ES2102144T3 - Nuevos derivados de estradieno de 11-benzaldoxima-17beta metoxi-17alfa-metoximetilo un procedimiento para su produccion y productos medicinales que contienen estos compuestos. - Google Patents

Nuevos derivados de estradieno de 11-benzaldoxima-17beta metoxi-17alfa-metoximetilo un procedimiento para su produccion y productos medicinales que contienen estos compuestos.

Info

Publication number
ES2102144T3
ES2102144T3 ES94250179T ES94250179T ES2102144T3 ES 2102144 T3 ES2102144 T3 ES 2102144T3 ES 94250179 T ES94250179 T ES 94250179T ES 94250179 T ES94250179 T ES 94250179T ES 2102144 T3 ES2102144 T3 ES 2102144T3
Authority
ES
Spain
Prior art keywords
compounds
metoximetilo
benzaldoxima
17alfa
metoxi
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94250179T
Other languages
English (en)
Inventor
Gerd Dr Schubert
Gunter Dr Kaufmann
Lothar Dr Sobeck
Michael Prof Dr Oettel
Walter Dr Elger
Anatoli Dr Kurischko
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jenapharm GmbH and Co KG
Original Assignee
Jenapharm GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jenapharm GmbH and Co KG filed Critical Jenapharm GmbH and Co KG
Application granted granted Critical
Publication of ES2102144T3 publication Critical patent/ES2102144T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36—Antigestagens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

SE DESCRIBEN NUEVOS DERIVADOS 11 UN PROCESO PARA SU ELABORACION Y LOS MEDICAMENTOS QUE CONTIENEN ESTOS COMPUESTOS. LOS COMPUESTOS DESCRITOS MUESTRAN EFECTOS FUERTES ANTIGESTAGENOS EN ACTIVIDAD REDUCIDA GLUCOCORTICOIDE.
ES94250179T 1993-09-20 1994-07-07 Nuevos derivados de estradieno de 11-benzaldoxima-17beta metoxi-17alfa-metoximetilo un procedimiento para su produccion y productos medicinales que contienen estos compuestos. Expired - Lifetime ES2102144T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4332284A DE4332284C2 (de) 1993-09-20 1993-09-20 11-Benzaldoxim-17beta-methoxy-17alpha-methoxymethyl-estradien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel

Publications (1)

Publication Number Publication Date
ES2102144T3 true ES2102144T3 (es) 1997-07-16

Family

ID=6498354

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94250179T Expired - Lifetime ES2102144T3 (es) 1993-09-20 1994-07-07 Nuevos derivados de estradieno de 11-benzaldoxima-17beta metoxi-17alfa-metoximetilo un procedimiento para su produccion y productos medicinales que contienen estos compuestos.

Country Status (19)

Country Link
EP (1) EP0648779B1 (es)
JP (1) JP2696672B2 (es)
KR (1) KR100190775B1 (es)
AT (1) ATE149513T1 (es)
AU (1) AU682373B2 (es)
CA (1) CA2130515C (es)
CZ (1) CZ289801B6 (es)
DE (2) DE4332284C2 (es)
DK (1) DK0648779T3 (es)
ES (1) ES2102144T3 (es)
FI (1) FI112948B (es)
GR (1) GR3023644T3 (es)
HU (1) HU219399B (es)
NO (1) NO304988B1 (es)
NZ (1) NZ264228A (es)
PL (1) PL179460B1 (es)
RU (1) RU2130944C1 (es)
SK (1) SK280315B6 (es)
UA (1) UA39101C2 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4332283A1 (de) * 1993-09-20 1995-04-13 Jenapharm Gmbh Neue 11-Benzaldoximestradien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US5576310A (en) * 1994-09-20 1996-11-19 Jenapharm Gmbh 11-benzaldoxime-17β-methoxy-17α-methoxymethyl-estrasdiene derivatives, methods for their production and pharmaceuticals containing such compounds
DE19745085A1 (de) * 1997-10-11 1999-04-15 Jenapharm Gmbh 11ß-Benzaldoxim-9alpha,10alpha-epoxy-estr-4-en-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Präparate
DE19809845A1 (de) 1998-03-03 1999-09-09 Jenapharm Gmbh S-substituierte 11beta-Benzaldoxim-estra-4,9-dien-kohlensäurethiolester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende pharmazeutische Zubereitungen
DE19906152B4 (de) 1999-02-10 2005-02-10 Jenapharm Gmbh & Co. Kg Wirkstoffhaltige Laminate für Transdermalsysteme
US7629334B1 (en) * 1999-08-31 2009-12-08 Bayer Schering Pharma Aktiengesellschaft Mesoprogrestins (progesterone receptor modulations) as a component of compositions for hormone replacement therapy (HRT)
SI20851B (sl) * 1999-08-31 2009-06-30 Bayer Schering Pharma Ag Mezoprogestini (modulatorji receptorja progesterona) kot komponenta pripravkov za nadomestno zdravljenje s hormoni (NZH)
EP1605949A2 (en) * 1999-08-31 2005-12-21 Schering Aktiengesellschaft Mesoprogestins (progesterone receptor modulators) as a component of female contraceptives
EE05172B1 (et) 1999-08-31 2009-06-15 Jenapharm Gmbh & Co. Kg Mesoprogestiinid (progesterooniretseptori modulaatorid) healoomuliste hormoons?ltuvate gnekoloogiliste haiguste raviks ja v„ltimiseks
DE19961219A1 (de) * 1999-12-15 2001-07-19 Jenapharm Gmbh 11beta-Phenylestratrien-Derivate mit Fluoralkylgruppen in der aromatischen Seitenkette, deren Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
DE10056676A1 (de) * 2000-11-10 2002-05-16 Jenapharm Gmbh Verfahren zur Herstellung von 4-/17alpha-substituierten-3-oxoestra-4,9-dien-11beta-yl)benzaldehyd-(1E oder 1Z)-oximen
DE10056677A1 (de) * 2000-11-10 2002-05-16 Jenapharm Gmbh Verfahren zur Herstellung von 4-(17a-Alkoxymethyl-17ß-substituierten-3-oxoestra-4,9-dien-11ß-yl)benzaldehyd-(1E)-oxim-Derivaten
EP1285927A3 (de) * 2001-08-16 2005-06-29 Schering Aktiengesellschaft Verwendung von Glucocorticoid-Rezeptorantagonisten zur Vorbeugung und Behandlung von Erkrankungen des männlichen Reproduktionssystems
DE10221034A1 (de) * 2002-05-03 2003-11-20 Schering Ag 17alpha-Fluoralkyl-11ß-benzaldoxim-Steroide, Verfahren zu deren Herstellung, diese Steroide enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln
DE10236405A1 (de) 2002-08-02 2004-02-19 Schering Ag Progesteronrezeptormodulatoren mit erhöhter antigonadotroper Aktivität für die weibliche Fertilitätskontrolle und Hormonersatztherapie
WO2004014935A1 (de) * 2002-08-02 2004-02-19 Schering Aktiengesellschaft Progesteronrezeptormodulatoren mit erhöhter antigonadotroper aktivität für die weibliche fertilitätskontrolle und hormonersatztherapie
DE102005059222B4 (de) * 2005-12-08 2007-10-11 Bayer Schering Pharma Ag 11ß-Benzaldoximderivate von D-Homoestra-4,9-dien-3-onen
ES2814343T3 (es) 2006-10-24 2021-03-26 Allergan Pharmaceuticals Int Ltd Composiciones y métodos para suprimir las proliferaciones endometriales
TWI539953B (zh) 2008-04-28 2016-07-01 瑞波若斯治療學公司 用於治療乳癌之組成物和方法
JP5894143B2 (ja) 2010-03-22 2016-03-23 リプロス セラピューティクス インコーポレイテッド 抗黄体ホルモンの無毒送達のための組成物および方法
KR102856539B1 (ko) 2023-11-01 2025-09-08 김종구 Tlc 응고지금 천공,쐐기,파쇄 작업 방법

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3504421A1 (de) * 1985-02-07 1986-08-07 Schering AG, 1000 Berlin und 4709 Bergkamen Neue 11ss-phenyl-gonane, deren herstellung und diese enthaltende pharmazeutische praeparate
NZ214998A (en) * 1985-02-07 1989-06-28 Schering Ag 13-(methyl or ethyl)-11-beta-phenyl-gonane derivatives; preparatory processes and pharmaceutical compositions
JP3202224B2 (ja) * 1989-08-04 2001-08-27 シエーリング アクチエンゲゼルシヤフト １１β―アリール―ゴナ―４，９―ジエン―３―オン、その製造方法及びそれを含有する調剤学的調製剤
DE4332283A1 (de) * 1993-09-20 1995-04-13 Jenapharm Gmbh Neue 11-Benzaldoximestradien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel

Also Published As

Publication number Publication date
KR950008531A (ko) 1995-04-19
AU7035194A (en) 1995-03-30
RU94029667A (ru) 1996-06-27
HU219399B (hu) 2001-04-28
HU9402695D0 (en) 1994-11-28
GR3023644T3 (en) 1997-08-29
SK280315B6 (sk) 1999-11-08
CA2130515A1 (en) 1995-03-21
PL305091A1 (en) 1995-04-03
DE4332284A1 (de) 1995-03-23
NZ264228A (en) 1995-04-27
DK0648779T3 (da) 1997-09-15
JPH07149790A (ja) 1995-06-13
CZ196994A3 (en) 1995-04-12
EP0648779A2 (de) 1995-04-19
DE4332284C2 (de) 1997-05-28
KR100190775B1 (ko) 1999-06-01
PL179460B1 (pl) 2000-09-29
FI112948B (fi) 2004-02-13
EP0648779B1 (de) 1997-03-05
SK95894A3 (en) 1995-04-12
EP0648779A3 (de) 1995-08-09
HUT68315A (en) 1995-06-28
NO942952D0 (no) 1994-08-09
AU682373B2 (en) 1997-10-02
CA2130515C (en) 2001-07-17
NO304988B1 (no) 1999-03-15
FI943688L (fi) 1995-03-21
DE59401919D1 (de) 1997-04-10
ATE149513T1 (de) 1997-03-15
RU2130944C1 (ru) 1999-05-27
CZ289801B6 (cs) 2002-04-17
FI943688A0 (fi) 1994-08-09
NO942952L (no) 1995-03-21
UA39101C2 (uk) 2001-06-15
JP2696672B2 (ja) 1998-01-14

Similar Documents

Publication Publication Date Title
ES2102144T3 (es) Nuevos derivados de estradieno de 11-benzaldoxima-17beta metoxi-17alfa-metoximetilo un procedimiento para su produccion y productos medicinales que contienen estos compuestos.
ES2108371T3 (es) Nuevos derivados de estradieno de 11-benzaldoxima, procedimientos para su produccion y farmacos conteniendo estos compuestos.
DE3366932D1 (en) New derivatives of biliary acids, process for the production thereof and pharmaceutical compositions containing the same
NO174877C (no) Fremgangsmåte for fremstilling av et legemiddel med antitumorvirkning
ES2144192T3 (es) Nuevos derivados de 1-fenil-2-dimetil-amino-metil-ciclohexan-1-ol, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
PT89094A (pt) Processo para a preparacao de 1-aril-3-quinolina-e 1-aril-3-isoquinolina-carboxamidas e de composicoes farmaceuticas que as contem
MX9200374A (es) Nuevos esteres esteroides, procedimiento para su preparacion y preparacion farmaceutica que los contiene.
AR002039A1 (es) Pirido[3.2-e]pirazinonas con efecto antiasmatico, y procedimiento para su preparacion y los medicamentos que los contienen y su preparación
ES2102475T3 (es) Nuevas alquil-amidas heterociclicas, su procedimiento de preparacion y composiciones farmaceuticas que las contienen.
HUT39603A (en) Process for producing pharmaceutical compositions containing synergistic combinations of flupirtin and nonsteroide antiphlogistics
GR850472B (es)
MX9304793A (es) Glicanas de actividad inmunoestimulante.
ES2054715T3 (es) Nuevos derivados de naftaleno y productos farmaceuticos antialergicos y antiinflamatorios.
MX9205916A (es) Derivados de acido ciclohexanoacetico, proceso para su preparacion y composicion farmaceutica que los comprende
ES2104808T3 (es) Derivados de 4,13-dioxabiciclo(8.2.1.)tridecenona, procedimiento y productos intermedios para su preparacion y medicamentos que contienen estos compuestos.
PT90888A (pt) Processo para a preparacao de composicoes farmaceuticas contendo prostaglandinas
MX9300628A (es) Nuevos derivados de taxano, procedimiento para su preparacion y composicion farmaceutica que los contiene.
MX9301235A (es) DERIVADOS 1,4-DIOXINO(2,3-B)PIRIDINA. á
PT89214A (pt) Processo para a preparacao de novos derivados de aminoacidos ciclicos e de composicoes farmaceuticas que os contem
ES2043943T3 (es) Procedimiento para la preparacion de compuestos con actividad analgesica central.
PT80656B (pt) Processo para a preparacao de um novo antibiotico antitumor depsipeptidico ciclico e de composicoes farmaceuticas que o contem
HUT39437A (en) Process for producing new morpholinol derivatives and pharmaceutical compositions containing them as active agents
FR2556218B1 (fr) Produit pharmaceutique pour application locale constitue par l'association d'un principe actif medicamenteux-agent enzymatique
PT88681A (pt) A process for the preparation of pharmaceutical compositions containing piperidinoalkanol derivatives
PT1001942E (pt) Poli-hidroxibutilpirazinas sua preparacao e medicamentos que as contem

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 648779

Country of ref document: ES