RU2741021C2 - Соединения для стимуляции роста волос и/или ингибирования или замедления выпадения волос у человека и композиции для их применения - Google Patents
Соединения для стимуляции роста волос и/или ингибирования или замедления выпадения волос у человека и композиции для их применения Download PDFInfo
- Publication number
- RU2741021C2 RU2741021C2 RU2018144755A RU2018144755A RU2741021C2 RU 2741021 C2 RU2741021 C2 RU 2741021C2 RU 2018144755 A RU2018144755 A RU 2018144755A RU 2018144755 A RU2018144755 A RU 2018144755A RU 2741021 C2 RU2741021 C2 RU 2741021C2
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- Prior art keywords
- sandalwood
- pentanol
- composition
- hair
- methyl
- Prior art date
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| IT102016000051626 | 2016-05-19 | ||
| PCT/EP2017/062110 WO2017198818A1 (en) | 2016-05-19 | 2017-05-19 | Compounds for promoting hair growth and/or inhibiting or delaying hair loss in humans, and compositions for such uses |
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| RS (1) | RS61407B1 (OSRAM) |
| RU (1) | RU2741021C2 (OSRAM) |
| SG (2) | SG10202011357RA (OSRAM) |
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Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT201800005585A1 (it) * | 2018-05-22 | 2019-11-22 | Composti per prevenire e trattare affezioni della pelle o della mucosa con componente infiammatoria | |
| WO2020069522A1 (en) * | 2018-09-29 | 2020-04-02 | Robert J Petcavich | Natural product composition for stimulating hair growth |
| FR3110425B1 (fr) * | 2020-05-19 | 2022-09-09 | Isp Investments Llc | Procede d’obtention d’un extrait de bois de santal, compositions le comprenant et ses utilisations cosmetiques |
| WO2022112419A1 (en) * | 2020-11-30 | 2022-06-02 | Wella Germany Gmbh | Anti-hair-loss composition |
| US11999691B2 (en) | 2020-12-19 | 2024-06-04 | Actera Ingredients, Inc. | Odorless active agents |
| JP7642955B2 (ja) * | 2021-02-04 | 2025-03-11 | 株式会社ファンケル | 嗅覚受容体発現促進用組成物 |
| WO2022202714A1 (ja) | 2021-03-22 | 2022-09-29 | 株式会社 資生堂 | メルケル細胞活性化剤、シナプス小胞の増強剤、神経伝達物質放出促進剤、メルケル細胞の神経伝達物質放出活性の評価方法、並びにメルケル細胞の神経伝達物質放出促進剤のスクリーニング方法 |
| EP4408540A4 (en) * | 2021-10-01 | 2025-09-24 | Coty Inc | COMPOSITIONS COMPRISING OR2AT4 AGONISTS |
| IT202200010358A1 (it) * | 2022-05-18 | 2023-11-18 | Giuliani Spa | Agonista del recettore olfattivo 2a4/7 per promuovere la crescita di capelli e migliorare l’aspetto estetico / olfactory receptor 2a4/7 agonist for promoting hair growth and improving aesthetic aspect |
| EP4531801A1 (en) | 2022-05-25 | 2025-04-09 | Wella Germany GmbH | Improving hair structure |
| EP4545063A1 (en) * | 2023-10-23 | 2025-04-30 | Wella Germany GmbH | Cosmetical use of a topically applicable rinse-of composition (rc) |
| EP4620463A1 (en) * | 2024-03-22 | 2025-09-24 | CUTANEON - Skin & Hair Innovations GmbH | Active agent for use in hair growth regulation |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4052341A (en) * | 1976-04-29 | 1977-10-04 | Givaudan Corporation | 3-methyl-5-(2,2,3-trimethylcyclopent-3-en-1-yl)pentan-2-ol compound and perfume compositions |
| EP1238650A2 (en) * | 2001-03-07 | 2002-09-11 | Takasago International Corporation | Antimicrobial flavor and oral care composition containing the same |
| EP1346720A2 (en) * | 2002-03-22 | 2003-09-24 | Takasago International Corporation | Composition for deodorizing hair dyeing and hair bleaching compositions |
| US7879910B1 (en) * | 2006-10-10 | 2011-02-01 | Jan Marini Skin Research, Inc. | Compositions and methods for promoting lush hair growth |
| EA020293B1 (ru) * | 2008-02-01 | 2014-10-30 | Мэри Кэй Инк. | Применение композиции, содержащей этил-линалул, для ухода за кожей |
| EP2916878A1 (en) * | 2012-11-07 | 2015-09-16 | Kimberly-Clark Worldwide, Inc. | Triggerable compositions for two-stage, controlled release of active chemistry |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1075250A (zh) | 1992-10-27 | 1993-08-18 | 海南南洋实业有限公司 | 香波的生产方法 |
| JP4020284B2 (ja) * | 1999-05-27 | 2007-12-12 | 株式会社マンダム | 育毛剤原料及び育毛剤組成物 |
| JP2001151644A (ja) * | 1999-11-29 | 2001-06-05 | Kao Corp | 頭皮臭用香料組成物 |
| JP3947149B2 (ja) | 2002-10-28 | 2007-07-18 | 高砂香料工業株式会社 | 消臭剤組成物 |
| JP2006160698A (ja) * | 2004-12-10 | 2006-06-22 | Noevir Co Ltd | Vegf産生促進剤、育毛剤、及び創傷治癒剤 |
| CN102000293A (zh) | 2010-12-05 | 2011-04-06 | 孟凡伟 | 一种中药养发配方 |
| CN103735443A (zh) | 2013-12-10 | 2014-04-23 | 河南孟诜堂药业有限公司 | 一种止脱柔顺洗发液及其制备方法 |
| EP2957283B1 (de) * | 2014-06-19 | 2022-12-21 | Symrise AG | Verfahren zur Identifizierung von Medikamenten zur Beschleunigung der Wundheilung |
-
2016
- 2016-05-19 IT ITUA2016A003604A patent/ITUA20163604A1/it unknown
-
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- 2017-05-19 WO PCT/EP2017/062110 patent/WO2017198818A1/en not_active Ceased
- 2017-05-19 SI SI201730632T patent/SI3458020T1/sl unknown
- 2017-05-19 EP EP17730678.4A patent/EP3458020B1/en active Active
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- 2017-05-19 KR KR1020187035315A patent/KR102452350B1/ko active Active
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- 2017-05-19 BR BR112018073626-0A patent/BR112018073626B1/pt active IP Right Grant
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-
2021
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Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4052341A (en) * | 1976-04-29 | 1977-10-04 | Givaudan Corporation | 3-methyl-5-(2,2,3-trimethylcyclopent-3-en-1-yl)pentan-2-ol compound and perfume compositions |
| EP1238650A2 (en) * | 2001-03-07 | 2002-09-11 | Takasago International Corporation | Antimicrobial flavor and oral care composition containing the same |
| EP1346720A2 (en) * | 2002-03-22 | 2003-09-24 | Takasago International Corporation | Composition for deodorizing hair dyeing and hair bleaching compositions |
| US7879910B1 (en) * | 2006-10-10 | 2011-02-01 | Jan Marini Skin Research, Inc. | Compositions and methods for promoting lush hair growth |
| EA020293B1 (ru) * | 2008-02-01 | 2014-10-30 | Мэри Кэй Инк. | Применение композиции, содержащей этил-линалул, для ухода за кожей |
| EP2916878A1 (en) * | 2012-11-07 | 2015-09-16 | Kimberly-Clark Worldwide, Inc. | Triggerable compositions for two-stage, controlled release of active chemistry |
Non-Patent Citations (2)
| Title |
|---|
| V.G. Belikov "Pharmaceutical chemistry", textbook, 2007, Moscow, "MEDpress-inform", pp. 27-29. * |
| В.Г. Беликов "Фармацевтическая химия", учебное пособие, 2007, Москва, "МЕДпресс-информ", стр.27-29. * |
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