SE416810C - Forfarande for framstellning av xantinderivat med antiallergisk aktivitet - Google Patents

Forfarande for framstellning av xantinderivat med antiallergisk aktivitet

Info

Publication number
SE416810C
SE416810C SE7711581A SE7711581A SE416810C SE 416810 C SE416810 C SE 416810C SE 7711581 A SE7711581 A SE 7711581A SE 7711581 A SE7711581 A SE 7711581A SE 416810 C SE416810 C SE 416810C
Authority
SE
Sweden
Prior art keywords
compound
preparation
methyl
propyl
formula
Prior art date
Application number
SE7711581A
Other languages
English (en)
Swedish (sv)
Other versions
SE7711581L (sv
SE416810B (sv
Inventor
S H A M Bergstrand
P G Kjellin
C G A Persson
L M Sorenby
Original Assignee
Draco Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Draco Ab filed Critical Draco Ab
Priority to SE7711581A priority Critical patent/SE416810C/sv
Priority to ZA00785335A priority patent/ZA785335B/xx
Priority to US05/947,002 priority patent/US4233303A/en
Priority to DE7878850015T priority patent/DE2862017D1/de
Priority to AU40365/78A priority patent/AU521585B2/en
Priority to NZ188566A priority patent/NZ188566A/en
Priority to EP78850015A priority patent/EP0001735B1/en
Priority to AT0714478A priority patent/AT363491B/de
Priority to CA313,026A priority patent/CA1109470A/en
Priority to DD78208423A priority patent/DD139855A5/de
Priority to DK453778A priority patent/DK148260C/da
Priority to HU78DA359A priority patent/HU180219B/hu
Priority to FI783126A priority patent/FI66383C/fi
Priority to SU782675299A priority patent/SU755199A3/ru
Priority to CS786669A priority patent/CS208756B2/cs
Priority to IT51499/78A priority patent/IT1109208B/it
Priority to IE2041/78A priority patent/IE47884B1/en
Priority to NO783471A priority patent/NO147562C/no
Priority to JP12573978A priority patent/JPS5479296A/ja
Publication of SE7711581L publication Critical patent/SE7711581L/xx
Publication of SE416810B publication Critical patent/SE416810B/sv
Publication of SE416810C publication Critical patent/SE416810C/sv
Priority to SG855/84A priority patent/SG85584G/en
Priority to HK63/85A priority patent/HK6385A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SE7711581A 1977-10-14 1977-10-14 Forfarande for framstellning av xantinderivat med antiallergisk aktivitet SE416810C (sv)

Priority Applications (21)

Application Number Priority Date Filing Date Title
SE7711581A SE416810C (sv) 1977-10-14 1977-10-14 Forfarande for framstellning av xantinderivat med antiallergisk aktivitet
ZA00785335A ZA785335B (en) 1977-10-14 1978-09-19 Xanthine derivatives
US05/947,002 US4233303A (en) 1977-10-14 1978-09-29 Xanthine derivatives
DE7878850015T DE2862017D1 (en) 1977-10-14 1978-10-03 Xanthine derivatives having antiallergic activity and pharmacological preparations containing them
AU40365/78A AU521585B2 (en) 1977-10-14 1978-10-03 Xanthine derivatives
NZ188566A NZ188566A (en) 1977-10-14 1978-10-03 Certain 1,8-dialkyl-3-hydrocarbyl-3,7-dihydro-1h-purine-2,6-diones
EP78850015A EP0001735B1 (en) 1977-10-14 1978-10-03 Xanthine derivatives having antiallergic activity and pharmacological preparations containing them
AT0714478A AT363491B (de) 1977-10-14 1978-10-04 Verfahren zur herstellung von neuen 1,3,8trisubstituierten xanthinen und deren salzen
CA313,026A CA1109470A (en) 1977-10-14 1978-10-10 Xanthine derivatives
DD78208423A DD139855A5 (de) 1977-10-14 1978-10-12 Verfahren zur herstellung von xanthinderivaten
DK453778A DK148260C (da) 1977-10-14 1978-10-12 Analogifremgangsmaade til fremstilling af 1,3,8-trisubstituerede xantinderivater eller salte deraf
HU78DA359A HU180219B (en) 1977-10-14 1978-10-13 Process for producing substituted xantine derivatives and salts
FI783126A FI66383C (fi) 1977-10-14 1978-10-13 Foerfarande foer framstaellning av farmakologiskt aktiva xantinderivat
SU782675299A SU755199A3 (en) 1977-10-14 1978-10-13 Method of preparing xanthine derivatives or their salts
CS786669A CS208756B2 (en) 1977-10-14 1978-10-13 Method of preparation of the 1,3,8-substituted xantines
IT51499/78A IT1109208B (it) 1977-10-14 1978-10-13 Procedimento per la produzione di derivati della xantina e prodotto relativo
IE2041/78A IE47884B1 (en) 1977-10-14 1978-10-13 Xanthine derivatives having antiallergic activity and pharmacological preparations containing them
NO783471A NO147562C (no) 1977-10-14 1978-10-13 Analogifremgangsmaate for fremstilling av terapeutisk virksomme xantinderivater
JP12573978A JPS5479296A (en) 1977-10-14 1978-10-14 Xanthine derivative
SG855/84A SG85584G (en) 1977-10-14 1984-11-29 Xanthine derivatives having antiallergic activity and pharmacological preparations containing them
HK63/85A HK6385A (en) 1977-10-14 1985-01-24 Xanthine derivatives having antiallergic activity and pharmacological preparations containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE7711581A SE416810C (sv) 1977-10-14 1977-10-14 Forfarande for framstellning av xantinderivat med antiallergisk aktivitet

Publications (3)

Publication Number Publication Date
SE7711581L SE7711581L (sv) 1979-04-15
SE416810B SE416810B (sv) 1981-02-09
SE416810C true SE416810C (sv) 1982-07-19

Family

ID=20332576

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7711581A SE416810C (sv) 1977-10-14 1977-10-14 Forfarande for framstellning av xantinderivat med antiallergisk aktivitet

Country Status (21)

Country Link
US (1) US4233303A (cs)
EP (1) EP0001735B1 (cs)
JP (1) JPS5479296A (cs)
AT (1) AT363491B (cs)
AU (1) AU521585B2 (cs)
CA (1) CA1109470A (cs)
CS (1) CS208756B2 (cs)
DD (1) DD139855A5 (cs)
DE (1) DE2862017D1 (cs)
DK (1) DK148260C (cs)
FI (1) FI66383C (cs)
HK (1) HK6385A (cs)
HU (1) HU180219B (cs)
IE (1) IE47884B1 (cs)
IT (1) IT1109208B (cs)
NO (1) NO147562C (cs)
NZ (1) NZ188566A (cs)
SE (1) SE416810C (cs)
SG (1) SG85584G (cs)
SU (1) SU755199A3 (cs)
ZA (1) ZA785335B (cs)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7810947L (sv) * 1978-10-20 1980-04-21 Draco Ab 3-alkylxanthines
SE8002910L (sv) * 1980-04-18 1981-10-19 Draco Ab 3,8-dialkylxantiner, forfarande for deras framstellning, beredning och metoder for behandling av kronisk obstruktiv luftvegssjukdom och kardiovaskulera sjukdomar
US4755517A (en) * 1986-07-31 1988-07-05 Warner-Lambert Company Derivatives of xanthine, pharmaceutical compositions and methods of use therefor
US5298508A (en) * 1988-07-19 1994-03-29 The United States Of America As Represented By The Department Of Health And Human Services Irreversible inhibitors of adenosine receptors
US5321029A (en) * 1988-11-14 1994-06-14 Beecham-Wuelfing Gmbh & Co.K.G. Xanthines
GB8826595D0 (en) * 1988-11-14 1988-12-21 Beecham Wuelfing Gmbh & Co Kg Active compounds
IT1229195B (it) * 1989-03-10 1991-07-25 Poli Ind Chimica Spa Derivati xantinici ad attivita' broncodilatatrice e loro applicazioni terapeutiche.
GB8929208D0 (en) * 1989-12-27 1990-02-28 Almirall Lab New xanthine derivatives
US5047534A (en) * 1990-03-26 1991-09-10 Merrell Dow Pharmaceuticals Inc. Selective adenosine receptor agents
US5342841A (en) * 1992-03-12 1994-08-30 Kyowa Hakko Kogyo Co., Ltd. Xanthine derivatives
US5366977A (en) * 1992-09-29 1994-11-22 The United States Of America, As Represented By The Department Of Health And Human Services Method of treating cystic fibrosis using 8-cyclopentyl-1,3-dipropylxanthine or xanthine amino congeners
US5395836A (en) * 1993-04-07 1995-03-07 Kyowa Hakko Kogyo Co., Ltd. 8-tricycloalkyl xanthine derivatives
GB9312853D0 (en) * 1993-06-22 1993-08-04 Euro Celtique Sa Chemical compounds
US5922751A (en) * 1994-06-24 1999-07-13 Euro-Celtique, S.A. Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same
US5591776A (en) * 1994-06-24 1997-01-07 Euro-Celtique, S.A. Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV
US5661153A (en) * 1994-07-19 1997-08-26 Japan Energy Corporation 1-arylpyrimidine derivatives and pharmaceutical use thereof
AU4527996A (en) * 1994-12-13 1996-07-03 Euro-Celtique S.A. Trisubstituted thioxanthines
WO1996018399A1 (en) * 1994-12-13 1996-06-20 Euro-Celtique, S.A. Aryl thioxanthines
US6166041A (en) * 1995-10-11 2000-12-26 Euro-Celtique, S.A. 2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma
US6075016A (en) * 1996-04-10 2000-06-13 Euro-Celtique S.A. 6,5-fused aromatic ring systems having enhanced phosphodiesterase IV inhibitory activity
US5864037A (en) 1996-06-06 1999-01-26 Euro-Celtique, S.A. Methods for the synthesis of chemical compounds having PDE-IV inhibitory activity
BRPI0409699A (pt) 2003-04-25 2006-04-18 Novacardia Inc métodos de indução do efeito diurético, de indução, manutenção ou restauração do efeito diurético de diurético não modificador de adenosina, de manutenção, restauração ou melhoria da função renal em paciente, de indução de diurese, de prevenção do inìcio de deficiência renal em paciente com sobrecarga de fluidos ou chf, de tratamento de paciente que sofre de chf e de melhoria dos resultados globais da saúde, composição farmacêutica e seus usos
MXPA06011823A (es) * 2004-04-16 2006-12-15 Novacardia Inc Terapia de combinacion, que comprende un antagonista del receptor de la adenosina a1 y un inhibidor de la aldosterona.
US20070049757A1 (en) * 2005-08-26 2007-03-01 Rieger Jayson M Methods for the synthesis of substituted amino uracils

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1911279A1 (de) * 1969-03-05 1970-11-12 Eckert Dr Theodor Verfahren zur Erhoehung der Resorptionsfaehigkeit von Arzneistoffen
US3900474A (en) * 1973-05-14 1975-08-19 Kendall & Co Trifluoroalkyl, fluorobenzyl, pentafluorobenzyl, fluorobenzenesulfonyl, and pentafluorobenzenesulfonyl theophyllines
US4061753A (en) * 1976-02-06 1977-12-06 Interx Research Corporation Treating psoriasis with transient pro-drug forms of xanthine derivatives
CA1077932A (en) 1976-03-31 1980-05-20 Berlex Laboratories, Inc. Xanthine compounds and method of treating bronchospastic and allergic diseases
US4120947A (en) * 1976-03-31 1978-10-17 Cooper Laboratories, Inc. Xanthine compounds and method of treating bronchospastic and allergic diseases

Also Published As

Publication number Publication date
DK148260C (da) 1986-02-10
EP0001735B1 (en) 1982-09-01
HK6385A (en) 1985-02-01
DK148260B (da) 1985-05-20
AU521585B2 (en) 1982-04-22
SE7711581L (sv) 1979-04-15
IE47884B1 (en) 1984-07-11
FI66383B (fi) 1984-06-29
HU180219B (en) 1983-02-28
ATA714478A (de) 1980-09-15
AU4036578A (en) 1980-04-17
IE782041L (en) 1979-04-14
AT363491B (de) 1981-08-10
US4233303A (en) 1980-11-11
CA1109470A (en) 1981-09-22
EP0001735A1 (en) 1979-05-02
CS208756B2 (en) 1981-09-15
SE416810B (sv) 1981-02-09
NO147562B (no) 1983-01-24
IT1109208B (it) 1985-12-16
IT7851499A0 (it) 1978-10-13
NO147562C (no) 1983-05-18
SG85584G (en) 1985-06-07
DD139855A5 (de) 1980-01-23
DE2862017D1 (en) 1982-10-28
NO783471L (no) 1979-04-18
NZ188566A (en) 1984-07-06
SU755199A3 (en) 1980-08-07
ZA785335B (en) 1979-09-26
FI783126A7 (fi) 1979-04-15
DK453778A (da) 1979-04-15
FI66383C (fi) 1984-10-10
JPS5479296A (en) 1979-06-25

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