RU2766680C1 - Новые варианты гиалуронидазы и содержащая их фармацевтическая композиция - Google Patents

Новые варианты гиалуронидазы и содержащая их фармацевтическая композиция Download PDF

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RU2766680C1
RU2766680C1 RU2020130922A RU2020130922A RU2766680C1 RU 2766680 C1 RU2766680 C1 RU 2766680C1 RU 2020130922 A RU2020130922 A RU 2020130922A RU 2020130922 A RU2020130922 A RU 2020130922A RU 2766680 C1 RU2766680 C1 RU 2766680C1
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amino acid
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terminus
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variants
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Сун Чэ ПАК
Хе-Син ЧОН
Сон Чу ЛИ
Сон-А Ю
Хён-Нам СОН
Чан У ЛИ
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Алтеоген, Инк
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    • A—HUMAN NECESSITIES
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    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
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    • C12N5/0682—Cells of the female genital tract, e.g. endometrium; Non-germinal cells from ovaries, e.g. ovarian follicle cells
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2474—Hyaluronoglucosaminidase (3.2.1.35), i.e. hyaluronidase
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01035—Hyaluronoglucosaminidase (3.2.1.35), i.e. hyaluronidase
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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    • C12N2800/00—Nucleic acids vectors
    • C12N2800/10—Plasmid DNA
    • C12N2800/106—Plasmid DNA for vertebrates
    • C12N2800/107—Plasmid DNA for vertebrates for mammalian

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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Cell Biology (AREA)
  • Reproductive Health (AREA)
  • Plant Pathology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
RU2020130922A 2018-07-25 2019-07-25 Новые варианты гиалуронидазы и содержащая их фармацевтическая композиция RU2766680C1 (ru)

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KR10-2018-0086308 2018-07-25
KR20180086308 2018-07-25
KR10-2019-0029758 2019-03-15
KR20190029758 2019-03-15
PCT/KR2019/009215 WO2020022791A1 (ko) 2018-07-25 2019-07-25 신규 히알루론산 가수분해 효소 변이체 및 이를 포함하는 약제학적 조성물

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US (2) US12371683B2 (OSRAM)
EP (1) EP3636752A4 (OSRAM)
JP (3) JP7204729B2 (OSRAM)
KR (3) KR20210023798A (OSRAM)
CN (5) CN118853631A (OSRAM)
AU (2) AU2019311658B2 (OSRAM)
BR (1) BR112020019041A2 (OSRAM)
CA (1) CA3093885A1 (OSRAM)
MX (1) MX2020009824A (OSRAM)
RU (1) RU2766680C1 (OSRAM)
WO (1) WO2020022791A1 (OSRAM)

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WO2023249408A1 (ko) 2022-06-22 2023-12-28 (주)알테오젠 N-말단 및/또는 c-말단이 절단된 가용성 ph20 폴리펩티드 및 이의 용도
KR102621518B1 (ko) * 2022-06-29 2024-01-10 주식회사 오디스젠 중성 pH에서 활성을 나타내는 히알루로니다제 Hyal1변이체
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KR20250086876A (ko) * 2023-12-06 2025-06-16 (주)한국비엠아이 히알루로니다제 폴리펩티드와 약물을 포함하는 피하투여용 조성물
WO2025136032A1 (ko) * 2023-12-21 2025-06-26 주식회사 오디스젠 개선된 특성을 갖는 히알루로니다제 hyal2 변이체
KR102896967B1 (ko) * 2023-12-21 2025-12-09 주식회사 오디스젠 개선된 특성을 갖는 히알루로니다제 Hyal2 변이체
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CN119776311B (zh) * 2024-12-13 2025-12-19 江南大学 一种透明质酸合酶突变体及其应用

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