SE9103612D0 - New peptide derivatives - Google Patents

New peptide derivatives

Info

Publication number
SE9103612D0
SE9103612D0 SE9103612A SE9103612A SE9103612D0 SE 9103612 D0 SE9103612 D0 SE 9103612D0 SE 9103612 A SE9103612 A SE 9103612A SE 9103612 A SE9103612 A SE 9103612A SE 9103612 D0 SE9103612 D0 SE 9103612D0
Authority
SE
Sweden
Prior art keywords
peptide derivatives
new peptide
hypercoaguability
treating
disclosed
Prior art date
Application number
SE9103612A
Other languages
English (en)
Swedish (sv)
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Priority to SE9103612A priority Critical patent/SE9103612D0/xx
Publication of SE9103612D0 publication Critical patent/SE9103612D0/xx
Priority to TW081109412A priority patent/TW223078B/zh
Priority to ZA929099A priority patent/ZA929099B/xx
Priority to IL103910A priority patent/IL103910A0/xx
Priority to EP92924993A priority patent/EP0618926B1/en
Priority to AT92924993T priority patent/ATE190066T1/de
Priority to NZ246106A priority patent/NZ246106A/en
Priority to PCT/SE1992/000832 priority patent/WO1993011152A1/en
Priority to CZ953338A priority patent/CZ333895A3/cs
Priority to NZ280762A priority patent/NZ280762A/en
Priority to DE69230727T priority patent/DE69230727T2/de
Priority to CA002125175A priority patent/CA2125175C/en
Priority to JP51005393A priority patent/JP3306826B2/ja
Priority to CZ941296A priority patent/CZ129694A3/cs
Priority to AU31209/93A priority patent/AU670052B2/en
Priority to HU9401474A priority patent/HUT70431A/hu
Priority to SK631-94A priority patent/SK63194A3/sk
Priority to US07/984,884 priority patent/US5614499A/en
Priority to MX9206938A priority patent/MX9206938A/es
Priority to MA23019A priority patent/MA22729A1/fr
Priority to TNTNSN92109A priority patent/TNSN92109A1/fr
Priority to IS3954A priority patent/IS3954A/is
Priority to SI19929200363A priority patent/SI9200363A/sl
Priority to CN92115304A priority patent/CN1076199A/zh
Priority to YU104592A priority patent/YU104592A/sh
Priority to APAP/P/1992/000457A priority patent/AP353A/en
Priority to FI942645A priority patent/FI115770B/fi
Priority to NO19942066A priority patent/NO311361B1/no
Priority to EE9400455A priority patent/EE9400455A/xx
Priority to US08/484,426 priority patent/US5747460A/en
Priority to US08/480,818 priority patent/US5955433A/en
Priority to US08/481,810 priority patent/US5736521A/en
Priority to AU50616/96A priority patent/AU683793B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/12—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SE9103612A 1991-12-04 1991-12-04 New peptide derivatives SE9103612D0 (sv)

Priority Applications (33)

Application Number Priority Date Filing Date Title
SE9103612A SE9103612D0 (sv) 1991-12-04 1991-12-04 New peptide derivatives
TW081109412A TW223078B (en, 2012) 1991-12-04 1992-11-24
ZA929099A ZA929099B (en) 1991-12-04 1992-11-24 New peptide derivatives.
IL103910A IL103910A0 (en) 1991-12-04 1992-11-27 New peptide derivatives and pharmaceutical compositions containing them
CA002125175A CA2125175C (en) 1991-12-04 1992-12-01 New peptide derivatives
AU31209/93A AU670052B2 (en) 1991-12-04 1992-12-01 New peptide derivatives
SK631-94A SK63194A3 (en) 1991-12-04 1992-12-01 Peptide derivatives
NZ246106A NZ246106A (en) 1991-12-04 1992-12-01 Modified peptides derived from human fibrinogen aalpha-chain
PCT/SE1992/000832 WO1993011152A1 (en) 1991-12-04 1992-12-01 New peptide derivatives
CZ953338A CZ333895A3 (en) 1991-12-04 1992-12-01 Starting compounds for synthesis of serine-prosthetic inhibitor
NZ280762A NZ280762A (en) 1991-12-04 1992-12-01 Noragmatine derivatives and their use in preparing serine protease inhibitors
DE69230727T DE69230727T2 (de) 1991-12-04 1992-12-01 Neuartige peptidderivate
AT92924993T ATE190066T1 (de) 1991-12-04 1992-12-01 Neuartige peptidderivate
JP51005393A JP3306826B2 (ja) 1991-12-04 1992-12-01 新規なペプチド誘導体
CZ941296A CZ129694A3 (en) 1991-12-04 1992-12-01 Novel peptide derivatives
EP92924993A EP0618926B1 (en) 1991-12-04 1992-12-01 New peptide derivatives
HU9401474A HUT70431A (en) 1991-12-04 1992-12-01 New peptide derivatives
MA23019A MA22729A1 (fr) 1991-12-04 1992-12-02 Nouveaux derives de peptide
US07/984,884 US5614499A (en) 1991-12-04 1992-12-02 Peptide derivatives as thrombin inhibitors
MX9206938A MX9206938A (es) 1991-12-04 1992-12-02 Nuevos derivados peptidos, proceso para su preparacion y preparacion farmaceutica que comprende tales derivados.
TNTNSN92109A TNSN92109A1 (fr) 1991-12-04 1992-12-03 Nouveaux derives de peptide
IS3954A IS3954A (is) 1991-12-04 1992-12-03 Hliðstæð aðferð við framleiðslu nýrra peptíðafleiða
SI19929200363A SI9200363A (en) 1991-12-04 1992-12-04 New peptide derivatives
CN92115304A CN1076199A (zh) 1991-12-04 1992-12-04 新的肽衍生物
YU104592A YU104592A (sh) 1991-12-04 1992-12-04 Novi peptidni derivati
APAP/P/1992/000457A AP353A (en) 1991-12-04 1992-12-04 New peptides derivatives.
FI942645A FI115770B (fi) 1991-12-04 1994-06-03 Menetelmä farmakologisesti aktiivisten peptidijohdannaisten valmistamiseksi
NO19942066A NO311361B1 (no) 1991-12-04 1994-06-03 Peptidderivater, fremgangsmåte for fremstilling, farmasöytisk preparat og anvendelse av peptidderivatene
EE9400455A EE9400455A (et) 1991-12-04 1994-11-23 Peptiidi derivaadid, nende valmistamise protsess, neid sisaldavad ravimpreparaadid ja nende kasutamine
US08/484,426 US5747460A (en) 1991-12-04 1995-06-07 Method of treatment and prophylaxis of venous thrombosis
US08/480,818 US5955433A (en) 1991-12-04 1995-06-07 Method of thrombin inhibition
US08/481,810 US5736521A (en) 1991-12-04 1995-06-07 Method of treatment and prophylaxis of arterial thrombosis
AU50616/96A AU683793B2 (en) 1991-12-04 1996-04-12 Synthesis of a serine protease inhibitor

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9103612A SE9103612D0 (sv) 1991-12-04 1991-12-04 New peptide derivatives

Publications (1)

Publication Number Publication Date
SE9103612D0 true SE9103612D0 (sv) 1991-12-04

Family

ID=20384531

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9103612A SE9103612D0 (sv) 1991-12-04 1991-12-04 New peptide derivatives

Country Status (27)

Country Link
US (4) US5614499A (en, 2012)
EP (1) EP0618926B1 (en, 2012)
JP (1) JP3306826B2 (en, 2012)
CN (1) CN1076199A (en, 2012)
AP (1) AP353A (en, 2012)
AT (1) ATE190066T1 (en, 2012)
AU (2) AU670052B2 (en, 2012)
CA (1) CA2125175C (en, 2012)
CZ (2) CZ129694A3 (en, 2012)
DE (1) DE69230727T2 (en, 2012)
EE (1) EE9400455A (en, 2012)
FI (1) FI115770B (en, 2012)
HU (1) HUT70431A (en, 2012)
IL (1) IL103910A0 (en, 2012)
IS (1) IS3954A (en, 2012)
MA (1) MA22729A1 (en, 2012)
MX (1) MX9206938A (en, 2012)
NO (1) NO311361B1 (en, 2012)
NZ (2) NZ246106A (en, 2012)
SE (1) SE9103612D0 (en, 2012)
SI (1) SI9200363A (en, 2012)
SK (1) SK63194A3 (en, 2012)
TN (1) TNSN92109A1 (en, 2012)
TW (1) TW223078B (en, 2012)
WO (1) WO1993011152A1 (en, 2012)
YU (1) YU104592A (en, 2012)
ZA (1) ZA929099B (en, 2012)

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SE9602263D0 (sv) 1996-06-07 1996-06-07 Astra Ab New amino acid derivatives
JP2000514788A (ja) * 1996-06-25 2000-11-07 イーライ・リリー・アンド・カンパニー 抗凝固剤
US6200967B1 (en) 1996-06-25 2001-03-13 Eli Lilly And Company Anticoagulant agents
SE9602646D0 (sv) 1996-07-04 1996-07-04 Astra Ab Pharmaceutically-useful compounds
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AR013084A1 (es) 1997-06-19 2000-12-13 Astrazeneca Ab Derivados de amidino utiles como inhibidores de la trombina, composicion farmaceutica, utilizacion de dichos compuestos para la preparacion demedicamentos y proceso para la preparacion de los compuestos mencionados
SE9704543D0 (sv) 1997-12-05 1997-12-05 Astra Ab New compounds
WO1999037668A1 (de) 1998-01-26 1999-07-29 Basf Aktiengesellschaft Thrombininhibitoren
JP2003529528A (ja) * 1998-04-24 2003-10-07 ３−ディメンショナル ファーマシューティカルズ， インコーポレイテッド プロテアーゼインヒビターとしてのアミノ酸アミジノヒドラゾン、アルコキシグアニジン、およびアミノグアニジン
SE9802938D0 (sv) 1998-09-01 1998-09-01 Astra Ab Improved stability for injection solutions
SE9802973D0 (sv) 1998-09-03 1998-09-03 Astra Ab Immediate release tablet
SE9804313D0 (sv) 1998-12-14 1998-12-14 Astra Ab New compounds
JP2002535250A (ja) 1999-01-13 2002-10-22 アストラゼネカ アクチボラグ 新規アミジノベンジルアミン誘導体およびトロンビン阻害物質としてのそれらの使用
KR20000060566A (ko) * 1999-03-17 2000-10-16 이경하 치환된 방향족 아미딘 유도체 및 이를 함유하는 의약조성물
AR023510A1 (es) 1999-04-21 2002-09-04 Astrazeneca Ab Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina.
AR023819A1 (es) * 1999-05-03 2002-09-04 Astrazeneca Ab FORMULACIoN FARMACEUTICA, KIT DE PARTES Y UTILIZACION DE DICHA FORMULACION
US6290662B1 (en) * 1999-05-28 2001-09-18 John K. Morris Portable, self-contained apparatus for deep vein thrombosis (DVT) prophylaxis
SE9902202D0 (sv) * 1999-06-10 1999-06-10 Astra Ab Production of aggregates
SE0001803D0 (sv) 2000-05-16 2000-05-16 Astrazeneca Ab New compounds i
US6433186B1 (en) 2000-08-16 2002-08-13 Astrazeneca Ab Amidino derivatives and their use as thormbin inhibitors
JP2002155086A (ja) * 2000-11-16 2002-05-28 Ube Ind Ltd ７ａ−アルコキシ−４Ｈ−ピラノ［３，２−ｄ］−オキサゾール−２（３Ｈ）−オン類、及びその製造法
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SE0201661D0 (sv) 2002-05-31 2002-05-31 Astrazeneca Ab New salts
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RU2712194C1 (ru) * 2019-10-02 2020-01-27 Федеральное государственное бюджетное учреждение "Государственный научно-исследовательский институт генетики и селекции промышленных микроорганизмов Национального исследовательского центра "Курчатовский институт" (НИЦ "Курчатовский институт" - ГосНИИгенетика) Антикоагулянтное лекарственное средство, представляющее собой синтетический дипептид Ac-Trp-Arg-Pip ⋅HCl, фармацевтическая композиция, включающая это антикоагулянтное лекарственное средство

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AU5061696A (en) 1996-08-01
US5747460A (en) 1998-05-05
EP0618926B1 (en) 2000-03-01
HU9401474D0 (en) 1994-08-29
FI115770B (fi) 2005-07-15
DE69230727D1 (de) 2000-04-06
FI942645L (fi) 1994-06-03
EP0618926A1 (en) 1994-10-12
MA22729A1 (fr) 1993-07-01
SK63194A3 (en) 1994-12-07
MX9206938A (es) 1993-06-01
AU670052B2 (en) 1996-07-04
US5955433A (en) 1999-09-21
CN1076199A (zh) 1993-09-15
CA2125175A1 (en) 1993-06-10
IS3954A (is) 1993-06-05
FI942645A0 (fi) 1994-06-03
CA2125175C (en) 2001-09-11
CZ129694A3 (en) 1994-12-15
DE69230727T2 (de) 2000-08-03
EE9400455A (et) 1996-06-17
WO1993011152A1 (en) 1993-06-10
ZA929099B (en) 1993-06-07
ATE190066T1 (de) 2000-03-15
IL103910A0 (en) 1993-04-04
HUT70431A (en) 1995-10-30
AP353A (en) 1994-08-14
TNSN92109A1 (fr) 1993-06-08
CZ333895A3 (en) 1996-04-17
NZ246106A (en) 1996-07-26
US5614499A (en) 1997-03-25
SI9200363A (en) 1993-06-30
NO942066L (no) 1994-06-03
US5736521A (en) 1998-04-07
YU104592A (sh) 1995-12-04
JPH09500356A (ja) 1997-01-14
TW223078B (en, 2012) 1994-05-01
AU3120993A (en) 1993-06-28
NO942066D0 (no) 1994-06-03
NO311361B1 (no) 2001-11-19
AU683793B2 (en) 1997-11-20
AP9200457A0 (en) 1993-01-31
NZ280762A (en) 1998-08-26
JP3306826B2 (ja) 2002-07-24

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