RU2739037C3 - Композиция для контролируемой стимуляции яичников - Google Patents
Композиция для контролируемой стимуляции яичниковInfo
- Publication number
- RU2739037C3 RU2739037C3 RU2017106756A RU2017106756A RU2739037C3 RU 2739037 C3 RU2739037 C3 RU 2739037C3 RU 2017106756 A RU2017106756 A RU 2017106756A RU 2017106756 A RU2017106756 A RU 2017106756A RU 2739037 C3 RU2739037 C3 RU 2739037C3
- Authority
- RU
- Russia
- Prior art keywords
- sialylation
- fsh
- pharmaceutical composition
- patient
- total
- Prior art date
Links
- 230000002611 ovarian Effects 0.000 title 1
- 230000000638 stimulation Effects 0.000 title 1
- 102000012673 Follicle Stimulating Hormone Human genes 0.000 claims 13
- 108010079345 Follicle Stimulating Hormone Proteins 0.000 claims 13
- 229940028334 follicle stimulating hormone Drugs 0.000 claims 13
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- 230000009450 sialylation Effects 0.000 claims 6
- 206010033266 Ovarian Hyperstimulation Syndrome Diseases 0.000 claims 4
- 208000000509 infertility Diseases 0.000 claims 4
- 230000036512 infertility Effects 0.000 claims 4
- 231100000535 infertility Toxicity 0.000 claims 4
- 210000002966 serum Anatomy 0.000 claims 4
- 230000037396 body weight Effects 0.000 claims 3
- 229940088597 hormone Drugs 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Reproductive Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Diabetes (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Claims (4)
1. Применение фармацевтической композиции, содержащей фолликулостимулирующий гормон (ФСГ), для лечения бесплодия у пациентки, имеющей сывороточный уровень антимюллеровского гормона (АМГ) не менее 35 пмоль/л, где фармацевтическая композиция предназначена для введения в дозе, равной от 0,10 до 0,11 мкг рекомбинантного ФСГ на кг массы тела пациента в сутки, и где указанный ФСГ включает а2,3- и а2,6-сиалирование, где от 11,5% до 15,76% общего сиалирования представляет собой а2,6-сиалирование и от 84,24 до 88,5% общего сиалирования представляет собой а2,3-сиалирование.
2. Применение фармацевтической композиции, содержащей ФСГ, для лечения бесплодия у пациентки, имеющей риск синдрома гиперстимуляции яичников (СГСЯ), имеющей сывороточный уровень АМГ не менее 35 пмоль/л, где фармацевтическая композиция предназначена для введения в дозе, равной от 0,10 до 0,11 мкг рекомбинантного ФСГ на кг массы тела пациента в сутки, и где указанный ФСГ включает а2,3- и а2,6-сиалирование, где от 11,5% до 15,76% общего сиалирования представляет собой а2,6-сиалирование и от 84,24 до 88,5% общего сиалирования представляет собой а2,3-сиалирование.
3. Применение фармацевтической композиции, содержащей ФСГ, для лечения бесплодия у пациентки, имеющей риск синдрома гиперстимуляции яичников (СГСЯ) и имеющей сывороточный уровень АМГ не менее 15 пмоль/л, где фармацевтическая композиция предназначена для введения в дозе, равной от 0,10 до 0,19 мкг рекомбинантного ФСГ на кг массы тела пациента в сутки, и где указанный ФСГ включает а2,3- и а2,6-сиалирование, где от 11,5% до 15,76% общего сиалирования представляет собой а2,6-сиалирование и от 84,24 до 88,5% общего сиалирования представляет собой а2,3-сиалирование.
4. Применение фармацевтической композиции, содержащей рекомбинантный фолликулостимулирующий гормон (ФСГ), для лечения бесплодия у пациентки, имеющей сывороточный уровень АМГ 0,05 пмоль/л или выше, где фармацевтическая композиция содержит дозу, равную 12 мкг рекомбинантного ФСГ.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11176803 | 2011-08-08 | ||
| EP11176803.2 | 2011-08-08 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2014102924A Division RU2613324C3 (ru) | 2011-08-08 | 2012-08-08 | Композиция для контролируемой стимуляции яичников |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2020137769A Division RU2020137769A (ru) | 2020-11-18 | Композиция для контролируемой стимуляции яичников |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| RU2017106756A RU2017106756A (ru) | 2019-01-23 |
| RU2017106756A3 RU2017106756A3 (ru) | 2020-07-09 |
| RU2739037C2 RU2739037C2 (ru) | 2020-12-21 |
| RU2739037C3 true RU2739037C3 (ru) | 2021-09-08 |
Family
ID=46785372
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2014102924A RU2613324C3 (ru) | 2011-08-08 | 2012-08-08 | Композиция для контролируемой стимуляции яичников |
| RU2017106756A RU2739037C3 (ru) | 2011-08-08 | 2012-08-08 | Композиция для контролируемой стимуляции яичников |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2014102924A RU2613324C3 (ru) | 2011-08-08 | 2012-08-08 | Композиция для контролируемой стимуляции яичников |
Country Status (31)
| Country | Link |
|---|---|
| US (4) | US9694052B2 (ru) |
| EP (9) | EP2821080B1 (ru) |
| JP (5) | JP6161609B2 (ru) |
| KR (7) | KR20190140098A (ru) |
| CN (2) | CN103732243A (ru) |
| AR (1) | AR087476A1 (ru) |
| AU (3) | AU2012293647B2 (ru) |
| BR (2) | BR112014002884A2 (ru) |
| CA (1) | CA2844282A1 (ru) |
| CY (1) | CY1117214T1 (ru) |
| DK (8) | DK3756681T5 (ru) |
| ES (8) | ES2871405T3 (ru) |
| FI (2) | FI3756681T3 (ru) |
| HK (2) | HK1204923A1 (ru) |
| HR (8) | HRP20230607T1 (ru) |
| HU (8) | HUE053716T2 (ru) |
| IL (2) | IL300380A (ru) |
| JO (1) | JO3092B1 (ru) |
| LT (7) | LT3195875T (ru) |
| MX (4) | MX348981B (ru) |
| PL (8) | PL3195875T3 (ru) |
| PT (6) | PT3195875T (ru) |
| RS (8) | RS54561B1 (ru) |
| RU (2) | RU2613324C3 (ru) |
| SA (1) | SA112330762B1 (ru) |
| SI (8) | SI4005588T1 (ru) |
| SM (1) | SMT201600038B (ru) |
| TR (2) | TR201900071T4 (ru) |
| TW (2) | TWI555530B (ru) |
| WO (1) | WO2013020996A1 (ru) |
| ZA (2) | ZA201400952B (ru) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI488640B (zh) | 2008-04-16 | 2015-06-21 | Ferring Int Ct Sa | 藥學製劑 |
| TWI604850B (zh) * | 2009-10-05 | 2017-11-11 | 菲瑞茵國際中心股份有限公司 | 藥學製劑 |
| JO3092B1 (ar) | 2011-08-08 | 2017-03-15 | Ferring Bv | مركب لتحفيز مسيطر عليه للمبيض |
| EP3237608B1 (en) * | 2014-12-22 | 2019-10-09 | F. Hoffmann-La Roche AG | Cmp-dependent sialidase activity |
| EP3662925B1 (en) * | 2015-04-17 | 2021-04-07 | Ferring B.V. | Composition comprising fsh for treatment of infertility |
| CN107709350A (zh) | 2015-06-26 | 2018-02-16 | 辉凌公司 | 纯化和/或病毒灭活的方法 |
| KR20180052128A (ko) * | 2015-09-17 | 2018-05-17 | 글리코토페 게엠베하 | 증가된 안정성을 갖는 포유동물 난포-자극 호르몬 조성물 |
| TWI778979B (zh) * | 2016-09-30 | 2022-10-01 | 瑞士商麥歐文科學有限公司 | 治療女性不孕症之方法 |
| CN111050787A (zh) | 2017-09-01 | 2020-04-21 | 辉凌公司 | 用于受控的卵巢刺激的组合物 |
| CN112088011A (zh) | 2018-04-30 | 2020-12-15 | 辉凌公司 | 用于受控的卵巢刺激的组合物 |
| TWI846743B (zh) * | 2018-10-17 | 2024-07-01 | 荷蘭商菲林公司 | 用於控制性卵巢刺激之組成物及方法 |
| US11576920B2 (en) | 2019-03-18 | 2023-02-14 | The Menopause Method, Inc. | Composition and method to aid in hormone replacement therapy |
| CN110841060A (zh) * | 2019-11-21 | 2020-02-28 | 上海交通大学 | Choriogonadotropin alfa在治疗多囊卵巢综合征中的应用 |
| TW202237173A (zh) | 2020-12-09 | 2022-10-01 | 荷蘭商菲林公司 | 用於受控的卵巢刺激之組成物及方法 |
| AU2022451605A1 (en) | 2022-04-01 | 2024-09-26 | Ferring B.V. | Mixed protocol for treatment of infertility |
| WO2023227761A1 (en) | 2022-05-26 | 2023-11-30 | Ferring B.V. | Compositions and methods for treatment of infertility in males |
| WO2024008971A1 (en) | 2022-07-08 | 2024-01-11 | Ferring B.V. | Compositions and methods for intrauterine insemination (iui) |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW518235B (en) | 1997-01-15 | 2003-01-21 | Akzo Nobel Nv | A gonadotropin-containing pharmaceutical composition with improved stability on prolong storage |
| EP1074265A1 (en) * | 1999-08-03 | 2001-02-07 | Erasmus Universiteit Rotterdam | Use of AMH and/or AMH agonists and/or AMH antagonists for long-term control of female fertility |
| DK1438336T3 (da) * | 2001-10-22 | 2006-10-02 | Applied Research Systems | Gonadotropiner til follikeldannelse |
| US20040248784A1 (en) * | 2003-06-03 | 2004-12-09 | Marco Filicori | Unitary combinations of FSH and hCG |
| US8501719B2 (en) * | 2005-11-08 | 2013-08-06 | American Infertility Of New York | Androgen treatment in females |
| TWI488640B (zh) | 2008-04-16 | 2015-06-21 | Ferring Int Ct Sa | 藥學製劑 |
| TWI604850B (zh) * | 2009-10-05 | 2017-11-11 | 菲瑞茵國際中心股份有限公司 | 藥學製劑 |
| EP2417982A1 (en) | 2010-07-30 | 2012-02-15 | Ferring B.V. | Stabilization of gonadotropins |
| WO2012016576A1 (en) | 2010-08-04 | 2012-02-09 | Glycotope Gmbh | Improved recombinant human follicle-stimulating hormone |
| PL2621517T5 (pl) * | 2010-09-29 | 2024-01-29 | Ferring B.V. | Kompozycja do stosowania w leczeniu niepłodności |
| JO3092B1 (ar) | 2011-08-08 | 2017-03-15 | Ferring Bv | مركب لتحفيز مسيطر عليه للمبيض |
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2012
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