SE504185C2 - Lagringsstabil vattenlösning för infusion av trombininhibitorer - Google Patents

Lagringsstabil vattenlösning för infusion av trombininhibitorer

Info

Publication number
SE504185C2
SE504185C2 SE9403831A SE9403831A SE504185C2 SE 504185 C2 SE504185 C2 SE 504185C2 SE 9403831 A SE9403831 A SE 9403831A SE 9403831 A SE9403831 A SE 9403831A SE 504185 C2 SE504185 C2 SE 504185C2
Authority
SE
Sweden
Prior art keywords
hooc
nag
pic
cha
solution according
Prior art date
Application number
SE9403831A
Other languages
English (en)
Swedish (sv)
Other versions
SE9403831L (sv
SE9403831D0 (sv
Inventor
Ulla Stjernfelt
Mats Sundgren
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Priority to SE9403831A priority Critical patent/SE504185C2/sv
Publication of SE9403831D0 publication Critical patent/SE9403831D0/xx
Priority to TW084110363A priority patent/TW407057B/zh
Priority to DE69522702T priority patent/DE69522702T2/de
Priority to PL95320342A priority patent/PL320342A1/xx
Priority to SK535-97A priority patent/SK53597A3/sk
Priority to CZ19971294A priority patent/CZ287256B6/cs
Priority to NZ295492A priority patent/NZ295492A/en
Priority to EE9700218A priority patent/EE9700218A/xx
Priority to JP8515235A priority patent/JPH10508598A/ja
Priority to EP95938085A priority patent/EP0789585B1/en
Priority to AT95938085T priority patent/ATE205399T1/de
Priority to RU97108965/14A priority patent/RU2164803C2/ru
Priority to CA002203396A priority patent/CA2203396A1/en
Priority to AU38846/95A priority patent/AU695719B2/en
Priority to KR1019970703043A priority patent/KR100416677B1/ko
Priority to DK95938085T priority patent/DK0789585T3/da
Priority to CN95196108A priority patent/CN1090508C/zh
Priority to BR9509634A priority patent/BR9509634A/pt
Priority to HU9800400A priority patent/HU217073B/hu
Priority to US08/557,189 priority patent/US5830865A/en
Priority to MX9703339A priority patent/MX9703339A/es
Priority to PCT/SE1995/001228 priority patent/WO1996014084A1/en
Priority to PT95938085T priority patent/PT789585E/pt
Priority to ES95938085T priority patent/ES2163528T3/es
Priority to MYPI95003226A priority patent/MY112593A/en
Priority to IL11587995A priority patent/IL115879A/en
Priority to ZA959377A priority patent/ZA959377B/xx
Priority to TR95/01391A priority patent/TR199501391A2/xx
Publication of SE9403831L publication Critical patent/SE9403831L/xx
Publication of SE504185C2 publication Critical patent/SE504185C2/sv
Priority to IS4468A priority patent/IS4468A/is
Priority to NO19972065A priority patent/NO322048B1/no
Priority to FI971949A priority patent/FI971949A0/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SE9403831A 1994-11-08 1994-11-08 Lagringsstabil vattenlösning för infusion av trombininhibitorer SE504185C2 (sv)

Priority Applications (31)

Application Number Priority Date Filing Date Title
SE9403831A SE504185C2 (sv) 1994-11-08 1994-11-08 Lagringsstabil vattenlösning för infusion av trombininhibitorer
TW084110363A TW407057B (en) 1994-11-08 1995-10-04 A storage stable water solution for infusion containing a thrombin inhibitor
ES95938085T ES2163528T3 (es) 1994-11-08 1995-10-19 Una solucion acuosa para infusion, estable al almacenamiento, que contiene un inhibidor de trombina.
KR1019970703043A KR100416677B1 (ko) 1994-11-08 1995-10-19 트롬빈억제제를함유하는주입용저장안정성수용액
BR9509634A BR9509634A (pt) 1994-11-08 1995-10-19 Solução aquosa concentrada estável ao armazenamento para infusao uso da mesma e processos de preparação da mesma de tratamento de um paciente necessitando de um inibidor de trombina e de estabilização de um inibidor de trombina ativo
SK535-97A SK53597A3 (en) 1994-11-08 1995-10-19 A storage stable water solution for infusion containing a thrombin inhibitor
CZ19971294A CZ287256B6 (en) 1994-11-08 1995-10-19 Concentrated aqueous solution for infusion being stable when stored and process for preparing thereof
NZ295492A NZ295492A (en) 1994-11-08 1995-10-19 Storage stable aqueous infusion for iv administration comprising a thrombin inhibitor
EE9700218A EE9700218A (et) 1994-11-08 1995-10-19 Trombiini inhibiitorit sisaldav säilituskindel vesilahus süstimiseks
JP8515235A JPH10508598A (ja) 1994-11-08 1995-10-19 トロンビン阻害剤を含有する貯蔵安定な輸液用水溶液
EP95938085A EP0789585B1 (en) 1994-11-08 1995-10-19 A storage stable water solution for infusion containing a thrombin inhibitor
AT95938085T ATE205399T1 (de) 1994-11-08 1995-10-19 Eine lagerstabile wässrige lösung zur infusion die einen thrombininhibitor enthält
RU97108965/14A RU2164803C2 (ru) 1994-11-08 1995-10-19 Содержащий ингибитор тромбина водный раствор для внутривенного введения, стабильный при хранении
CA002203396A CA2203396A1 (en) 1994-11-08 1995-10-19 A storage stable water solution for infusion containing a thrombin inhibitor
AU38846/95A AU695719B2 (en) 1994-11-08 1995-10-19 A storage stable water solution for infusion containing a thrombin inhibitor
DE69522702T DE69522702T2 (de) 1994-11-08 1995-10-19 Eine lagerstabile wässrige lösung zur infusion die einen thrombininhibitor enthält
DK95938085T DK0789585T3 (da) 1994-11-08 1995-10-19 Opbevaringsstabil vandopløsning til infusion indeholdende en trombinhæmmer
CN95196108A CN1090508C (zh) 1994-11-08 1995-10-19 输注用含凝血酶抑制剂的贮存稳定的水溶液
PL95320342A PL320342A1 (en) 1994-11-08 1995-10-19 Thrombin inhibitor containing infusion solution, stable during storage
HU9800400A HU217073B (hu) 1994-11-08 1995-10-19 Trombin inhibitort tartalmazó, tárolás közben stabil, vizes, infúziós törzsoldat és eljárás előállítására
US08/557,189 US5830865A (en) 1994-11-08 1995-10-19 Storage stable water solution for infusion containing a thrombin inhibitor
MX9703339A MX9703339A (es) 1994-11-08 1995-10-19 Solucion acuosa para infusion, estable al almacenamiento, que contiene un inhibidor de trombina.
PCT/SE1995/001228 WO1996014084A1 (en) 1994-11-08 1995-10-19 A storage stable water solution for infusion containing a thrombin inhibitor
PT95938085T PT789585E (pt) 1994-11-08 1995-10-19 Solucao aquosa para infusao estavel a armazenagem contendo um inibidor de trombina
MYPI95003226A MY112593A (en) 1994-11-08 1995-10-26 A storage stable water solution for infusion containing a thrombin inhibitor
IL11587995A IL115879A (en) 1994-11-08 1995-11-06 A water-containing infusion-resistant solution containing a thrombin inhibitor
ZA959377A ZA959377B (en) 1994-11-08 1995-11-06 A storage stable water solution for infusion containing a thrombin inhibitor
TR95/01391A TR199501391A2 (tr) 1994-11-08 1995-11-08 Bir trombin inhibitör ihtiva eden infüzyon icin bir depolama icin dayanikli su mahlulu.
IS4468A IS4468A (is) 1994-11-08 1997-04-21 Vatnslausn til inndælingar sem er stöðug við geymslu og inniheldur þrombín-hemil
NO19972065A NO322048B1 (no) 1994-11-08 1997-05-05 Lagringsstabil vannopplosning for infusjon inneholdende en trombininhibitor, fremgangsmate for fremstilling av slik vannopplosning og anvendelse derav.
FI971949A FI971949A0 (fi) 1994-11-08 1997-05-07 Varastoinninkestävä, trombiini-inhibiittoria sisältävä vesiliuos infuusiota varten

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9403831A SE504185C2 (sv) 1994-11-08 1994-11-08 Lagringsstabil vattenlösning för infusion av trombininhibitorer

Publications (3)

Publication Number Publication Date
SE9403831D0 SE9403831D0 (sv) 1994-11-08
SE9403831L SE9403831L (sv) 1996-05-09
SE504185C2 true SE504185C2 (sv) 1996-12-02

Family

ID=20395892

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9403831A SE504185C2 (sv) 1994-11-08 1994-11-08 Lagringsstabil vattenlösning för infusion av trombininhibitorer

Country Status (31)

Country Link
US (1) US5830865A (ko)
EP (1) EP0789585B1 (ko)
JP (1) JPH10508598A (ko)
KR (1) KR100416677B1 (ko)
CN (1) CN1090508C (ko)
AT (1) ATE205399T1 (ko)
AU (1) AU695719B2 (ko)
BR (1) BR9509634A (ko)
CA (1) CA2203396A1 (ko)
CZ (1) CZ287256B6 (ko)
DE (1) DE69522702T2 (ko)
DK (1) DK0789585T3 (ko)
EE (1) EE9700218A (ko)
ES (1) ES2163528T3 (ko)
FI (1) FI971949A0 (ko)
HU (1) HU217073B (ko)
IL (1) IL115879A (ko)
IS (1) IS4468A (ko)
MX (1) MX9703339A (ko)
MY (1) MY112593A (ko)
NO (1) NO322048B1 (ko)
NZ (1) NZ295492A (ko)
PL (1) PL320342A1 (ko)
PT (1) PT789585E (ko)
RU (1) RU2164803C2 (ko)
SE (1) SE504185C2 (ko)
SK (1) SK53597A3 (ko)
TR (1) TR199501391A2 (ko)
TW (1) TW407057B (ko)
WO (1) WO1996014084A1 (ko)
ZA (1) ZA959377B (ko)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9301916D0 (sv) * 1993-06-03 1993-06-03 Ab Astra New peptides derivatives
US6984627B1 (en) * 1993-06-03 2006-01-10 Astrazeneca Ab Peptide derivatives
AR005245A1 (es) 1995-12-21 1999-04-28 Astrazeneca Ab Prodrogas de inhibidores de trombina, una formulación farmaceutica que las comprende, el uso de dichas prodrogas para la manufactura de un medicamento y un procedimiento para su preparacion
SE9802974D0 (sv) * 1998-09-03 1998-09-03 Astra Ab New crystalline forms
US6462021B1 (en) 2000-11-06 2002-10-08 Astrazeneca Ab Use of low molecular weight thrombin inhibitor
EP2982668A3 (en) 2002-12-03 2016-04-13 Pharmacyclics LLC 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors for the treatment of thromboembolic disorders
US7345093B2 (en) * 2004-04-27 2008-03-18 Formatech, Inc. Methods of enhancing solubility of compounds
US10143652B2 (en) 2009-09-23 2018-12-04 Curirx Inc. Methods for the preparation of liposomes
WO2011038073A1 (en) * 2009-09-23 2011-03-31 Formatech, Inc. Methods for the preparation of liposomes comprising docetaxel
US20110070294A1 (en) * 2009-09-23 2011-03-24 Javeri Indu Methods for the Administration of Drugs Using Liposomes

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9103612D0 (sv) * 1991-12-04 1991-12-04 Astra Ab New peptide derivatives
US5466131A (en) * 1994-03-22 1995-11-14 Micropump Corporation Multiple-chamber gear pump with hydraulically connected chambers

Also Published As

Publication number Publication date
IS4468A (is) 1997-04-21
KR970706844A (ko) 1997-12-01
MY112593A (en) 2001-07-31
SE9403831L (sv) 1996-05-09
DE69522702D1 (de) 2001-10-18
CZ287256B6 (en) 2000-10-11
AU3884695A (en) 1996-05-31
PT789585E (pt) 2002-01-30
DK0789585T3 (da) 2001-11-12
ATE205399T1 (de) 2001-09-15
US5830865A (en) 1998-11-03
EP0789585B1 (en) 2001-09-12
JPH10508598A (ja) 1998-08-25
IL115879A (en) 2001-08-08
CN1090508C (zh) 2002-09-11
FI971949A (fi) 1997-05-07
FI971949A0 (fi) 1997-05-07
CZ129497A3 (cs) 1998-02-18
DE69522702T2 (de) 2002-07-11
RU2164803C2 (ru) 2001-04-10
CA2203396A1 (en) 1996-05-17
HUT77560A (hu) 1998-06-29
IL115879A0 (en) 1996-01-31
NO972065L (no) 1997-05-05
TR199501391A2 (tr) 1996-06-21
EE9700218A (et) 1998-02-16
KR100416677B1 (ko) 2004-06-16
CN1162921A (zh) 1997-10-22
PL320342A1 (en) 1997-09-29
BR9509634A (pt) 1998-01-06
ES2163528T3 (es) 2002-02-01
HU217073B (hu) 1999-11-29
SK53597A3 (en) 1998-07-08
NO972065D0 (no) 1997-05-05
MX9703339A (es) 1997-07-31
NO322048B1 (no) 2006-08-07
SE9403831D0 (sv) 1994-11-08
NZ295492A (en) 1998-06-26
AU695719B2 (en) 1998-08-20
ZA959377B (en) 1996-05-08
WO1996014084A1 (en) 1996-05-17
EP0789585A1 (en) 1997-08-20
TW407057B (en) 2000-10-01

Similar Documents

Publication Publication Date Title
SE504185C2 (sv) Lagringsstabil vattenlösning för infusion av trombininhibitorer
BRPI0616127A2 (pt) formulação de argatroban
SE464061B (sv) Framstaellning av stabil, frystorkad cis-platina(ii)-diammindiklorid ur en vatten-alkoholloesning
BR112017006112B1 (pt) Formulação de proteína de fusão recombinante
CN105434373A (zh) 一种注射用奥拉西坦冻干制剂及其制备方法
JP2021534253A (ja) 液体ベンダムスチン医薬組成物
EP1479393B1 (en) Stabilized albumin preparations
US20220096414A1 (en) Levothyroxine liquid formulations
Scheiner et al. Thiamine destruction by sodium bisulfite in infusion solutions
CN104189891B (zh) 一种不含人血清蛋白的重组人促红素制剂
EP1423124B1 (en) Lyophilized formulation comprising olanzapine
Rosenberg et al. Cimetidine hydrochloride compatibility. I: Chemical aspects and room temperature stability in intravenous infusion fluids
Stendal et al. Drug stability and pyridine generation in ceftazidime injection
CN111450242A (zh) 一种比伐芦定注射制剂及其制备方法和应用
Nedich The compatibility of extemporaneously added drug additives with Travasol (amino acid) injection
UA136549U (uk) Готовий лікарський засіб для лікування гіперамоніємічних станів
CN104490771A (zh) 胞磷胆碱钠注射液药物组合物和制法
KR101461271B1 (ko) 시베레스타트 나트륨염 또는 그 수화물을 함유하는 주사용 제제
Guichard et al. Article III
JPH10287569A (ja) アシクロビル又はその塩の輸液型キット注射剤
SA112340153B1 (ar) ايبوبروفين للحقن التسريبي في الوريد
CA2541265A1 (en) Pharmaceutical composition comprising 5-methyl-2-(2'-chloro-6'-fluoroanilino)phenylacetic acid
CN105640984A (zh) 一种弱碱性葡萄糖氯化钠注射液药物组合物

Legal Events

Date Code Title Description
NUG Patent has lapsed

Ref document number: 9403831-2

Format of ref document f/p: F