SE433935B - SET TO MAKE NEW ARYLOXIAMINOBUTANOLS, STEREOISOMERS AND POISONOUS ACID ADDITION SALTS THEREOF - Google Patents
SET TO MAKE NEW ARYLOXIAMINOBUTANOLS, STEREOISOMERS AND POISONOUS ACID ADDITION SALTS THEREOFInfo
- Publication number
- SE433935B SE433935B SE7501801A SE7501801A SE433935B SE 433935 B SE433935 B SE 433935B SE 7501801 A SE7501801 A SE 7501801A SE 7501801 A SE7501801 A SE 7501801A SE 433935 B SE433935 B SE 433935B
- Authority
- SE
- Sweden
- Prior art keywords
- compounds
- general formula
- stereoisomers
- acid addition
- addition salts
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
- C07C217/30—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring
- C07C217/32—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
- C07C217/34—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by halogen atoms, by trihalomethyl, nitro or nitroso groups, or by singly-bound oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
- C07C217/30—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/52—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups or amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Novel aryloxyaminobutanols of the general formula (I) <IMAGE> in which R represents an optionally substituted aryl group and R<1> represents an alkyl, cycloalkyl or aralkyl group, it being possible for the aryl group to be substituted, and also the stereoisomers and the non-toxic acid addition salts of these compounds, are beta-receptor blockers and have antiarrhythmic action. The compounds are prepared by reacting compounds of the general formula (III) <IMAGE> and compounds of the general formula (IV> X-R<1> (IV> in which X represents a leaving group, or reacting compounds of the general formula (III) with compounds of the general formula (V) <IMAGE> and simultaneously or subsequently reducing, and if desired reacting the resulting compounds of the general formula (I) to give their non-toxic acid addition salts or liberating them from their salts. The stereoisomers of the formula III can be used as starting materials.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HUCI1449A HU169464B (en) | 1974-02-20 | 1974-02-20 |
Publications (2)
Publication Number | Publication Date |
---|---|
SE7501801L SE7501801L (en) | 1975-08-21 |
SE433935B true SE433935B (en) | 1984-06-25 |
Family
ID=10994508
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE7501801A SE433935B (en) | 1974-02-20 | 1975-02-18 | SET TO MAKE NEW ARYLOXIAMINOBUTANOLS, STEREOISOMERS AND POISONOUS ACID ADDITION SALTS THEREOF |
Country Status (22)
Country | Link |
---|---|
JP (1) | JPS5929063B2 (en) |
AT (1) | AT339281B (en) |
BE (1) | BE825745A (en) |
BG (2) | BG26367A4 (en) |
CA (1) | CA1074338A (en) |
CH (1) | CH619684A5 (en) |
CS (1) | CS199578B2 (en) |
DD (1) | DD119414A5 (en) |
DE (1) | DE2506355C2 (en) |
DK (1) | DK141935B (en) |
ES (2) | ES434784A1 (en) |
FI (1) | FI61304C (en) |
FR (1) | FR2261001B1 (en) |
GB (1) | GB1457086A (en) |
HU (1) | HU169464B (en) |
IL (1) | IL46634A (en) |
NL (1) | NL182698C (en) |
NO (1) | NO141754C (en) |
PL (2) | PL99025B1 (en) |
SE (1) | SE433935B (en) |
SU (1) | SU1025327A3 (en) |
YU (2) | YU36916B (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL48309A (en) * | 1974-10-25 | 1980-01-31 | Robins Co Inc A H | 1-aryloxy-4-amino-2-butanols and pharmaceutical compositions containing them |
EP0097000B1 (en) * | 1982-06-10 | 1987-09-09 | Beecham Wuelfing GmbH & Co KG | Amine derivatives |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE368197B (en) * | 1968-11-18 | 1974-06-24 | Pfizer | |
GB1245148A (en) * | 1968-11-18 | 1971-09-08 | Pfizer Ltd | Propanolamine derivatives |
SE384853B (en) * | 1972-04-04 | 1976-05-24 | Haessle Ab | PROCEDURE FOR THE PREPARATION OF NEW AMINES |
AT304472B (en) * | 1969-09-24 | 1973-01-10 | Ici Ltd | Process for the preparation of new substituted 1-phenoxy-2-hydroxy-3-alkylaminopropanes and their acid addition salts |
-
1974
- 1974-02-20 HU HUCI1449A patent/HU169464B/hu unknown
-
1975
- 1975-02-14 IL IL46634A patent/IL46634A/en unknown
- 1975-02-14 DE DE2506355A patent/DE2506355C2/en not_active Expired
- 1975-02-17 ES ES434784A patent/ES434784A1/en not_active Expired
- 1975-02-17 DD DD184260A patent/DD119414A5/xx unknown
- 1975-02-17 AT AT114075A patent/AT339281B/en not_active IP Right Cessation
- 1975-02-18 FI FI750443A patent/FI61304C/en not_active IP Right Cessation
- 1975-02-18 BG BG7530300A patent/BG26367A4/xx unknown
- 1975-02-18 FR FR7504961A patent/FR2261001B1/fr not_active Expired
- 1975-02-18 SE SE7501801A patent/SE433935B/en not_active IP Right Cessation
- 1975-02-18 YU YU0373/75A patent/YU36916B/en unknown
- 1975-02-18 BG BG7529004A patent/BG26366A3/xx not_active Expired
- 1975-02-19 GB GB705075A patent/GB1457086A/en not_active Expired
- 1975-02-19 NO NO750566A patent/NO141754C/en unknown
- 1975-02-19 SU SU752108001A patent/SU1025327A3/en active
- 1975-02-19 PL PL1975193962A patent/PL99025B1/en unknown
- 1975-02-19 DK DK60875AA patent/DK141935B/en not_active IP Right Cessation
- 1975-02-19 PL PL1975178154A patent/PL99023B1/en unknown
- 1975-02-19 NL NLAANVRAGE7501951,A patent/NL182698C/en not_active IP Right Cessation
- 1975-02-19 CH CH206475A patent/CH619684A5/en not_active IP Right Cessation
- 1975-02-19 CA CA220,429A patent/CA1074338A/en not_active Expired
- 1975-02-20 JP JP50020452A patent/JPS5929063B2/en not_active Expired
- 1975-02-20 CS CS751129A patent/CS199578B2/en unknown
- 1975-02-20 BE BE153530A patent/BE825745A/en not_active IP Right Cessation
-
1976
- 1976-11-15 ES ES453326A patent/ES453326A1/en not_active Expired
-
1981
- 1981-07-08 YU YU1676/81A patent/YU37116B/en unknown
Also Published As
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NUG | Patent has lapsed |
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