EA200001024A1 - Производные аминогуанидина и алкоксигуанидина и способ их получения (варианты), фармацевтическая композиция и способ ингибирования протеолиза у млекопитающего, способ лечения различных заболеваний млекопитающего, способы ингибирования индуцированной тромбином агрегации тромбоцитов и свертывания фибриногена в плазме, тромбина, агрегации тромбоцитов и образования тромбов в крови, устройство для сбора крови, искусственного кровообращения и хранения крови - Google Patents
Производные аминогуанидина и алкоксигуанидина и способ их получения (варианты), фармацевтическая композиция и способ ингибирования протеолиза у млекопитающего, способ лечения различных заболеваний млекопитающего, способы ингибирования индуцированной тромбином агрегации тромбоцитов и свертывания фибриногена в плазме, тромбина, агрегации тромбоцитов и образования тромбов в крови, устройство для сбора крови, искусственного кровообращения и хранения кровиInfo
- Publication number
- EA200001024A1 EA200001024A1 EA200001024A EA200001024A EA200001024A1 EA 200001024 A1 EA200001024 A1 EA 200001024A1 EA 200001024 A EA200001024 A EA 200001024A EA 200001024 A EA200001024 A EA 200001024A EA 200001024 A1 EA200001024 A1 EA 200001024A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- blood
- inhibiting
- thrombin
- methods
- compounds
- Prior art date
Links
- 230000002401 inhibitory effect Effects 0.000 title abstract 7
- 238000000034 method Methods 0.000 title abstract 5
- 239000008280 blood Substances 0.000 title abstract 4
- 210000004369 blood Anatomy 0.000 title abstract 4
- 241000124008 Mammalia Species 0.000 title abstract 3
- 208000007536 Thrombosis Diseases 0.000 title abstract 2
- HAMNKKUPIHEESI-UHFFFAOYSA-N aminoguanidine Chemical compound NNC(N)=N HAMNKKUPIHEESI-UHFFFAOYSA-N 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 238000003860 storage Methods 0.000 title abstract 2
- 208000010110 spontaneous platelet aggregation Diseases 0.000 title 2
- 102000008946 Fibrinogen Human genes 0.000 title 1
- 108010049003 Fibrinogen Proteins 0.000 title 1
- 239000002473 artificial blood Substances 0.000 title 1
- 230000017531 blood circulation Effects 0.000 title 1
- 230000015271 coagulation Effects 0.000 title 1
- 238000005345 coagulation Methods 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 229940012952 fibrinogen Drugs 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 230000017854 proteolysis Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 8
- 230000015572 biosynthetic process Effects 0.000 abstract 4
- 108090000190 Thrombin Proteins 0.000 abstract 2
- 230000002785 anti-thrombosis Effects 0.000 abstract 2
- 239000000463 material Substances 0.000 abstract 2
- 229960004072 thrombin Drugs 0.000 abstract 2
- 102000009123 Fibrin Human genes 0.000 abstract 1
- 108010073385 Fibrin Proteins 0.000 abstract 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 abstract 1
- 108091005804 Peptidases Proteins 0.000 abstract 1
- 102000035195 Peptidases Human genes 0.000 abstract 1
- 239000003146 anticoagulant agent Substances 0.000 abstract 1
- 229940127219 anticoagulant drug Drugs 0.000 abstract 1
- 238000010241 blood sampling Methods 0.000 abstract 1
- 230000002612 cardiopulmonary effect Effects 0.000 abstract 1
- 229950003499 fibrin Drugs 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/16—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with acylated ring nitrogen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Materials For Medical Uses (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
Abstract
Настоящее изобретение относится к соединениям, содержащим аминогуанидин и алкоксигуанидин, включающим соединения формулы (I), где X означает O или NH, L означает -O- или -SO-, a R-R, R-R, R, R, R, Y, Z, n и m определены в описании изобретения, а также к их гидратам, сольватам или фармацевтически приемлемым солям, причем упомянутые соединения ингибируют протеолитические ферменты, такие как тромбин. Описаны также способы получения соединений формулы (I). Некоторые соединения проявляют антитромботическую активность путем прямого селективного ингибирования тромбина, а некоторые соединения используют в качестве промежуточных производных для получения соединений с антитромботической активностью. Изобретение включает композицию для ингибирования снижения тромбоцитов в крови, ингибирования образования агрегатов тромбоцитов в крови, ингибирования образования фибрина, ингибирования образования тромбов и ингибирования образования эмбола у млекопитающего. Соединения по изобретению могут быть также использованы в качестве антикоагулянтов, включенных в материалы или физически связанных с материалами, используемыми для производства устройств для систем отбора крови, искусственного кровообращения и хранения крови.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8056898P | 1998-04-03 | 1998-04-03 | |
| US09/283,241 US6344486B1 (en) | 1998-04-03 | 1999-04-01 | Benzamide and sulfonamide substituted aminoguanidines and alkoxyguanidines as protease inhibitors |
| PCT/US1999/007420 WO1999051571A1 (en) | 1998-04-03 | 1999-04-05 | Benzamide and sulfonamide substituted aminoguanidines and alkoxyguanidines as protease inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200001024A1 true EA200001024A1 (ru) | 2001-04-23 |
| EA003461B1 EA003461B1 (ru) | 2003-06-26 |
Family
ID=26763687
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200001024A EA003461B1 (ru) | 1998-04-03 | 1999-04-05 | Производные аминогуанидина и алкоксигуанидина (варианты) и способ их получения (варианты), фармацевтическая композиция и способ ингибирования протеолиза у млекопитающего, способ лечения различных заболеваний млекопитающего, способы ингибирования индуцированной тромбином агрегации тромбоцитов и свертывания фибриногена в плазме, тромбина, агрегации тромбоцитов и образования тромбов в крови, устройство для сбора крови, искусственного кровообращения и хранения крови |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US6344486B1 (ru) |
| EP (1) | EP1070049B1 (ru) |
| JP (1) | JP2002510673A (ru) |
| KR (1) | KR20010042396A (ru) |
| CN (1) | CN1303365A (ru) |
| AT (1) | ATE270269T1 (ru) |
| AU (1) | AU755805B2 (ru) |
| BR (1) | BR9909338A (ru) |
| CA (1) | CA2326759A1 (ru) |
| DE (1) | DE69918421T2 (ru) |
| EA (1) | EA003461B1 (ru) |
| HU (1) | HUP0102371A3 (ru) |
| IL (1) | IL138799A0 (ru) |
| NO (1) | NO20004871L (ru) |
| NZ (1) | NZ507050A (ru) |
| PL (1) | PL343244A1 (ru) |
| WO (1) | WO1999051571A1 (ru) |
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| US20060199811A1 (en) * | 1997-07-31 | 2006-09-07 | Pfirrmann Rolf W | Method of treatment for preventing or reducing tumor growth in the liver of patient |
| US20050124608A1 (en) * | 2001-04-03 | 2005-06-09 | Redmond H. P. | Treatment of cancers |
| US8304390B2 (en) * | 1997-07-31 | 2012-11-06 | Ed. Geistlich Soehne Ag Fuer Chemische Industrie | Method of treatment for preventing or reducing tumor growth in the liver of patient |
| US6344486B1 (en) | 1998-04-03 | 2002-02-05 | 3-Dimensional Pharmaceuticals, Inc. | Benzamide and sulfonamide substituted aminoguanidines and alkoxyguanidines as protease inhibitors |
| US6348504B1 (en) * | 1999-03-30 | 2002-02-19 | Richard E. Olson | Oxime ethers as IIb/IIa antagonists |
| US7345039B2 (en) * | 1999-06-04 | 2008-03-18 | Ed. Geistlich Soehne Ag Fuer Chemische Industrie | Enhancement of effectiveness of 5-fluorouracil in treatment of tumor metastases and cancer |
| US8030301B2 (en) * | 1999-06-04 | 2011-10-04 | Ed. Geistlich Soehne Ag Fuer Chemische Industrie | Treatment of cancers with methylol-containing compounds and at least one electrolyte |
| US7892530B2 (en) * | 1999-06-04 | 2011-02-22 | Ed. Geistlich Soehne Ag Fuer Chemische Industrie | Treatment of tumor metastases and cancer |
| AU2001277242A1 (en) | 2000-08-04 | 2002-02-18 | 3-Dimensional Pharmaceuticals, Inc. | Cyclic oxyguanidine protease inhibitors |
| US6486174B2 (en) | 2000-08-07 | 2002-11-26 | 3-Dimensional Pharmaceuticals, Inc. | Tetrahydroisoquinoline-3-carboxylic acid alkoxyguanidines as integrin antagonists |
| US20020037897A1 (en) * | 2000-08-07 | 2002-03-28 | 3-Dimensional Pharmaceuticals, Inc. | Tetrahydroisoquinoline-3-carboxylic acid alkoxyguanidines as integrin antagonists |
| UA75093C2 (en) * | 2000-10-06 | 2006-03-15 | Dimensional Pharm Inc | Aminopyridinyl-,aminoguanidinyl-, and alkoxyguanidinesubstituted phenylsubstituted phenylacetamides as protease inhibitors |
| AR040126A1 (es) | 2002-05-29 | 2005-03-16 | Glaxo Group Ltd | Compuesto de fenilsulfonilo, composicion farmaceutica que lo comprende y su uso para la elaboracion de un medicamento |
| CN100513398C (zh) | 2002-12-03 | 2009-07-15 | Axys药物公司 | 作为因子viia抑制剂的2-(2-羟基联苯-3-基)-1h-苯并咪唑-5-甲脒衍生物 |
| CA2511178A1 (en) * | 2002-12-20 | 2004-07-15 | Migenix Corp. | Ligands of adenine nucleotide translocase (ant) and compositions and methods related thereto |
| US20040198777A1 (en) * | 2002-12-20 | 2004-10-07 | Mitokor, Inc. | Ligands of adenine nucleotide translocase (ANT) and compositions and methods related thereto |
| AU2004201264B2 (en) * | 2003-03-28 | 2009-12-24 | Ed. Geistlich Soehne Ag Fuer Chemische Industrie | Adhesive Antineoplastic Compositions |
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| US7678767B2 (en) | 2004-06-16 | 2010-03-16 | Pneumrx, Inc. | Glue compositions for lung volume reduction |
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| CN103402549A (zh) | 2010-12-31 | 2013-11-20 | 考瑞多制药公司 | 精氨酸酶抑制剂及其使用方法 |
| US9788539B2 (en) | 2011-05-17 | 2017-10-17 | Velico Medical, Inc. | Platelet protection solution having beta-galactosidase and sialidase inhibitors |
| CN103702556A (zh) | 2011-05-17 | 2014-04-02 | 维利科医疗公司 | 使用唾液酸酶抑制剂改进的血小板保存 |
| CA2887083A1 (en) | 2012-10-05 | 2014-04-10 | Velico Medical, Inc. | Platelet additive solution having a beta-galactosidase inhibitor |
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| CN104530113A (zh) * | 2014-12-22 | 2015-04-22 | 上海树农化工有限公司 | 邻氟苯甲酸类化合物及其制备方法 |
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-
1999
- 1999-04-01 US US09/283,241 patent/US6344486B1/en not_active Expired - Lifetime
- 1999-04-05 KR KR1020007010967A patent/KR20010042396A/ko not_active Application Discontinuation
- 1999-04-05 PL PL99343244A patent/PL343244A1/xx not_active Application Discontinuation
- 1999-04-05 AT AT99914339T patent/ATE270269T1/de not_active IP Right Cessation
- 1999-04-05 NZ NZ507050A patent/NZ507050A/xx unknown
- 1999-04-05 DE DE69918421T patent/DE69918421T2/de not_active Expired - Fee Related
- 1999-04-05 JP JP2000542293A patent/JP2002510673A/ja active Pending
- 1999-04-05 BR BR9909338-3A patent/BR9909338A/pt not_active IP Right Cessation
- 1999-04-05 EP EP99914339A patent/EP1070049B1/en not_active Expired - Lifetime
- 1999-04-05 WO PCT/US1999/007420 patent/WO1999051571A1/en active IP Right Grant
- 1999-04-05 CA CA002326759A patent/CA2326759A1/en not_active Abandoned
- 1999-04-05 EA EA200001024A patent/EA003461B1/ru not_active IP Right Cessation
- 1999-04-05 HU HU0102371A patent/HUP0102371A3/hu unknown
- 1999-04-05 AU AU32210/99A patent/AU755805B2/en not_active Ceased
- 1999-04-05 CN CN99806626A patent/CN1303365A/zh active Pending
- 1999-04-05 IL IL13879999A patent/IL138799A0/xx unknown
-
2000
- 2000-09-28 NO NO20004871A patent/NO20004871L/no not_active Application Discontinuation
-
2001
- 2001-02-28 US US09/796,319 patent/US6344466B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| KR20010042396A (ko) | 2001-05-25 |
| NO20004871D0 (no) | 2000-09-28 |
| AU755805B2 (en) | 2002-12-19 |
| NZ507050A (en) | 2003-06-30 |
| EA003461B1 (ru) | 2003-06-26 |
| ATE270269T1 (de) | 2004-07-15 |
| WO1999051571A1 (en) | 1999-10-14 |
| CN1303365A (zh) | 2001-07-11 |
| BR9909338A (pt) | 2000-12-12 |
| PL343244A1 (en) | 2001-07-30 |
| JP2002510673A (ja) | 2002-04-09 |
| US6344486B1 (en) | 2002-02-05 |
| US20010031870A1 (en) | 2001-10-18 |
| CA2326759A1 (en) | 1999-10-14 |
| US6344466B2 (en) | 2002-02-05 |
| DE69918421D1 (de) | 2004-08-05 |
| EP1070049A1 (en) | 2001-01-24 |
| NO20004871L (no) | 2000-11-30 |
| HUP0102371A3 (en) | 2002-11-28 |
| DE69918421T2 (de) | 2005-07-21 |
| HUP0102371A2 (hu) | 2001-12-28 |
| AU3221099A (en) | 1999-10-25 |
| IL138799A0 (en) | 2001-10-31 |
| EP1070049B1 (en) | 2004-06-30 |
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| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
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