RU95105991A - Конъюгат, вакцина, способы усиления иммуногенности, способы иммунизации - Google Patents

Конъюгат, вакцина, способы усиления иммуногенности, способы иммунизации

Info

Publication number
RU95105991A
RU95105991A RU95105991/14A RU95105991A RU95105991A RU 95105991 A RU95105991 A RU 95105991A RU 95105991/14 A RU95105991/14 A RU 95105991/14A RU 95105991 A RU95105991 A RU 95105991A RU 95105991 A RU95105991 A RU 95105991A
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RU
Russia
Prior art keywords
antigen
methods
immunization
immunogenic properties
immunogenicity
Prior art date
Application number
RU95105991/14A
Other languages
English (en)
Inventor
Р.Кохен Ирун
Us]
Фридкин Матитьяху
Конен-Вайсман Стефани
Il]
De]
Original Assignee
Йеда Рисерч Энд Дивелопмент Компани Лимитед (Il)
Йеда Рисерч энд Дивелопмент Компани Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Йеда Рисерч Энд Дивелопмент Компани Лимитед (Il), Йеда Рисерч энд Дивелопмент Компани Лимитед filed Critical Йеда Рисерч Энд Дивелопмент Компани Лимитед (Il)
Publication of RU95105991A publication Critical patent/RU95105991A/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A61K39/0275—Salmonella
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6043—Heat shock proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
    • A61K2039/627—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier characterised by the linker
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Steroid Compounds (AREA)

Abstract

Разработан метод усиления иммуногенности молекул антигена, обладающих слабыми иммуногенными свойствами, который превращает их в пригодные для иммунизации антигены. Метод состоит в приготовлении коньюгатов антигена со слабыми иммуногенными свойствами и синтетического пептидного носителя, несущего Т-клеточную антигенную детерминанту, полученную из последовательности человеческого бтш 65 или его аналога, при этом последние обладают способностью существенно повышать иммуногенность указанного антигена.

Claims (1)

  1. Разработан метод усиления иммуногенности молекул антигена, обладающих слабыми иммуногенными свойствами, который превращает их в пригодные для иммунизации антигены. Метод состоит в приготовлении коньюгатов антигена со слабыми иммуногенными свойствами и синтетического пептидного носителя, несущего Т-клеточную антигенную детерминанту, полученную из последовательности человеческого бтш 65 или его аналога, при этом последние обладают способностью существенно повышать иммуногенность указанного антигена.
RU95105991/14A 1992-07-30 1993-07-28 Конъюгат, вакцина, способы усиления иммуногенности, способы иммунизации RU95105991A (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL102687 1992-07-30
IL102687A IL102687A (en) 1992-07-30 1992-07-30 Conjugates of poorly immunogenic antigens and synthetic pepide carriers and vaccines comprising them

Publications (1)

Publication Number Publication Date
RU95105991A true RU95105991A (ru) 1997-02-27

Family

ID=11063877

Family Applications (1)

Application Number Title Priority Date Filing Date
RU95105991/14A RU95105991A (ru) 1992-07-30 1993-07-28 Конъюгат, вакцина, способы усиления иммуногенности, способы иммунизации

Country Status (18)

Country Link
EP (1) EP0658120B1 (ru)
JP (1) JP4087898B2 (ru)
KR (1) KR100290632B1 (ru)
AT (1) ATE188612T1 (ru)
AU (1) AU683421B2 (ru)
BR (1) BR9306820A (ru)
CA (1) CA2141454C (ru)
CZ (1) CZ22995A3 (ru)
DE (1) DE69327587T2 (ru)
FI (1) FI950405A (ru)
HU (1) HU218425B (ru)
IL (1) IL102687A (ru)
NO (1) NO950328L (ru)
NZ (1) NZ255143A (ru)
PL (1) PL174082B1 (ru)
RU (1) RU95105991A (ru)
SK (1) SK11295A3 (ru)
WO (1) WO1994003208A1 (ru)

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