HK25383A - Preparation of 2-aryl-propionic acids by direct coupling utilizing a mixed magnesium halide complex - Google Patents
Preparation of 2-aryl-propionic acids by direct coupling utilizing a mixed magnesium halide complexInfo
- Publication number
- HK25383A HK25383A HK253/83A HK25383A HK25383A HK 25383 A HK25383 A HK 25383A HK 253/83 A HK253/83 A HK 253/83A HK 25383 A HK25383 A HK 25383A HK 25383 A HK25383 A HK 25383A
- Authority
- HK
- Hong Kong
- Prior art keywords
- aryl
- preparation
- direct coupling
- magnesium halide
- propionic acids
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
- C07C65/24—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
- C07C53/15—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing halogen
- C07C53/19—Acids containing three or more carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
- C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
- C07C63/14—Monocyclic dicarboxylic acids
- C07C63/15—Monocyclic dicarboxylic acids all carboxyl groups bound to carbon atoms of the six-membered aromatic ring
- C07C63/24—1,3 - Benzenedicarboxylic acid
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Compounds of the formula aryl CH(CH3)COOMgX, in which aryl denotes 6-methoxy-2-naphthyl, 4-alkylphenyl or 4'-fluoro-4-biphenyl, and X denotes chlorine or bromine, and their etherates, are described. They are prepared by treating a solution of the corresponding arylmagnesium bromide with the solution of a complex of the formula CH3CH(Br)COOMgX in an aprotic solvent containing an ether. The compounds are important intermediates in the synthesis of known 2-arylpropionic acids of therapeutic importance.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US76907077A | 1977-02-16 | 1977-02-16 | |
US05/863,290 US4144397A (en) | 1977-02-16 | 1977-12-19 | Preparation of 2-aryl-propionic acids by direct coupling utilizing a mixed magnesium halide complex |
Publications (1)
Publication Number | Publication Date |
---|---|
HK25383A true HK25383A (en) | 1983-08-12 |
Family
ID=27118118
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK254/83A HK25483A (en) | 1977-02-16 | 1983-08-04 | 2-aryl-propionic acid precursors |
HK253/83A HK25383A (en) | 1977-02-16 | 1983-08-04 | Preparation of 2-aryl-propionic acids by direct coupling utilizing a mixed magnesium halide complex |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK254/83A HK25483A (en) | 1977-02-16 | 1983-08-04 | 2-aryl-propionic acid precursors |
Country Status (18)
Country | Link |
---|---|
CH (3) | CH640499A5 (en) |
DD (3) | DD137099A5 (en) |
DK (1) | DK156898C (en) |
ES (1) | ES467037A1 (en) |
FI (1) | FI64571C (en) |
HK (2) | HK25483A (en) |
HU (2) | HU179309B (en) |
IE (1) | IE46614B1 (en) |
IL (1) | IL54019A (en) |
IT (1) | IT1107880B (en) |
MY (2) | MY8400040A (en) |
NO (1) | NO145435C (en) |
NZ (1) | NZ186472A (en) |
PL (1) | PL108144B1 (en) |
PT (1) | PT67654B (en) |
SE (3) | SE430155B (en) |
SU (2) | SU1003749A3 (en) |
YU (3) | YU41427B (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8915531D0 (en) * | 1989-07-06 | 1989-08-23 | Ass Octel | Alkaline earth,transition and lanthanide metal inorganic salt complexes |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1459084A (en) * | 1973-05-24 | 1976-12-22 | Boots Co Ltd | Preparation of arylalkanoic acid |
-
1978
- 1978-02-09 HU HU78SI1618A patent/HU179309B/en unknown
- 1978-02-09 HU HU802271A patent/HU183210B/en unknown
- 1978-02-09 FI FI780417A patent/FI64571C/en not_active IP Right Cessation
- 1978-02-10 IT IT67279/78A patent/IT1107880B/en active
- 1978-02-10 IL IL54019A patent/IL54019A/en unknown
- 1978-02-13 DK DK064578A patent/DK156898C/en not_active IP Right Cessation
- 1978-02-13 YU YU329/78A patent/YU41427B/en unknown
- 1978-02-13 SE SE7801648A patent/SE430155B/en not_active IP Right Cessation
- 1978-02-14 PT PT67654A patent/PT67654B/en unknown
- 1978-02-14 NZ NZ186472A patent/NZ186472A/en unknown
- 1978-02-14 IE IE320/78A patent/IE46614B1/en not_active IP Right Cessation
- 1978-02-15 DD DD78203717A patent/DD137099A5/en not_active IP Right Cessation
- 1978-02-15 DD DD78214578A patent/DD148212A5/en not_active IP Right Cessation
- 1978-02-15 CH CH167578A patent/CH640499A5/en not_active IP Right Cessation
- 1978-02-15 DD DD78214577A patent/DD145107A5/en not_active IP Right Cessation
- 1978-02-15 SU SU782580499A patent/SU1003749A3/en active
- 1978-02-15 NO NO780524A patent/NO145435C/en unknown
- 1978-02-16 ES ES467037A patent/ES467037A1/en not_active Expired
- 1978-02-16 PL PL1978204667A patent/PL108144B1/en unknown
- 1978-10-11 SU SU782672198A patent/SU963462A3/en active
-
1982
- 1982-03-09 SE SE8201458A patent/SE453093B/en not_active IP Right Cessation
- 1982-03-09 SE SE8201459A patent/SE453094B/en not_active IP Right Cessation
- 1982-09-07 CH CH531782A patent/CH640498A5/en not_active IP Right Cessation
- 1982-09-07 CH CH531882A patent/CH640500A5/en not_active IP Right Cessation
-
1983
- 1983-03-10 YU YU587/83A patent/YU43302B/en unknown
- 1983-03-10 YU YU588/83A patent/YU42843B/en unknown
- 1983-08-04 HK HK254/83A patent/HK25483A/en not_active IP Right Cessation
- 1983-08-04 HK HK253/83A patent/HK25383A/en not_active IP Right Cessation
-
1984
- 1984-12-30 MY MY40/84A patent/MY8400040A/en unknown
- 1984-12-30 MY MY39/84A patent/MY8400039A/en unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SE8406138D0 (en) | NEW RETINOIDE | |
FR2381736A1 (en) | MIXED COMPLEX OF MAGNESIUM HALOGENIDE OF CERTAIN 2-ARYL-PROPIONIC ACIDS AND PROCESS FOR THEIR PREPARATION | |
PT67654A (en) | Preparation of 2-aryl-propionic acids by direct coupling utilizing a mixed magnesium halide complex | |
ES481650A1 (en) | Mixed anhydride steroid intermediate and process for preparing steroid intermediates. | |
IL64662A (en) | Preparation of monochloromethyl ketones and the novel 1-chloro-3,3-dimethylpent-4-en-2-one produced thereby | |
ES445263A1 (en) | Dimercaptoethyl ether sulfonium compounds and use as antiinflammatory and antirheumatic agents | |
JPS5265237A (en) | Preparation of hydroquinone derivatives | |
JPS55139332A (en) | Phenol ether compound | |
JPS5265236A (en) | Preparation of hydroquinone derivatives | |
JPS54100398A (en) | Meso-tetra(p-sulfophenyl)porphine derivative | |
JPS5239671A (en) | Process for preparing indole-3-thioether compounds | |
JPS55153777A (en) | Improved method of preparation of 3-methyl-3-(substituted phenyl)-glycidic ester | |
JPS55118425A (en) | Preparation of alkenyl halide | |
ES472098A1 (en) | Procedure for the preparation of a mixed magnesium halogenure complex of propionic alpha-bromine acid. (Machine-translation by Google Translate, not legally binding) | |
ES472097A1 (en) | Procedure for obtaining a mixed magnesium halogenural complex of 2-aril propionic acid. (Machine-translation by Google Translate, not legally binding) | |
JPS57106645A (en) | Preparation of 4-bromo-3-methylchrotonic acid ester | |
JPS5473772A (en) | Isoxazoline-3-one derivative | |
JPS559059A (en) | Preparation of dicyclohexyl neophyltin halide | |
ZA78922B (en) | Preparation of 2-aryl-propionic acids by direct coupling utilizing a mixed magnesium halide complex | |
JPS5634647A (en) | Preparation of phenoxyalkene derivative | |
JPS549250A (en) | Synthesis of n-mono-substituted aminobenzophenone derivatives | |
ES478504A1 (en) | A procedure for the preparation of trans-2,8-dibencilciclocanonan. (Machine-translation by Google Translate, not legally binding) | |
JPS5481253A (en) | 2-methyl-2-hydroxyperhydrotriquinacene | |
JPS5545638A (en) | Exo-5-halomethyl-endo-2,3-trimethylene norbornane | |
JPS56118036A (en) | Preparation of cis-olefin derivative |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PE | Patent expired |