CH651551A5 - Derives de l'indole, leur preparation et compositions pharmaceutiques les contenant. - Google Patents

Derives de l'indole, leur preparation et compositions pharmaceutiques les contenant. Download PDF

Info

Publication number
CH651551A5
CH651551A5 CH5159/81A CH515981A CH651551A5 CH 651551 A5 CH651551 A5 CH 651551A5 CH 5159/81 A CH5159/81 A CH 5159/81A CH 515981 A CH515981 A CH 515981A CH 651551 A5 CH651551 A5 CH 651551A5
Authority
CH
Switzerland
Prior art keywords
compound
group
formula
general formula
indole
Prior art date
Application number
CH5159/81A
Other languages
English (en)
French (fr)
Inventor
David Edmund Bays
Colin Frederick Webb
Michael Dennis Dowle
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of CH651551A5 publication Critical patent/CH651551A5/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/72—Hydrazones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
CH5159/81A 1980-08-12 1981-08-11 Derives de l'indole, leur preparation et compositions pharmaceutiques les contenant. CH651551A5 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8026286 1980-08-12

Publications (1)

Publication Number Publication Date
CH651551A5 true CH651551A5 (fr) 1985-09-30

Family

ID=10515410

Family Applications (1)

Application Number Title Priority Date Filing Date
CH5159/81A CH651551A5 (fr) 1980-08-12 1981-08-11 Derives de l'indole, leur preparation et compositions pharmaceutiques les contenant.

Country Status (16)

Country Link
US (1) US4650810A (enExample)
JP (1) JPS5764669A (enExample)
AU (1) AU548467B2 (enExample)
BE (1) BE889929A (enExample)
CA (1) CA1169428A (enExample)
CH (1) CH651551A5 (enExample)
DE (1) DE3131728A1 (enExample)
DK (1) DK157920C (enExample)
ES (5) ES8301210A1 (enExample)
FR (1) FR2488607A1 (enExample)
IE (1) IE51491B1 (enExample)
IT (1) IT1171449B (enExample)
NL (1) NL8103769A (enExample)
NZ (1) NZ197996A (enExample)
SE (1) SE454880B (enExample)
ZA (1) ZA815540B (enExample)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR79215B (enExample) * 1982-06-07 1984-10-22 Glaxo Group Ltd
GB8332435D0 (en) * 1983-12-06 1984-01-11 Glaxo Group Ltd Chemical compounds
GB8419575D0 (en) * 1984-08-01 1984-09-05 Glaxo Group Ltd Chemical compounds
EP0225726B1 (en) * 1985-11-08 1991-04-17 Glaxo Group Limited Indole derivatives
GB8530507D0 (en) * 1985-12-11 1986-01-22 Glaxo Group Plc Chemical compounds
US5270333A (en) * 1986-01-28 1993-12-14 Glaxo Group Limited Indole derivatives
GB8607824D0 (en) * 1986-03-27 1986-04-30 Glaxo Group Ltd Chemical compounds
CZ288351B6 (en) * 1990-06-07 2001-05-16 Astrazeneca Ab Nitrogenous heterocyclic compound, process of its preparation and use as well as a medicament containing thereof
CZ283018B6 (cs) * 1991-02-01 1997-12-17 Merck Sharp And Dohme Limited Deriváty imidazolu, triazolu a tetrazolu a farmaceutické přípravky na jejich bázi
US5254383A (en) * 1992-09-14 1993-10-19 Allied-Signal Inc. Composites having improved penetration resistance and articles fabricated from same
FR2701026B1 (fr) * 1993-02-02 1995-03-31 Adir Nouveaux dérivés de l'indole, de l'indazole et du benzisoxazole, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
US5468768A (en) * 1994-01-06 1995-11-21 Bristol-Myers Squibb Company Antimigraine derivatives of indolylcycloalkanylamines
ES2084560B1 (es) * 1994-03-09 1997-01-16 Almirall Lab Procedimiento de preparacion de derivados el indol.
US5891885A (en) * 1996-10-09 1999-04-06 Algos Pharmaceutical Corporation Method for treating migraine
US20030096379A1 (en) * 2001-03-28 2003-05-22 Kilgore James L. Method for producing tryptamine derivatives
US20030198669A1 (en) * 2001-07-05 2003-10-23 R.T. Alamo Ventures I, Llc Compositions and methods for rapid dissolving formulations of dihydroergotamine and caffeine for the treatment of migraine
US20030017175A1 (en) * 2001-07-05 2003-01-23 R.T. Alamo Ventures I, Inc. Sublingual administration of dihydroergotamine for the treatment of migraine
US6685951B2 (en) 2001-07-05 2004-02-03 R. T. Alamo Ventures I, Inc. Administration of dihydroergotamine as a sublingual spray or aerosol for the treatment of migraine
CA2508290C (en) * 2002-12-20 2017-02-28 Ciba Specialty Chemicals Holding Inc. Synthesis of amines and intermediates for the synthesis thereof
PL2425820T3 (pl) * 2007-02-11 2015-08-31 Map Pharmaceuticals Inc Sposób terapeutycznego stosowania dhe w celu umożliwienia szybkiego złagodzenia migreny przy jednoczesnym zminimalizowaniu profilu działań niepożądanych
US8173813B2 (en) * 2007-03-23 2012-05-08 Neuraxon, Inc. Quinolone and tetrahydroquinolone and related compounds having NOS inhibitory activity
US8293781B2 (en) 2007-03-29 2012-10-23 Daiichi Sankyo Company, Limited Indole derivatives having cPLA2 inhibiting activity and applications and production methods of the same
US20110171141A1 (en) * 2009-06-26 2011-07-14 Kellerman Donald J Administration of dihydroergotamine mesylate particles using a metered dose inhaler
DK2734634T3 (da) 2011-07-22 2019-10-21 Univ Chicago Igf-1 til anvendelse til behandling af migræne
EP2935280A4 (en) 2012-12-21 2016-05-25 Map Pharmaceuticals Inc 8'-HYDROXY-DIHYDROERGOTAMINE COMPOUNDS AND COMPOSITIONS

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3182071A (en) * 1961-06-27 1965-05-04 Warner Lambert Pharmaceutical Acylated indole derivatives
US3472870A (en) * 1966-08-29 1969-10-14 Mead Johnson & Co Sulfonamidotryptamines
ZA795239B (en) * 1978-10-12 1980-11-26 Glaxo Group Ltd Heterocyclic compounds

Also Published As

Publication number Publication date
ES8500902A1 (es) 1984-11-01
ZA815540B (en) 1983-03-30
NL8103769A (nl) 1982-03-01
DK157920B (da) 1990-03-05
SE454880B (sv) 1988-06-06
ES520785A0 (es) 1984-11-01
ES8500903A1 (es) 1984-11-01
FR2488607B1 (enExample) 1984-11-16
NZ197996A (en) 1985-08-16
ES513933A0 (es) 1984-01-16
ES504693A0 (es) 1982-12-01
DE3131728A1 (de) 1982-03-11
ES520784A0 (es) 1984-11-01
DK157920C (da) 1990-08-06
IT1171449B (it) 1987-06-10
ES8402268A1 (es) 1984-01-16
IT8149084A0 (it) 1981-08-11
DK357081A (da) 1982-02-13
ES8504706A1 (es) 1985-05-01
JPH0247462B2 (enExample) 1990-10-19
AU548467B2 (en) 1985-12-12
SE8104781L (sv) 1982-02-13
ES520783A0 (es) 1985-05-01
IT8149084A1 (it) 1983-02-11
BE889929A (fr) 1982-02-11
US4650810A (en) 1987-03-17
JPS5764669A (en) 1982-04-19
ES8301210A1 (es) 1982-12-01
IE51491B1 (en) 1987-01-07
CA1169428A (en) 1984-06-19
DE3131728C2 (enExample) 1992-04-30
IE811830L (en) 1982-02-12
FR2488607A1 (fr) 1982-02-19
AU7399481A (en) 1982-02-18

Similar Documents

Publication Publication Date Title
BE1000071A4 (fr) Derives d'indole, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2488607A1 (fr) Derives de l'indole, leur preparation et leurs utilisations pharmaceutiques
CH657359A5 (fr) Derives d'indole, procedes pour leur preparation et composition pharmaceutique les contenant.
CH666026A5 (fr) Derive d'indole.
CH651550A5 (fr) Derives de l'indole, leur preparation et compositions pharmaceutiques les contenant.
CH663411A5 (fr) Derives d'indole utiles comme medicaments.
JPH0148896B2 (enExample)
CH652394A5 (fr) Derives indoliques, leur preparation et medicaments les renfermant.
EP0611766A1 (fr) Dérivés de 2-amido-thiazoles polysubstitués, procédé de préparation, composition pharmaceutique et utilisation de ces dérivés pour la préparation d'un médicament
CH667647A5 (fr) 5-alkenesulfonamides indoles.
CH667454A5 (fr) Derives d'indoles.
CH671017A5 (enExample)
EP0677042A1 (fr) Ligands selectifs des recepteurs 5ht 1d?-5ht 1b? derives d'indole-piperazine utiles comme medicaments
EP1007524B1 (fr) Derives d'indole comme agonistes de 5-ht1b et 5-ht1d
GB2082175A (en) Heterocyclic compounds
FR2612517A1 (fr) Derives de benzoxazine, procedes de preparation de ces derives et compositions pharmaceutiques les contenant
FR2600061A1 (fr) Derives d'indole, composition pharmaceutique les contenant et procede pour leur preparation
EP1966173A2 (fr) Derives heterocycliques, leur preparation et leur application en therapeutique.
FR2894579A1 (fr) Derives diaryltriazolmethylamine, leur preparation et leur application en therapeutique.
WO1995029154A1 (fr) Nouveaux derives de benzylamines, leur procede de fabrication et les compositions pharmaceutiques les renfermant
EP0580465A1 (fr) Nouvelle utilisation thérapeutique d'hétérocyclyl-pipérazines comme 5-HT3 agonistes et nouveaux dérivés
LU85915A1 (fr) Nouveaux derives d'indole utiles comme medicaments et intermediaires et procedes pour leur preparation
BE848963A (fr) Phenylindolines et procede pour les produire

Legal Events

Date Code Title Description
PL Patent ceased
PL Patent ceased