PL204667A1 - METHOD OF MAKING 2-ARYLPROPIONIC ACIDS AND METHOD OF MAKING NEW MAGNESIUM COMPLEX COMPOUNDS AS INTERMEDIATE PRODUCTS - Google Patents

METHOD OF MAKING 2-ARYLPROPIONIC ACIDS AND METHOD OF MAKING NEW MAGNESIUM COMPLEX COMPOUNDS AS INTERMEDIATE PRODUCTS

Info

Publication number
PL204667A1
PL204667A1 PL20466778A PL20466778A PL204667A1 PL 204667 A1 PL204667 A1 PL 204667A1 PL 20466778 A PL20466778 A PL 20466778A PL 20466778 A PL20466778 A PL 20466778A PL 204667 A1 PL204667 A1 PL 204667A1
Authority
PL
Poland
Prior art keywords
making
arylpropionic acids
intermediate products
complex compounds
magnesium complex
Prior art date
Application number
PL20466778A
Other languages
Polish (pl)
Other versions
PL108144B1 (en
Original Assignee
Syntex Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/863,290 external-priority patent/US4144397A/en
Application filed by Syntex Corp filed Critical Syntex Corp
Publication of PL204667A1 publication Critical patent/PL204667A1/en
Publication of PL108144B1 publication Critical patent/PL108144B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
    • C07C65/24—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/15—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing halogen
    • C07C53/19—Acids containing three or more carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
    • C07C63/14—Monocyclic dicarboxylic acids
    • C07C63/15—Monocyclic dicarboxylic acids all carboxyl groups bound to carbon atoms of the six-membered aromatic ring
    • C07C63/24—1,3 - Benzenedicarboxylic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Compounds of the formula aryl CH(CH3)COOMgX, in which aryl denotes 6-methoxy-2-naphthyl, 4-alkylphenyl or 4'-fluoro-4-biphenyl, and X denotes chlorine or bromine, and their etherates, are described. They are prepared by treating a solution of the corresponding arylmagnesium bromide with the solution of a complex of the formula CH3CH(Br)COOMgX in an aprotic solvent containing an ether. The compounds are important intermediates in the synthesis of known 2-arylpropionic acids of therapeutic importance.
PL1978204667A 1977-02-16 1978-02-16 METHOD OF PRODUCING 2-ARYLPROPIONIC ACIDS PL108144B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76907077A 1977-02-16 1977-02-16
US05/863,290 US4144397A (en) 1977-02-16 1977-12-19 Preparation of 2-aryl-propionic acids by direct coupling utilizing a mixed magnesium halide complex

Publications (2)

Publication Number Publication Date
PL204667A1 true PL204667A1 (en) 1978-12-04
PL108144B1 PL108144B1 (en) 1980-03-31

Family

ID=27118118

Family Applications (1)

Application Number Title Priority Date Filing Date
PL1978204667A PL108144B1 (en) 1977-02-16 1978-02-16 METHOD OF PRODUCING 2-ARYLPROPIONIC ACIDS

Country Status (18)

Country Link
CH (3) CH640499A5 (en)
DD (3) DD137099A5 (en)
DK (1) DK156898C (en)
ES (1) ES467037A1 (en)
FI (1) FI64571C (en)
HK (2) HK25383A (en)
HU (2) HU179309B (en)
IE (1) IE46614B1 (en)
IL (1) IL54019A (en)
IT (1) IT1107880B (en)
MY (2) MY8400039A (en)
NO (1) NO145435C (en)
NZ (1) NZ186472A (en)
PL (1) PL108144B1 (en)
PT (1) PT67654B (en)
SE (3) SE430155B (en)
SU (2) SU1003749A3 (en)
YU (3) YU41427B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8915531D0 (en) * 1989-07-06 1989-08-23 Ass Octel Alkaline earth,transition and lanthanide metal inorganic salt complexes

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1459084A (en) * 1973-05-24 1976-12-22 Boots Co Ltd Preparation of arylalkanoic acid

Also Published As

Publication number Publication date
DK64578A (en) 1978-08-17
HK25483A (en) 1983-08-12
SU1003749A3 (en) 1983-03-07
SE430155B (en) 1983-10-24
NO780524L (en) 1978-08-17
YU42843B (en) 1988-12-31
IT7867279A0 (en) 1978-02-10
SU963462A3 (en) 1982-09-30
MY8400040A (en) 1984-12-31
SE7801648L (en) 1978-08-17
YU58783A (en) 1983-12-31
HU179309B (en) 1982-09-28
SE453094B (en) 1988-01-11
DK156898C (en) 1990-03-12
NO145435B (en) 1981-12-14
DK156898B (en) 1989-10-16
HK25383A (en) 1983-08-12
PL108144B1 (en) 1980-03-31
IT1107880B (en) 1985-12-02
NO145435C (en) 1982-03-24
MY8400039A (en) 1984-12-31
CH640499A5 (en) 1984-01-13
YU58883A (en) 1983-12-31
NZ186472A (en) 1979-08-31
FI64571C (en) 1983-12-12
DD137099A5 (en) 1979-08-15
DD145107A5 (en) 1980-11-19
SE8201458L (en) 1982-03-09
IE46614B1 (en) 1983-08-10
ES467037A1 (en) 1978-11-01
PT67654B (en) 1979-07-19
CH640500A5 (en) 1984-01-13
SE8201459L (en) 1982-03-09
YU32978A (en) 1983-06-30
CH640498A5 (en) 1984-01-13
YU41427B (en) 1987-06-30
FI780417A (en) 1978-08-17
HU183210B (en) 1984-04-28
FI64571B (en) 1983-08-31
IL54019A0 (en) 1978-04-30
PT67654A (en) 1978-03-01
YU43302B (en) 1989-06-30
SE453093B (en) 1988-01-11
DD148212A5 (en) 1981-05-13
IL54019A (en) 1981-06-29
IE780320L (en) 1978-08-16

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Legal Events

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RECP Rectifications of patent specification