RU94029667A - ПРОИЗВОДНЫЕ 11β -БЕНЗАЛЬДОКСИМ-ЭСТРА-4,9-ДИЕНА, СПОСОБ ИХ ПОЛУЧЕНИЯ И СОДЕРЖАЩИЕ ЭТИ СОЕДИНЕНИЯ ЛЕКАРСТВЕННЫЕ СРЕДСТВА - Google Patents

ПРОИЗВОДНЫЕ 11β -БЕНЗАЛЬДОКСИМ-ЭСТРА-4,9-ДИЕНА, СПОСОБ ИХ ПОЛУЧЕНИЯ И СОДЕРЖАЩИЕ ЭТИ СОЕДИНЕНИЯ ЛЕКАРСТВЕННЫЕ СРЕДСТВА

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Publication number
RU94029667A
RU94029667A RU94029667/04A RU94029667A RU94029667A RU 94029667 A RU94029667 A RU 94029667A RU 94029667/04 A RU94029667/04 A RU 94029667/04A RU 94029667 A RU94029667 A RU 94029667A RU 94029667 A RU94029667 A RU 94029667A
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RU
Russia
Prior art keywords
compounds
preparing
drugs containing
benzaldoxime
estra
Prior art date
Application number
RU94029667/04A
Other languages
English (en)
Other versions
RU2130944C1 (ru
Inventor
Шуберт Герд
De]
Кауфман Гюнтер
Зобек Лотар
Оеттель Михаель
Эльгер Вальтер
Куришко Анатоли
Original Assignee
Йенафарм ГмбХ (DE)
Йенафарм ГмбХ
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Publication date
Application filed by Йенафарм ГмбХ (DE), Йенафарм ГмбХ filed Critical Йенафарм ГмбХ (DE)
Publication of RU94029667A publication Critical patent/RU94029667A/ru
Application granted granted Critical
Publication of RU2130944C1 publication Critical patent/RU2130944C1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36—Antigestagens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

Предложены новые производные 11-бензальдокримэстрадиена общей формулы I, приведенной в описании, и их фармацевтически приемлемые соли, способ их получения и содержащие эти соединения лекарственные средства. Эти соединения обладают сильными антигестагенными воздействиями при более незначительной глюкокортикоидной активности.

Claims (1)

  1. Предложены новые производные 11-бензальдокримэстрадиена общей формулы I, приведенной в описании, и их фармацевтически приемлемые соли, способ их получения и содержащие эти соединения лекарственные средства. Эти соединения обладают сильными антигестагенными воздействиями при более незначительной глюкокортикоидной активности.
RU94029667/04A 1993-09-20 1994-08-11 ПРОИЗВОДНЫЕ β БЕНЗАЛЬДОКСИМ-ЭСТРА-4,9-ДИЕНА, СПОСОБ ИХ ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ RU2130944C1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DEP4332284.0 1993-09-20
DE4332284A DE4332284C2 (de) 1993-09-20 1993-09-20 11-Benzaldoxim-17beta-methoxy-17alpha-methoxymethyl-estradien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DEP43322840 1993-09-20

Publications (2)

Publication Number Publication Date
RU94029667A true RU94029667A (ru) 1996-06-27
RU2130944C1 RU2130944C1 (ru) 1999-05-27

Family

ID=6498354

Family Applications (1)

Application Number Title Priority Date Filing Date
RU94029667/04A RU2130944C1 (ru) 1993-09-20 1994-08-11 ПРОИЗВОДНЫЕ β БЕНЗАЛЬДОКСИМ-ЭСТРА-4,9-ДИЕНА, СПОСОБ ИХ ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ

Country Status (19)

Country Link
EP (1) EP0648779B1 (ru)
JP (1) JP2696672B2 (ru)
KR (1) KR100190775B1 (ru)
AT (1) ATE149513T1 (ru)
AU (1) AU682373B2 (ru)
CA (1) CA2130515C (ru)
CZ (1) CZ289801B6 (ru)
DE (2) DE4332284C2 (ru)
DK (1) DK0648779T3 (ru)
ES (1) ES2102144T3 (ru)
FI (1) FI112948B (ru)
GR (1) GR3023644T3 (ru)
HU (1) HU219399B (ru)
NO (1) NO304988B1 (ru)
NZ (1) NZ264228A (ru)
PL (1) PL179460B1 (ru)
RU (1) RU2130944C1 (ru)
SK (1) SK280315B6 (ru)
UA (1) UA39101C2 (ru)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4332283A1 (de) * 1993-09-20 1995-04-13 Jenapharm Gmbh Neue 11-Benzaldoximestradien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US5576310A (en) * 1994-09-20 1996-11-19 Jenapharm Gmbh 11-benzaldoxime-17β-methoxy-17α-methoxymethyl-estrasdiene derivatives, methods for their production and pharmaceuticals containing such compounds
DE19745085A1 (de) * 1997-10-11 1999-04-15 Jenapharm Gmbh 11ß-Benzaldoxim-9alpha,10alpha-epoxy-estr-4-en-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Präparate
DE19809845A1 (de) 1998-03-03 1999-09-09 Jenapharm Gmbh S-substituierte 11beta-Benzaldoxim-estra-4,9-dien-kohlensäurethiolester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende pharmazeutische Zubereitungen
DE19906152B4 (de) 1999-02-10 2005-02-10 Jenapharm Gmbh & Co. Kg Wirkstoffhaltige Laminate für Transdermalsysteme
US7629334B1 (en) * 1999-08-31 2009-12-08 Bayer Schering Pharma Aktiengesellschaft Mesoprogrestins (progesterone receptor modulations) as a component of compositions for hormone replacement therapy (HRT)
PL353994A1 (en) * 1999-08-31 2003-12-15 Jenapharm Gmbh & Co.Kgjenapharm Gmbh & Co.Kg Mesoprogestins (progesterone receptor modulators) as a component of female contraceptives
CZ301412B6 (cs) 1999-08-31 2010-02-24 Bayer Schering Pharma Aktiengesellschaft Použití specifických mesoprogestinu jako farmaceutické složky pro výrobu léciva pro hormonální substitucní lécbu
KR100864547B1 (ko) 1999-08-31 2008-10-20 바이엘 쉐링 파마 악티엔게젤샤프트 양성 호르몬 의존성 부인과 질병의 치료 및 예방을 위한메조프로게스틴 (프로게스테론 수용체 조절물질)
DE19961219A1 (de) * 1999-12-15 2001-07-19 Jenapharm Gmbh 11beta-Phenylestratrien-Derivate mit Fluoralkylgruppen in der aromatischen Seitenkette, deren Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
DE10056677A1 (de) * 2000-11-10 2002-05-16 Jenapharm Gmbh Verfahren zur Herstellung von 4-(17a-Alkoxymethyl-17ß-substituierten-3-oxoestra-4,9-dien-11ß-yl)benzaldehyd-(1E)-oxim-Derivaten
DE10056676A1 (de) * 2000-11-10 2002-05-16 Jenapharm Gmbh Verfahren zur Herstellung von 4-/17alpha-substituierten-3-oxoestra-4,9-dien-11beta-yl)benzaldehyd-(1E oder 1Z)-oximen
EP1285927A3 (de) * 2001-08-16 2005-06-29 Schering Aktiengesellschaft Verwendung von Glucocorticoid-Rezeptorantagonisten zur Vorbeugung und Behandlung von Erkrankungen des männlichen Reproduktionssystems
DE10221034A1 (de) 2002-05-03 2003-11-20 Schering Ag 17alpha-Fluoralkyl-11ß-benzaldoxim-Steroide, Verfahren zu deren Herstellung, diese Steroide enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln
EP1525215B1 (de) * 2002-08-02 2006-09-06 Schering Aktiengesellschaft Progesteronrezeptormodulatoren mit erhöhter antigonadotroper aktivität für die weibliche fertilitätskontrolle und hormonersatztherapie
DE10236405A1 (de) 2002-08-02 2004-02-19 Schering Ag Progesteronrezeptormodulatoren mit erhöhter antigonadotroper Aktivität für die weibliche Fertilitätskontrolle und Hormonersatztherapie
DE102005059222B4 (de) * 2005-12-08 2007-10-11 Bayer Schering Pharma Ag 11ß-Benzaldoximderivate von D-Homoestra-4,9-dien-3-onen
SI3263112T1 (sl) 2006-10-24 2020-10-30 Allergan Pharmaceuticals International Limited Sestavki in metode za zaviranje endometrijskih proliferacij
TWI539953B (zh) 2008-04-28 2016-07-01 瑞波若斯治療學公司 用於治療乳癌之組成物和方法
KR102166867B1 (ko) 2010-03-22 2020-10-19 앨러간 파마슈티컬스 인터내셔널 리미티드 항프로게스틴의 비독성 전달을 위한 조성물들과 그 방법들

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU580843B2 (en) * 1985-02-07 1989-02-02 Schering Aktiengesellschaft 11``-phenyl-gonanes, their manufacture and pharmaceutical preparations containing them
DE3504421A1 (de) * 1985-02-07 1986-08-07 Schering AG, 1000 Berlin und 4709 Bergkamen Neue 11ss-phenyl-gonane, deren herstellung und diese enthaltende pharmazeutische praeparate
EP0411733B1 (de) * 1989-08-04 1998-10-21 Schering Aktiengesellschaft 11 Beta-Aryl-gona-4,9-dien-3-one
DE4332283A1 (de) * 1993-09-20 1995-04-13 Jenapharm Gmbh Neue 11-Benzaldoximestradien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel

Also Published As

Publication number Publication date
HUT68315A (en) 1995-06-28
NO304988B1 (no) 1999-03-15
HU9402695D0 (en) 1994-11-28
CZ289801B6 (cs) 2002-04-17
NZ264228A (en) 1995-04-27
UA39101C2 (ru) 2001-06-15
CA2130515C (en) 2001-07-17
FI943688A (fi) 1995-03-21
FI943688A0 (fi) 1994-08-09
CZ196994A3 (en) 1995-04-12
JP2696672B2 (ja) 1998-01-14
CA2130515A1 (en) 1995-03-21
ES2102144T3 (es) 1997-07-16
EP0648779B1 (de) 1997-03-05
DE4332284A1 (de) 1995-03-23
EP0648779A3 (de) 1995-08-09
ATE149513T1 (de) 1997-03-15
PL179460B1 (pl) 2000-09-29
SK95894A3 (en) 1995-04-12
AU682373B2 (en) 1997-10-02
NO942952L (no) 1995-03-21
DE4332284C2 (de) 1997-05-28
KR950008531A (ko) 1995-04-19
JPH07149790A (ja) 1995-06-13
NO942952D0 (no) 1994-08-09
EP0648779A2 (de) 1995-04-19
SK280315B6 (sk) 1999-11-08
DE59401919D1 (de) 1997-04-10
FI112948B (fi) 2004-02-13
HU219399B (hu) 2001-04-28
KR100190775B1 (ko) 1999-06-01
PL305091A1 (en) 1995-04-03
RU2130944C1 (ru) 1999-05-27
DK0648779T3 (da) 1997-09-15
GR3023644T3 (en) 1997-08-29
AU7035194A (en) 1995-03-30

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