SE8201459L - MAGNESIUM HALOGENIDE COMPLEX OF ALFA-BROMOPROPIONIC ACID AND PROCEDURE FOR PRODUCING THEREOF - Google Patents

MAGNESIUM HALOGENIDE COMPLEX OF ALFA-BROMOPROPIONIC ACID AND PROCEDURE FOR PRODUCING THEREOF

Info

Publication number
SE8201459L
SE8201459L SE8201459A SE8201459A SE8201459L SE 8201459 L SE8201459 L SE 8201459L SE 8201459 A SE8201459 A SE 8201459A SE 8201459 A SE8201459 A SE 8201459A SE 8201459 L SE8201459 L SE 8201459L
Authority
SE
Sweden
Prior art keywords
alfa
procedure
producing
bromopropionic acid
complex
Prior art date
Application number
SE8201459A
Other languages
Swedish (sv)
Other versions
SE453094B (en
Inventor
G J Matthews
R A Arnold
Original Assignee
Syntex Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/863,290 external-priority patent/US4144397A/en
Application filed by Syntex Corp filed Critical Syntex Corp
Publication of SE8201459L publication Critical patent/SE8201459L/en
Publication of SE453094B publication Critical patent/SE453094B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
    • C07C65/24—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/15—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing halogen
    • C07C53/19—Acids containing three or more carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
    • C07C63/14—Monocyclic dicarboxylic acids
    • C07C63/15—Monocyclic dicarboxylic acids all carboxyl groups bound to carbon atoms of the six-membered aromatic ring
    • C07C63/24—1,3 - Benzenedicarboxylic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Compounds of the formula aryl CH(CH3)COOMgX, in which aryl denotes 6-methoxy-2-naphthyl, 4-alkylphenyl or 4'-fluoro-4-biphenyl, and X denotes chlorine or bromine, and their etherates, are described. They are prepared by treating a solution of the corresponding arylmagnesium bromide with the solution of a complex of the formula CH3CH(Br)COOMgX in an aprotic solvent containing an ether. The compounds are important intermediates in the synthesis of known 2-arylpropionic acids of therapeutic importance.

Claims (1)

PatentkravPatent claims 1. Forening med formeln CH3-CH(BOCOOMgX eller ett eterat darav, van i X betecknar klor eller boom.A compound of the formula CH3-CH (BOCOOMgX or an ether thereof), used in X denotes chlorine or boom.
SE8201459A 1977-02-16 1982-03-09 USE OF A MAGNESIUM HALOGENIDE COMPLEX OF ALFA-BROMOPROPIONIC ACID AS INTERMEDIATE FOR THE PREPARATION OF 2-ARYLPROPIONIC ACIDS SE453094B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76907077A 1977-02-16 1977-02-16
US05/863,290 US4144397A (en) 1977-02-16 1977-12-19 Preparation of 2-aryl-propionic acids by direct coupling utilizing a mixed magnesium halide complex

Publications (2)

Publication Number Publication Date
SE8201459L true SE8201459L (en) 1982-03-09
SE453094B SE453094B (en) 1988-01-11

Family

ID=27118118

Family Applications (3)

Application Number Title Priority Date Filing Date
SE7801648A SE430155B (en) 1977-02-16 1978-02-13 SET TO MAKE 2-ARYLPROPIONIC ACIDS
SE8201458A SE453093B (en) 1977-02-16 1982-03-09 PROCEDURE FOR PREPARING A MAGNESIUM HALOGENIDE COMPLEX OF 2-ARYL PROPIONIC ACIDS AND USING THIS FOR PREPARATION OF 2-ARYL PROPIONIC ACIDS
SE8201459A SE453094B (en) 1977-02-16 1982-03-09 USE OF A MAGNESIUM HALOGENIDE COMPLEX OF ALFA-BROMOPROPIONIC ACID AS INTERMEDIATE FOR THE PREPARATION OF 2-ARYLPROPIONIC ACIDS

Family Applications Before (2)

Application Number Title Priority Date Filing Date
SE7801648A SE430155B (en) 1977-02-16 1978-02-13 SET TO MAKE 2-ARYLPROPIONIC ACIDS
SE8201458A SE453093B (en) 1977-02-16 1982-03-09 PROCEDURE FOR PREPARING A MAGNESIUM HALOGENIDE COMPLEX OF 2-ARYL PROPIONIC ACIDS AND USING THIS FOR PREPARATION OF 2-ARYL PROPIONIC ACIDS

Country Status (18)

Country Link
CH (3) CH640499A5 (en)
DD (3) DD148212A5 (en)
DK (1) DK156898C (en)
ES (1) ES467037A1 (en)
FI (1) FI64571C (en)
HK (2) HK25383A (en)
HU (2) HU179309B (en)
IE (1) IE46614B1 (en)
IL (1) IL54019A (en)
IT (1) IT1107880B (en)
MY (2) MY8400039A (en)
NO (1) NO145435C (en)
NZ (1) NZ186472A (en)
PL (1) PL108144B1 (en)
PT (1) PT67654B (en)
SE (3) SE430155B (en)
SU (2) SU1003749A3 (en)
YU (3) YU41427B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8915531D0 (en) * 1989-07-06 1989-08-23 Ass Octel Alkaline earth,transition and lanthanide metal inorganic salt complexes

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1459084A (en) * 1973-05-24 1976-12-22 Boots Co Ltd Preparation of arylalkanoic acid

Also Published As

Publication number Publication date
IE780320L (en) 1978-08-16
ES467037A1 (en) 1978-11-01
IT1107880B (en) 1985-12-02
MY8400040A (en) 1984-12-31
NZ186472A (en) 1979-08-31
FI780417A (en) 1978-08-17
SE430155B (en) 1983-10-24
CH640500A5 (en) 1984-01-13
DK64578A (en) 1978-08-17
HK25483A (en) 1983-08-12
SE453094B (en) 1988-01-11
NO145435B (en) 1981-12-14
YU58783A (en) 1983-12-31
HU183210B (en) 1984-04-28
NO145435C (en) 1982-03-24
SU963462A3 (en) 1982-09-30
HK25383A (en) 1983-08-12
YU58883A (en) 1983-12-31
CH640499A5 (en) 1984-01-13
SE8201458L (en) 1982-03-09
IL54019A (en) 1981-06-29
YU32978A (en) 1983-06-30
YU43302B (en) 1989-06-30
NO780524L (en) 1978-08-17
DK156898B (en) 1989-10-16
MY8400039A (en) 1984-12-31
PL108144B1 (en) 1980-03-31
FI64571B (en) 1983-08-31
FI64571C (en) 1983-12-12
IL54019A0 (en) 1978-04-30
DD148212A5 (en) 1981-05-13
IT7867279A0 (en) 1978-02-10
HU179309B (en) 1982-09-28
DD145107A5 (en) 1980-11-19
YU42843B (en) 1988-12-31
DD137099A5 (en) 1979-08-15
DK156898C (en) 1990-03-12
IE46614B1 (en) 1983-08-10
PT67654A (en) 1978-03-01
CH640498A5 (en) 1984-01-13
SE453093B (en) 1988-01-11
SE7801648L (en) 1978-08-16
YU41427B (en) 1987-06-30
PT67654B (en) 1979-07-19
PL204667A1 (en) 1978-12-04
SU1003749A3 (en) 1983-03-07

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