IT202200010358A1 - Agonista del recettore olfattivo 2a4/7 per promuovere la crescita di capelli e migliorare l’aspetto estetico / olfactory receptor 2a4/7 agonist for promoting hair growth and improving aesthetic aspect - Google Patents

Agonista del recettore olfattivo 2a4/7 per promuovere la crescita di capelli e migliorare l’aspetto estetico / olfactory receptor 2a4/7 agonist for promoting hair growth and improving aesthetic aspect Download PDF

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Publication number
IT202200010358A1
IT202200010358A1 IT102022000010358A IT202200010358A IT202200010358A1 IT 202200010358 A1 IT202200010358 A1 IT 202200010358A1 IT 102022000010358 A IT102022000010358 A IT 102022000010358A IT 202200010358 A IT202200010358 A IT 202200010358A IT 202200010358 A1 IT202200010358 A1 IT 202200010358A1
Authority
IT
Italy
Prior art keywords
agonist
hair growth
olfactory receptor
promoting hair
aesthetic aspect
Prior art date
Application number
IT102022000010358A
Other languages
English (en)
Original Assignee
Giuliani Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Giuliani Spa filed Critical Giuliani Spa
Priority to IT102022000010358A priority Critical patent/IT202200010358A1/it
Priority to PCT/EP2023/063421 priority patent/WO2023222847A1/en
Publication of IT202200010358A1 publication Critical patent/IT202200010358A1/it

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/002—Preparations for repairing the hair, e.g. hair cure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients
    • A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
    • A61K2800/782—Enzyme inhibitors; Enzyme antagonists

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Cosmetics (AREA)
IT102022000010358A 2022-05-18 2022-05-18 Agonista del recettore olfattivo 2a4/7 per promuovere la crescita di capelli e migliorare l’aspetto estetico / olfactory receptor 2a4/7 agonist for promoting hair growth and improving aesthetic aspect IT202200010358A1 (it)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IT102022000010358A IT202200010358A1 (it) 2022-05-18 2022-05-18 Agonista del recettore olfattivo 2a4/7 per promuovere la crescita di capelli e migliorare l’aspetto estetico / olfactory receptor 2a4/7 agonist for promoting hair growth and improving aesthetic aspect
PCT/EP2023/063421 WO2023222847A1 (en) 2022-05-18 2023-05-18 Olfactory receptor 2a4/7 agonist for promoting hair growth and improving aesthetic aspect

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT102022000010358A IT202200010358A1 (it) 2022-05-18 2022-05-18 Agonista del recettore olfattivo 2a4/7 per promuovere la crescita di capelli e migliorare l’aspetto estetico / olfactory receptor 2a4/7 agonist for promoting hair growth and improving aesthetic aspect

Publications (1)

Publication Number Publication Date
IT202200010358A1 true IT202200010358A1 (it) 2023-11-18

Family

ID=82482571

Family Applications (1)

Application Number Title Priority Date Filing Date
IT102022000010358A IT202200010358A1 (it) 2022-05-18 2022-05-18 Agonista del recettore olfattivo 2a4/7 per promuovere la crescita di capelli e migliorare l’aspetto estetico / olfactory receptor 2a4/7 agonist for promoting hair growth and improving aesthetic aspect

Country Status (2)

Country Link
IT (1) IT202200010358A1 (it)
WO (1) WO2023222847A1 (it)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2033623A1 (en) * 2007-09-07 2009-03-11 Cutech S.R.L. Compositions comprising ornithine ketoglutarate (OKG)
WO2017198818A1 (en) * 2016-05-19 2017-11-23 Giuliani S.P.A. Compounds for promoting hair growth and/or inhibiting or delaying hair loss in humans, and compositions for such uses

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2033623A1 (en) * 2007-09-07 2009-03-11 Cutech S.R.L. Compositions comprising ornithine ketoglutarate (OKG)
WO2017198818A1 (en) * 2016-05-19 2017-11-23 Giuliani S.P.A. Compounds for promoting hair growth and/or inhibiting or delaying hair loss in humans, and compositions for such uses

Non-Patent Citations (17)

* Cited by examiner, † Cited by third party
Title
AHN SY ET AL.: "Effect of IGF-I on hair growth is related to the anti-apoptotic effect of IGF-I and up-regulation of PDGF-A and PDGF-B", ANN. DERMATOL., vol. 24, 2012, pages 26 - 31
CAS , no. 25485-88-5
CHÉRET JÉRÉMY ET AL: "Olfactory receptor OR2AT4 regulates human hair growth", NATURE COMMUNICATIONS, vol. 9, no. 1, 1 December 2018 (2018-12-01), XP055922250, Retrieved from the Internet <URL:https://www.nature.com/articles/s41467-018-05973-0.pdf> DOI: 10.1038/s41467-018-05973-0 *
EDELKAMP J ET AL: "Treatment with cyclohexyl salicylate, an olfactory receptor 2A4/7 agonist, promotes human hair follicle growth and bulge stem cell progeny expansion", 51ST ANNUAL ESDR MEETING, 28 September 2022 (2022-09-28), XP093009802 *
EDELKAMP JGHERARDINI JBERTOLINI M: "Methods to study human hair follicle growth ex vivo: human microdissected hair follicle and human full thickness skin organ culture", METHODS MOL. BIOL., vol. 2154, 2020, pages 105 - 119
FISCHER TW ET AL.: "Differential effects of caffeine on hair shaft elongation, matrix and outer root sheath keratinocyte proliferation, and transforming growth factor-¡32/insulin-like growth factor-1 -mediated regulation of the hair cycle in male and female human hair follicles in vitro", BR. J. DERMATOL, vol. 171, 2014, pages 1031 - 1043
FISCHER TW ET AL.: "Differential effects of caffeine on hair shaft elongation, matrix and outer root sheath keratinocyte proliferation, and transforming growth factor-¡32/insulin-like growth factor-1-mediated regulation of the hair cycle in male and female human hair follicles in vitro", BR. J. DERMATOL., vol. 171, 2014, pages 1031 - 1043
FISCHER TW ET AL.: "Differential effects of caffeine on hair shaft elongation, matrix and outer root sheath keratinocyte proliferation, and transforming growth factor-p2/insulin-like growth factor-1-mediated regulation of the hair cycle in male and female human hair follicles in vitro", BR. J. DERMATOL., vol. 171, 2014, pages 1031 - 1043
HASLAM, I.S.HARDMAN, J.A.PAUS, R.: "Topically applied nicotinamide inhibits human hair follicle growth ex vivo", J. INVEST. DERMATOL., vol. 138, 2018, pages 1420 - 1422
KLOEPPER JE ET AL.: "Methods in hair research: how to objectively distinguish between anagen and catagen in human hair follicle organ culture", EXP. DERMATOL, vol. 19, 2010, pages 305 - 312
KLOEPPER JE ET AL.: "Methods in hair research: how to objectively distinguish between anagen and catagen in human hair follicle organ culture", EXP. DERMATOL., vol. 19, 2010, pages 305 - 312
LANGAN EA ET AL.: "Human hair follicle organ culture: theory, application and perpsectives", EXP. DERMATOL., vol. 24, 2015, pages 903 - 911
LEE SUNG-JOON ET AL: "Therapeutic potential of ectopic olfactory and taste receptors", NATURE REVIEWS DRUG DISCOVERY, NATURE PUBLISHING GROUP, GB, vol. 18, no. 2, 30 November 2018 (2018-11-30), pages 116 - 138, XP036688583, ISSN: 1474-1776, [retrieved on 20181130], DOI: 10.1038/S41573-018-0002-3 *
PURBA TS ET AL.: "A primer for studying cell cycle dynamics of the human hair follicle", EXP. DERMATOL., vol. 25, 2016, pages 663 - 668
SAMUELOV L ET AL.: "P-cadherin regulates human hair growth and cycling via canonical Wnt signaling and transforming growth factor-p2", J. INVEST. DERMATOL., vol. 132, 2012, pages 2332 - 2341
SAMUELOV L ET AL.: "P-cadherin regulates human hair growth and cycling via canonical Wnt signaling and transforming growth factory", J. INVEST. DERMATOL., vol. 132, 2012, pages 2332 - 2341
TSAI ET AL., EXP DERMATOL, 2017

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WO2023222847A1 (en) 2023-11-23

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