SE449099B - 3,4-disubstituerade 1,2,5-tiadiazol-1-oxider och 1,1-dioxider, forfarande for deras framstellning samt farmaceutiska kompositioner innehallande dessa - Google Patents

3,4-disubstituerade 1,2,5-tiadiazol-1-oxider och 1,1-dioxider, forfarande for deras framstellning samt farmaceutiska kompositioner innehallande dessa

Info

Publication number
SE449099B
SE449099B SE8006148A SE8006148A SE449099B SE 449099 B SE449099 B SE 449099B SE 8006148 A SE8006148 A SE 8006148A SE 8006148 A SE8006148 A SE 8006148A SE 449099 B SE449099 B SE 449099B
Authority
SE
Sweden
Prior art keywords
lower alkyl
thiadiazole
amino
methanol
solution
Prior art date
Application number
SE8006148A
Other languages
English (en)
Swedish (sv)
Other versions
SE8006148L (sv
Inventor
Ronnie Ray Crenshaw
Aldo Antonio Algieri
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of SE8006148L publication Critical patent/SE8006148L/
Publication of SE449099B publication Critical patent/SE449099B/sv

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/08—1,2,5-Oxadiazoles; Hydrogenated 1,2,5-oxadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/40—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/10—1,2,5-Thiadiazoles; Hydrogenated 1,2,5-thiadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Lubricants (AREA)
SE8006148A 1979-09-04 1980-09-03 3,4-disubstituerade 1,2,5-tiadiazol-1-oxider och 1,1-dioxider, forfarande for deras framstellning samt farmaceutiska kompositioner innehallande dessa SE449099B (sv)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7251779A 1979-09-04 1979-09-04
US11718280A 1980-01-31 1980-01-31
US16383180A 1980-06-07 1980-06-07

Publications (2)

Publication Number Publication Date
SE8006148L SE8006148L (sv) 1981-04-15
SE449099B true SE449099B (sv) 1987-04-06

Family

ID=27372107

Family Applications (5)

Application Number Title Priority Date Filing Date
SE8006148A SE449099B (sv) 1979-09-04 1980-09-03 3,4-disubstituerade 1,2,5-tiadiazol-1-oxider och 1,1-dioxider, forfarande for deras framstellning samt farmaceutiska kompositioner innehallande dessa
SE8403107A SE456580B (sv) 1979-09-04 1984-06-08 Mellanprodukter for framstellning av 3,4-disubstituerade 1,2,5-tiadiazol-1-oxider och -1,1-dioxider som er h 71-receptorantagonister
SE8403109A SE456581B (sv) 1979-09-04 1984-06-08 Mellanprodukter for framstellning av 3,4-disubstituerade 1,2,5-tiadiazol-1-oxider och -1,1-dioxider som er h 71-receptorantagonister
SE8403108A SE456582B (sv) 1979-09-04 1984-06-08 Mellanprodukter for framstellning av 3,4-disubstituerade 1,2,5-tiadiazol-1-oxider och -1,1-dioxider, som er h 71-receptorantagonister
SE8403111A SE461733B (sv) 1979-09-04 1984-06-08 Foerfarande foer framstaellning av 3,4-disubstituerade 1,2,5-tiadiazol-1-oxider och -1,1-dioxider

Family Applications After (4)

Application Number Title Priority Date Filing Date
SE8403107A SE456580B (sv) 1979-09-04 1984-06-08 Mellanprodukter for framstellning av 3,4-disubstituerade 1,2,5-tiadiazol-1-oxider och -1,1-dioxider som er h 71-receptorantagonister
SE8403109A SE456581B (sv) 1979-09-04 1984-06-08 Mellanprodukter for framstellning av 3,4-disubstituerade 1,2,5-tiadiazol-1-oxider och -1,1-dioxider som er h 71-receptorantagonister
SE8403108A SE456582B (sv) 1979-09-04 1984-06-08 Mellanprodukter for framstellning av 3,4-disubstituerade 1,2,5-tiadiazol-1-oxider och -1,1-dioxider, som er h 71-receptorantagonister
SE8403111A SE461733B (sv) 1979-09-04 1984-06-08 Foerfarande foer framstaellning av 3,4-disubstituerade 1,2,5-tiadiazol-1-oxider och -1,1-dioxider

Country Status (23)

Country Link
US (1) US4374248A (fi)
AR (1) AR240559A1 (fi)
AT (2) AT376978B (fi)
CA (4) CA1167841A (fi)
CH (2) CH658055A5 (fi)
CS (1) CS235951B2 (fi)
CY (2) CY1360A (fi)
DE (2) DE3051146C2 (fi)
DK (4) DK160611C (fi)
FI (1) FI76795C (fi)
GB (2) GB2067987B (fi)
HK (2) HK41387A (fi)
IE (2) IE50997B1 (fi)
KE (2) KE3685A (fi)
LU (1) LU82753A1 (fi)
MY (2) MY8700735A (fi)
NL (3) NL189197C (fi)
NO (4) NO160003C (fi)
NZ (1) NZ194831A (fi)
PT (1) PT71764B (fi)
SE (5) SE449099B (fi)
SG (1) SG61187G (fi)
ZW (1) ZW20580A1 (fi)

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NZ186965A (en) * 1977-04-20 1980-02-21 Ici Ltd Guanidino derivatives and pharmaceutical compositions
US4165378A (en) * 1977-04-20 1979-08-21 Ici Americas Inc. Guanidine derivatives of imidazoles and thiazoles
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DE3175201D1 (en) * 1980-04-30 1986-10-02 Merck & Co Inc Aminothiadiazoles as gastric secretion inhibitors
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ATE19880T1 (de) * 1981-08-24 1986-06-15 Merck & Co Inc Thiadiazole oxyde mit antisekretorischer wirkung.

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US4374248A (en) 1983-02-15
PT71764B (en) 1983-04-28
SG61187G (en) 1987-10-23
DK269090D0 (da) 1990-11-09
PT71764A (en) 1980-09-30
CY1360A (en) 1987-08-07
DK268990D0 (da) 1990-11-09
IE50997B1 (en) 1986-09-03
GB2067987B (en) 1984-07-11
DE3051146C2 (de) 1991-05-02
NL189197B (nl) 1992-09-01
NL8004967A (nl) 1981-03-06
KE3742A (en) 1987-09-04
ATA443480A (de) 1984-06-15
IE861175L (en) 1981-03-04
DK164363C (da) 1992-11-02
DK164700C (da) 1992-12-21
SE8403107D0 (sv) 1984-06-08
NO161737C (no) 1989-09-20
SE8403108L (sv) 1984-06-08
GB8318949D0 (en) 1983-08-17
IE51235B1 (en) 1986-11-12
DK268990A (da) 1990-11-09
DK164700B (da) 1992-08-03
NO160003C (no) 1989-03-01
NO162664C (no) 1990-01-31
HK89187A (en) 1987-12-11
CA1263114A (en) 1989-11-21
GB2132190B (en) 1985-01-03
NO802576L (no) 1981-03-05
NO862501L (no) 1987-03-05
NZ194831A (en) 1984-11-09
DK269190D0 (da) 1990-11-09
CA1263115A (en) 1989-11-21
CA1248962A (en) 1989-01-17
GB2067987A (en) 1981-08-05
MY8700585A (en) 1987-12-31
NO161737B (no) 1989-06-12
DK160611C (da) 1991-09-16
KE3685A (en) 1987-01-30
CH658055A5 (de) 1986-10-15
SE456581B (sv) 1988-10-17
SE8403111D0 (sv) 1984-06-08
IE801851L (en) 1981-03-04
DK371880A (da) 1981-03-05
FI76795B (fi) 1988-08-31
DE3033169C2 (de) 1989-08-03
CH649764A5 (de) 1985-06-14
NO862501D0 (no) 1986-06-23
NO162664B (no) 1989-10-23
ZW20580A1 (en) 1981-01-21
DK269090A (da) 1990-11-09
NO160781B (no) 1989-02-20
SE8403111L (sv) 1984-06-08
SE8403108D0 (sv) 1984-06-08
HK41387A (en) 1987-06-05
LU82753A1 (fr) 1981-04-17
FI76795C (fi) 1988-12-12
DK164702B (da) 1992-08-03
NO871420D0 (no) 1987-04-06
SE8403109D0 (sv) 1984-06-08
ATA64584A (de) 1984-07-15
NO160003B (no) 1988-11-21
MY8700735A (en) 1987-12-31
SE8006148L (sv) 1981-04-15
DK164702C (da) 1992-12-21
DK164363B (da) 1992-06-15
SE8403107L (sv) 1984-06-08
FI802740A (fi) 1981-03-05
NO871421D0 (no) 1987-04-06
DK160611B (da) 1991-04-02
SE461733B (sv) 1990-03-19
CY1402A (en) 1987-12-18
AR240559A1 (es) 1990-05-31
NL9201237A (nl) 1993-03-01
CA1167841A (en) 1984-05-22
NO160781C (no) 1989-05-31
NL189197C (nl) 1993-02-01
DE3033169A1 (de) 1981-03-19
AT376978B (de) 1985-01-25
DK269190A (da) 1990-11-09
AT377257B (de) 1985-02-25
SE456580B (sv) 1988-10-17
CS235951B2 (en) 1985-05-15
SE456582B (sv) 1988-10-17
GB2132190A (en) 1984-07-04
SE8403109L (sv) 1984-06-08
NL9201236A (nl) 1993-03-01

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