HU179309B - Process for producing 2-aryl-propionic acids - Google Patents

Process for producing 2-aryl-propionic acids

Info

Publication number
HU179309B
HU179309B HU78SI1618A HUSI001618A HU179309B HU 179309 B HU179309 B HU 179309B HU 78SI1618 A HU78SI1618 A HU 78SI1618A HU SI001618 A HUSI001618 A HU SI001618A HU 179309 B HU179309 B HU 179309B
Authority
HU
Hungary
Prior art keywords
aryl
producing
coomgx
propionic acids
compounds
Prior art date
Application number
HU78SI1618A
Other languages
Hungarian (hu)
Inventor
J Gary Matthews
A Robert Arnold
Original Assignee
Syntex Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/863,290 external-priority patent/US4144397A/en
Application filed by Syntex Corp filed Critical Syntex Corp
Publication of HU179309B publication Critical patent/HU179309B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
    • C07C65/24—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/15—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing halogen
    • C07C53/19—Acids containing three or more carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
    • C07C63/14—Monocyclic dicarboxylic acids
    • C07C63/15—Monocyclic dicarboxylic acids all carboxyl groups bound to carbon atoms of the six-membered aromatic ring
    • C07C63/24—1,3 - Benzenedicarboxylic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Compounds of the formula aryl CH(CH3)COOMgX, in which aryl denotes 6-methoxy-2-naphthyl, 4-alkylphenyl or 4'-fluoro-4-biphenyl, and X denotes chlorine or bromine, and their etherates, are described. They are prepared by treating a solution of the corresponding arylmagnesium bromide with the solution of a complex of the formula CH3CH(Br)COOMgX in an aprotic solvent containing an ether. The compounds are important intermediates in the synthesis of known 2-arylpropionic acids of therapeutic importance.
HU78SI1618A 1977-02-16 1978-02-09 Process for producing 2-aryl-propionic acids HU179309B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76907077A 1977-02-16 1977-02-16
US05/863,290 US4144397A (en) 1977-02-16 1977-12-19 Preparation of 2-aryl-propionic acids by direct coupling utilizing a mixed magnesium halide complex

Publications (1)

Publication Number Publication Date
HU179309B true HU179309B (en) 1982-09-28

Family

ID=27118118

Family Applications (2)

Application Number Title Priority Date Filing Date
HU78SI1618A HU179309B (en) 1977-02-16 1978-02-09 Process for producing 2-aryl-propionic acids
HU802271A HU183210B (en) 1977-02-16 1978-02-09 Process for preparing complexes of 2-aryl-propionic acids

Family Applications After (1)

Application Number Title Priority Date Filing Date
HU802271A HU183210B (en) 1977-02-16 1978-02-09 Process for preparing complexes of 2-aryl-propionic acids

Country Status (18)

Country Link
CH (3) CH640499A5 (en)
DD (3) DD137099A5 (en)
DK (1) DK156898C (en)
ES (1) ES467037A1 (en)
FI (1) FI64571C (en)
HK (2) HK25383A (en)
HU (2) HU179309B (en)
IE (1) IE46614B1 (en)
IL (1) IL54019A (en)
IT (1) IT1107880B (en)
MY (2) MY8400039A (en)
NO (1) NO145435C (en)
NZ (1) NZ186472A (en)
PL (1) PL108144B1 (en)
PT (1) PT67654B (en)
SE (3) SE430155B (en)
SU (2) SU1003749A3 (en)
YU (3) YU41427B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8915531D0 (en) * 1989-07-06 1989-08-23 Ass Octel Alkaline earth,transition and lanthanide metal inorganic salt complexes

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1459084A (en) * 1973-05-24 1976-12-22 Boots Co Ltd Preparation of arylalkanoic acid

Also Published As

Publication number Publication date
DK64578A (en) 1978-08-17
HK25483A (en) 1983-08-12
SU1003749A3 (en) 1983-03-07
SE430155B (en) 1983-10-24
NO780524L (en) 1978-08-17
YU42843B (en) 1988-12-31
IT7867279A0 (en) 1978-02-10
SU963462A3 (en) 1982-09-30
PL204667A1 (en) 1978-12-04
MY8400040A (en) 1984-12-31
SE7801648L (en) 1978-08-17
YU58783A (en) 1983-12-31
SE453094B (en) 1988-01-11
DK156898C (en) 1990-03-12
NO145435B (en) 1981-12-14
DK156898B (en) 1989-10-16
HK25383A (en) 1983-08-12
PL108144B1 (en) 1980-03-31
IT1107880B (en) 1985-12-02
NO145435C (en) 1982-03-24
MY8400039A (en) 1984-12-31
CH640499A5 (en) 1984-01-13
YU58883A (en) 1983-12-31
NZ186472A (en) 1979-08-31
FI64571C (en) 1983-12-12
DD137099A5 (en) 1979-08-15
DD145107A5 (en) 1980-11-19
SE8201458L (en) 1982-03-09
IE46614B1 (en) 1983-08-10
ES467037A1 (en) 1978-11-01
PT67654B (en) 1979-07-19
CH640500A5 (en) 1984-01-13
SE8201459L (en) 1982-03-09
YU32978A (en) 1983-06-30
CH640498A5 (en) 1984-01-13
YU41427B (en) 1987-06-30
FI780417A (en) 1978-08-17
HU183210B (en) 1984-04-28
FI64571B (en) 1983-08-31
IL54019A0 (en) 1978-04-30
PT67654A (en) 1978-03-01
YU43302B (en) 1989-06-30
SE453093B (en) 1988-01-11
DD148212A5 (en) 1981-05-13
IL54019A (en) 1981-06-29
IE780320L (en) 1978-08-16

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Legal Events

Date Code Title Description
HU90 Patent valid on 900628