DE69813554D1 - Cyclische harnstoff- und lactamderivate von benzo(5,6)cycloheptapyridinen zur verwendung als farnesyl-protein-transferase-hemmer - Google Patents

Cyclische harnstoff- und lactamderivate von benzo(5,6)cycloheptapyridinen zur verwendung als farnesyl-protein-transferase-hemmer

Info

Publication number
DE69813554D1
DE69813554D1 DE69813554T DE69813554T DE69813554D1 DE 69813554 D1 DE69813554 D1 DE 69813554D1 DE 69813554 T DE69813554 T DE 69813554T DE 69813554 T DE69813554 T DE 69813554T DE 69813554 D1 DE69813554 D1 DE 69813554D1
Authority
DE
Germany
Prior art keywords
cycloheptapyridines
benzo
protein transferase
transferase inhibitor
cyclic urea
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69813554T
Other languages
English (en)
Other versions
DE69813554T2 (de
Inventor
George Njoroge
Bancha Vibulbhan
A Pinto
M Girijavallabhan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme Corp
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of DE69813554D1 publication Critical patent/DE69813554D1/de
Publication of DE69813554T2 publication Critical patent/DE69813554T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69813554T 1997-06-17 1998-06-15 Cyclische harnstoff- und lactamderivate von benzo(5,6)cycloheptapyridinen zur verwendung als farnesyl-protein-transferase-hemmer Expired - Lifetime DE69813554T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/877,399 US5852034A (en) 1997-06-17 1997-06-17 Benzo(5,6)cycloheptapyridine cyclic ureas and lactams useful as farnesyl protein transferase inhibitors
US877399 1997-06-17
PCT/US1998/011502 WO1998057963A1 (en) 1997-06-17 1998-06-15 Benzo(5,6)cycloheptapyridine cyclic ureas and lactams useful as farnesyl protein transferase inhibitors

Publications (2)

Publication Number Publication Date
DE69813554D1 true DE69813554D1 (de) 2003-05-22
DE69813554T2 DE69813554T2 (de) 2004-02-26

Family

ID=25369892

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69813554T Expired - Lifetime DE69813554T2 (de) 1997-06-17 1998-06-15 Cyclische harnstoff- und lactamderivate von benzo(5,6)cycloheptapyridinen zur verwendung als farnesyl-protein-transferase-hemmer

Country Status (15)

Country Link
US (2) US5852034A (de)
EP (1) EP0991644B1 (de)
JP (1) JP3515787B2 (de)
KR (1) KR20010013892A (de)
CN (1) CN1267297A (de)
AT (1) ATE237611T1 (de)
AU (1) AU744182B2 (de)
CA (1) CA2293712C (de)
DE (1) DE69813554T2 (de)
ES (1) ES2195352T3 (de)
HK (1) HK1024909A1 (de)
HU (1) HUP0004521A3 (de)
IL (1) IL133414A0 (de)
NZ (1) NZ501570A (de)
WO (1) WO1998057963A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6524832B1 (en) 1994-02-04 2003-02-25 Arch Development Corporation DNA damaging agents in combination with tyrosine kinase inhibitors
US6130229A (en) * 1996-10-09 2000-10-10 Schering Corporation Tricyclic compounds having activity as RAS-FPT inhibitors
US6211193B1 (en) * 1997-06-17 2001-04-03 Schering Corporation Compounds useful for inhibition of farnesyl protein transferase
US6632455B2 (en) 1997-12-22 2003-10-14 Schering Corporation Molecular dispersion composition with enhanced bioavailability
US6271378B1 (en) 1998-12-18 2001-08-07 Schering Corporation Process for preparing tricyclic compounds having antihistaminic activity
US6316462B1 (en) 1999-04-09 2001-11-13 Schering Corporation Methods of inducing cancer cell death and tumor regression
DK1255537T3 (da) * 2000-02-04 2006-08-21 Janssen Pharmaceutica Nv Farnesylproteintransferasehæmmere til behandling af brystcancer
AU3514302A (en) 2000-11-29 2002-06-11 Schering Corp 0ovel farnesyl protein transferase inhibitors
US20070148660A1 (en) * 2005-06-16 2007-06-28 The Regents Of The University Of California Treatment of maladaptive substance use with H-ras antagonists

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5089496A (en) * 1986-10-31 1992-02-18 Schering Corporation Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies
US5661152A (en) * 1993-10-15 1997-08-26 Schering Corporation Tricyclic sulfonamide compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
IL111235A (en) * 1993-10-15 2001-03-19 Schering Plough Corp Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them
US5719148A (en) * 1993-10-15 1998-02-17 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
JP2001521489A (ja) * 1996-09-13 2001-11-06 シェーリング コーポレイション ファルネシルタンパク質トランスフェラーゼインヒビターである三環式抗腫瘍性化合物

Also Published As

Publication number Publication date
IL133414A0 (en) 2001-04-30
CA2293712A1 (en) 1998-12-23
AU7953898A (en) 1999-01-04
EP0991644A1 (de) 2000-04-12
JP3515787B2 (ja) 2004-04-05
HK1024909A1 (en) 2000-10-27
CN1267297A (zh) 2000-09-20
NZ501570A (en) 2001-06-29
HUP0004521A2 (hu) 2001-10-28
KR20010013892A (ko) 2001-02-26
US6039683A (en) 2000-03-21
JP2000513033A (ja) 2000-10-03
ES2195352T3 (es) 2003-12-01
AU744182B2 (en) 2002-02-14
DE69813554T2 (de) 2004-02-26
EP0991644B1 (de) 2003-04-16
WO1998057963A1 (en) 1998-12-23
CA2293712C (en) 2004-01-06
HUP0004521A3 (en) 2002-01-28
US5852034A (en) 1998-12-22
ATE237611T1 (de) 2003-05-15

Similar Documents

Publication Publication Date Title
AU554362B2 (en) Carboxyalkyl dipeptides
TW368501B (en) 7-(2-aminoethyl)-benzothiazolones
DE69813554D1 (de) Cyclische harnstoff- und lactamderivate von benzo(5,6)cycloheptapyridinen zur verwendung als farnesyl-protein-transferase-hemmer
NO991229D0 (no) Substituerte benzosykloheptapyridinderivater for inhibering av farnesylproteintransferase
NO991235D0 (no) Forbindelser anvendelige for inhibering av farnesylproteintransferase
BG103271A (en) Derivatives of n-(benzothiazol-2-yl) piperidine-1-ethaneamines, method for their preparation and application as therapeutical means
AU2717100A (en) Prenyl transferase inhibitors
UA26459C2 (uk) Іhгібітор впливу амілоїдhих білків
FI953618A (fi) Kondensoituneita heterosyklisiä glutamiinijohdannaisia antiproliferatiivisina aineina
ATE94050T1 (de) Mittel zur verhinderung von zahnbelagbildung.
DE69528984D1 (de) Hemmung der leukotrienbiosynthese mittels harnstoffderivaten
NO991232D0 (no) Substituerte benzosykloheptapyridinderivater anvendelige for inhibering av farnesylproteintransferase
AU1847401A (en) Diketopiperazine derivatives to inhibit thrombin
NO991231D0 (no) Forbindelser for inhibering av farnesylproteintransferase

Legal Events

Date Code Title Description
8364 No opposition during term of opposition