ES2851899T3 - Compuestos para promover el crecimiento del cabello y/o para inhibir o retrasar la caída del cabello en humanos, y composiciones para dichos usos - Google Patents
Compuestos para promover el crecimiento del cabello y/o para inhibir o retrasar la caída del cabello en humanos, y composiciones para dichos usos Download PDFInfo
- Publication number
- ES2851899T3 ES2851899T3 ES17730678T ES17730678T ES2851899T3 ES 2851899 T3 ES2851899 T3 ES 2851899T3 ES 17730678 T ES17730678 T ES 17730678T ES 17730678 T ES17730678 T ES 17730678T ES 2851899 T3 ES2851899 T3 ES 2851899T3
- Authority
- ES
- Spain
- Prior art keywords
- methyl
- together form
- compound
- hydrogen
- double bond
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 150000001875 compounds Chemical class 0.000 title claims abstract description 37
- 230000003779 hair growth Effects 0.000 title claims abstract description 18
- 201000004384 Alopecia Diseases 0.000 title claims abstract description 14
- 230000003676 hair loss Effects 0.000 title claims abstract description 14
- 208000024963 hair loss Diseases 0.000 title claims abstract description 14
- 239000000203 mixture Substances 0.000 title claims description 20
- 230000001737 promoting effect Effects 0.000 title claims description 7
- 230000002401 inhibitory effect Effects 0.000 title description 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract description 24
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 19
- 210000004761 scalp Anatomy 0.000 claims abstract description 19
- 239000001257 hydrogen Substances 0.000 claims abstract description 18
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims abstract description 16
- 239000002537 cosmetic Substances 0.000 claims abstract description 12
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims abstract description 12
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims abstract description 6
- NGYMOTOXXHCHOC-UHFFFAOYSA-N 3-methyl-5-(2,2,3-trimethylcyclopent-3-en-1-yl)pentan-2-ol Chemical compound CC(O)C(C)CCC1CC=C(C)C1(C)C NGYMOTOXXHCHOC-UHFFFAOYSA-N 0.000 claims description 14
- 239000004615 ingredient Substances 0.000 claims description 7
- 238000011200 topical administration Methods 0.000 claims description 4
- 239000004480 active ingredient Substances 0.000 claims description 2
- 230000001225 therapeutic effect Effects 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- CYVGAJHMMVDTDZ-UHFFFAOYSA-N 2-methyl-4-(2,2,3-trimethylcyclopent-3-en-1-yl)butan-1-ol Chemical compound OCC(C)CCC1CC=C(C)C1(C)C CYVGAJHMMVDTDZ-UHFFFAOYSA-N 0.000 claims 3
- KHQDWCKZXLWDNM-KPKJPENVSA-N (e)-2-ethyl-4-(2,2,3-trimethylcyclopent-3-en-1-yl)but-2-en-1-ol Chemical compound CC\C(CO)=C/CC1CC=C(C)C1(C)C KHQDWCKZXLWDNM-KPKJPENVSA-N 0.000 claims 1
- MTVBNJVZZAQKRV-BJMVGYQFSA-N (e)-2-methyl-4-(2,2,3-trimethylcyclopent-3-en-1-yl)but-2-en-1-ol Chemical compound OCC(/C)=C/CC1CC=C(C)C1(C)C MTVBNJVZZAQKRV-BJMVGYQFSA-N 0.000 claims 1
- QZFSNJAQFWEXEA-MDZDMXLPSA-N (e)-3,3-dimethyl-5-(2,2,3-trimethylcyclopent-3-en-1-yl)pent-4-en-2-ol Chemical compound CC(O)C(C)(C)\C=C\C1CC=C(C)C1(C)C QZFSNJAQFWEXEA-MDZDMXLPSA-N 0.000 claims 1
- -1 2,2,3-trimethylcyclopent-3-en-1-yl Chemical group 0.000 claims 1
- OAKFACUIGQLOCA-UHFFFAOYSA-N [1-methyl-2-[(1,2,2-trimethyl-3-bicyclo[3.1.0]hexanyl)methyl]cyclopropyl]methanol Chemical compound OCC1(C)CC1CC1C(C)(C)C2(C)CC2C1 OAKFACUIGQLOCA-UHFFFAOYSA-N 0.000 claims 1
- AMQJEAYHLZJPGS-UHFFFAOYSA-N N-Pentanol Chemical compound CCCCCO AMQJEAYHLZJPGS-UHFFFAOYSA-N 0.000 description 70
- 210000003780 hair follicle Anatomy 0.000 description 40
- 101710153620 Olfactory receptor 2AT4 Proteins 0.000 description 32
- 102100035503 Olfactory receptor 2AT4 Human genes 0.000 description 32
- 210000002510 keratinocyte Anatomy 0.000 description 18
- 210000004209 hair Anatomy 0.000 description 16
- 239000011159 matrix material Substances 0.000 description 16
- 230000000638 stimulation Effects 0.000 description 13
- 239000003205 fragrance Substances 0.000 description 12
- 240000000513 Santalum album Species 0.000 description 11
- 235000008632 Santalum album Nutrition 0.000 description 11
- 239000003981 vehicle Substances 0.000 description 11
- 238000010586 diagram Methods 0.000 description 10
- 230000000694 effects Effects 0.000 description 10
- 108050002069 Olfactory receptors Proteins 0.000 description 9
- 230000003778 catagen phase Effects 0.000 description 9
- 230000014509 gene expression Effects 0.000 description 9
- 102000012547 Olfactory receptors Human genes 0.000 description 8
- 239000000556 agonist Substances 0.000 description 8
- 238000010166 immunofluorescence Methods 0.000 description 8
- 230000006907 apoptotic process Effects 0.000 description 7
- 230000035755 proliferation Effects 0.000 description 7
- 239000010671 sandalwood oil Substances 0.000 description 7
- 238000012360 testing method Methods 0.000 description 7
- 230000003698 anagen phase Effects 0.000 description 6
- 230000007423 decrease Effects 0.000 description 6
- 210000003491 skin Anatomy 0.000 description 6
- CYVGAJHMMVDTDZ-JQWIXIFHSA-N (2s)-2-methyl-4-[(1s)-2,2,3-trimethylcyclopent-3-en-1-yl]butan-1-ol Chemical compound OC[C@@H](C)CC[C@H]1CC=C(C)C1(C)C CYVGAJHMMVDTDZ-JQWIXIFHSA-N 0.000 description 5
- 210000001519 tissue Anatomy 0.000 description 5
- RGSFGYAAUTVSQA-UHFFFAOYSA-N Cyclopentane Chemical compound C1CCCC1 RGSFGYAAUTVSQA-UHFFFAOYSA-N 0.000 description 4
- 239000005557 antagonist Substances 0.000 description 4
- 239000003102 growth factor Substances 0.000 description 4
- 239000002453 shampoo Substances 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- FWBHETKCLVMNFS-UHFFFAOYSA-N 4',6-Diamino-2-phenylindol Chemical compound C1=CC(C(=N)N)=CC=C1C1=CC2=CC=C(C(N)=N)C=C2N1 FWBHETKCLVMNFS-UHFFFAOYSA-N 0.000 description 3
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 3
- 238000012313 Kruskal-Wallis test Methods 0.000 description 3
- 230000004913 activation Effects 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 238000011260 co-administration Methods 0.000 description 3
- 230000001934 delay Effects 0.000 description 3
- 239000002781 deodorant agent Substances 0.000 description 3
- 238000011534 incubation Methods 0.000 description 3
- 230000006698 induction Effects 0.000 description 3
- 210000001208 inner root sheath cell Anatomy 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 210000000056 organ Anatomy 0.000 description 3
- 238000010149 post-hoc-test Methods 0.000 description 3
- 210000004918 root sheath Anatomy 0.000 description 3
- 230000029663 wound healing Effects 0.000 description 3
- PDEQKAVEYSOLJX-YHYXMXQVSA-N α-santal-10-en-12-ol Chemical compound C1C2C3(C)C2CC1C3(C)CC/C=C(CO)/C PDEQKAVEYSOLJX-YHYXMXQVSA-N 0.000 description 3
- 239000001306 (7E,9E,11E,13E)-pentadeca-7,9,11,13-tetraen-1-ol Substances 0.000 description 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 241000283707 Capra Species 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 238000000692 Student's t-test Methods 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- 230000001640 apoptogenic effect Effects 0.000 description 2
- 230000034720 apoptotic signaling pathway Effects 0.000 description 2
- 230000000903 blocking effect Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000000723 chemosensory effect Effects 0.000 description 2
- 229940125904 compound 1 Drugs 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 230000003111 delayed effect Effects 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000002500 effect on skin Effects 0.000 description 2
- 210000002322 enterochromaffin cell Anatomy 0.000 description 2
- 230000031774 hair cycle Effects 0.000 description 2
- DMEGYFMYUHOHGS-UHFFFAOYSA-N heptamethylene Natural products C1CCCCCC1 DMEGYFMYUHOHGS-UHFFFAOYSA-N 0.000 description 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 2
- 150000002431 hydrogen Chemical class 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 230000029411 keratinocyte apoptotic process Effects 0.000 description 2
- 239000002609 medium Substances 0.000 description 2
- 238000011201 multiple comparisons test Methods 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 235000019198 oils Nutrition 0.000 description 2
- 239000002304 perfume Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000002062 proliferating effect Effects 0.000 description 2
- 235000018102 proteins Nutrition 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 238000010186 staining Methods 0.000 description 2
- 238000005728 strengthening Methods 0.000 description 2
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 2
- 239000002023 wood Substances 0.000 description 2
- MJTPMXWJHPOWGH-UHFFFAOYSA-N 2-Phenoxyethyl isobutyrate Chemical compound CC(C)C(=O)OCCOC1=CC=CC=C1 MJTPMXWJHPOWGH-UHFFFAOYSA-N 0.000 description 1
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 1
- OSCJHTSDLYVCQC-UHFFFAOYSA-N 2-ethylhexyl 4-[[4-[4-(tert-butylcarbamoyl)anilino]-6-[4-(2-ethylhexoxycarbonyl)anilino]-1,3,5-triazin-2-yl]amino]benzoate Chemical compound C1=CC(C(=O)OCC(CC)CCCC)=CC=C1NC1=NC(NC=2C=CC(=CC=2)C(=O)NC(C)(C)C)=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=N1 OSCJHTSDLYVCQC-UHFFFAOYSA-N 0.000 description 1
- 240000001606 Adenanthera pavonina Species 0.000 description 1
- 235000011470 Adenanthera pavonina Nutrition 0.000 description 1
- 230000003777 Anagen VI Effects 0.000 description 1
- 244000061520 Angelica archangelica Species 0.000 description 1
- 241000213006 Angelica dahurica Species 0.000 description 1
- 208000001840 Dandruff Diseases 0.000 description 1
- 240000004670 Glycyrrhiza echinata Species 0.000 description 1
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 description 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 description 1
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 description 1
- 235000001287 Guettarda speciosa Nutrition 0.000 description 1
- 235000000177 Indigofera tinctoria Nutrition 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 244000062250 Kaempferia rotunda Species 0.000 description 1
- 235000013422 Kaempferia rotunda Nutrition 0.000 description 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
- 229930182816 L-glutamine Natural products 0.000 description 1
- 241000218378 Magnolia Species 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- 101150116725 OR2AT4 gene Proteins 0.000 description 1
- 244000136948 Ocimum sanctum Species 0.000 description 1
- 235000004072 Ocimum sanctum Nutrition 0.000 description 1
- 101710200212 Olfactory receptor 1 Proteins 0.000 description 1
- 238000010222 PCR analysis Methods 0.000 description 1
- 235000006484 Paeonia officinalis Nutrition 0.000 description 1
- 244000170916 Paeonia officinalis Species 0.000 description 1
- 240000004371 Panax ginseng Species 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 229930040373 Paraformaldehyde Natural products 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- 108700020962 Peroxidase Proteins 0.000 description 1
- 102000003992 Peroxidases Human genes 0.000 description 1
- 235000008331 Pinus X rigitaeda Nutrition 0.000 description 1
- 235000011613 Pinus brutia Nutrition 0.000 description 1
- 241000018646 Pinus brutia Species 0.000 description 1
- 244000014047 Polianthes tuberosa Species 0.000 description 1
- 235000016067 Polianthes tuberosa Nutrition 0.000 description 1
- 206010060862 Prostate cancer Diseases 0.000 description 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 1
- 241000220317 Rosa Species 0.000 description 1
- 244000178231 Rosmarinus officinalis Species 0.000 description 1
- 235000008631 Santalum Nutrition 0.000 description 1
- 241001496113 Santalum Species 0.000 description 1
- 108020004459 Small interfering RNA Proteins 0.000 description 1
- 235000004338 Syringa vulgaris Nutrition 0.000 description 1
- 244000297179 Syringa vulgaris Species 0.000 description 1
- 229920004890 Triton X-100 Polymers 0.000 description 1
- 239000013504 Triton X-100 Substances 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 238000012197 amplification kit Methods 0.000 description 1
- 230000003720 anagen prolongation Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000003542 behavioural effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 230000012292 cell migration Effects 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 230000035605 chemotaxis Effects 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 239000010634 clove oil Substances 0.000 description 1
- 239000003240 coconut oil Substances 0.000 description 1
- 235000019864 coconut oil Nutrition 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 229940125898 compound 5 Drugs 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 125000004145 cyclopenten-1-yl group Chemical group [H]C1=C(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- 238000012350 deep sequencing Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 230000003828 downregulation Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000005014 ectopic expression Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000010642 eucalyptus oil Substances 0.000 description 1
- 229940044949 eucalyptus oil Drugs 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 230000037308 hair color Effects 0.000 description 1
- 239000000118 hair dye Substances 0.000 description 1
- 210000004919 hair shaft Anatomy 0.000 description 1
- 239000008266 hair spray Substances 0.000 description 1
- 210000005260 human cell Anatomy 0.000 description 1
- 229960000890 hydrocortisone Drugs 0.000 description 1
- 238000002991 immunohistochemical analysis Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 229940097275 indigo Drugs 0.000 description 1
- COHYTHOBJLSHDF-UHFFFAOYSA-N indigo powder Natural products N1C2=CC=CC=C2C(=O)C1=C1C(=O)C2=CC=CC=C2N1 COHYTHOBJLSHDF-UHFFFAOYSA-N 0.000 description 1
- 239000000411 inducer Substances 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 238000000021 kinase assay Methods 0.000 description 1
- 239000000171 lavandula angustifolia l. flower oil Substances 0.000 description 1
- 229940010454 licorice Drugs 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- 210000002850 nasal mucosa Anatomy 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 210000001331 nose Anatomy 0.000 description 1
- 235000019645 odor Nutrition 0.000 description 1
- 238000001543 one-way ANOVA Methods 0.000 description 1
- 229920002866 paraformaldehyde Polymers 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000011533 pre-incubation Methods 0.000 description 1
- 230000003658 preventing hair loss Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 210000000064 prostate epithelial cell Anatomy 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 235000002020 sage Nutrition 0.000 description 1
- 125000004084 sesquiterpene group Chemical group 0.000 description 1
- 230000019491 signal transduction Effects 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 238000001256 steam distillation Methods 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 230000002381 testicular Effects 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 238000013042 tunel staining Methods 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 210000002268 wool Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/02—Preparations for cleaning the hair
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Emergency Medicine (AREA)
- Birds (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITUA2016A003604A ITUA20163604A1 (it) | 2016-05-19 | 2016-05-19 | Composti atti a promuovere la crescita dei capelli nell'uomo e/o a fermarne o ritardarne la caduta, e composizioni per tali usi |
| PCT/EP2017/062110 WO2017198818A1 (en) | 2016-05-19 | 2017-05-19 | Compounds for promoting hair growth and/or inhibiting or delaying hair loss in humans, and compositions for such uses |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2851899T3 true ES2851899T3 (es) | 2021-09-09 |
Family
ID=56990747
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES17730678T Active ES2851899T3 (es) | 2016-05-19 | 2017-05-19 | Compuestos para promover el crecimiento del cabello y/o para inhibir o retrasar la caída del cabello en humanos, y composiciones para dichos usos |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US10898419B2 (OSRAM) |
| EP (1) | EP3458020B1 (OSRAM) |
| JP (1) | JP7034944B2 (OSRAM) |
| KR (1) | KR102452350B1 (OSRAM) |
| CN (1) | CN109310597B (OSRAM) |
| AU (1) | AU2017267278B2 (OSRAM) |
| BR (1) | BR112018073626B1 (OSRAM) |
| CA (1) | CA3024001C (OSRAM) |
| CY (1) | CY1123780T1 (OSRAM) |
| DK (1) | DK3458020T3 (OSRAM) |
| ES (1) | ES2851899T3 (OSRAM) |
| HR (1) | HRP20210223T1 (OSRAM) |
| HU (1) | HUE053265T2 (OSRAM) |
| IT (1) | ITUA20163604A1 (OSRAM) |
| LT (1) | LT3458020T (OSRAM) |
| MA (1) | MA45043B1 (OSRAM) |
| MD (1) | MD3458020T2 (OSRAM) |
| MX (1) | MX379050B (OSRAM) |
| PL (1) | PL3458020T3 (OSRAM) |
| PT (1) | PT3458020T (OSRAM) |
| RS (1) | RS61407B1 (OSRAM) |
| RU (1) | RU2741021C2 (OSRAM) |
| SG (2) | SG11201810318RA (OSRAM) |
| SI (1) | SI3458020T1 (OSRAM) |
| SM (1) | SMT202100139T1 (OSRAM) |
| UA (1) | UA124236C2 (OSRAM) |
| WO (1) | WO2017198818A1 (OSRAM) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT201800005585A1 (it) * | 2018-05-22 | 2019-11-22 | Composti per prevenire e trattare affezioni della pelle o della mucosa con componente infiammatoria | |
| CA3114373A1 (en) * | 2018-09-29 | 2020-04-02 | Robert J. Petcavich | Natural product composition for stimulating hair growth |
| FR3110425B1 (fr) * | 2020-05-19 | 2022-09-09 | Isp Investments Llc | Procede d’obtention d’un extrait de bois de santal, compositions le comprenant et ses utilisations cosmetiques |
| EP4251274A1 (en) | 2020-11-30 | 2023-10-04 | Wella Germany GmbH | Anti-hair-loss composition |
| US11999691B2 (en) | 2020-12-19 | 2024-06-04 | Actera Ingredients, Inc. | Odorless active agents |
| JP7642955B2 (ja) * | 2021-02-04 | 2025-03-11 | 株式会社ファンケル | 嗅覚受容体発現促進用組成物 |
| JPWO2022202714A1 (OSRAM) | 2021-03-22 | 2022-09-29 | ||
| EP4408540A4 (en) * | 2021-10-01 | 2025-09-24 | Coty Inc | COMPOSITIONS COMPRISING OR2AT4 AGONISTS |
| IT202200010358A1 (it) * | 2022-05-18 | 2023-11-18 | Giuliani Spa | Agonista del recettore olfattivo 2a4/7 per promuovere la crescita di capelli e migliorare l’aspetto estetico / olfactory receptor 2a4/7 agonist for promoting hair growth and improving aesthetic aspect |
| EP4531801A1 (en) | 2022-05-25 | 2025-04-09 | Wella Germany GmbH | Improving hair structure |
| EP4545063A1 (en) * | 2023-10-23 | 2025-04-30 | Wella Germany GmbH | Cosmetical use of a topically applicable rinse-of composition (rc) |
| EP4620463A1 (en) * | 2024-03-22 | 2025-09-24 | CUTANEON - Skin & Hair Innovations GmbH | Active agent for use in hair growth regulation |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4052341A (en) | 1976-04-29 | 1977-10-04 | Givaudan Corporation | 3-methyl-5-(2,2,3-trimethylcyclopent-3-en-1-yl)pentan-2-ol compound and perfume compositions |
| CN1075250A (zh) | 1992-10-27 | 1993-08-18 | 海南南洋实业有限公司 | 香波的生产方法 |
| JP4020284B2 (ja) | 1999-05-27 | 2007-12-12 | 株式会社マンダム | 育毛剤原料及び育毛剤組成物 |
| JP2001151644A (ja) | 1999-11-29 | 2001-06-05 | Kao Corp | 頭皮臭用香料組成物 |
| JP3877537B2 (ja) | 2001-03-07 | 2007-02-07 | 高砂香料工業株式会社 | 口腔用組成物用抗菌剤およびそれを含む口腔用組成物 |
| JP2003277246A (ja) * | 2002-03-22 | 2003-10-02 | Takasago Internatl Corp | 消臭剤組成物 |
| JP3947149B2 (ja) | 2002-10-28 | 2007-07-18 | 高砂香料工業株式会社 | 消臭剤組成物 |
| JP2006160698A (ja) * | 2004-12-10 | 2006-06-22 | Noevir Co Ltd | Vegf産生促進剤、育毛剤、及び創傷治癒剤 |
| US7879910B1 (en) * | 2006-10-10 | 2011-02-01 | Jan Marini Skin Research, Inc. | Compositions and methods for promoting lush hair growth |
| KR101199672B1 (ko) | 2008-02-01 | 2012-11-09 | 마리 케이 인코포레이티드 | 방향성 피부활성 성분을 사용하여 피부를 치료하는 방법 |
| CN102000293A (zh) | 2010-12-05 | 2011-04-06 | 孟凡伟 | 一种中药养发配方 |
| US9585826B2 (en) | 2012-11-07 | 2017-03-07 | Kimberly-Clark Worldwide, Inc. | Triggerable compositions for two-stage, controlled release of active chemistry |
| CN103735443A (zh) | 2013-12-10 | 2014-04-23 | 河南孟诜堂药业有限公司 | 一种止脱柔顺洗发液及其制备方法 |
| EP2957283B1 (de) * | 2014-06-19 | 2022-12-21 | Symrise AG | Verfahren zur Identifizierung von Medikamenten zur Beschleunigung der Wundheilung |
-
2016
- 2016-05-19 IT ITUA2016A003604A patent/ITUA20163604A1/it unknown
-
2017
- 2017-05-19 CA CA3024001A patent/CA3024001C/en active Active
- 2017-05-19 BR BR112018073626-0A patent/BR112018073626B1/pt active IP Right Grant
- 2017-05-19 EP EP17730678.4A patent/EP3458020B1/en active Active
- 2017-05-19 MD MDE20190369T patent/MD3458020T2/ro unknown
- 2017-05-19 PT PT177306784T patent/PT3458020T/pt unknown
- 2017-05-19 SI SI201730632T patent/SI3458020T1/sl unknown
- 2017-05-19 MA MA45043A patent/MA45043B1/fr unknown
- 2017-05-19 WO PCT/EP2017/062110 patent/WO2017198818A1/en not_active Ceased
- 2017-05-19 RU RU2018144755A patent/RU2741021C2/ru active
- 2017-05-19 US US16/302,472 patent/US10898419B2/en active Active
- 2017-05-19 SG SG11201810318RA patent/SG11201810318RA/en unknown
- 2017-05-19 KR KR1020187035315A patent/KR102452350B1/ko active Active
- 2017-05-19 RS RS20210106A patent/RS61407B1/sr unknown
- 2017-05-19 DK DK17730678.4T patent/DK3458020T3/da active
- 2017-05-19 LT LTEP17730678.4T patent/LT3458020T/lt unknown
- 2017-05-19 SG SG10202011357RA patent/SG10202011357RA/en unknown
- 2017-05-19 SM SM20210139T patent/SMT202100139T1/it unknown
- 2017-05-19 JP JP2018559992A patent/JP7034944B2/ja active Active
- 2017-05-19 UA UAA201811736A patent/UA124236C2/uk unknown
- 2017-05-19 HU HUE17730678A patent/HUE053265T2/hu unknown
- 2017-05-19 AU AU2017267278A patent/AU2017267278B2/en active Active
- 2017-05-19 HR HRP20210223TT patent/HRP20210223T1/hr unknown
- 2017-05-19 PL PL17730678T patent/PL3458020T3/pl unknown
- 2017-05-19 CN CN201780030965.7A patent/CN109310597B/zh active Active
- 2017-05-19 ES ES17730678T patent/ES2851899T3/es active Active
- 2017-05-19 MX MX2018013763A patent/MX379050B/es unknown
-
2021
- 2021-02-05 CY CY20211100098T patent/CY1123780T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2851899T3 (es) | Compuestos para promover el crecimiento del cabello y/o para inhibir o retrasar la caída del cabello en humanos, y composiciones para dichos usos | |
| Wang et al. | Transforming growth-beta 1 contributes to isoflurane postconditioning against cerebral ischemia–reperfusion injury by regulating the c-Jun N-terminal kinase signaling pathway | |
| JP6193968B2 (ja) | 発毛を調節するための組成物および方法 | |
| Vidali et al. | Thyroid hormones enhance mitochondrial function in human epidermis | |
| US20220323532A1 (en) | Compositions comprising plant-derived exosome-like nanovesicles or exosomes and methods of use thereof | |
| Zhou et al. | Largazole, an inhibitor of class I histone deacetylases, attenuates inflammatory corneal neovascularization | |
| Andrade et al. | An update on nanocarriers for follicular-targeted drug delivery for androgenetic alopecia topical treatment | |
| ES2608558T3 (es) | Uso de extractos de Salvia haenkei en composiciones contra la senescencia | |
| WO2002022088A1 (en) | Hair nourishments and method of screening the same | |
| ES2765486T3 (es) | Composición para prevenir la pérdida de cabello o promover el crecimiento de cabello, que contiene derivado de ácido oleanólico y sal farmacéuticamente aceptable del mismo | |
| Schaper-Gerhardt et al. | The mTOR-inhibitor Sirolimus decreases the cyclosporine-induced expression of the oncogene ATF3 in human keratinocytes | |
| JPS63203625A (ja) | 5α−リダクタ−ゼ阻害剤 | |
| KR102890438B1 (ko) | 탈모 증상 완화능을 갖는 두피 유래 펩타이드 | |
| CN1946372B (zh) | 使用热休克蛋白抑制剂制备减少毛发生长的制剂的用途 | |
| JP6368219B2 (ja) | エストロゲン受容体β活性化剤 | |
| Wang et al. | Natural phenylethanoid glycoside forsythoside A alleviates androgenetic alopecia by selectively inhibiting TRPV3 channels in mice | |
| WO2021147740A1 (zh) | Mapk/erk通路抑制剂在拮抗皮肤老化与辐射性皮肤早衰中的应用 | |
| US11680264B2 (en) | Methods of modulating melanosome pH and melanin level in cells | |
| HK40006226A (en) | Compounds for promoting hair growth and/or inhibiting or delaying hair loss in humans, and compositions for such uses | |
| HK40006226B (en) | Compounds for promoting hair growth and/or inhibiting or delaying hair loss in humans, and compositions for such uses | |
| WO2023056029A1 (en) | Beta3-adrenergic agonists for treatment of disorders of hair growth | |
| JP2010159252A (ja) | メラノソーム輸送抑制剤及びその方法 | |
| Quan et al. | Dehydroepiandrosterone Suppresses Keloid Fibroblasts Fibrosis by Inhibiting the TGF-β1/Smad Signaling Pathway | |
| Dong et al. | Rejuvenating senescent hair follicles: a novel conjugated linoleic acid based nanovesicle approach to treat androgenic alopecia | |
| KR20140131193A (ko) | 태반성장인자를 표적으로 하는 모발 성장 조절 방법 및 조성물 |