist Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (28)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9703376A SE9703376D0 (sv) | 1997-09-18 | 1997-09-18 | A new combination |
| ZA987804A ZA987804B (en) | 1997-09-18 | 1998-08-27 | A combination of a monoamine oxidase inhibitor and a H5-HT1b antagonists or agonist |
| KR1020007002835A KR20010024087A (ko) | 1997-09-18 | 1998-09-09 | 모노아민 옥시다제 억제제 및 ｈ5-ＨＴ1Ｂ 길항제 또는부분 작용제의 배합물 |
| MXPA00002616A MXPA00002616A (es) | 1997-09-18 | 1998-09-09 | Combinacion de un inhibidor de la monoamina-oxidasa y un antagonista o agonista parcial de h5-ht1b. |
| IL13477598A IL134775A0 (en) | 1997-09-18 | 1998-09-09 | A COMBINATION OF A MONOAMINE OXIDASE INHIBITOR AND A h5-HT1B ANTAGONIST OR PARTIAL AGONIST |
| BR9812236-3A BR9812236A (pt) | 1997-09-18 | 1998-09-09 | Combinação de componentes, uso desta, processos para a preparação da mesma, para o tratamento de distúrbios afetivos, para o tratamento de depressão, e para melhorar o inìcio de ação terapêutica, formulação farmacêutica, e, kit |
| DK98944376T DK1014986T3 (da) | 1997-09-18 | 1998-09-09 | Kombination af en inhibitor for monoaminoxidase og en antagonist eller delvis agonist for h5-HT 1 beta |
| JP2000511500A JP2001516719A (ja) | 1997-09-18 | 1998-09-09 | モノアミンオキシダーゼ阻害剤およびｈ５−ＨＴ１Ｂアンタゴニストまたは部分的アゴニストの組み合わせ |
| CA002302204A CA2302204A1 (en) | 1997-09-18 | 1998-09-09 | A combination of a monoamine oxidase inhibitor and a h5-ht1b antagonist or partial agonist |
| IDW20000522D ID25789A (id) | 1997-09-18 | 1998-09-09 | KOMBINASI DARI INHIBITOR MONOAMINA OKSIDASI DAN ANTAGONIS ATAU SEBAGIAN AGONIS h5-HT1B |
| AT98944376T ATE270889T1 (de) | 1997-09-18 | 1998-09-09 | Monoaminoxidase inhibitor- und h5-ht 1 beta antagonist oder partiellagonist enthaltende mischung |
| AU91931/98A AU752719B2 (en) | 1997-09-18 | 1998-09-09 | A combination of a monoamine oxidase inhibitor and a h5-HT 1B antagonist or partial agonist |
| HU0100621A HUP0100621A2 (hu) | 1997-09-18 | 1998-09-09 | Monoamin oxidáz inhibitor hatású vegyületek és h5-HT1B antagonista vagy részleges agonista hatású vegyületek kombinációját tartalmazó gyógyászati készítmények |
| SK283-2000A SK2832000A3 (en) | 1997-09-18 | 1998-09-09 | A COMBINATION OF A MONOAMINE OXIDASE INHIBITOR AND A H5-HT1Bì (54) ANTAGONIST OR PARTIAL AGONIST |
| PL98339368A PL339368A1 (en) | 1997-09-18 | 1998-09-09 | Composition of monoamine oxidase inhibitor and antagonist or partial agonist of h5-ht 1b |
| US09/171,578 US6159970A (en) | 1997-09-18 | 1998-09-09 | Combination of a monoamine oxidase inhibitor and a h5-HT1B antagonist or partial agonist |
| PT98944376T PT1014986E (pt) | 1997-09-18 | 1998-09-09 | Uma combinacao de um inibidor da monoamino-oxidase e de um antagonista ou de umagonista parcial do h5-ht 1 beta |
| CN98811114A CN1278727A (zh) | 1997-09-18 | 1998-09-09 | 单胺氧化酶抑制剂和h5－ht1B拮抗剂或部分激动剂的组合 |
| KR1020007002830A KR20010024084A (ko) | 1997-09-18 | 1998-09-09 | 모노아민 옥시다제 억제제 및 ｈ5-ＨＴ1Ｂ 길항제 또는부분 작용제의 배합물 |
| DE69825062T DE69825062T2 (de) | 1997-09-18 | 1998-09-09 | Monoaminoxidase inhibitor- und h5-ht 1 beta antagonist oder partiellagonist enthaltende mischung |
| EP98944376A EP1014986B1 (en) | 1997-09-18 | 1998-09-09 | A COMBINATION OF A MONOAMINE OXIDASE INHIBITOR AND A h5-HT 1 BETA ANTAGONIST OR PARTIAL AGONIST |
| EEP200000146A EE200000146A (et) | 1997-09-18 | 1998-09-09 | Monoamiini oksüdaasi inhibiitori kombinatsioon h5-HT 1B antagonisti või osalise agonistiga |
| TR2000/00725T TR200000725T2 (tr) | 1997-09-18 | 1998-09-09 | Bir monoamin oksidaz inhibitörü ve h5-HT1B antagonistinin bileşimi |
| PCT/SE1998/001602 WO1999013878A1 (en) | 1997-09-18 | 1998-09-09 | A COMBINATION OF A MONOAMINE OXIDASE INHIBITOR AND A h5-HT1B ANTAGONIST OR PARTIAL AGONIST |
| ES98944376T ES2222603T3 (es) | 1997-09-18 | 1998-09-09 | Una combinacion de un inhibidor de la monoamino-oxidasa y un antagonista o agonista parcial de h5-ht1 beta. |
| ARP980104635A AR013503A1 (es) | 1997-09-18 | 1998-09-17 | Una combinacion de un inhibidor de la monoamina oxidasa y un antagonista o agonista parcial selectivo de h5-ht(1b), formulacion farmaceutica, usos ymetodo de preparacion |
| IS5401A IS5401A (is) | 1997-09-18 | 2000-03-14 | Samsetning mónóamínoxídasa hemils og h5-HT1B mótlyfs eða gerandefnis með hlutaverkun |
| NO20001400A NO20001400L (no) | 1997-09-18 | 2000-03-17 | Kombinasjon av en monoaminooksidaseinhibitor og en h5-HT1B antagonist eller partiell agonist |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9703376A SE9703376D0 (sv) | 1997-09-18 | 1997-09-18 | A new combination |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SE9703376D0 true SE9703376D0 (sv) | 1997-09-18 |
Family
ID=20408296
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE9703376A SE9703376D0 (sv) | 1997-09-18 | 1997-09-18 | A new combination |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US6159970A (enExample) |
| EP (1) | EP1014986B1 (enExample) |
| JP (1) | JP2001516719A (enExample) |
| KR (2) | KR20010024087A (enExample) |
| CN (1) | CN1278727A (enExample) |
| AR (1) | AR013503A1 (enExample) |
| AT (1) | ATE270889T1 (enExample) |
| AU (1) | AU752719B2 (enExample) |
| BR (1) | BR9812236A (enExample) |
| CA (1) | CA2302204A1 (enExample) |
| DE (1) | DE69825062T2 (enExample) |
| DK (1) | DK1014986T3 (enExample) |
| EE (1) | EE200000146A (enExample) |
| ES (1) | ES2222603T3 (enExample) |
| HU (1) | HUP0100621A2 (enExample) |
| ID (1) | ID25789A (enExample) |
| IL (1) | IL134775A0 (enExample) |
| IS (1) | IS5401A (enExample) |
| MX (1) | MXPA00002616A (enExample) |
| NO (1) | NO20001400L (enExample) |
| PL (1) | PL339368A1 (enExample) |
| PT (1) | PT1014986E (enExample) |
| SE (1) | SE9703376D0 (enExample) |
| SK (1) | SK2832000A3 (enExample) |
| TR (1) | TR200000725T2 (enExample) |
| WO (1) | WO1999013878A1 (enExample) |
| ZA (1) | ZA987804B (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4957948A (en) * | 1988-05-05 | 1990-09-18 | Interface, Inc. | Biocidal protective coating for heat exchanger coils |
| SE9601110D0 (sv) | 1996-03-22 | 1996-03-22 | Astra Ab | Substituted 1,2,3,4-tetrahydronaphthalene derivatives |
| WO2002066454A1 (fr) * | 2001-02-21 | 2002-08-29 | Sankyo Company, Limited | Derives de chromene |
| ES2323451T7 (es) * | 2001-07-20 | 2011-08-01 | Psychogenics Inc. | Tratamiento para el trastorno de hiperactividad con deficit de atencion. |
| US7732162B2 (en) | 2003-05-05 | 2010-06-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases |
| US20090054453A1 (en) * | 2006-03-17 | 2009-02-26 | Lilian Alcaraz | Novel Tetralins as 5-HT6 Modulators |
| US8278345B2 (en) | 2006-11-09 | 2012-10-02 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| SI2091948T1 (sl) | 2006-11-30 | 2012-07-31 | Probiodrug Ag | Novi inhibitorji glutaminil ciklaze |
| EA200901140A1 (ru) | 2007-03-01 | 2010-04-30 | Пробиодруг Аг | Новое применение ингибиторов глутаминилциклазы |
| EP2142514B1 (en) | 2007-04-18 | 2014-12-24 | Probiodrug AG | Thiourea derivatives as glutaminyl cyclase inhibitors |
| CN102695546B (zh) | 2009-09-11 | 2014-09-10 | 前体生物药物股份公司 | 作为谷氨酰胺酰环化酶抑制剂的杂环衍生物 |
| WO2011107530A2 (en) | 2010-03-03 | 2011-09-09 | Probiodrug Ag | Novel inhibitors |
| SG183229A1 (en) | 2010-03-10 | 2012-09-27 | Probiodrug Ag | Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5) |
| EP2560953B1 (en) | 2010-04-21 | 2016-01-06 | Probiodrug AG | Inhibitors of glutaminyl cyclase |
| WO2012123563A1 (en) | 2011-03-16 | 2012-09-20 | Probiodrug Ag | Benz imidazole derivatives as inhibitors of glutaminyl cyclase |
| DK3461819T3 (da) | 2017-09-29 | 2020-08-10 | Probiodrug Ag | Inhibitorer af glutaminylcyklase |
| WO2020183011A1 (en) | 2019-03-14 | 2020-09-17 | Institut Curie | Htr1d inhibitors and uses thereof in the treatment of cancer |
| CN110179988A (zh) * | 2019-07-10 | 2019-08-30 | 王大伟 | 五羟色胺再摄取抑制剂和单胺氧化酶抑制剂联合在制备治疗抑郁症或早泄药物中的应用 |
| EP4633638A1 (en) * | 2022-12-14 | 2025-10-22 | Luminous Mind Inc. | Treatment of psychological factors affecting other medical conditions (pfaomc) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9119932D0 (en) * | 1991-09-18 | 1991-10-30 | Glaxo Group Ltd | Chemical compounds |
| DE69232003T2 (de) * | 1991-09-18 | 2002-04-25 | Glaxo Group Ltd., Greenford | Benzanilidderivate als 5-HT1D-Antagonisten |
| SE9601110D0 (sv) * | 1996-03-22 | 1996-03-22 | Astra Ab | Substituted 1,2,3,4-tetrahydronaphthalene derivatives |
-
1997
- 1997-09-18 SE SE9703376A patent/SE9703376D0/xx unknown
-
1998
- 1998-08-27 ZA ZA987804A patent/ZA987804B/xx unknown
- 1998-09-09 IL IL13477598A patent/IL134775A0/xx unknown
- 1998-09-09 WO PCT/SE1998/001602 patent/WO1999013878A1/en not_active Ceased
- 1998-09-09 CN CN98811114A patent/CN1278727A/zh active Pending
- 1998-09-09 PT PT98944376T patent/PT1014986E/pt unknown
- 1998-09-09 DK DK98944376T patent/DK1014986T3/da active
- 1998-09-09 KR KR1020007002835A patent/KR20010024087A/ko not_active Ceased
- 1998-09-09 KR KR1020007002830A patent/KR20010024084A/ko not_active Withdrawn
- 1998-09-09 PL PL98339368A patent/PL339368A1/xx unknown
- 1998-09-09 US US09/171,578 patent/US6159970A/en not_active Expired - Fee Related
- 1998-09-09 BR BR9812236-3A patent/BR9812236A/pt not_active IP Right Cessation
- 1998-09-09 CA CA002302204A patent/CA2302204A1/en not_active Abandoned
- 1998-09-09 EP EP98944376A patent/EP1014986B1/en not_active Expired - Lifetime
- 1998-09-09 ID IDW20000522D patent/ID25789A/id unknown
- 1998-09-09 TR TR2000/00725T patent/TR200000725T2/xx unknown
- 1998-09-09 JP JP2000511500A patent/JP2001516719A/ja active Pending
- 1998-09-09 AT AT98944376T patent/ATE270889T1/de not_active IP Right Cessation
- 1998-09-09 HU HU0100621A patent/HUP0100621A2/hu unknown
- 1998-09-09 SK SK283-2000A patent/SK2832000A3/sk unknown
- 1998-09-09 ES ES98944376T patent/ES2222603T3/es not_active Expired - Lifetime
- 1998-09-09 DE DE69825062T patent/DE69825062T2/de not_active Expired - Fee Related
- 1998-09-09 EE EEP200000146A patent/EE200000146A/xx unknown
- 1998-09-09 MX MXPA00002616A patent/MXPA00002616A/es unknown
- 1998-09-09 AU AU91931/98A patent/AU752719B2/en not_active Ceased
- 1998-09-17 AR ARP980104635A patent/AR013503A1/es unknown
-
2000
- 2000-03-14 IS IS5401A patent/IS5401A/is unknown
- 2000-03-17 NO NO20001400A patent/NO20001400L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| US6159970A (en) | 2000-12-12 |
| DE69825062D1 (de) | 2004-08-19 |
| SK2832000A3 (en) | 2000-09-12 |
| CA2302204A1 (en) | 1999-03-25 |
| NO20001400L (no) | 2000-05-05 |
| NO20001400D0 (no) | 2000-03-17 |
| ZA987804B (en) | 1999-03-18 |
| HUP0100621A2 (hu) | 2001-08-28 |
| ES2222603T3 (es) | 2005-02-01 |
| AU752719B2 (en) | 2002-09-26 |
| EP1014986A1 (en) | 2000-07-05 |
| JP2001516719A (ja) | 2001-10-02 |
| MXPA00002616A (es) | 2002-04-24 |
| DK1014986T3 (da) | 2004-10-25 |
| IS5401A (is) | 2000-03-14 |
| EE200000146A (et) | 2001-02-15 |
| CN1278727A (zh) | 2001-01-03 |
| ID25789A (id) | 2000-11-02 |
| ATE270889T1 (de) | 2004-07-15 |
| AR013503A1 (es) | 2000-12-27 |
| PT1014986E (pt) | 2004-10-29 |
| EP1014986B1 (en) | 2004-07-14 |
| KR20010024084A (ko) | 2001-03-26 |
| PL339368A1 (en) | 2000-12-18 |
| BR9812236A (pt) | 2000-07-18 |
| KR20010024087A (ko) | 2001-03-26 |
| IL134775A0 (en) | 2001-04-30 |
| TR200000725T2 (tr) | 2000-08-21 |
| DE69825062T2 (de) | 2005-08-25 |
| AU9193198A (en) | 1999-04-05 |
| WO1999013878A1 (en) | 1999-03-25 |
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