ES2195352T3 - Ureas ciclicas de benzo(5,6)cicloheptapiridina y lactamas utiles como inhibidores de la farnesil-protein-transferasa. - Google Patents

Ureas ciclicas de benzo(5,6)cicloheptapiridina y lactamas utiles como inhibidores de la farnesil-protein-transferasa.

Info

Publication number
ES2195352T3
ES2195352T3 ES98930064T ES98930064T ES2195352T3 ES 2195352 T3 ES2195352 T3 ES 2195352T3 ES 98930064 T ES98930064 T ES 98930064T ES 98930064 T ES98930064 T ES 98930064T ES 2195352 T3 ES2195352 T3 ES 2195352T3
Authority
ES
Spain
Prior art keywords
sup
useful
cyclheptapiridine
lactamas
farnesil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98930064T
Other languages
English (en)
Inventor
F George Njoroge
Bancha Vibulbhan
Patrick A Pinto
Viyyoor M Girijavallabhan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme Corp
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of ES2195352T3 publication Critical patent/ES2195352T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La invención se refiere a compuestos de fórmula (I) útiles para inhibir la función Ras y por lo tanto inhibir o tratar el anormal crecimiento de células, o las sales o solvatos farmacéuticamente aceptables de éstos, en la fórmula (I) R y R{sup,2} son halo; R{sup,1} y R{sup,3} son H y halo, siempre que al menos uno sea H; W es N, CH, o C cuando el doble enlace esté presente en la posición C-11; R{sup,4} es -C(CH{sub,2}){sub,n}-R{sup,5} o (II); R{sup,5} es (III); R{sup,6} es R{sup,5} o (IV); Z{sup,1} y Z{sup,2} se seleccionan independientemente entre el grupo que consiste en =O y =S; n es 1-6 y n{sub,1} es 0, ó 1.
ES98930064T 1997-06-17 1998-06-15 Ureas ciclicas de benzo(5,6)cicloheptapiridina y lactamas utiles como inhibidores de la farnesil-protein-transferasa. Expired - Lifetime ES2195352T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/877,399 US5852034A (en) 1997-06-17 1997-06-17 Benzo(5,6)cycloheptapyridine cyclic ureas and lactams useful as farnesyl protein transferase inhibitors

Publications (1)

Publication Number Publication Date
ES2195352T3 true ES2195352T3 (es) 2003-12-01

Family

ID=25369892

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98930064T Expired - Lifetime ES2195352T3 (es) 1997-06-17 1998-06-15 Ureas ciclicas de benzo(5,6)cicloheptapiridina y lactamas utiles como inhibidores de la farnesil-protein-transferasa.

Country Status (15)

Country Link
US (2) US5852034A (es)
EP (1) EP0991644B1 (es)
JP (1) JP3515787B2 (es)
KR (1) KR20010013892A (es)
CN (1) CN1267297A (es)
AT (1) ATE237611T1 (es)
AU (1) AU744182B2 (es)
CA (1) CA2293712C (es)
DE (1) DE69813554T2 (es)
ES (1) ES2195352T3 (es)
HK (1) HK1024909A1 (es)
HU (1) HUP0004521A3 (es)
IL (1) IL133414A0 (es)
NZ (1) NZ501570A (es)
WO (1) WO1998057963A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6524832B1 (en) 1994-02-04 2003-02-25 Arch Development Corporation DNA damaging agents in combination with tyrosine kinase inhibitors
US6130229A (en) * 1996-10-09 2000-10-10 Schering Corporation Tricyclic compounds having activity as RAS-FPT inhibitors
US6211193B1 (en) * 1997-06-17 2001-04-03 Schering Corporation Compounds useful for inhibition of farnesyl protein transferase
US6632455B2 (en) 1997-12-22 2003-10-14 Schering Corporation Molecular dispersion composition with enhanced bioavailability
US6271378B1 (en) 1998-12-18 2001-08-07 Schering Corporation Process for preparing tricyclic compounds having antihistaminic activity
US6316462B1 (en) 1999-04-09 2001-11-13 Schering Corporation Methods of inducing cancer cell death and tumor regression
DK1255537T3 (da) * 2000-02-04 2006-08-21 Janssen Pharmaceutica Nv Farnesylproteintransferasehæmmere til behandling af brystcancer
US6528523B2 (en) 2000-11-29 2003-03-04 Schering Corporation Farnesyl protein transferase inhibitors
US20070148660A1 (en) * 2005-06-16 2007-06-28 The Regents Of The University Of California Treatment of maladaptive substance use with H-ras antagonists

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5089496A (en) * 1986-10-31 1992-02-18 Schering Corporation Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies
US5661152A (en) * 1993-10-15 1997-08-26 Schering Corporation Tricyclic sulfonamide compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
IL111235A (en) * 1993-10-15 2001-03-19 Schering Plough Corp Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them
US5719148A (en) * 1993-10-15 1998-02-17 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
EP0929544B1 (en) * 1996-09-13 2004-11-10 Schering Corporation Tricyclic antitumor compounds being farnesyl protein transferase inhibitors

Also Published As

Publication number Publication date
JP2000513033A (ja) 2000-10-03
CA2293712A1 (en) 1998-12-23
NZ501570A (en) 2001-06-29
IL133414A0 (en) 2001-04-30
KR20010013892A (ko) 2001-02-26
ATE237611T1 (de) 2003-05-15
US6039683A (en) 2000-03-21
HUP0004521A2 (hu) 2001-10-28
WO1998057963A1 (en) 1998-12-23
HUP0004521A3 (en) 2002-01-28
US5852034A (en) 1998-12-22
EP0991644B1 (en) 2003-04-16
DE69813554D1 (de) 2003-05-22
HK1024909A1 (en) 2000-10-27
DE69813554T2 (de) 2004-02-26
AU7953898A (en) 1999-01-04
EP0991644A1 (en) 2000-04-12
CN1267297A (zh) 2000-09-20
CA2293712C (en) 2004-01-06
AU744182B2 (en) 2002-02-14
JP3515787B2 (ja) 2004-04-05

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