ES2164881T3 - Derivados de 6-carboxamido dihidropirano. - Google Patents
Derivados de 6-carboxamido dihidropirano.Info
- Publication number
- ES2164881T3 ES2164881T3 ES96911872T ES96911872T ES2164881T3 ES 2164881 T3 ES2164881 T3 ES 2164881T3 ES 96911872 T ES96911872 T ES 96911872T ES 96911872 T ES96911872 T ES 96911872T ES 2164881 T3 ES2164881 T3 ES 2164881T3
- Authority
- ES
- Spain
- Prior art keywords
- sup
- sub
- rent
- optionally
- replaced
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- -1 AMINO, HYDROXY Chemical class 0.000 abstract 1
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- 102000005348 Neuraminidase Human genes 0.000 abstract 1
- 108010006232 Neuraminidase Proteins 0.000 abstract 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical class O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Luminescent Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
COMPUESTOS DE FORMULA (I), EN DONDE R SUP,1} REPRESENTA OR SUP,5}, SR SUP,5}, NR SUP,5}R SUP,6}, N(OR SUP,5}) R SUP,6} O N(NR SUP,5}R SUP,6})R SUP,6}; X REPRESENTA OH, N SUB,3}, NR SUP,3}R SUP,4} O NR SUP,4}CO SUB,2}R SUP,15}; Y REPRESENTA H O NHR SUP,2}; R SUP,2} REPRESENTA UN GRUPO SO SUB,2}R SUP,7} O COR SUP,7}; R SUP,3} REPRESENTA H, C SUB,1-6}ALQUIL O C( = NR SUP,8})NR SUP,9}R SUP,10}; R SUP,4} REPRESENTA H O C SUB,16}ALQUIL; R SUP,5} REPRESENTA H, C SUB,1-20}ALQUIL, C SUB,38}CICLOALQUIL, C SUB,2-20}ALQUENIL, C SUB,2-20}ALQUINIL, CHR SUP,11}COR SUP,12} O C SUB,1-20}ALQUIL SUSTITUIDO POR UNO O MAS GRUPOS SELECCIONADOS DESDE NR SUP,13}R SUP,14}, NR SUP,13}COR SUP,14}, CO SUB,2}R SUP,13}, OR SUP,13}, C SUB,38}CICLOALQUIL Y OPCIONALMENTE ARIL SUSTITUIDO; CADA R SUP,6} REPRESENTA INDEPENDIENTEMENTE H, C SUB,1-6}ALQUIL, C SUB,38}CICLOALQUIL, C SUB,2-6} ALQUENIL, C SUB,2-20}ALQUINIL, ARIL O C SUB,1-4}ALQUIL SUSTITUIDO POR UNO O MAS GRUPOS SELECCIONADOS DESDE NR SUP,13}R SUP,14}, COR SUP,13},C SUB,3-8}CICLOALQUIL, CN, N SUB,3}, OR SUP,13} Y OPCIONALMENTE ARIL SUSTITUIDO; O R SUP,5} Y R SUP,6} JUNTOS FORMAN UNA CADENA C SUB,2-6} HIDROCARBONADA QUE OPCIONALMENTE PUEDE CONTENER UN GRUPO NR SUP,13}, LA CUAL CADENA ES SUSTITUIDA OPCIONALMENTE POR 1, 2, 3, O 4 GRUPOS SELECCIONADOS DESDE GRUPOS OXO Y C SUB,1-6}ALQUIL, LOS CUALES GRUPOS PUEDEN SER OPCIONALMENTE HIDROXI SUSTITUIDOS U OPCIONALMENTE ARIL SUSTITUIDOS; R SUP,7} REPRESENTA C SUB,16}ALQUIL OPCIONALMENTE SUSTITUIDO POR UNO O MAS ATOMOS HALOGENOS, C SUB,3-8}CICLOALQUIL U OPCIONALMENTE ARIL SUSTITUIDO; R SUP,8}, R SUP,9} Y R SUP,10} REPRESENTAN CADA UNO INDEPENDIENTEMENTE H, C SUB,1-6}ALQUIL, AMINO, HIDROXI ,CIANO O NITRO; R SUP,11} REPRESENTA LA CADENA SECUNDARIA DE UN D SUP,14}, OR SUP,13} O R SUP,13}; CADA R SUP,13} Y CADA R SUP,14} REPRESENTA INDEPENDIENTEMENTE H, C SUB,1-6}ALQUIL U OPCIONALMENTE ARILC SUB,1-4}ALQUIL SUSTITUIDO; R SUP,15} REPRESENTA C SUB,1-6}ALQUIL; Y SUS DERIVADOS FARMACEUTICAMENTE ACEPTABLES SON INHIBIDORES DE LA NEURAMINIDASA UTILES EN EL TRATAMIENTO DE LAS INFECCIONES VIRICAS.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9510141.6A GB9510141D0 (en) | 1995-05-19 | 1995-05-19 | Chemical compounds |
GBGB9525389.4A GB9525389D0 (en) | 1995-12-12 | 1995-12-12 | Chemical compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2164881T3 true ES2164881T3 (es) | 2002-03-01 |
Family
ID=26307051
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES96911872T Expired - Lifetime ES2164881T3 (es) | 1995-05-19 | 1996-05-13 | Derivados de 6-carboxamido dihidropirano. |
Country Status (15)
Country | Link |
---|---|
US (1) | US5990156A (es) |
EP (1) | EP0833825B1 (es) |
JP (1) | JP4162712B2 (es) |
KR (1) | KR19990014910A (es) |
CN (1) | CN1184473A (es) |
AT (1) | ATE206116T1 (es) |
AU (1) | AU709127B2 (es) |
CA (1) | CA2220754A1 (es) |
CZ (1) | CZ366697A3 (es) |
DE (1) | DE69615555T2 (es) |
ES (1) | ES2164881T3 (es) |
HU (1) | HUP9801766A3 (es) |
NO (1) | NO975295L (es) |
PL (1) | PL323471A1 (es) |
WO (1) | WO1996036628A1 (es) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU228450B1 (en) * | 1995-02-27 | 2013-03-28 | Gilead Sciences Inc | Novel selective inhibitors of viral or bacterial neuraminidases |
US5866601A (en) * | 1995-02-27 | 1999-02-02 | Gilead Sciences, Inc. | Carbocyclic compounds |
US5763483A (en) * | 1995-12-29 | 1998-06-09 | Gilead Sciences, Inc. | Carbocyclic compounds |
US6518438B2 (en) | 1996-08-23 | 2003-02-11 | Gilead Sciences, Inc. | Preparation of cyclohexene carboxylate derivatives |
US5859284A (en) * | 1996-08-23 | 1999-01-12 | Gilead Sciences, Inc. | Preparation of carbocyclic compounds |
US5994377A (en) * | 1996-10-21 | 1999-11-30 | Gilead Sciences, Inc. | Piperidine compounds |
US5886213A (en) * | 1997-08-22 | 1999-03-23 | Gilead Sciences, Inc. | Preparation of carbocyclic compounds |
US20040053999A1 (en) * | 1997-09-17 | 2004-03-18 | Bischofberger Norbert W. | Novel compounds and methods for synthesis and therapy |
TW477783B (en) * | 1997-12-12 | 2002-03-01 | Gilead Sciences Inc | Novel compounds useful as neuraminidase inhibitors and pharmaceutical compositions containing same |
EP1040094B9 (en) * | 1997-12-17 | 2015-09-09 | Biocryst Pharmaceuticals Inc. | Substituted cyclopentane and cyclopentene compounds useful as neuraminidase inhibitors |
US6518305B1 (en) | 1998-04-23 | 2003-02-11 | Abbott Laboratories | Five-membered carbocyclic and heterocyclic inhibitors of neuraminidases |
US6455571B1 (en) | 1998-04-23 | 2002-09-24 | Abbott Laboratories | Inhibitors of neuraminidases |
US6593314B1 (en) | 1999-10-19 | 2003-07-15 | Abbott Laboratories | Neuraminidase inhibitors |
WO2002076971A1 (en) * | 2001-03-08 | 2002-10-03 | Biocryst Pharmaceuticals, Inc. | Compounds useful for inhibiting paramyxovirus neuraminidase |
WO2002092555A1 (fr) * | 2001-05-11 | 2002-11-21 | Sankyo Company, Limited | Derives d'acides sialiques |
CA3059832C (en) * | 2009-05-04 | 2021-11-23 | Ian Schoenhofen | Method of producing non-2-enonate compounds |
CN115991702B (zh) * | 2021-12-09 | 2024-02-02 | 珠海市藤栢医药有限公司 | 芳基c-葡萄糖苷衍生物、其制备方法及其用途 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CZ288492B6 (en) * | 1990-04-24 | 2001-06-13 | Biota Scient Management | Derivatives of alpha-D-neuraminic acid, process of their preparation, their use and pharmaceutical preparations based thereon |
DE4131311A1 (de) * | 1991-09-20 | 1993-04-01 | Basf Ag | Dihydropyranderivate und diese enthaltende pflanzenschutzmittel |
AU659501B2 (en) * | 1991-10-23 | 1995-05-18 | Biota Scientific Management Pty Ltd | Antiviral 4-substituted-2-deoxy-2,3-didehydro-derivatives of alpha-D-neuraminic acid |
FR2687674B1 (fr) * | 1992-02-07 | 1995-05-19 | Roussel Uclaf | Nouveaux derives de la pyridone, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant. |
-
1996
- 1996-05-13 EP EP96911872A patent/EP0833825B1/en not_active Expired - Lifetime
- 1996-05-13 CA CA002220754A patent/CA2220754A1/en not_active Abandoned
- 1996-05-13 CN CN96194026A patent/CN1184473A/zh active Pending
- 1996-05-13 DE DE69615555T patent/DE69615555T2/de not_active Expired - Fee Related
- 1996-05-13 PL PL96323471A patent/PL323471A1/xx unknown
- 1996-05-13 KR KR1019970708256A patent/KR19990014910A/ko not_active Application Discontinuation
- 1996-05-13 AT AT96911872T patent/ATE206116T1/de not_active IP Right Cessation
- 1996-05-13 AU AU54932/96A patent/AU709127B2/en not_active Ceased
- 1996-05-13 CZ CZ973666A patent/CZ366697A3/cs unknown
- 1996-05-13 US US08/945,676 patent/US5990156A/en not_active Expired - Lifetime
- 1996-05-13 HU HU9801766A patent/HUP9801766A3/hu unknown
- 1996-05-13 WO PCT/AU1996/000289 patent/WO1996036628A1/en not_active Application Discontinuation
- 1996-05-13 JP JP53439196A patent/JP4162712B2/ja not_active Expired - Fee Related
- 1996-05-13 ES ES96911872T patent/ES2164881T3/es not_active Expired - Lifetime
-
1997
- 1997-11-18 NO NO975295A patent/NO975295L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CA2220754A1 (en) | 1996-11-21 |
CN1184473A (zh) | 1998-06-10 |
NO975295D0 (no) | 1997-11-18 |
HUP9801766A3 (en) | 2000-09-28 |
KR19990014910A (ko) | 1999-02-25 |
PL323471A1 (en) | 1998-03-30 |
EP0833825A4 (en) | 1998-10-07 |
JP4162712B2 (ja) | 2008-10-08 |
AU709127B2 (en) | 1999-08-19 |
DE69615555D1 (de) | 2001-10-31 |
NO975295L (no) | 1997-11-18 |
EP0833825B1 (en) | 2001-09-26 |
EP0833825A1 (en) | 1998-04-08 |
HUP9801766A2 (hu) | 2000-06-28 |
ATE206116T1 (de) | 2001-10-15 |
US5990156A (en) | 1999-11-23 |
JPH11505227A (ja) | 1999-05-18 |
WO1996036628A1 (en) | 1996-11-21 |
DE69615555T2 (de) | 2002-05-29 |
AU5493296A (en) | 1996-11-29 |
CZ366697A3 (cs) | 1998-04-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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