MX9703339A - Solucion acuosa para infusion, estable al almacenamiento, que contiene un inhibidor de trombina. - Google Patents
Solucion acuosa para infusion, estable al almacenamiento, que contiene un inhibidor de trombina.Info
- Publication number
- MX9703339A MX9703339A MX9703339A MX9703339A MX9703339A MX 9703339 A MX9703339 A MX 9703339A MX 9703339 A MX9703339 A MX 9703339A MX 9703339 A MX9703339 A MX 9703339A MX 9703339 A MX9703339 A MX 9703339A
- Authority
- MX
- Mexico
- Prior art keywords
- storage stable
- thrombin inhibitor
- water solution
- stable water
- infusion containing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Esta invencion se relaciona con una solucion acuosa concentrada para infusion, estable al almacenamiento, que tiene un pH en el intervalo de 1.0 a 2.5 y que contiene un inhibidor activo de trombina que tiene la formula: HOOC-CH2- Y, en la que Y es (R)-Cha-Pic-Nag o (R)-Cgl-Aze-Pab, como una sal o como una base libre del mismo, con un proceso para su preparacion y con un método para tratamiento de un paciente en necesidad de tal formulacion.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9403831A SE504185C2 (sv) | 1994-11-08 | 1994-11-08 | Lagringsstabil vattenlösning för infusion av trombininhibitorer |
| PCT/SE1995/001228 WO1996014084A1 (en) | 1994-11-08 | 1995-10-19 | A storage stable water solution for infusion containing a thrombin inhibitor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX9703339A true MX9703339A (es) | 1997-07-31 |
Family
ID=20395892
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX9703339A MX9703339A (es) | 1994-11-08 | 1995-10-19 | Solucion acuosa para infusion, estable al almacenamiento, que contiene un inhibidor de trombina. |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US5830865A (es) |
| EP (1) | EP0789585B1 (es) |
| JP (1) | JPH10508598A (es) |
| KR (1) | KR100416677B1 (es) |
| CN (1) | CN1090508C (es) |
| AT (1) | ATE205399T1 (es) |
| AU (1) | AU695719B2 (es) |
| BR (1) | BR9509634A (es) |
| CA (1) | CA2203396A1 (es) |
| CZ (1) | CZ287256B6 (es) |
| DE (1) | DE69522702T2 (es) |
| DK (1) | DK0789585T3 (es) |
| EE (1) | EE9700218A (es) |
| ES (1) | ES2163528T3 (es) |
| FI (1) | FI971949A0 (es) |
| HU (1) | HU217073B (es) |
| IL (1) | IL115879A (es) |
| IS (1) | IS4468A (es) |
| MX (1) | MX9703339A (es) |
| MY (1) | MY112593A (es) |
| NO (1) | NO322048B1 (es) |
| NZ (1) | NZ295492A (es) |
| PL (1) | PL320342A1 (es) |
| PT (1) | PT789585E (es) |
| RU (1) | RU2164803C2 (es) |
| SE (1) | SE504185C2 (es) |
| SK (1) | SK53597A3 (es) |
| TR (1) | TR199501391A2 (es) |
| TW (1) | TW407057B (es) |
| WO (1) | WO1996014084A1 (es) |
| ZA (1) | ZA959377B (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9301916D0 (sv) * | 1993-06-03 | 1993-06-03 | Ab Astra | New peptides derivatives |
| US6984627B1 (en) * | 1993-06-03 | 2006-01-10 | Astrazeneca Ab | Peptide derivatives |
| TWI238827B (en) * | 1995-12-21 | 2005-09-01 | Astrazeneca Ab | Prodrugs of thrombin inhibitors |
| SE9802974D0 (sv) * | 1998-09-03 | 1998-09-03 | Astra Ab | New crystalline forms |
| US6462021B1 (en) | 2000-11-06 | 2002-10-08 | Astrazeneca Ab | Use of low molecular weight thrombin inhibitor |
| DK1569912T3 (en) | 2002-12-03 | 2015-06-29 | Pharmacyclics Inc | 2- (2-hydroxybiphenyl-3-yl) -1h-benzoimidazole-5-carboxamidine derivatives as factor VIIa inhibitors. |
| US7345093B2 (en) * | 2004-04-27 | 2008-03-18 | Formatech, Inc. | Methods of enhancing solubility of compounds |
| US10143652B2 (en) | 2009-09-23 | 2018-12-04 | Curirx Inc. | Methods for the preparation of liposomes |
| WO2011038068A1 (en) * | 2009-09-23 | 2011-03-31 | Formatech, Inc. | Methods for the preparation of liposomes |
| US20110070294A1 (en) * | 2009-09-23 | 2011-03-24 | Javeri Indu | Methods for the Administration of Drugs Using Liposomes |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9103612D0 (sv) * | 1991-12-04 | 1991-12-04 | Astra Ab | New peptide derivatives |
| US5466131A (en) * | 1994-03-22 | 1995-11-14 | Micropump Corporation | Multiple-chamber gear pump with hydraulically connected chambers |
-
1994
- 1994-11-08 SE SE9403831A patent/SE504185C2/sv not_active IP Right Cessation
-
1995
- 1995-10-04 TW TW084110363A patent/TW407057B/zh not_active IP Right Cessation
- 1995-10-19 AU AU38846/95A patent/AU695719B2/en not_active Ceased
- 1995-10-19 CN CN95196108A patent/CN1090508C/zh not_active Expired - Fee Related
- 1995-10-19 EE EE9700218A patent/EE9700218A/xx unknown
- 1995-10-19 WO PCT/SE1995/001228 patent/WO1996014084A1/en active IP Right Grant
- 1995-10-19 ES ES95938085T patent/ES2163528T3/es not_active Expired - Lifetime
- 1995-10-19 RU RU97108965/14A patent/RU2164803C2/ru active
- 1995-10-19 CZ CZ19971294A patent/CZ287256B6/cs not_active IP Right Cessation
- 1995-10-19 US US08/557,189 patent/US5830865A/en not_active Expired - Fee Related
- 1995-10-19 MX MX9703339A patent/MX9703339A/es not_active IP Right Cessation
- 1995-10-19 PL PL95320342A patent/PL320342A1/xx unknown
- 1995-10-19 CA CA002203396A patent/CA2203396A1/en not_active Abandoned
- 1995-10-19 SK SK535-97A patent/SK53597A3/sk unknown
- 1995-10-19 HU HU9800400A patent/HU217073B/hu not_active IP Right Cessation
- 1995-10-19 BR BR9509634A patent/BR9509634A/pt active Search and Examination
- 1995-10-19 PT PT95938085T patent/PT789585E/pt unknown
- 1995-10-19 KR KR1019970703043A patent/KR100416677B1/ko not_active IP Right Cessation
- 1995-10-19 JP JP8515235A patent/JPH10508598A/ja not_active Ceased
- 1995-10-19 DE DE69522702T patent/DE69522702T2/de not_active Expired - Fee Related
- 1995-10-19 NZ NZ295492A patent/NZ295492A/en unknown
- 1995-10-19 DK DK95938085T patent/DK0789585T3/da active
- 1995-10-19 EP EP95938085A patent/EP0789585B1/en not_active Expired - Lifetime
- 1995-10-19 AT AT95938085T patent/ATE205399T1/de not_active IP Right Cessation
- 1995-10-26 MY MYPI95003226A patent/MY112593A/en unknown
- 1995-11-06 ZA ZA959377A patent/ZA959377B/xx unknown
- 1995-11-06 IL IL11587995A patent/IL115879A/en not_active IP Right Cessation
- 1995-11-08 TR TR95/01391A patent/TR199501391A2/xx unknown
-
1997
- 1997-04-21 IS IS4468A patent/IS4468A/is unknown
- 1997-05-05 NO NO19972065A patent/NO322048B1/no unknown
- 1997-05-07 FI FI971949A patent/FI971949A0/fi not_active Application Discontinuation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration | ||
| MM | Annulment or lapse due to non-payment of fees |