RU94032284A - Карбоксамиды, способ их получения, фармацевтическая композиция, применение - Google Patents
Карбоксамиды, способ их получения, фармацевтическая композиция, применениеInfo
- Publication number
- RU94032284A RU94032284A RU94032284/04A RU94032284A RU94032284A RU 94032284 A RU94032284 A RU 94032284A RU 94032284/04 A RU94032284/04 A RU 94032284/04A RU 94032284 A RU94032284 A RU 94032284A RU 94032284 A RU94032284 A RU 94032284A
- Authority
- RU
- Russia
- Prior art keywords
- carboxamides
- preparation
- pharmaceutical composition
- formula
- fibrinogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Новые карбоксамиды формулы, приведенной в описании, а также их гидраты или сольваты ингибируют накопление тромбоцитов, индуцированное тромбином, и свертывание фибриногена в плазме крови. Названные вещества можно получать из соответствующей кислоты и соответствующего амина HNCHQ.
Claims (1)
- Новые карбоксамиды формулы, приведенной в описании, а также их гидраты или сольваты ингибируют накопление тромбоцитов, индуцированное тромбином, и свертывание фибриногена в плазме крови. Названные вещества можно получать из соответствующей кислоты и соответствующего амина H2NCH2Q.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH2667/93 | 1993-09-07 | ||
CH266793 | 1993-09-07 | ||
CH215094 | 1994-07-05 | ||
CH2150/94 | 1994-07-05 |
Publications (2)
Publication Number | Publication Date |
---|---|
RU94032284A true RU94032284A (ru) | 1996-07-20 |
RU2125991C1 RU2125991C1 (ru) | 1999-02-10 |
Family
ID=25689654
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU94032284A RU2125991C1 (ru) | 1993-09-07 | 1994-09-07 | Карбоксамиды, их гидраты или сольваты и физиологически совместимые соли |
Country Status (15)
Country | Link |
---|---|
US (1) | US5559232A (ru) |
EP (1) | EP0641779A1 (ru) |
JP (1) | JP2614984B2 (ru) |
CN (1) | CN1107839A (ru) |
AU (1) | AU684295B2 (ru) |
CA (1) | CA2130864A1 (ru) |
CZ (1) | CZ213594A3 (ru) |
FI (1) | FI944100A (ru) |
HU (1) | HUT70616A (ru) |
IL (1) | IL110834A (ru) |
NO (1) | NO301976B1 (ru) |
NZ (1) | NZ264357A (ru) |
PH (1) | PH30480A (ru) |
RU (1) | RU2125991C1 (ru) |
TW (1) | TW394760B (ru) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2465267C2 (ru) * | 2003-01-16 | 2012-10-27 | Акадиа Фармасьютикалз Инк. | Селективные обратные агонисты серотонин 2а/2с рецептора, применяемые в качестве лекарственных средств при нейродегенеративных заболеваниях |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6984627B1 (en) | 1993-06-03 | 2006-01-10 | Astrazeneca Ab | Peptide derivatives |
EP0684238A3 (en) * | 1994-04-27 | 1997-01-15 | Hoffmann La Roche | Process for the preparation of dicarboxamides. |
US5536867A (en) * | 1994-04-27 | 1996-07-16 | Hoffmann-La Roche Inc. | Process for the manufacture of dicarboxamides |
DE4437137A1 (de) * | 1994-10-18 | 1996-04-25 | Hoechst Schering Agrevo Gmbh | Substituierte Cycloalkylamino- und -alkoxy-Heterocyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Schädlingsbekämpfungsmittel |
GB9424353D0 (en) * | 1994-12-02 | 1995-01-18 | Ici Plc | Surfactants |
SA96170106A (ar) * | 1995-07-06 | 2005-12-03 | أسترا أكتيبولاج | مشتقات حامض أميني جديدة |
TW541316B (en) * | 1995-12-21 | 2003-07-11 | Astrazeneca Ab | Prodrugs of thrombin inhibitors |
SE9602263D0 (sv) | 1996-06-07 | 1996-06-07 | Astra Ab | New amino acid derivatives |
SE9602646D0 (sv) | 1996-07-04 | 1996-07-04 | Astra Ab | Pharmaceutically-useful compounds |
ATE334975T1 (de) | 1997-05-30 | 2006-08-15 | Takeda Pharmaceutical | Sulfonamidderivate, ihre herstellung und verwendung |
AR013084A1 (es) | 1997-06-19 | 2000-12-13 | Astrazeneca Ab | Derivados de amidino utiles como inhibidores de la trombina, composicion farmaceutica, utilizacion de dichos compuestos para la preparacion demedicamentos y proceso para la preparacion de los compuestos mencionados |
SE9704543D0 (sv) | 1997-12-05 | 1997-12-05 | Astra Ab | New compounds |
ZA99607B (en) * | 1998-01-27 | 1999-07-27 | Rhone Poulenc Rorer Pharma | Substituted oxoazaheterocyclyl factor xa inhibitors. |
EP1054005A4 (en) | 1998-02-05 | 2003-02-05 | Takeda Chemical Industries Ltd | SULFAMIDE DERIVATIVES, THEIR PRODUCTION PROCESS AND THEIR USE |
PL343837A1 (en) * | 1998-05-05 | 2001-09-10 | Warner Lambert Co | SUCCINAMIDE INHIBITORS OF INTERLEUKIN-1β CONVERTING ENZYME |
SE9804313D0 (sv) | 1998-12-14 | 1998-12-14 | Astra Ab | New compounds |
ES2295004T3 (es) | 1999-01-13 | 2008-04-16 | Astrazeneca Ab | Nuevos derivados amidinobencilaminicos y su uso como inhibidores de trombina. |
WO2000078747A1 (fr) | 1999-06-22 | 2000-12-28 | Takeda Chemical Industries, Ltd. | Derives acylhydrazine, procede d'elaboration et utilisation |
SE0001803D0 (sv) | 2000-05-16 | 2000-05-16 | Astrazeneca Ab | New compounds i |
EP1302462A4 (en) * | 2000-07-17 | 2007-07-18 | Takeda Pharmaceutical | Sulphonic derivatives, process for their preparation and their use |
US6433186B1 (en) | 2000-08-16 | 2002-08-13 | Astrazeneca Ab | Amidino derivatives and their use as thormbin inhibitors |
AR035216A1 (es) | 2000-12-01 | 2004-05-05 | Astrazeneca Ab | Derivados de acido mandelico ,derivados farmaceuticamente aceptables, uso de estos derivados para la fabricacion de medicamentos, metodos de tratamiento ,procesos para la preparacion de estos derivados, y compuestos intermediarios |
US7129233B2 (en) | 2000-12-01 | 2006-10-31 | Astrazeneca Ab | Mandelic acid derivatives and their use as thrombin inhibitors |
AR034517A1 (es) | 2001-06-21 | 2004-02-25 | Astrazeneca Ab | Formulacion farmaceutica |
SE0201659D0 (sv) | 2002-05-31 | 2002-05-31 | Astrazeneca Ab | Modified release pharmaceutical formulation |
SE0201661D0 (sv) | 2002-05-31 | 2002-05-31 | Astrazeneca Ab | New salts |
AU2003284596A1 (en) * | 2002-11-22 | 2004-06-18 | Takeda Pharmaceutical Company Limited | Imidazole derivative, process for producing the same, and use |
WO2004083173A2 (en) * | 2003-03-18 | 2004-09-30 | Merck & Co., Inc. | Ketopiperazine derivatives as bradykinin antagonists |
US7781424B2 (en) | 2003-05-27 | 2010-08-24 | Astrazeneca Ab | Modified release pharmaceutical formulation |
BRPI0411673A (pt) | 2003-06-20 | 2006-08-08 | Amgen Inc | composto, sal farmaceuticamente aceitável, composição farmacêutica, e, uso de um composto |
US7795205B2 (en) | 2004-04-12 | 2010-09-14 | Canyon Pharmaceuticals, Inc. | Methods for effecting regression of tumor mass and size in a metastasized pancreatic tumor |
TWI396686B (zh) | 2004-05-21 | 2013-05-21 | Takeda Pharmaceutical | 環狀醯胺衍生物、以及其製品和用法 |
JP3964417B2 (ja) | 2004-09-27 | 2007-08-22 | 国立大学法人金沢大学 | インドール誘導体を有効成分とするα2受容体遮断剤及び血管拡張剤 |
JP2006298785A (ja) * | 2005-04-18 | 2006-11-02 | Mitsui Chemicals Inc | ジアミン誘導体、その製造方法およびそれらを有効成分とする殺菌剤 |
US7524354B2 (en) * | 2005-07-07 | 2009-04-28 | Research Foundation Of State University Of New York | Controlled synthesis of highly monodispersed gold nanoparticles |
AU2007233123A1 (en) | 2006-03-30 | 2007-10-11 | Palatin Technologies, Inc. | Linear natriuretic peptide constructs |
US7964181B2 (en) * | 2006-03-30 | 2011-06-21 | Palatin Technologies, Inc. | Amino acid surrogates for peptidic constructs |
CA2647143A1 (en) * | 2006-03-30 | 2007-10-11 | Palatin Technologies, Inc. | Cyclic natriuretic peptide constructs |
JP5424867B2 (ja) * | 2006-03-30 | 2014-02-26 | パラティン・テクノロジーズ・インコーポレーテッド | ペプチド構築物のためのアミノ酸代用物 |
US8114844B2 (en) * | 2006-03-30 | 2012-02-14 | Palatin Technologies, Inc. | Linear and cyclic melanocortin receptor-specific peptidomimetics |
US8580746B2 (en) | 2006-03-30 | 2013-11-12 | Palatin Technologies, Inc. | Amide linkage cyclic natriuretic peptide constructs |
SG174080A1 (en) * | 2006-09-13 | 2011-09-29 | Sanofi Aventis | Isoserine derivatives for use as coagulation factor ixa inhibitors |
TW200827336A (en) | 2006-12-06 | 2008-07-01 | Astrazeneca Ab | New crystalline forms |
EP2104497B1 (de) * | 2006-12-06 | 2015-02-25 | Sanofi | Sulfamidderivate als inhibitoren von tafia |
PL2155721T3 (pl) * | 2007-05-07 | 2011-07-29 | Novartis Ag | Związki organiczne |
US20090061000A1 (en) * | 2007-08-31 | 2009-03-05 | Astrazeneca Ab | Pharmaceutical formulation use 030 |
JP5531011B2 (ja) | 2008-06-06 | 2014-06-25 | サノフイ | TAFIaの阻害剤としての大環状尿素およびスルファミド誘導体 |
CA2727925A1 (en) | 2008-06-23 | 2009-12-30 | Astrazeneca Ab | New heterocyclic carboxamides for use as thrombin inhibitors |
US8354444B2 (en) | 2008-09-18 | 2013-01-15 | Hoffmann-La Roche Inc. | Substituted pyrrolidine-2-carboxamides |
ES2535341T3 (es) * | 2010-11-12 | 2015-05-08 | Fujifilm Corporation | Derivado de pirazino[2,3-d]isoxazol |
KR20160018557A (ko) | 2013-06-10 | 2016-02-17 | 사노피 | TAFIa의 저해제로서의 마크로사이클릭 우레아 유도체, 이의 제법 및 의약품으로서의 이의 용도 |
CN104016944B (zh) * | 2014-06-16 | 2016-05-18 | 山东大学 | N-(2-(胺甲基)苯基)噻唑-4-甲酰胺衍生物及其制备方法与应用 |
CN104003984B (zh) * | 2014-06-16 | 2016-03-02 | 山东大学 | 噻唑-4-甲酰基哌嗪衍生物及其制备方法与应用 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
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SE420919B (sv) * | 1973-08-13 | 1981-11-09 | Mitsubishi Chem Ind | Forfarande for framstellning av n?722-dansyl-l-argininderivat och farmaceutiskt godtagbara syradditionssalter derav |
US4258192A (en) * | 1977-12-16 | 1981-03-24 | Mitsubishi Chemical Industries Limited | N2 -Arylsulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof |
US4433152A (en) * | 1981-05-25 | 1984-02-21 | Nippon Chemiphar Co., Ltd. | Amidinopiperidine derivatives |
SE8203887D0 (sv) * | 1982-06-23 | 1982-06-23 | Kabivitrum Ab | Nya trombininhiberande foreningar |
US5053393A (en) * | 1988-07-20 | 1991-10-01 | Monsanto Company | Novel platelet-aggregation inhibitor |
US4879313A (en) * | 1988-07-20 | 1989-11-07 | Mosanto Company | Novel platelet-aggregation inhibitors |
US5037808A (en) * | 1988-07-20 | 1991-08-06 | Monsanto Co. | Indolyl platelet-aggregation inhibitors |
US5084466A (en) * | 1989-01-31 | 1992-01-28 | Hoffmann-La Roche Inc. | Novel carboxamide pyridine compounds which have useful pharmaceutical utility |
TW201303B (ru) * | 1990-07-05 | 1993-03-01 | Hoffmann La Roche | |
US5481021A (en) * | 1991-03-06 | 1996-01-02 | G. D. Searle & Co. | Phenyl amidines derivatives useful as platelet aggregation inhibitors |
TW223629B (ru) * | 1992-03-06 | 1994-05-11 | Hoffmann La Roche |
-
1994
- 1994-08-23 TW TW083107736A patent/TW394760B/zh active
- 1994-08-25 CA CA002130864A patent/CA2130864A1/en not_active Abandoned
- 1994-08-30 EP EP94113488A patent/EP0641779A1/de not_active Withdrawn
- 1994-08-31 NZ NZ264357A patent/NZ264357A/en unknown
- 1994-09-01 IL IL11083494A patent/IL110834A/en not_active IP Right Cessation
- 1994-09-02 AU AU72807/94A patent/AU684295B2/en not_active Ceased
- 1994-09-02 HU HU9402527A patent/HUT70616A/hu unknown
- 1994-09-02 US US08/300,821 patent/US5559232A/en not_active Expired - Fee Related
- 1994-09-02 PH PH48901A patent/PH30480A/en unknown
- 1994-09-05 JP JP6234541A patent/JP2614984B2/ja not_active Expired - Lifetime
- 1994-09-05 CZ CZ942135A patent/CZ213594A3/cs unknown
- 1994-09-06 CN CN94109150A patent/CN1107839A/zh active Pending
- 1994-09-06 NO NO943294A patent/NO301976B1/no not_active IP Right Cessation
- 1994-09-07 RU RU94032284A patent/RU2125991C1/ru active
- 1994-09-07 FI FI944100A patent/FI944100A/fi unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2465267C2 (ru) * | 2003-01-16 | 2012-10-27 | Акадиа Фармасьютикалз Инк. | Селективные обратные агонисты серотонин 2а/2с рецептора, применяемые в качестве лекарственных средств при нейродегенеративных заболеваниях |
Also Published As
Publication number | Publication date |
---|---|
JP2614984B2 (ja) | 1997-05-28 |
AU7280794A (en) | 1995-03-23 |
US5559232A (en) | 1996-09-24 |
JPH07112970A (ja) | 1995-05-02 |
AU684295B2 (en) | 1997-12-11 |
NO943294D0 (no) | 1994-09-06 |
RU2125991C1 (ru) | 1999-02-10 |
CN1107839A (zh) | 1995-09-06 |
HUT70616A (en) | 1995-10-30 |
NZ264357A (en) | 1996-05-28 |
PH30480A (en) | 1997-05-28 |
NO943294L (no) | 1995-03-08 |
HU9402527D0 (en) | 1994-10-28 |
TW394760B (en) | 2000-06-21 |
IL110834A0 (en) | 1994-11-28 |
EP0641779A1 (de) | 1995-03-08 |
NO301976B1 (no) | 1998-01-05 |
IL110834A (en) | 1998-08-16 |
FI944100A0 (fi) | 1994-09-07 |
CZ213594A3 (en) | 1995-12-13 |
FI944100A (fi) | 1995-03-08 |
CA2130864A1 (en) | 1995-03-08 |
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