RU97108050A - Способ ингибирования состояний, связанных с нейропептидом y - Google Patents

Способ ингибирования состояний, связанных с нейропептидом y

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Publication number
RU97108050A
RU97108050A RU97108050/14A RU97108050A RU97108050A RU 97108050 A RU97108050 A RU 97108050A RU 97108050/14 A RU97108050/14 A RU 97108050/14A RU 97108050 A RU97108050 A RU 97108050A RU 97108050 A RU97108050 A RU 97108050A
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RU
Russia
Prior art keywords
neuropeptide
excess
condition associated
compound
conditions associated
Prior art date
Application number
RU97108050/14A
Other languages
English (en)
Other versions
RU2188015C2 (ru
Inventor
Фредерик Брунс Роберт (младший)
Ричард Гелерт Дональд
Джеффри Хоуберт Джеймс
Генри Уолкер Лунн Уильям
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/326,675 external-priority patent/US6562862B1/en
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of RU97108050A publication Critical patent/RU97108050A/ru
Application granted granted Critical
Publication of RU2188015C2 publication Critical patent/RU2188015C2/ru

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Claims (8)

1. Способ ингибирования физиологического расстройства, связанного с избытком нейропептида Y, включающий введение нуждающемуся в этом человеку, эффективного количества соединения формулы 1
Figure 00000001

где R1 и R3 независимо представляют водород, -CH3,
Figure 00000002

где Ar представляет необязательно замещенный фенил;
R2 выбран из группы, состоящей из пирролидино, гексаметиленимино и пиперидино; или его фармацевтически приемлемой соли или сольвата.
2. Способ по п.1, отличающийся тем, что указанное соединение представляет собой его хлористоводородную соль.
3. Способ по п. 1, отличающийся тем, что указанное введение является профилактическим.
4. Способ по п.1, отличающийся тем, что указанное соединение представляет собой
Figure 00000003

или его хлористоводородную соль.
5. Способ по п.1, отличающийся тем, что состоянием, связанным с избытком нейропептида Y, является тревога.
6. Способ по п.1, отличающийся тем, что состоянием, связанным с избытком нейропептида Y, является ожирение.
7. Способ по п.1, отличающийся тем, что состоянием, связанным с избытком нейропептида Y, является депрессия.
8. Способ по п.1, отличающийся тем, что состоянием, связанным с избытком нейропептида Y, является боль или восприятие повреждающих воздействий нервными центрами.
RU97108050/14A 1994-10-20 1995-10-19 Способ ингибирования нейропептида y RU2188015C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/326,675 1994-10-20
US08/326,675 US6562862B1 (en) 1994-10-20 1994-10-20 Methods of inhibiting physiological conditions associated with an excess of neuropeptide Y

Publications (2)

Publication Number Publication Date
RU97108050A true RU97108050A (ru) 1999-05-10
RU2188015C2 RU2188015C2 (ru) 2002-08-27

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Family Applications (1)

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RU97108050/14A RU2188015C2 (ru) 1994-10-20 1995-10-19 Способ ингибирования нейропептида y

Country Status (19)

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US (5) US6562862B1 (ru)
EP (1) EP0785785A4 (ru)
JP (1) JPH10507757A (ru)
KR (1) KR970706818A (ru)
CN (1) CN1091598C (ru)
AU (1) AU689664B2 (ru)
CA (1) CA2200990A1 (ru)
CZ (1) CZ287411B6 (ru)
FI (1) FI971635A (ru)
HU (1) HUT76852A (ru)
IL (1) IL115663A (ru)
MY (1) MY132056A (ru)
NO (1) NO971520D0 (ru)
NZ (1) NZ295575A (ru)
RU (1) RU2188015C2 (ru)
TW (1) TW410156B (ru)
UA (1) UA46744C2 (ru)
WO (1) WO1996012490A1 (ru)
ZA (1) ZA958800B (ru)

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5492927A (en) * 1993-12-21 1996-02-20 Eli Lilly And Company Non-peptide tachykinin receptor antagonists to treat allergy
US5602024A (en) 1994-12-02 1997-02-11 Synaptic Pharmaceutical Corporation DNA encoding a hypothalamic atypical neuropeptide Y/peptide YY receptor (Y5) and uses thereof
US5989920A (en) * 1994-12-02 1999-11-23 Synaptic Pharmaceutical Corporation Methods of modifying feeding behavior compounds useful in such methods and DNA encoding a hypothalmic atypical neuropeptide Y/peptide YY receptor Y5
US5494929A (en) * 1995-01-12 1996-02-27 Eli Lilly And Company Methods of inhibiting growth hormone effects
US5840747A (en) * 1995-06-07 1998-11-24 Eli Lilly And Company Calcium channel antagonists
US5532254A (en) * 1995-06-07 1996-07-02 Eli Lilly And Company Modulation of calcium channels using benzothiophenes
EP0759441A3 (en) * 1995-06-30 1999-06-30 Eli Lilly And Company Methods of treating neuropeptide Y-associated conditions
US6790656B1 (en) 1996-01-24 2004-09-14 Synaptic Pharmaceutical Corporation DNA encoding galanin GALR2 receptors
US5972624A (en) * 1996-01-24 1999-10-26 Synaptic Pharmaceutical Corporation Method of identifying ligands which bind recombinant galanin receptor (GALR2)
US6113876A (en) * 1996-01-29 2000-09-05 Eli Lilly And Company Methods of increasing sphincter competence
JP2000503991A (ja) * 1996-01-29 2000-04-04 イーライ・リリー・アンド・カンパニー 括約筋受容能力を増大させる方法
AU4159297A (en) 1996-08-23 1998-03-06 Agouron Acquisition Corp. Neuropeptide-y ligands
US6329197B2 (en) 1996-10-09 2001-12-11 Synaptic Pharmaceutical Corporation DNA encoding galanin GALR3 receptors and uses thereof
FR2754709B1 (fr) 1996-10-23 1999-03-05 Sanofi Sa Composition cosmetique contenant un antagoniste des recepteurs du neuropeptide gamma et alpha 2 antagonistes susceptibles d'etre incorpores dans une telle composition
US5900418A (en) * 1997-02-10 1999-05-04 Synapse Pharmaceuticals International, Inc. Method for treatment of obesity
JP2000510870A (ja) * 1997-02-14 2000-08-22 バイエル・コーポレーシヨン Ｎｐｙ５受容体アンタゴニストとしてのアミド類
AU6144098A (en) * 1997-02-14 1998-09-08 Bayer Corporation Amide derivatives as selective neuropeptide y receptor antagonists
US6245817B1 (en) 1997-02-14 2001-06-12 Bayer Corporation NPY5 receptor antagonists and methods for using same
US6048900A (en) * 1998-02-13 2000-04-11 Bayer Corporation Amide derivatives and methods for using the same as selective neuropeptide Y receptor antagonists
ZA982877B (en) * 1997-04-09 1999-10-04 Lilly Co Eli Treatment of central nervous system disorders with selective estrogen receptor modulators.
US6258837B1 (en) * 1997-04-23 2001-07-10 Banyu Pharmaceutical Co., Ltd. Neuropeptide Y receptor antagonist
US6713265B1 (en) 1997-06-04 2004-03-30 Synaptic Pharmaceutical Corporation Methods of modifying feeding behavior, compounds useful in such methods, and DNA encoding a hypothalamic atypical neuropeptide Y/peptide YY receptor (Y5)
EP0896822B1 (en) * 1997-08-05 2003-03-12 Pfizer Products Inc. 4-Aminopyrrole (3,2-d) pyrimidines as neuropeptide Y receptor antagonists
JP3711238B2 (ja) 1997-08-05 2005-11-02 ファイザー・プロダクツ・インク 神経ペプチドＹ受容体アンタゴニストとしての４−アミノピロ−ル（３，２−ｄ）ピリミジン
US6008232A (en) * 1997-08-20 1999-12-28 Eli Lilly And Company Methods for preventing headaches
WO1999008523A1 (en) * 1997-08-21 1999-02-25 Eli Lilly And Company Methods for inhibiting fibrous inflammatory disease and riedel's thyroiditis
WO1999008526A1 (en) * 1997-08-21 1999-02-25 Eli Lilly And Company Methods for inhibiting temporomandibular disorders
US5990129A (en) * 1997-09-23 1999-11-23 Eli Lilly And Company Methods for regulating trkA expression
US20050107327A1 (en) * 1997-12-19 2005-05-19 Hormos Medical Corporation Method for reducing overproduction of neuropeptide Y in an individual
US6391922B1 (en) 1998-01-13 2002-05-21 Synchroneuron, Llc Treatment of posttraumatic stress disorder, obsessive-compulsive disorder and related neuropsychiatric disorders
US6187777B1 (en) 1998-02-06 2001-02-13 Amgen Inc. Compounds and methods which modulate feeding behavior and related diseases
GB2344050A (en) * 1998-11-26 2000-05-31 Ferring Bv Agents useful in the treatment of reproductive disorders.
DK1027891T3 (da) 1999-01-27 2005-05-09 Pfizer Prod Inc Neuropeptid-Y-antagonister
US6410565B1 (en) 1999-02-03 2002-06-25 Eli Lilly And Company α1-adrenergic receptor antagonists
DE19905961A1 (de) * 1999-02-12 2000-08-17 Stefan Neubauer Verwendung von Östrogenen zur Behandlung der Herzinsuffizienz
AU3511500A (en) * 1999-03-05 2000-09-21 Trustees Of University Technology Corporation, The Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide-induced clinical conditions
AU2935200A (en) 1999-04-30 2000-11-17 Pfizer Products Inc. Compounds for the treatment of obesity
CA2379640C (en) * 1999-09-30 2006-11-28 Neurogen Corporation Certain alkylene diamine-substituted heterocycles
AU7896100A (en) * 1999-10-14 2001-04-23 Endorecherche Inc. Selective estrogen receptor modulators in the treatment or reduction of the riskof acquiring hypertension, cardiovascular diseases, and insulin resistance
WO2001053477A1 (en) * 2000-01-20 2001-07-26 Baylor College Of Medicine Methods and compositions for control of bone formation via modulation of neuropeptide y activity
JP2001261674A (ja) * 2000-03-22 2001-09-26 Mitsui Chemicals Inc ベンゾチオフェン誘導体およびそれを有効成分として含有する核内レセプター作動薬
US20020061897A1 (en) 2000-03-30 2002-05-23 Elliott Richard L. Neuropeptide Y antagonists
US6511984B2 (en) 2000-03-30 2003-01-28 Pfizer Inc. Neuropeptide Y antagonists
AU2001273144A1 (en) 2000-07-06 2002-01-21 Wyeth Use of substituted indole compounds for treating neuropeptide y-related conditions
TWI303990B (en) * 2000-10-17 2008-12-11 Pfizer Prod Inc New use of estrogen agonists/antagonists for improving vascular health
AU2756602A (en) * 2001-04-25 2002-10-31 Pfizer Products Inc. Methods and kits for treating depression or preventing deterioration of cognitive function
IL162269A0 (en) 2001-12-05 2005-11-20 Baylor College Medicine Methods and compositions for control of bone formation via modulation of sympathetic tone
US6958347B2 (en) * 2002-12-18 2005-10-25 Pfizer Inc. Aminophenanthridinone and aminophenanthridine as NPY-5 antagonists
US6949564B2 (en) * 2002-12-18 2005-09-27 Pfizer Inc. NPY-5 antagonists
JP2004224756A (ja) * 2003-01-24 2004-08-12 Sumika Fine Chemicals Co Ltd ２，６−ジハロゲノ−８−置換−プリン化合物およびその製造方法
US20040220242A1 (en) * 2003-05-02 2004-11-04 Leland Shapiro Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide induced clinical conditions
US7371871B2 (en) 2003-05-05 2008-05-13 Probiodrug Ag Inhibitors of glutaminyl cyclase
ES2228268B1 (es) * 2003-07-30 2006-07-01 Laboratorios Del Dr. Esteve, S.A. Combinacion de sustancias activas conteniendo al menos un compuesto con afinidad por el receptor del neuropeptido y (npy) y al menos un compuesto con afinidad por el receptor 5-ht6.
EP1680120A2 (en) 2003-11-03 2006-07-19 Probiodrug AG Combinations useful for the treatment of neuronal disorders
JP4996926B2 (ja) 2004-02-05 2012-08-08 プロビオドルグ エージー グルタミニルシクラーゼの新規の阻害剤
US8642079B2 (en) * 2004-02-23 2014-02-04 Hormos Medical Corporation Solid formulations of ospemifene
US8758821B2 (en) * 2004-05-04 2014-06-24 Hormos Medical Ltd. Oral formulations of ospemifene
CA2565134C (en) * 2004-05-04 2013-05-21 Veli-Matti Lehtola Novel oral formulations of ospemifene
CA2588087A1 (en) * 2004-11-15 2006-05-18 Obe Therapy Biotechnology S.A.S. Methods of reducing body fat
AU2006235200A1 (en) * 2005-04-15 2006-10-19 Regenertech Pty Limited Use of Neuropeptide Y (NPY) and agonists and antagonists thereof for tissue regeneration
JP5379692B2 (ja) 2006-11-09 2013-12-25 プロビオドルグ エージー 潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての３−ヒドロキシ−１，５−ジヒドロ−ピロール−２−オン誘導体
JP5523107B2 (ja) 2006-11-30 2014-06-18 プロビオドルグ エージー グルタミニルシクラーゼの新規阻害剤
US7504530B2 (en) * 2007-02-14 2009-03-17 Hormos Medical Ltd. Methods for the preparation of fispemifene from ospemifene
PT2121553E (pt) * 2007-02-14 2012-07-26 Hormos Medical Ltd Método para a preparação de derivados de trifenilbuteno com valor terapêutico
ZA200905537B (en) 2007-03-01 2010-10-27 Probiodrug Ag New use of glutaminyl cyclase inhibitors
ES2533484T3 (es) 2007-04-18 2015-04-10 Probiodrug Ag Derivados de tiourea como inhibidores de la glutaminil ciclasa
WO2009071601A1 (en) 2007-12-03 2009-06-11 Obe Therapy Biotechnology Boropeptide inhibitors of enteropeptidase and their uses in treatment of obesity, overweight and/or diseases associated with an abnormal fat metabolism
EA022007B1 (ru) 2009-09-11 2015-10-30 Пробиодруг Аг Гетероциклические производные в качестве ингибиторов глутаминилциклазы
JP6026284B2 (ja) 2010-03-03 2016-11-16 プロビオドルグ エージー グルタミニルシクラーゼの阻害剤
KR101790806B1 (ko) 2010-03-10 2017-11-20 프로비오드룩 아게 글루타미닐 사이클라제(ｑｃ, ｅｃ 2.3.2.5)의 헤테로사이클릭 억제제
EP2560953B1 (en) 2010-04-21 2016-01-06 Probiodrug AG Inhibitors of glutaminyl cyclase
WO2012123563A1 (en) 2011-03-16 2012-09-20 Probiodrug Ag Benz imidazole derivatives as inhibitors of glutaminyl cyclase
WO2014060639A1 (en) 2012-10-19 2014-04-24 Fermion Oy A process for the preparation of ospemifene
ME03061B (me) * 2013-02-19 2019-01-20 Novartis Ag Derivati benzotiofena i njihove kompozicije kao selektivni degraderi estrogenskog receptora
PL3461819T3 (pl) 2017-09-29 2020-11-30 Probiodrug Ag Inhibitory cyklazy glutaminylowej

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4133814A (en) 1975-10-28 1979-01-09 Eli Lilly And Company 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
US4380635A (en) 1981-04-03 1983-04-19 Eli Lilly And Company Synthesis of acylated benzothiophenes
US4418068A (en) 1981-04-03 1983-11-29 Eli Lilly And Company Antiestrogenic and antiandrugenic benzothiophenes
US4891357A (en) * 1985-02-11 1990-01-02 University Of Florida Methods and compositions for stimulation of appetite
US5075321A (en) 1987-03-24 1991-12-24 University Of Pennsylvania Methods of treating diseases characterized by interactions of IgG-containing immune complexes with macrophage Fc receptors using antiestrogenic benzothiophenes
JP3157882B2 (ja) 1991-11-15 2001-04-16 帝国臓器製薬株式会社 新規なベンゾチオフエン誘導体
AU672182B2 (en) 1991-11-27 1996-09-26 Novo Nordisk A/S Piperidine derivatives and their use in treating psychosis
TW366342B (en) 1992-07-28 1999-08-11 Lilly Co Eli The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss
TW383306B (en) * 1992-12-22 2000-03-01 Lilly Co Eli New use of 2-phenyl-3-aroylbenzothiophenes in lowering serum cholesterol
US5482949A (en) 1993-03-19 1996-01-09 Eli Lilly And Company Sulfonate derivatives of 3-aroylbenzo[b]thiophenes
DE4311870C2 (de) 1993-04-10 1998-07-30 Altramed Holdings Ltd Verwendung eines Anti-Östrigens zur Therapie und Prophylaxe von Demenz-Erkrankungen
US5445941A (en) 1993-06-21 1995-08-29 Eli Lilly And Company Method for screening anti-osteoporosis agents
DK0635264T3 (da) 1993-06-24 1997-10-20 Lilly Co Eli Anti-østrogene 2-phenyl-3-aroylbenzothiazepiner som hypoglykæmiske midler
TW303299B (ru) 1993-07-22 1997-04-21 Lilly Co Eli
US5468773A (en) 1993-08-25 1995-11-21 Eli Lilly And Company Methods for inhibiting bone loss and cartilage degradation using wortmannin and its analogs
US5457113A (en) 1993-10-15 1995-10-10 Eli Lilly And Company Methods for inhibiting vascular smooth muscle cell proliferation and restinosis
US5476862A (en) 1993-12-21 1995-12-19 Eli Lilly And Company Methods of increasing thrombomodulin expression
US5578613A (en) 1993-12-21 1996-11-26 Eli Lilly And Company Methods for inhibiting weight gain or inducing weight loss
US5439931A (en) 1993-12-21 1995-08-08 Eli Lilly And Company Method for increasing libido in post-menopausal women
US5441965A (en) 1993-12-21 1995-08-15 Eli Lilly And Company Methods of inhibiting thrombin
US5447941A (en) * 1993-12-21 1995-09-05 Eli Lilly And Company Methods of inhibiting pulmonary hypertensive diseases with raloxifene and related benzothiophenes
US5492927A (en) 1993-12-21 1996-02-20 Eli Lilly And Company Non-peptide tachykinin receptor antagonists to treat allergy
US6417198B1 (en) * 1993-12-21 2002-07-09 Eli Lilly And Company Methods of inhibiting CNS problems in post-menopausal women
AU8155694A (en) 1993-12-21 1995-06-29 Eli Lilly And Company Methods of inhibiting obsessive-compulsive and consumptive disorders
US5552415A (en) * 1993-12-21 1996-09-03 Eli Lilly And Company Method of inhibiting Alzheimer's Disease
US5574047A (en) 1993-12-21 1996-11-12 Eli Lilly And Company Methods of inhibiting imperfect tissue repair

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