SE454880B - 3-aminoalkyl-1h-indol-5-acetamider, forfarande for framstellning av dessa och en farmaceutisk komposition for behandling av migren - Google Patents

3-aminoalkyl-1h-indol-5-acetamider, forfarande for framstellning av dessa och en farmaceutisk komposition for behandling av migren

Info

Publication number
SE454880B
SE454880B SE8104781A SE8104781A SE454880B SE 454880 B SE454880 B SE 454880B SE 8104781 A SE8104781 A SE 8104781A SE 8104781 A SE8104781 A SE 8104781A SE 454880 B SE454880 B SE 454880B
Authority
SE
Sweden
Prior art keywords
compound
formula
group
indole
solution
Prior art date
Application number
SE8104781A
Other languages
English (en)
Swedish (sv)
Other versions
SE8104781L (sv
Inventor
D E Bays
C F Webb
M D Dowle
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of SE8104781L publication Critical patent/SE8104781L/xx
Publication of SE454880B publication Critical patent/SE454880B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/72—Hydrazones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
SE8104781A 1980-08-12 1981-08-11 3-aminoalkyl-1h-indol-5-acetamider, forfarande for framstellning av dessa och en farmaceutisk komposition for behandling av migren SE454880B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8026286 1980-08-12

Publications (2)

Publication Number Publication Date
SE8104781L SE8104781L (sv) 1982-02-13
SE454880B true SE454880B (sv) 1988-06-06

Family

ID=10515410

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8104781A SE454880B (sv) 1980-08-12 1981-08-11 3-aminoalkyl-1h-indol-5-acetamider, forfarande for framstellning av dessa och en farmaceutisk komposition for behandling av migren

Country Status (16)

Country Link
US (1) US4650810A (enExample)
JP (1) JPS5764669A (enExample)
AU (1) AU548467B2 (enExample)
BE (1) BE889929A (enExample)
CA (1) CA1169428A (enExample)
CH (1) CH651551A5 (enExample)
DE (1) DE3131728A1 (enExample)
DK (1) DK157920C (enExample)
ES (5) ES8301210A1 (enExample)
FR (1) FR2488607A1 (enExample)
IE (1) IE51491B1 (enExample)
IT (1) IT1171449B (enExample)
NL (1) NL8103769A (enExample)
NZ (1) NZ197996A (enExample)
SE (1) SE454880B (enExample)
ZA (1) ZA815540B (enExample)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR79215B (enExample) * 1982-06-07 1984-10-22 Glaxo Group Ltd
GB8332435D0 (en) * 1983-12-06 1984-01-11 Glaxo Group Ltd Chemical compounds
GB8419575D0 (en) * 1984-08-01 1984-09-05 Glaxo Group Ltd Chemical compounds
EP0225726B1 (en) * 1985-11-08 1991-04-17 Glaxo Group Limited Indole derivatives
GB8530507D0 (en) * 1985-12-11 1986-01-22 Glaxo Group Plc Chemical compounds
US5270333A (en) * 1986-01-28 1993-12-14 Glaxo Group Limited Indole derivatives
GB8607824D0 (en) * 1986-03-27 1986-04-30 Glaxo Group Ltd Chemical compounds
CZ288351B6 (en) * 1990-06-07 2001-05-16 Astrazeneca Ab Nitrogenous heterocyclic compound, process of its preparation and use as well as a medicament containing thereof
CZ283018B6 (cs) * 1991-02-01 1997-12-17 Merck Sharp And Dohme Limited Deriváty imidazolu, triazolu a tetrazolu a farmaceutické přípravky na jejich bázi
US5254383A (en) * 1992-09-14 1993-10-19 Allied-Signal Inc. Composites having improved penetration resistance and articles fabricated from same
FR2701026B1 (fr) * 1993-02-02 1995-03-31 Adir Nouveaux dérivés de l'indole, de l'indazole et du benzisoxazole, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
US5468768A (en) * 1994-01-06 1995-11-21 Bristol-Myers Squibb Company Antimigraine derivatives of indolylcycloalkanylamines
ES2084560B1 (es) * 1994-03-09 1997-01-16 Almirall Lab Procedimiento de preparacion de derivados el indol.
US5891885A (en) * 1996-10-09 1999-04-06 Algos Pharmaceutical Corporation Method for treating migraine
US20030096379A1 (en) * 2001-03-28 2003-05-22 Kilgore James L. Method for producing tryptamine derivatives
US20030198669A1 (en) * 2001-07-05 2003-10-23 R.T. Alamo Ventures I, Llc Compositions and methods for rapid dissolving formulations of dihydroergotamine and caffeine for the treatment of migraine
US20030017175A1 (en) * 2001-07-05 2003-01-23 R.T. Alamo Ventures I, Inc. Sublingual administration of dihydroergotamine for the treatment of migraine
US6685951B2 (en) 2001-07-05 2004-02-03 R. T. Alamo Ventures I, Inc. Administration of dihydroergotamine as a sublingual spray or aerosol for the treatment of migraine
CA2508290C (en) * 2002-12-20 2017-02-28 Ciba Specialty Chemicals Holding Inc. Synthesis of amines and intermediates for the synthesis thereof
PL2425820T3 (pl) * 2007-02-11 2015-08-31 Map Pharmaceuticals Inc Sposób terapeutycznego stosowania dhe w celu umożliwienia szybkiego złagodzenia migreny przy jednoczesnym zminimalizowaniu profilu działań niepożądanych
US8173813B2 (en) * 2007-03-23 2012-05-08 Neuraxon, Inc. Quinolone and tetrahydroquinolone and related compounds having NOS inhibitory activity
US8293781B2 (en) 2007-03-29 2012-10-23 Daiichi Sankyo Company, Limited Indole derivatives having cPLA2 inhibiting activity and applications and production methods of the same
US20110171141A1 (en) * 2009-06-26 2011-07-14 Kellerman Donald J Administration of dihydroergotamine mesylate particles using a metered dose inhaler
DK2734634T3 (da) 2011-07-22 2019-10-21 Univ Chicago Igf-1 til anvendelse til behandling af migræne
EP2935280A4 (en) 2012-12-21 2016-05-25 Map Pharmaceuticals Inc 8'-HYDROXY-DIHYDROERGOTAMINE COMPOUNDS AND COMPOSITIONS

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3182071A (en) * 1961-06-27 1965-05-04 Warner Lambert Pharmaceutical Acylated indole derivatives
US3472870A (en) * 1966-08-29 1969-10-14 Mead Johnson & Co Sulfonamidotryptamines
ZA795239B (en) * 1978-10-12 1980-11-26 Glaxo Group Ltd Heterocyclic compounds

Also Published As

Publication number Publication date
ES8500902A1 (es) 1984-11-01
ZA815540B (en) 1983-03-30
NL8103769A (nl) 1982-03-01
CH651551A5 (fr) 1985-09-30
DK157920B (da) 1990-03-05
ES520785A0 (es) 1984-11-01
ES8500903A1 (es) 1984-11-01
FR2488607B1 (enExample) 1984-11-16
NZ197996A (en) 1985-08-16
ES513933A0 (es) 1984-01-16
ES504693A0 (es) 1982-12-01
DE3131728A1 (de) 1982-03-11
ES520784A0 (es) 1984-11-01
DK157920C (da) 1990-08-06
IT1171449B (it) 1987-06-10
ES8402268A1 (es) 1984-01-16
IT8149084A0 (it) 1981-08-11
DK357081A (da) 1982-02-13
ES8504706A1 (es) 1985-05-01
JPH0247462B2 (enExample) 1990-10-19
AU548467B2 (en) 1985-12-12
SE8104781L (sv) 1982-02-13
ES520783A0 (es) 1985-05-01
IT8149084A1 (it) 1983-02-11
BE889929A (fr) 1982-02-11
US4650810A (en) 1987-03-17
JPS5764669A (en) 1982-04-19
ES8301210A1 (es) 1982-12-01
IE51491B1 (en) 1987-01-07
CA1169428A (en) 1984-06-19
DE3131728C2 (enExample) 1992-04-30
IE811830L (en) 1982-02-12
FR2488607A1 (fr) 1982-02-19
AU7399481A (en) 1982-02-18

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