RU98120360A - Фармацевтические композиции на основе микофенолята с энтеросолюбильным покрытием - Google Patents
Фармацевтические композиции на основе микофенолята с энтеросолюбильным покрытиемInfo
- Publication number
- RU98120360A RU98120360A RU98120360/14A RU98120360A RU98120360A RU 98120360 A RU98120360 A RU 98120360A RU 98120360/14 A RU98120360/14 A RU 98120360/14A RU 98120360 A RU98120360 A RU 98120360A RU 98120360 A RU98120360 A RU 98120360A
- Authority
- RU
- Russia
- Prior art keywords
- mycophenolate
- composition
- salt
- enteric coated
- pharmaceutically acceptable
- Prior art date
Links
- HPNSFSBZBAHARI-RUDMXATFSA-N mycophenolic acid Chemical compound OC1=C(C\C=C(/C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-RUDMXATFSA-N 0.000 title claims 7
- 229940014456 MYCOPHENOLATE Drugs 0.000 title claims 4
- 229960000951 Mycophenolic Acid Drugs 0.000 title claims 4
- 239000008194 pharmaceutical composition Substances 0.000 title claims 3
- 239000011248 coating agent Substances 0.000 title 1
- 238000000576 coating method Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 claims 7
- 230000001861 immunosuppresant Effects 0.000 claims 4
- 239000003018 immunosuppressive agent Substances 0.000 claims 4
- 230000001506 immunosuppresive Effects 0.000 claims 3
- 230000002265 prevention Effects 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000011780 sodium chloride Substances 0.000 claims 2
- PMATZTZNYRCHOR-CGLBZJNRSA-N (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-[(E,1R,2R)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17 Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 1
- 229940119017 Cyclosporine Drugs 0.000 claims 1
- 108010036949 Cyclosporine Proteins 0.000 claims 1
- 206010062016 Immunosuppression Diseases 0.000 claims 1
- 206010052779 Transplant rejections Diseases 0.000 claims 1
- 210000004027 cells Anatomy 0.000 claims 1
- 229960001265 ciclosporin Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 200000000018 inflammatory disease Diseases 0.000 claims 1
- 230000000968 intestinal Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000001404 mediated Effects 0.000 claims 1
- 210000000056 organs Anatomy 0.000 claims 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N sodium Chemical group [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 claims 1
- 210000001519 tissues Anatomy 0.000 claims 1
Claims (7)
1. Фармацевтическая композиция, включающая соль микофенолята, причем эта композиция приспособлена для высвобождения микофенолята в верхней части кишечного тракта.
2. Фармацевтическая композиция, включающая фармацевтически приемлемую соль микофенолята с нанесенным энтеросолюбильным покрытием.
3. Применение фармацевтически приемлемой соли микофенолята с нанесенным энтеросолюбильным покрытием или композиции по п. 1 или 2 при изготовлении лекарственного средства, обладающего иммунодепрессантной активностью, в частности для предупреждения или лечения отторжения трансплантата, являющегося аллотрансплантатом или ксенотрансплантатом нативного или трансгенного органа, ткани или клетки; для лечения или предупреждения опосредованных иммунной системой и/или воспалительных заболеваний; необязательно наряду с одновременным или раздельным введением другого иммунодепрессанта.
4. Способ иммунодепрессии пациента, включающий введение терапевтически эффективного количества фармацевтически приемлемого микофенолята с нанесенным энтеросолюбильным покрытием или композиции по п. 1 или 2 пациенту, нуждающемуся в такой иммунодепрессии, необязательно наряду с одновременным или раздельным введением другого иммунодепрессанта.
5. Композиция, содержащая фармацевтически приемлемую соль микофенолята с нанесенным энтеросолюбильным покрытием или композицию по п. 1 или 2 и другой иммунодепрессант, для одновременного, последовательного или раздельного введения.
6. Композиция, применение или способ по любому из предыдущих пунктов, где соль представляет собой мононатриевую соль.
7. Композиция, применение или способ по любому из предыдущих пунктов, где присутствует другой иммунодепрессант, например, циклоспорин.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9607564.3A GB9607564D0 (en) | 1996-04-12 | 1996-04-12 | Organic compounds |
| GB9622028.0 | 1996-10-24 | ||
| GB9607564.3 | 1996-10-24 | ||
| GBGB9622028.0A GB9622028D0 (en) | 1996-10-24 | 1996-10-24 | Organic compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU98120360A true RU98120360A (ru) | 2000-09-20 |
| RU2203659C2 RU2203659C2 (ru) | 2003-05-10 |
Family
ID=26309105
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU0098120360A RU2615397C2 (ru) | 1996-04-12 | 1997-04-10 | Фармацевтические композиции на основе соли микофеноловой кислоты с энтеросолюбильным покрытием |
| RU98120360/14A RU2203659C2 (ru) | 1996-04-12 | 1997-04-10 | Фармацевтические композиции на основе соли микофеноловой кислоты с энтеросолюбильным покрытием |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU0098120360A RU2615397C2 (ru) | 1996-04-12 | 1997-04-10 | Фармацевтические композиции на основе соли микофеноловой кислоты с энтеросолюбильным покрытием |
Country Status (34)
| Country | Link |
|---|---|
| US (3) | US6025391A (ru) |
| EP (2) | EP1221316A1 (ru) |
| JP (2) | JP3779732B2 (ru) |
| CN (1) | CN1104238C (ru) |
| AR (2) | AR006583A1 (ru) |
| AT (2) | ATE259228T1 (ru) |
| AU (1) | AU725388B2 (ru) |
| BE (1) | BE1010963A3 (ru) |
| BR (1) | BR9708624A (ru) |
| CO (1) | CO4900024A1 (ru) |
| CY (1) | CY2243B1 (ru) |
| CZ (1) | CZ291811B6 (ru) |
| DE (4) | DE69727559T2 (ru) |
| DK (1) | DK0892640T3 (ru) |
| ES (2) | ES2216141T3 (ru) |
| FR (1) | FR2747920B1 (ru) |
| GB (1) | GB2326339B (ru) |
| GR (1) | GR1002893B (ru) |
| HK (2) | HK1051484A1 (ru) |
| HU (1) | HU224919B1 (ru) |
| ID (1) | ID18663A (ru) |
| IE (1) | IE970267A1 (ru) |
| IL (1) | IL126431A (ru) |
| IT (1) | IT1297045B1 (ru) |
| LU (1) | LU91094I2 (ru) |
| MY (1) | MY119049A (ru) |
| NL (1) | NL300157I2 (ru) |
| NO (2) | NO322891B1 (ru) |
| NZ (1) | NZ332117A (ru) |
| PT (1) | PT892640E (ru) |
| RU (2) | RU2615397C2 (ru) |
| TR (1) | TR199802056T2 (ru) |
| TW (1) | TW457098B (ru) |
| WO (1) | WO1997038689A2 (ru) |
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| GB0301259D0 (en) | 2003-01-20 | 2003-02-19 | Novartis Ag | Organic compounds |
| GB0314553D0 (en) * | 2003-06-21 | 2003-07-30 | Weatherford Lamb | Electric submersible pumps |
| US8993599B2 (en) * | 2003-07-18 | 2015-03-31 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
| AR045957A1 (es) * | 2003-10-03 | 2005-11-16 | Novartis Ag | Composicion farmaceutica y combinacion |
| PT1729797E (pt) * | 2004-03-22 | 2008-12-17 | Solvay Pharm Gmbh | Composições farmacêuticas orais de produtos contendo lipase, em particular de pancreatina, contendo tensioactivos |
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| GB0419355D0 (en) * | 2004-08-31 | 2004-09-29 | Novartis Ag | Organic compounds |
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| US11266607B2 (en) | 2005-08-15 | 2022-03-08 | AbbVie Pharmaceuticals GmbH | Process for the manufacture and use of pancreatin micropellet cores |
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| ES2339297T3 (es) * | 2006-06-29 | 2010-05-18 | Ivax Pharmaceuticals S.R.O. | Regulacion de la produccion de metabolitos acidos. |
| US20080182998A1 (en) * | 2007-01-25 | 2008-07-31 | Apotex Fermentation Inc. | Novel crystalline mycophenolate sodium polymorph and processes to manufacture same |
| US20080176937A1 (en) * | 2007-01-23 | 2008-07-24 | Apotex Fermentation Inc. | Novel crystalline mycophenolate sodium polymorph and processes to manufacture same |
| TW200904982A (en) * | 2007-04-11 | 2009-02-01 | Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag | Method for reducing impurity level in mycophenolic acid fermentation |
| EP2187872A4 (en) * | 2007-08-13 | 2013-09-18 | Panacea Biotec Ltd | EXTENDED RELEASE COMPOSITIONS COMPRISING SODIUM MYCOPHENOLATE AND METHODS RELATING THERETO |
| US20090130063A1 (en) * | 2007-11-15 | 2009-05-21 | Solvay Pharmaceuticals Gmbh | Process for separating and determining the viral load in a pancreatin sample |
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| US20110086102A1 (en) * | 2009-10-13 | 2011-04-14 | Teva Pharmaceutical Industries Ltd. | Delayed release compositions |
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| US8669281B1 (en) | 2013-03-14 | 2014-03-11 | Alkermes Pharma Ireland Limited | Prodrugs of fumarates and their use in treating various diseases |
| WO2014167442A1 (en) | 2013-03-26 | 2014-10-16 | Wockhardt Limited | Pharmaceutical compositions comprising mycophenolic acid or salts thereof |
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1997
- 1997-04-01 ID IDP971201A patent/ID18663A/id unknown
- 1997-04-08 BE BE9700319A patent/BE1010963A3/fr not_active IP Right Cessation
- 1997-04-10 CO CO97018556A patent/CO4900024A1/es unknown
- 1997-04-10 RU RU0098120360A patent/RU2615397C2/ru active
- 1997-04-10 AT AT97919330T patent/ATE259228T1/de active
- 1997-04-10 BR BR9708624A patent/BR9708624A/pt not_active IP Right Cessation
- 1997-04-10 EP EP02001803A patent/EP1221316A1/en not_active Withdrawn
- 1997-04-10 DE DE69727559T patent/DE69727559T2/de not_active Expired - Lifetime
- 1997-04-10 AR ARP970101419A patent/AR006583A1/es active IP Right Grant
- 1997-04-10 MY MYPI97001573A patent/MY119049A/en unknown
- 1997-04-10 IL IL12643197A patent/IL126431A/xx active Protection Beyond IP Right Term
- 1997-04-10 RU RU98120360/14A patent/RU2203659C2/ru active
- 1997-04-10 HU HU9903373A patent/HU224919B1/hu active Protection Beyond IP Right Term
- 1997-04-10 DE DE1997627559 patent/DE122004000038I2/de active Active
- 1997-04-10 GR GR970100135A patent/GR1002893B/el not_active IP Right Cessation
- 1997-04-10 DE DE200412000038 patent/DE122004000038I1/de active Pending
- 1997-04-10 JP JP53672597A patent/JP3779732B2/ja not_active Expired - Lifetime
- 1997-04-10 DE DE19781690T patent/DE19781690D2/de not_active Expired - Lifetime
- 1997-04-10 ES ES97919330T patent/ES2216141T3/es not_active Expired - Lifetime
- 1997-04-10 EP EP97919330A patent/EP0892640B1/en not_active Expired - Lifetime
- 1997-04-10 IE IE970267A patent/IE970267A1/en not_active IP Right Cessation
- 1997-04-10 DK DK97919330T patent/DK0892640T3/da active
- 1997-04-10 CN CN97193760A patent/CN1104238C/zh not_active Expired - Lifetime
- 1997-04-10 PT PT97919330T patent/PT892640E/pt unknown
- 1997-04-10 NZ NZ332117A patent/NZ332117A/xx not_active IP Right Cessation
- 1997-04-10 WO PCT/EP1997/001800 patent/WO1997038689A2/en active IP Right Grant
- 1997-04-10 CZ CZ19983267A patent/CZ291811B6/cs not_active IP Right Cessation
- 1997-04-10 ES ES009850018A patent/ES2178510B1/es not_active Expired - Fee Related
- 1997-04-10 AT AT0905997A patent/AT408415B/de not_active IP Right Cessation
- 1997-04-10 US US09/077,398 patent/US6025391A/en not_active Expired - Lifetime
- 1997-04-10 AU AU23843/97A patent/AU725388B2/en not_active Expired
- 1997-04-10 GB GB9821304A patent/GB2326339B/en not_active Expired - Lifetime
- 1997-04-10 TW TW086104578A patent/TW457098B/zh not_active IP Right Cessation
- 1997-04-10 TR TR1998/02056T patent/TR199802056T2/xx unknown
- 1997-04-11 IT IT97RM000207A patent/IT1297045B1/it active IP Right Grant
- 1997-04-11 FR FR9704496A patent/FR2747920B1/fr not_active Expired - Lifetime
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1998
- 1998-10-09 NO NO19984728A patent/NO322891B1/no not_active IP Right Cessation
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1999
- 1999-04-13 HK HK03100274.4A patent/HK1051484A1/zh unknown
- 1999-04-13 HK HK99101579A patent/HK1016490A1/xx not_active IP Right Cessation
- 1999-12-22 US US09/469,536 patent/US6172107B1/en not_active Expired - Lifetime
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2000
- 2000-10-23 US US09/694,209 patent/US6306900B1/en not_active Expired - Lifetime
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2001
- 2001-10-12 CY CY0100032A patent/CY2243B1/xx unknown
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2004
- 2004-08-05 NL NL300157C patent/NL300157I2/nl unknown
- 2004-08-11 LU LU91094C patent/LU91094I2/fr unknown
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2005
- 2005-11-09 JP JP2005325141A patent/JP2006063086A/ja active Pending
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2007
- 2007-03-01 AR ARP070100839A patent/AR059693A2/es not_active Application Discontinuation
- 2007-03-26 NO NO2007004C patent/NO2007004I2/no unknown
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