SE461650B - B -dihydropolyprenylalkoholderivat och farmaceutisk komposition innehaallande detsamma - Google Patents

B -dihydropolyprenylalkoholderivat och farmaceutisk komposition innehaallande detsamma

Info

Publication number
SE461650B
SE461650B SE8303013A SE8303013A SE461650B SE 461650 B SE461650 B SE 461650B SE 8303013 A SE8303013 A SE 8303013A SE 8303013 A SE8303013 A SE 8303013A SE 461650 B SE461650 B SE 461650B
Authority
SE
Sweden
Prior art keywords
compound
compounds
solution
water
added
Prior art date
Application number
SE8303013A
Other languages
English (en)
Swedish (sv)
Other versions
SE8303013L (sv
SE8303013D0 (sv
Inventor
M Yamamoto
S Araki
H Yamamoto
I Yamatsu
T Suzuki
A Kajiwara
Y Suzuki
H Arai
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP57089806A external-priority patent/JPS58206517A/ja
Priority claimed from JP10620382A external-priority patent/JPS58225014A/ja
Priority claimed from JP18364282A external-priority patent/JPS5973513A/ja
Priority claimed from JP18364382A external-priority patent/JPS5973533A/ja
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of SE8303013D0 publication Critical patent/SE8303013D0/xx
Publication of SE8303013L publication Critical patent/SE8303013L/xx
Publication of SE461650B publication Critical patent/SE461650B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/147—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/02—Acyclic alcohols with carbon-to-carbon double bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/14—Unsaturated ethers
    • C07C43/15—Unsaturated ethers containing only non-aromatic carbon-to-carbon double bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/04—Saturated compounds containing keto groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/203—Unsaturated compounds containing keto groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/08—Preparation of carboxylic acids or their salts, halides or anhydrides from nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/377—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
    • C07C51/38—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups by decarboxylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/03—Monocarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/007—Esters of unsaturated alcohols having the esterified hydroxy group bound to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
    • C07C69/12—Acetic acid esters
    • C07C69/14—Acetic acid esters of monohydroxylic compounds
    • C07C69/145—Acetic acid esters of monohydroxylic compounds of unsaturated alcohols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/78—Benzoic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12C—BEER; PREPARATION OF BEER BY FERMENTATION; PREPARATION OF MALT FOR MAKING BEER; PREPARATION OF HOPS FOR MAKING BEER
    • C12C11/00—Fermentation processes for beer
    • C12C11/02—Pitching yeast

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Food Science & Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SE8303013A 1982-05-28 1983-05-27 B -dihydropolyprenylalkoholderivat och farmaceutisk komposition innehaallande detsamma SE461650B (sv)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP57089806A JPS58206517A (ja) 1982-05-28 1982-05-28 免疫機能不全による疾患の予防・治療剤
JP10620382A JPS58225014A (ja) 1982-06-22 1982-06-22 免疫機能不全による疾患の予防・治療剤
JP18364282A JPS5973513A (ja) 1982-10-21 1982-10-21 免疫機能不全による疾患の予防・治療剤
JP18364382A JPS5973533A (ja) 1982-10-21 1982-10-21 β，γ−ジヒドロポリプレニルアルコ−ル誘導体

Publications (3)

Publication Number Publication Date
SE8303013D0 SE8303013D0 (sv) 1983-05-27
SE8303013L SE8303013L (sv) 1983-11-29
SE461650B true SE461650B (sv) 1990-03-12

Family

ID=27467677

Family Applications (4)

Application Number Title Priority Date Filing Date
SE8303013A SE461650B (sv) 1982-05-28 1983-05-27 B -dihydropolyprenylalkoholderivat och farmaceutisk komposition innehaallande detsamma
SE8801515A SE502924C2 (sv) 1982-05-28 1988-04-22 Farmaceutisk komposition innehållande en verksam mängd av 3,7,11,15-tetrametyl-hexadeka-1-en-3-ol eller 3,7,11,15- tetrametyl-1,6,10,14-hexadekatetraen-3-ol
SE8801513A SE502922C2 (sv) 1982-05-28 1988-04-22 Användning av en polyprenylförening för framställning av profylaktiskt/terapeutiskt medel för humana och animala sjukdomar beroende på bristfälligt immunförsvar
SE8801514A SE502923C2 (sv) 1982-05-28 1988-04-22 Användning av en polyprenylförening för framställning av protylaktiskt/terapeutiskt medel för humana och animala sjukdomar beroende på bristfälligt immunförsvar

Family Applications After (3)

Application Number Title Priority Date Filing Date
SE8801515A SE502924C2 (sv) 1982-05-28 1988-04-22 Farmaceutisk komposition innehållande en verksam mängd av 3,7,11,15-tetrametyl-hexadeka-1-en-3-ol eller 3,7,11,15- tetrametyl-1,6,10,14-hexadekatetraen-3-ol
SE8801513A SE502922C2 (sv) 1982-05-28 1988-04-22 Användning av en polyprenylförening för framställning av profylaktiskt/terapeutiskt medel för humana och animala sjukdomar beroende på bristfälligt immunförsvar
SE8801514A SE502923C2 (sv) 1982-05-28 1988-04-22 Användning av en polyprenylförening för framställning av protylaktiskt/terapeutiskt medel för humana och animala sjukdomar beroende på bristfälligt immunförsvar

Country Status (12)

Country Link
US (3) US4624966A (es)
AT (1) AT389871B (es)
CA (1) CA1310660C (es)
CH (1) CH654823A5 (es)
DE (2) DE3318989C2 (es)
DK (1) DK171640B1 (es)
ES (3) ES8406992A1 (es)
FR (5) FR2527597B1 (es)
GB (7) GB2122610B (es)
IT (1) IT1164256B (es)
NL (1) NL194300C (es)
SE (4) SE461650B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3318989C2 (de) * 1982-05-28 1996-11-21 Eisai Co Ltd ß,gamma-Dihydropolyprenylalkoholderivate und diese enthaltende Arzneimittel und deren Verwendung
JPS6112622A (ja) * 1984-06-29 1986-01-21 Kuraray Co Ltd 造血幹細胞の分化増殖促進剤
JPH0759504B2 (ja) * 1986-01-23 1995-06-28 エーザイ株式会社 ポリプレニルアルコ−ル含有注射剤
US5070107A (en) * 1989-04-28 1991-12-03 Lidak Pharmaceuticals Systemic antiviral treatment
US5071879A (en) * 1989-04-28 1991-12-10 Lidak Pharmaceuticals Systemic antiviral treatment
JP3166991B2 (ja) * 1992-08-17 2001-05-14 日清製粉株式会社 （ｓ）−２，３−ジヒドロポリプレノール化合物を有効成分とする癌増殖抑制および／または癌転移抑制剤
US5602184A (en) * 1993-03-03 1997-02-11 The United States Of America As Represented By Department Of Health And Human Services Monoterpenes, sesquiterpenes and diterpenes as cancer therapy
WO1995016434A1 (en) * 1993-12-13 1995-06-22 Lidak Pharmaceuticals Sucrose ester c-20 to c-28 alcohol formulations
US5714645A (en) * 1995-10-31 1998-02-03 Kuraray Co., Ltd. Process for producing all trans-form polyprenols
GB2310138A (en) * 1996-02-19 1997-08-20 Juris Rubens Immunomodulating plant polyprenols
US5952392A (en) * 1996-09-17 1999-09-14 Avanir Pharmaceuticals Long-chain alcohols, alkanes, fatty acids and amides in the treatment of burns and viral inhibition
US6440980B1 (en) 1996-09-17 2002-08-27 Avanir Pharmaceuticals Synergistic inhibition of viral replication by long-chain hydrocarbons and nucleoside analogs
WO1998025599A1 (en) * 1996-12-12 1998-06-18 Pharmacia & Upjohn Company An oil composition of dihydropolyprenols
CA2234326C (en) * 1997-04-25 2001-07-31 Yoshin Tamai Process for preparing polyprenols
US6784207B2 (en) * 2000-08-04 2004-08-31 Roche Vitamins Inc. Phytanic acid derivative compositions
EA200400535A1 (ru) * 2001-10-16 2005-06-30 Аванир Фармасютикалз ПОДАВЛЕНИЕ ВИРУСОВ n-ДОКОСАНОЛОМ
US7015022B2 (en) * 2002-06-07 2006-03-21 University Of Medicine & Dentistry Of New Jersey Mammalian catalase-dependent oxidation processes and methods for stimulating oxidative activities
US20050158329A1 (en) 2004-01-21 2005-07-21 Ghosh Swapan K. Novel phytol derived immunoadjuvants and their use in vaccine formulations
US11110043B2 (en) 2015-11-16 2021-09-07 Wwu Alkenone-based formulations for topical applications

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR4055M (es) * 1964-01-20 1966-04-04
GB1459233A (en) 1973-08-29 1976-12-22 Inst Rech Chim Biolog Medicament containing a higher alkanol
US4059641A (en) * 1975-11-18 1977-11-22 Sankyo Company Limited Polyprenyl derivatives
JPS5391137A (en) * 1977-01-19 1978-08-10 Sumitomo Chem Co Ltd Stabilization of agrichemicals
JPS53145922A (en) * 1977-05-26 1978-12-19 Eisai Co Ltd Remedy for peptic ulcer containing prenyl ketone compound
GB2002231B (en) * 1977-08-10 1982-03-17 Eisai Co Ltd Hypertension treating agent
US4199587A (en) * 1977-08-10 1980-04-22 Eisai Co., Ltd. Method of treating hypertension with polyprenyl alcohol ester
JPS6058209B2 (ja) * 1978-12-01 1985-12-19 エーザイ株式会社 β，γ−ジヒドロポリプレニルアルコ−ルおよびそれからなる血圧降下剤
FR2443245A1 (fr) * 1978-12-07 1980-07-04 Nisshin Flour Milling Co Nouveaux agents anti-ulcere et compositions pharmaceutiques les contenant
EP0098620B1 (en) * 1980-05-30 1986-09-17 Eisai Co., Ltd. Alpha,beta-dihydropolyprenyl derivatives and a process for preparing these derivatives
CA1165240A (en) * 1980-07-09 1984-04-10 The Procter & Gamble Company Penetrating topical pharmaceutical compositions
JPS5791932A (en) * 1980-11-28 1982-06-08 Kuraray Co Ltd Polyprenyl compound
JPS57106618A (en) * 1980-12-24 1982-07-02 Eisai Co Ltd Anticancer agent consisting of polyprenyl compound
DE3163920D1 (en) * 1980-12-24 1984-07-05 Eisai Co Ltd Pharmaceutical preparations comprising polyprenyl compounds, especially as anti-cancer agents, and pharmaceutical compositions for the prevention and treatment of cancer and skin diseases
DE3318989C2 (de) * 1982-05-28 1996-11-21 Eisai Co Ltd ß,gamma-Dihydropolyprenylalkoholderivate und diese enthaltende Arzneimittel und deren Verwendung
DE69325935T2 (de) * 1992-03-17 2000-01-20 Eisai Co., Ltd. Hautbleichendes Mittel enthaltend Teprenone

Also Published As

Publication number Publication date
GB8508217D0 (en) 1985-05-09
GB2159712B (en) 1987-04-01
FR2527597A1 (fr) 1983-12-02
GB2159712A (en) 1985-12-11
SE8801513D0 (sv) 1988-04-22
DE3348500C2 (de) 1998-10-22
GB2159054A (en) 1985-11-27
ES529753A0 (es) 1985-07-16
GB2159713A (en) 1985-12-11
SE502922C2 (sv) 1996-02-19
FR2532848B1 (fr) 1986-04-11
FR2532848A1 (fr) 1984-03-16
GB2159054B (en) 1987-04-08
GB2159711B (en) 1987-04-01
SE8801514D0 (sv) 1988-04-22
SE502923C2 (sv) 1996-02-19
CH654823A5 (fr) 1986-03-14
CA1310660C (en) 1992-11-24
DE3318989A1 (de) 1983-12-01
US4624966A (en) 1986-11-25
SE8303013L (sv) 1983-11-29
FR2527597B1 (fr) 1989-02-10
GB2159710A (en) 1985-12-11
DE3318989C2 (de) 1996-11-21
ES522789A0 (es) 1984-09-01
GB2122610B (en) 1987-04-01
ATA197283A (de) 1989-07-15
DK239483D0 (da) 1983-05-27
NL194300C (nl) 2001-12-04
NL8301892A (nl) 1983-12-16
FR2532843A1 (fr) 1984-03-16
GB2159055A (en) 1985-11-27
FR2532844B1 (fr) 1986-10-03
GB8508220D0 (en) 1985-05-09
GB8508218D0 (en) 1985-05-09
US6288128B1 (en) 2001-09-11
SE502924C2 (sv) 1996-02-19
IT1164256B (it) 1987-04-08
IT8321364A0 (it) 1983-05-30
AT389871B (de) 1990-02-12
FR2569108A1 (fr) 1986-02-21
DK171640B1 (da) 1997-03-03
SE8801515L (sv) 1988-04-22
SE8801514L (sv) 1988-04-22
GB8508214D0 (en) 1985-05-09
DK239483A (da) 1983-11-29
GB2159710B (en) 1987-04-08
SE8801513L (sv) 1988-04-22
ES8406992A1 (es) 1984-09-01
ES8507444A1 (es) 1985-09-01
GB2122610A (en) 1984-01-18
FR2532844A1 (fr) 1984-03-16
NL194300B (nl) 2001-08-01
ES529754A0 (es) 1985-09-01
SE8801515D0 (sv) 1988-04-22
GB2159711A (en) 1985-12-11
FR2569108B1 (fr) 1990-03-02
SE8303013D0 (sv) 1983-05-27
GB8508219D0 (en) 1985-05-09
GB2159055B (en) 1987-04-08
GB8314419D0 (en) 1983-06-29
ES8506567A1 (es) 1985-07-16
US6111131A (en) 2000-08-29
IT8321364A1 (it) 1984-11-30

Similar Documents

Publication Publication Date Title
SE461650B (sv) B -dihydropolyprenylalkoholderivat och farmaceutisk komposition innehaallande detsamma
EP0196222B1 (en) Hypoglycemic agent
US3422196A (en) Utilizing 1 - (3,5 - dihydroxyphenyl)-1-hydroxy - 2 - isopropylaminoethane and salts thereof in the treatment of bronchial spasms
US5047428A (en) Expectorant comprising hydroxyalkylcysteine derivative
EP0002228B1 (en) Hydroxy naphthoquinone derivatives, their preparations for treating and preventing theileriosis in cattle and sheep, processes for their synthesis; naphthoquinone derivatives
US3176040A (en) Novel 2, 2'-(ethylenediimino)-di-1-butanols
US5280048A (en) β,γ-dihydropolyprenyl alcohol derivatives and pharmaceutical composition containing a polyprenyl compound
JP2012097003A (ja) ビキシン誘導体及び細胞保護剤
US5658958A (en) β, γ-dihydropolyprenyl alcohol derivatives effective at mitigating stress in animals
JP2835545B2 (ja) 白内障予防及び治療剤
FI62283C (fi) Foerfarande foer framstaellning av nya terapeutiskt anvaendbara n-2'-karboxifenyl-4-klorantranilsyraderivat
JPH0228108A (ja) 免疫機能不全による疾患の予防・治療剤
NL9900009A (nl) Beta, gamma-dihydropolyprenylalcoholderivaten en farmaceutisch preparaat, dat een polyprenylverbinding bevat.
JPS6353968B2 (es)
JPH0141624B2 (es)
JPS58206517A (ja) 免疫機能不全による疾患の予防・治療剤
GB2159709A (en) Pharmaceutical compositions of polyprenyl ketones
JPS5973533A (ja) β，γ−ジヒドロポリプレニルアルコ−ル誘導体
JPS61254546A (ja) キノン化合物
JPS58225014A (ja) 免疫機能不全による疾患の予防・治療剤
JPH0466575A (ja) ２―ニトロイミダゾール誘導体及びそれを含有する抗原虫剤
JPH03246223A (ja) 抗高脂血症剤および抗動脈硬化症剤
JPH10182672A (ja) 新規有機スズ化合物および抗腫瘍剤
JPH0769881A (ja) 抗ｈｉｖ剤

Legal Events

Date Code Title Description
NAL Patent in force

Ref document number: 8303013-0

Format of ref document f/p: F