RU99116321A - Форма производного тетрагидропиридина в виде микрочастиц - Google Patents
Форма производного тетрагидропиридина в виде микрочастицInfo
- Publication number
- RU99116321A RU99116321A RU99116321/04A RU99116321A RU99116321A RU 99116321 A RU99116321 A RU 99116321A RU 99116321/04 A RU99116321/04 A RU 99116321/04A RU 99116321 A RU99116321 A RU 99116321A RU 99116321 A RU99116321 A RU 99116321A
- Authority
- RU
- Russia
- Prior art keywords
- microparticles
- microns
- active ingredient
- unit dosage
- particles
- Prior art date
Links
- 239000011859 microparticle Substances 0.000 title claims 10
- VSWICNJIUPRZIK-UHFFFAOYSA-N 2-piperideine Chemical class C1CNC=CC1 VSWICNJIUPRZIK-UHFFFAOYSA-N 0.000 title 1
- 239000002245 particle Substances 0.000 claims 6
- 239000004480 active ingredient Substances 0.000 claims 4
- 239000002552 dosage form Substances 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 239000012458 free base Substances 0.000 claims 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- WVHBEIJGAINUBW-UHFFFAOYSA-N hydron;1-(2-naphthalen-2-ylethyl)-4-[3-(trifluoromethyl)phenyl]-3,6-dihydro-2H-pyridine;chloride Chemical compound Cl.FC(F)(F)C1=CC=CC(C=2CCN(CCC=3C=C4C=CC=CC4=CC=3)CC=2)=C1 WVHBEIJGAINUBW-UHFFFAOYSA-N 0.000 claims 1
- 239000004005 microsphere Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Claims (12)
1. Форма гидрохлорида 1-[2-(2-нафтил)этил]-4-(3-трифторметилфенил)-1,2,3,6-тетрагидропиридина в виде микрочастиц, состоящая из частиц, по крайней мере, 55% которых имеют диаметр меньше 50 мкм.
2. Форма по п.1 в виде микрочастиц, отличающаяся тем, что диаметр частиц меньше 25 мкм.
3. Форма по п.2 в виде микрочастиц, отличающаяся тем, что диаметр частиц меньше 15 мкм.
4. Форма по п.3 в виде микрочастиц, отличающаяся тем, что диаметр 80 - 85% совокупности частиц меньше 10 мкм.
5. Форма по любому из пп.1 - 4 в виде микрочастиц, отличающаяся тем, что частицы являются микросферами.
6. Форма по п.5 в виде микрочастиц, отличающаяся тем, что микрочастицы состоят из гидрохлорида 1-[2-(2-нафти)этил] -4-(3-трифторметилфенил)-1,2,3,6-тетрагидропиридина по существу в аморфной форме.
7. Форма по любому из пп.1 - 4 в виде микрочастиц, отличающаяся тем, что частицы являются микронизированными кристаллами.
8. Фармацевтическая композиция, содержащая форму по любому из пп.1 - 7 в виде микрочастиц в качестве активного ингредиента.
9. Композиция по п. 8, отличающаяся тем, что она представляет собой единичную дозированную форму.
10. Композиция по п.9, отличающаяся тем, что каждая единичная дозированная форма содержит 0,1 - 5 мг активного ингредиента (рассчитано для свободного основания).
11. Композиция по п.10, отличающаяся тем, что каждая единичная дозированная форма содержит 0,5 - 3 мг активного ингредиента (рассчитано для свободного основания).
12. Композиция по п.11, отличающаяся тем, что каждая единичная дозированная форма содержит 2 мг активного ингредиента (рассчитано для свободного основания).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR96/15905 | 1996-12-23 | ||
| FR9615905A FR2757510B1 (fr) | 1996-12-23 | 1996-12-23 | Forme microparticulaire d'un derive de tetrahydropyridine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU99116321A true RU99116321A (ru) | 2001-05-27 |
| RU2193031C2 RU2193031C2 (ru) | 2002-11-20 |
Family
ID=9499044
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU99116321/04A RU2193031C2 (ru) | 1996-12-23 | 1997-12-23 | Форма гидрохлорида 1-[2-(2-нафтил)этил]-4-(3-трифторметилфенил)-1,2,3,6-тетрагидропиридина в виде микрочастиц, фармацевтическая композиция на ее основе |
Country Status (38)
| Country | Link |
|---|---|
| US (4) | US20020028247A1 (ru) |
| EP (1) | EP0950051B1 (ru) |
| JP (2) | JP4422214B2 (ru) |
| KR (1) | KR100455797B1 (ru) |
| CN (1) | CN1088698C (ru) |
| AR (1) | AR009673A1 (ru) |
| AT (1) | ATE250032T1 (ru) |
| AU (1) | AU730302B2 (ru) |
| BR (1) | BR9714177A (ru) |
| CA (1) | CA2275593C (ru) |
| CO (1) | CO4920213A1 (ru) |
| CZ (1) | CZ294272B6 (ru) |
| DE (1) | DE69724999T2 (ru) |
| DK (1) | DK0950051T3 (ru) |
| DZ (1) | DZ2386A1 (ru) |
| EE (1) | EE04112B1 (ru) |
| EG (1) | EG24749A (ru) |
| ES (1) | ES2207758T3 (ru) |
| FR (1) | FR2757510B1 (ru) |
| HK (1) | HK1024000A1 (ru) |
| HU (1) | HU224348B1 (ru) |
| IL (1) | IL129937A (ru) |
| IN (1) | IN186977B (ru) |
| IS (1) | IS2064B (ru) |
| MY (1) | MY126298A (ru) |
| NO (1) | NO311569B1 (ru) |
| NZ (1) | NZ336129A (ru) |
| PL (1) | PL190098B1 (ru) |
| PT (1) | PT950051E (ru) |
| RU (1) | RU2193031C2 (ru) |
| SI (1) | SI0950051T1 (ru) |
| SK (1) | SK283917B6 (ru) |
| TR (1) | TR199901362T2 (ru) |
| TW (1) | TW534820B (ru) |
| UA (1) | UA66776C2 (ru) |
| WO (1) | WO1998028272A1 (ru) |
| YU (1) | YU49427B (ru) |
| ZA (1) | ZA9711579B (ru) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2330642C2 (ru) * | 2001-07-06 | 2008-08-10 | Лайфсайкл Фарма А/С | Регулируемая агломерация |
| BE1015641A4 (fr) * | 2003-05-26 | 2005-07-05 | Mariani Jean Paul | Micronisation 70. |
| RU2472490C1 (ru) * | 2011-08-05 | 2013-01-20 | Открытое акционерное общество "Биосинтез" | Средство для лечения кожных гнойных инфекций, составы и способы получения |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US562883A (en) * | 1896-06-30 | Thill-coupling | ||
| FR2531707A1 (fr) * | 1982-08-16 | 1984-02-17 | Midy Spa | Trifluoromethylphenyltetrahydropyridines substituees a activite anorexigene, un procede de preparation et compositions pharmaceutiques |
| US4826689A (en) * | 1984-05-21 | 1989-05-02 | University Of Rochester | Method for making uniformly sized particles from water-insoluble organic compounds |
| FR2627696B1 (fr) * | 1988-02-26 | 1991-09-13 | Fournier Innovation Synergie | Nouvelle forme galenique du fenofibrate |
| FR2639226B1 (fr) * | 1988-11-18 | 1993-11-05 | Sanofi | Utilisation de trifluoromethylphenyltetrahydropyridines pour la preparation de medicaments destines a combattre les troubles anxio-depressifs |
| FR2662355B1 (fr) * | 1990-05-22 | 1994-11-10 | Sanofi Sa | Utilisation de la 1-[2-(2-naphtyl)ethyl]-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine pour la preparation de medicaments destines au traitement de troubles cerebraux et neuronaux. |
| ES2127835T3 (es) * | 1992-10-26 | 1999-05-01 | Sanol Arznei Schwarz Gmbh | Procedimiento para la preparacion de microcapsulas. |
| US5662883A (en) * | 1995-01-10 | 1997-09-02 | Nanosystems L.L.C. | Microprecipitation of micro-nanoparticulate pharmaceutical agents |
| US5560932A (en) * | 1995-01-10 | 1996-10-01 | Nano Systems L.L.C. | Microprecipitation of nanoparticulate pharmaceutical agents |
| US6489334B2 (en) * | 1996-12-23 | 2002-12-03 | Sanofi-Synthelabo | Method for the crystallization of a tetrahydropyridin derivative and resulting crystalline forms |
| FR2763847B1 (fr) * | 1997-05-28 | 2003-06-06 | Sanofi Sa | Utilisation de tetrahydropyridines 4-substituees pour fabriquer des medicaments agissant sur le tgf-beta-1 |
| US20020147216A1 (en) * | 2000-01-31 | 2002-10-10 | Yuhong Zhou | Mucin synthesis inhibitors |
-
1996
- 1996-12-23 FR FR9615905A patent/FR2757510B1/fr not_active Expired - Fee Related
-
1997
- 1997-12-19 AR ARP970106030A patent/AR009673A1/es not_active Application Discontinuation
- 1997-12-22 DZ DZ970236A patent/DZ2386A1/xx active
- 1997-12-22 MY MYPI97006232A patent/MY126298A/en unknown
- 1997-12-23 NZ NZ336129A patent/NZ336129A/xx not_active IP Right Cessation
- 1997-12-23 JP JP52848298A patent/JP4422214B2/ja not_active Expired - Fee Related
- 1997-12-23 IL IL12993797A patent/IL129937A/en not_active IP Right Cessation
- 1997-12-23 AT AT97952987T patent/ATE250032T1/de active
- 1997-12-23 EP EP97952987A patent/EP0950051B1/fr not_active Expired - Lifetime
- 1997-12-23 SK SK829-99A patent/SK283917B6/sk not_active IP Right Cessation
- 1997-12-23 CZ CZ19992291A patent/CZ294272B6/cs not_active IP Right Cessation
- 1997-12-23 CN CN97180862A patent/CN1088698C/zh not_active Expired - Fee Related
- 1997-12-23 EE EEP199900263A patent/EE04112B1/xx not_active IP Right Cessation
- 1997-12-23 DE DE69724999T patent/DE69724999T2/de not_active Expired - Lifetime
- 1997-12-23 CA CA002275593A patent/CA2275593C/en not_active Expired - Fee Related
- 1997-12-23 UA UA99063520A patent/UA66776C2/ru unknown
- 1997-12-23 SI SI9730592T patent/SI0950051T1/xx unknown
- 1997-12-23 PT PT97952987T patent/PT950051E/pt unknown
- 1997-12-23 IN IN3767DE1997 patent/IN186977B/en unknown
- 1997-12-23 US US09/331,514 patent/US20020028247A1/en not_active Abandoned
- 1997-12-23 EG EG138497A patent/EG24749A/xx active
- 1997-12-23 ZA ZA9711579A patent/ZA9711579B/xx unknown
- 1997-12-23 ES ES97952987T patent/ES2207758T3/es not_active Expired - Lifetime
- 1997-12-23 CO CO97074790A patent/CO4920213A1/es unknown
- 1997-12-23 DK DK97952987T patent/DK0950051T3/da active
- 1997-12-23 HU HU0001181A patent/HU224348B1/hu not_active IP Right Cessation
- 1997-12-23 YU YU28899A patent/YU49427B/sh unknown
- 1997-12-23 BR BR9714177-1A patent/BR9714177A/pt not_active Application Discontinuation
- 1997-12-23 PL PL97334276A patent/PL190098B1/pl not_active IP Right Cessation
- 1997-12-23 RU RU99116321/04A patent/RU2193031C2/ru not_active IP Right Cessation
- 1997-12-23 KR KR10-1999-7005372A patent/KR100455797B1/ko not_active IP Right Cessation
- 1997-12-23 TR TR1999/01362T patent/TR199901362T2/xx unknown
- 1997-12-23 AU AU56685/98A patent/AU730302B2/en not_active Ceased
- 1997-12-23 WO PCT/FR1997/002394 patent/WO1998028272A1/fr active IP Right Grant
-
1998
- 1998-01-21 TW TW086119619A patent/TW534820B/zh not_active IP Right Cessation
-
1999
- 1999-06-10 IS IS5077A patent/IS2064B/xx unknown
- 1999-06-22 NO NO19993077A patent/NO311569B1/no not_active IP Right Cessation
-
2000
- 2000-05-30 HK HK00103194A patent/HK1024000A1/xx not_active IP Right Cessation
-
2002
- 2002-06-21 US US10/177,384 patent/US20020192292A1/en not_active Abandoned
-
2008
- 2008-06-13 US US12/138,582 patent/US20080255365A1/en not_active Abandoned
-
2009
- 2009-06-10 JP JP2009139083A patent/JP2009280581A/ja active Pending
- 2009-10-05 US US12/573,455 patent/US20100021541A1/en not_active Abandoned
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