GB1482047A - Bicyclohexane derivatives for use in the synthesis of prostaglandins - Google Patents

Bicyclohexane derivatives for use in the synthesis of prostaglandins

Info

Publication number
GB1482047A
GB1482047A GB2494075A GB2494075A GB1482047A GB 1482047 A GB1482047 A GB 1482047A GB 2494075 A GB2494075 A GB 2494075A GB 2494075 A GB2494075 A GB 2494075A GB 1482047 A GB1482047 A GB 1482047A
Authority
GB
United Kingdom
Prior art keywords
prostaglandins
image
synthesis
compounds
enantiomers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2494075A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of GB1482047A publication Critical patent/GB1482047A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C35/22—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system
    • C07C35/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings
    • C07C35/27—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings the condensed ring system containing six carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0016—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing only hydroxy, etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0025—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing keto groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/22—Radicals substituted by singly bound oxygen or sulfur atoms etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)

Abstract

Novel, optically active bicyclic oxetanes of the following formulae <IMAGE> or a racemic mixture of these compounds and their enantiomers are prepared, in which the substituents are described in Claim 1. These compounds are obtained by introducing the side chain into an appropriate, optically active, bicyclohexene of the formula <IMAGE> or a racemic mixture of this compound and its enantiomers, by reaction with an aldehyde of the formula <IMAGE> The resulting novel compounds can be used for the preparation of prostaglandins.
GB2494075A 1974-07-12 1975-06-11 Bicyclohexane derivatives for use in the synthesis of prostaglandins Expired GB1482047A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48829574A 1974-07-12 1974-07-12
US55270775A 1975-02-24 1975-02-24

Publications (1)

Publication Number Publication Date
GB1482047A true GB1482047A (en) 1977-08-03

Family

ID=27049301

Family Applications (3)

Application Number Title Priority Date Filing Date
GB2494075A Expired GB1482047A (en) 1974-07-12 1975-06-11 Bicyclohexane derivatives for use in the synthesis of prostaglandins
GB4889576A Expired GB1482049A (en) 1974-07-12 1975-06-11 Bicyclohexane derivatives for use in the synthesis of prostaglandins
GB4889476A Expired GB1482048A (en) 1974-07-12 1975-06-11 Oxatricyclooctane derivatives for use in the synthesis of prostaglandins

Family Applications After (2)

Application Number Title Priority Date Filing Date
GB4889576A Expired GB1482049A (en) 1974-07-12 1975-06-11 Bicyclohexane derivatives for use in the synthesis of prostaglandins
GB4889476A Expired GB1482048A (en) 1974-07-12 1975-06-11 Oxatricyclooctane derivatives for use in the synthesis of prostaglandins

Country Status (6)

Country Link
JP (1) JPS5134146A (en)
CH (2) CH619922A5 (en)
DE (1) DE2530221A1 (en)
FR (3) FR2285385A1 (en)
GB (3) GB1482047A (en)
NL (1) NL7508301A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4029681A (en) * 1976-02-13 1977-06-14 The Upjohn Company 13,14-Didehydro-PG analogs

Also Published As

Publication number Publication date
FR2285364B1 (en) 1980-07-18
CH619922A5 (en) 1980-10-31
GB1482049A (en) 1977-08-03
JPS5134146A (en) 1976-03-23
DE2530221A1 (en) 1976-01-29
CH615923A5 (en) 1980-02-29
FR2285385A1 (en) 1976-04-16
NL7508301A (en) 1976-01-14
FR2285385B1 (en) 1979-03-09
GB1482048A (en) 1977-08-03
FR2285364A1 (en) 1976-04-16
AU8243775A (en) 1977-01-06
FR2285373B1 (en) 1980-07-18
FR2285373A1 (en) 1976-04-16

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee