FR2527597B1 - Derives d'alcool b,g-dihydropolyprenylique et composition pharmaceutique contenant un compose polyprenylique - Google Patents

Derives d'alcool b,g-dihydropolyprenylique et composition pharmaceutique contenant un compose polyprenylique

Info

Publication number
FR2527597B1
FR2527597B1 FR838308941A FR8308941A FR2527597B1 FR 2527597 B1 FR2527597 B1 FR 2527597B1 FR 838308941 A FR838308941 A FR 838308941A FR 8308941 A FR8308941 A FR 8308941A FR 2527597 B1 FR2527597 B1 FR 2527597B1
Authority
FR
France
Prior art keywords
polyprenylic
dihydropolyprenylic
derivatives
alcohol
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR838308941A
Other languages
English (en)
Other versions
FR2527597A1 (fr
Inventor
Masaichi Yamamoto
Seiichi Araki
Hiroshi Yamamoto
Isao Yamatsu
Akiharu Kajiwara
Yoshikazu Suzuki
Haruyoshi Arai
Takeshi Suzuki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Co Ltd
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP57089806A external-priority patent/JPS58206517A/ja
Priority claimed from JP10620382A external-priority patent/JPS58225014A/ja
Priority claimed from JP18364282A external-priority patent/JPS5973513A/ja
Priority claimed from JP18364382A external-priority patent/JPS5973533A/ja
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of FR2527597A1 publication Critical patent/FR2527597A1/fr
Application granted granted Critical
Publication of FR2527597B1 publication Critical patent/FR2527597B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/147—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/02—Acyclic alcohols with carbon-to-carbon double bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/14—Unsaturated ethers
    • C07C43/15—Unsaturated ethers containing only non-aromatic carbon-to-carbon double bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/04—Saturated compounds containing keto groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/203—Unsaturated compounds containing keto groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/08—Preparation of carboxylic acids or their salts, halides or anhydrides from nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/377—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
    • C07C51/38—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups by decarboxylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/03—Monocarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/007—Esters of unsaturated alcohols having the esterified hydroxy group bound to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
    • C07C69/12—Acetic acid esters
    • C07C69/14—Acetic acid esters of monohydroxylic compounds
    • C07C69/145—Acetic acid esters of monohydroxylic compounds of unsaturated alcohols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/78—Benzoic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12C—BEER; PREPARATION OF BEER BY FERMENTATION; PREPARATION OF MALT FOR MAKING BEER; PREPARATION OF HOPS FOR MAKING BEER
    • C12C11/00—Fermentation processes for beer
    • C12C11/02—Pitching yeast
FR838308941A 1982-05-28 1983-05-30 Derives d'alcool b,g-dihydropolyprenylique et composition pharmaceutique contenant un compose polyprenylique Expired FR2527597B1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP57089806A JPS58206517A (ja) 1982-05-28 1982-05-28 免疫機能不全による疾患の予防・治療剤
JP10620382A JPS58225014A (ja) 1982-06-22 1982-06-22 免疫機能不全による疾患の予防・治療剤
JP18364282A JPS5973513A (ja) 1982-10-21 1982-10-21 免疫機能不全による疾患の予防・治療剤
JP18364382A JPS5973533A (ja) 1982-10-21 1982-10-21 β，γ−ジヒドロポリプレニルアルコ−ル誘導体

Publications (2)

Publication Number Publication Date
FR2527597A1 FR2527597A1 (fr) 1983-12-02
FR2527597B1 true FR2527597B1 (fr) 1989-02-10

Family

ID=27467677

Family Applications (5)

Application Number Title Priority Date Filing Date
FR838308941A Expired FR2527597B1 (fr) 1982-05-28 1983-05-30 Derives d'alcool b,g-dihydropolyprenylique et composition pharmaceutique contenant un compose polyprenylique
FR8317171A Expired FR2532844B1 (fr) 1982-05-28 1983-10-27 Composition pharmaceutique contenant un compose polyprenylique
FR8317169A Pending FR2532843A1 (fr) 1982-05-28 1983-10-27 Composition pharmaceutique comprenant a titre de principe actif le phytol ou l'isophytol
FR8317170A Expired FR2532848B1 (fr) 1982-05-28 1983-10-27 Composition pharmaceutique contenant un derive polyprenylique
FR858513026A Expired - Lifetime FR2569108B1 (fr) 1982-05-28 1985-09-02 Composition pharmaceutique contenant un compose polyprenylique

Family Applications After (4)

Application Number Title Priority Date Filing Date
FR8317171A Expired FR2532844B1 (fr) 1982-05-28 1983-10-27 Composition pharmaceutique contenant un compose polyprenylique
FR8317169A Pending FR2532843A1 (fr) 1982-05-28 1983-10-27 Composition pharmaceutique comprenant a titre de principe actif le phytol ou l'isophytol
FR8317170A Expired FR2532848B1 (fr) 1982-05-28 1983-10-27 Composition pharmaceutique contenant un derive polyprenylique
FR858513026A Expired - Lifetime FR2569108B1 (fr) 1982-05-28 1985-09-02 Composition pharmaceutique contenant un compose polyprenylique

Country Status (12)

Country Link
US (3) US4624966A (fr)
AT (1) AT389871B (fr)
CA (1) CA1310660C (fr)
CH (1) CH654823A5 (fr)
DE (2) DE3348500C2 (fr)
DK (1) DK171640B1 (fr)
ES (3) ES522789A0 (fr)
FR (5) FR2527597B1 (fr)
GB (7) GB2122610B (fr)
IT (1) IT1164256B (fr)
NL (1) NL194300C (fr)
SE (4) SE461650B (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3348500C2 (de) * 1982-05-28 1998-10-22 Eisai Co Ltd beta,gamma-Dihydropolyprenylalkoholderivat
JPS6112622A (ja) * 1984-06-29 1986-01-21 Kuraray Co Ltd 造血幹細胞の分化増殖促進剤
JPH0759504B2 (ja) * 1986-01-23 1995-06-28 エーザイ株式会社 ポリプレニルアルコ−ル含有注射剤
US5070107A (en) * 1989-04-28 1991-12-03 Lidak Pharmaceuticals Systemic antiviral treatment
US5071879A (en) * 1989-04-28 1991-12-10 Lidak Pharmaceuticals Systemic antiviral treatment
JP3166991B2 (ja) * 1992-08-17 2001-05-14 日清製粉株式会社 （ｓ）−２，３−ジヒドロポリプレノール化合物を有効成分とする癌増殖抑制および／または癌転移抑制剤
US5602184A (en) * 1993-03-03 1997-02-11 The United States Of America As Represented By Department Of Health And Human Services Monoterpenes, sesquiterpenes and diterpenes as cancer therapy
ES2309441T3 (es) * 1993-12-13 2008-12-16 Avanir Pharmaceuticals Formulaciones de alcohol de c20 a c28 y ester de sacarosa.
US5714645A (en) * 1995-10-31 1998-02-03 Kuraray Co., Ltd. Process for producing all trans-form polyprenols
GB2310138A (en) * 1996-02-19 1997-08-20 Juris Rubens Immunomodulating plant polyprenols
US5952392A (en) * 1996-09-17 1999-09-14 Avanir Pharmaceuticals Long-chain alcohols, alkanes, fatty acids and amides in the treatment of burns and viral inhibition
US6440980B1 (en) 1996-09-17 2002-08-27 Avanir Pharmaceuticals Synergistic inhibition of viral replication by long-chain hydrocarbons and nucleoside analogs
CA2269680A1 (fr) * 1996-12-12 1998-06-18 Pharmacia & Upjohn Company Composition huileuse a base de dihydropolyprenols
CA2234326C (fr) * 1997-04-25 2001-07-31 Yoshin Tamai Procede de preparation de polyprenols
US6784207B2 (en) * 2000-08-04 2004-08-31 Roche Vitamins Inc. Phytanic acid derivative compositions
BR0213323A (pt) * 2001-10-16 2005-01-25 Avanir Pharmaceuticals Inibição viral por n-docosanol
US7015022B2 (en) * 2002-06-07 2006-03-21 University Of Medicine & Dentistry Of New Jersey Mammalian catalase-dependent oxidation processes and methods for stimulating oxidative activities
US20050158329A1 (en) 2004-01-21 2005-07-21 Ghosh Swapan K. Novel phytol derived immunoadjuvants and their use in vaccine formulations
WO2017087539A1 (fr) 2015-11-16 2017-05-26 O'neil Gregory W Formulations à base d'alcénone pour applications topiques

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53145922A (en) * 1977-05-26 1978-12-19 Eisai Co Ltd Remedy for peptic ulcer containing prenyl ketone compound
FR4055M (fr) * 1964-01-20 1966-04-04
GB1459233A (en) 1973-08-29 1976-12-22 Inst Rech Chim Biolog Medicament containing a higher alkanol
US4059641A (en) * 1975-11-18 1977-11-22 Sankyo Company Limited Polyprenyl derivatives
JPS5391137A (en) * 1977-01-19 1978-08-10 Sumitomo Chem Co Ltd Stabilization of agrichemicals
US4199587A (en) * 1977-08-10 1980-04-22 Eisai Co., Ltd. Method of treating hypertension with polyprenyl alcohol ester
DE2834911C2 (de) * 1977-08-10 1985-11-21 Eisai Co., Ltd., Tokio/Tokyo Antihypertonikum
JPS6058209B2 (ja) * 1978-12-01 1985-12-19 エーザイ株式会社 β，γ−ジヒドロポリプレニルアルコ−ルおよびそれからなる血圧降下剤
FR2443245A1 (fr) * 1978-12-07 1980-07-04 Nisshin Flour Milling Co Nouveaux agents anti-ulcere et compositions pharmaceutiques les contenant
DE3168876D1 (en) * 1980-05-30 1985-03-28 Eisai Co Ltd Alpha,beta-dihydropolyprenyl derivatives for treating liver diseases
CA1165240A (fr) * 1980-07-09 1984-04-10 The Procter & Gamble Company Composes pharmaceutiques a usage topique
JPS5791932A (en) * 1980-11-28 1982-06-08 Kuraray Co Ltd Polyprenyl compound
DE3163920D1 (en) * 1980-12-24 1984-07-05 Eisai Co Ltd Pharmaceutical preparations comprising polyprenyl compounds, especially as anti-cancer agents, and pharmaceutical compositions for the prevention and treatment of cancer and skin diseases
JPS57106618A (en) * 1980-12-24 1982-07-02 Eisai Co Ltd Anticancer agent consisting of polyprenyl compound
DE3348500C2 (de) * 1982-05-28 1998-10-22 Eisai Co Ltd beta,gamma-Dihydropolyprenylalkoholderivat
DE69325935T2 (de) * 1992-03-17 2000-01-20 Eisai Co Ltd Hautbleichendes Mittel enthaltend Teprenone

Also Published As

Publication number Publication date
FR2569108A1 (fr) 1986-02-21
SE461650B (sv) 1990-03-12
SE8801514L (sv) 1988-04-22
ATA197283A (de) 1989-07-15
DE3318989A1 (de) 1983-12-01
NL194300C (nl) 2001-12-04
DK239483A (da) 1983-11-29
FR2532848A1 (fr) 1984-03-16
AT389871B (de) 1990-02-12
SE8801513D0 (sv) 1988-04-22
SE8801515L (sv) 1988-04-22
GB2159711B (en) 1987-04-01
US6288128B1 (en) 2001-09-11
GB2159712B (en) 1987-04-01
GB2159054A (en) 1985-11-27
GB2159055B (en) 1987-04-08
CA1310660C (fr) 1992-11-24
IT1164256B (it) 1987-04-08
US4624966A (en) 1986-11-25
CH654823A5 (fr) 1986-03-14
DK171640B1 (da) 1997-03-03
ES529754A0 (es) 1985-09-01
NL8301892A (nl) 1983-12-16
SE8303013D0 (sv) 1983-05-27
GB8508220D0 (en) 1985-05-09
SE8303013L (sv) 1983-11-29
GB8508217D0 (en) 1985-05-09
SE8801515D0 (sv) 1988-04-22
IT8321364A0 (it) 1983-05-30
SE502924C2 (sv) 1996-02-19
ES8506567A1 (es) 1985-07-16
DK239483D0 (da) 1983-05-27
SE502922C2 (sv) 1996-02-19
GB8508219D0 (en) 1985-05-09
FR2527597A1 (fr) 1983-12-02
SE8801514D0 (sv) 1988-04-22
DE3348500C2 (de) 1998-10-22
FR2532844A1 (fr) 1984-03-16
GB2159055A (en) 1985-11-27
GB2159712A (en) 1985-12-11
GB2159710A (en) 1985-12-11
GB8508214D0 (en) 1985-05-09
GB8508218D0 (en) 1985-05-09
ES8406992A1 (es) 1984-09-01
GB2159713A (en) 1985-12-11
GB8314419D0 (en) 1983-06-29
US6111131A (en) 2000-08-29
ES529753A0 (es) 1985-07-16
FR2532843A1 (fr) 1984-03-16
ES8507444A1 (es) 1985-09-01
IT8321364A1 (it) 1984-11-30
GB2159710B (en) 1987-04-08
SE502923C2 (sv) 1996-02-19
FR2532844B1 (fr) 1986-10-03
GB2159054B (en) 1987-04-08
GB2122610B (en) 1987-04-01
FR2532848B1 (fr) 1986-04-11
NL194300B (nl) 2001-08-01
SE8801513L (sv) 1988-04-22
GB2159711A (en) 1985-12-11
ES522789A0 (es) 1984-09-01
DE3318989C2 (de) 1996-11-21
GB2122610A (en) 1984-01-18
FR2569108B1 (fr) 1990-03-02

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