RU2727520C2 - Противогрибковые агенты - Google Patents
Противогрибковые агенты Download PDFInfo
- Publication number
- RU2727520C2 RU2727520C2 RU2017121370A RU2017121370A RU2727520C2 RU 2727520 C2 RU2727520 C2 RU 2727520C2 RU 2017121370 A RU2017121370 A RU 2017121370A RU 2017121370 A RU2017121370 A RU 2017121370A RU 2727520 C2 RU2727520 C2 RU 2727520C2
- Authority
- RU
- Russia
- Prior art keywords
- phenyl
- compound
- dimethyl
- pyrrol
- piperazin
- Prior art date
Links
- 229940121375 antifungal agent Drugs 0.000 title description 59
- 239000003429 antifungal agent Substances 0.000 title description 59
- 150000001875 compounds Chemical class 0.000 claims abstract description 167
- 150000003839 salts Chemical class 0.000 claims abstract description 98
- SUFPWYYDCOKDLL-UHFFFAOYSA-N 2-(1,5-dimethyl-3-phenylpyrrol-2-yl)-N-[4-[4-(5-fluoropyrimidin-2-yl)piperazin-1-yl]phenyl]-2-oxoacetamide Chemical compound CN1C(=C(C=C1C)C1=CC=CC=C1)C(C(=O)NC1=CC=C(C=C1)N1CCN(CC1)C1=NC=C(C=N1)F)=O SUFPWYYDCOKDLL-UHFFFAOYSA-N 0.000 claims abstract description 67
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- 238000000034 method Methods 0.000 claims abstract description 22
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- 238000001990 intravenous administration Methods 0.000 claims description 4
- 230000000694 effects Effects 0.000 abstract description 7
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- NOGCYMWWKOZATO-UHFFFAOYSA-N 2-(1,5-dimethyl-3-phenylpyrrol-2-yl)-N-[4-[4-(5-fluoropyrimidin-2-yl)piperazin-1-yl]-3-hydroxyphenyl]-2-oxoacetamide Chemical compound CN1C(=C(C=C1C)C1=CC=CC=C1)C(C(=O)NC1=CC(=C(C=C1)N1CCN(CC1)C1=NC=C(C=N1)F)O)=O NOGCYMWWKOZATO-UHFFFAOYSA-N 0.000 description 44
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- BCEHBSKCWLPMDN-MGPLVRAMSA-N voriconazole Chemical compound C1([C@H](C)[C@](O)(CN2N=CN=C2)C=2C(=CC(F)=CC=2)F)=NC=NC=C1F BCEHBSKCWLPMDN-MGPLVRAMSA-N 0.000 description 10
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Classifications
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- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A01G7/00—Botany in general
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- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
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- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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| GBGB1505891.0A GB201505891D0 (en) | 2015-04-07 | 2015-04-07 | Antifungal agents |
| GB1505891.0 | 2015-04-07 | ||
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| RU2810715C1 (ru) * | 2023-04-27 | 2023-12-28 | Федеральное государственное автономное образовательное учреждение высшего образования "Пермский государственный национальный исследовательский университет" | ПРИМЕНЕНИЕ 5-(4-МЕТОКСИФЕНИЛ)-7-МЕТИЛ-1,2,4,5-ТЕТРАГИДРО-3H-ПИРРОЛО[1,2-a][1,4]ДИАЗЕПИН-3-ОНА В КАЧЕСТВЕ ПРОТИВОГРИБКОВОГО СРЕДСТВА В ОТНОШЕНИИ ДРОЖЖЕВЫХ ГРИБОВ |
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| US11039617B2 (en) | 2013-01-30 | 2021-06-22 | Agrofresh Inc. | Large scale methods of uniformly coating packaging surfaces with a volatile antimicrobial to preserve food freshness |
| US10070649B2 (en) | 2013-01-30 | 2018-09-11 | Agrofresh Inc. | Volatile applications against pathogens |
| LT3221308T (lt) | 2014-11-21 | 2018-12-27 | F2G Limited | Priešgrybeliniai agentai |
| US9973887B2 (en) * | 2016-01-21 | 2018-05-15 | Google Llc | Sharing navigation data among co-located computing devices |
| EP3426029B1 (en) | 2016-03-07 | 2023-08-30 | AgroFresh Inc. | Synergistic methods of using benzoxaborole compounds and preservative gases as an antimicrobial for crops |
| GB201609222D0 (en) | 2016-05-25 | 2016-07-06 | F2G Ltd | Pharmaceutical formulation |
| KR20240110109A (ko) * | 2017-04-10 | 2024-07-12 | 싸이넥시스, 인크. | 조합하여 사용되는 항진균제 |
| JP2021505660A (ja) | 2017-11-30 | 2021-02-18 | ボラゲン，インコーポレーテッド | ベンゾキサボロール化合物およびその配合物 |
| US11236115B2 (en) | 2018-08-18 | 2022-02-01 | 5Metis, Inc. | Solid forms of substituted benzoxaborole and compositions thereof |
| US11819503B2 (en) | 2019-04-23 | 2023-11-21 | F2G Ltd | Method of treating coccidioides infection |
| WO2021239992A1 (en) | 2020-05-29 | 2021-12-02 | Centre National De La Recherche Scientifique | Antifungal prodrugs |
| CN112358974B (zh) * | 2020-12-09 | 2022-06-10 | 昆明理工大学 | 一株植物内生真菌黑附球菌fzt214及其应用 |
| CN114644634B (zh) * | 2020-12-21 | 2023-06-20 | 深圳市祥根生物医药有限公司 | 一种吡咯衍生物及其制备方法和用途 |
| CN115109040A (zh) * | 2021-03-23 | 2022-09-27 | 博瑞生物医药（苏州）股份有限公司 | 抗真菌化合物，包含其的药物组合物和制剂，及其应用 |
| CN113429396A (zh) * | 2021-06-08 | 2021-09-24 | 深圳市祥根生物医药有限公司 | 一种五元杂芳环衍生物及其制备方法和用途 |
| WO2025031458A1 (zh) * | 2023-08-08 | 2025-02-13 | 上海森辉医药有限公司 | 一种4-苯基哌啶衍生物及其应用 |
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Cited By (1)
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| RU2810715C1 (ru) * | 2023-04-27 | 2023-12-28 | Федеральное государственное автономное образовательное учреждение высшего образования "Пермский государственный национальный исследовательский университет" | ПРИМЕНЕНИЕ 5-(4-МЕТОКСИФЕНИЛ)-7-МЕТИЛ-1,2,4,5-ТЕТРАГИДРО-3H-ПИРРОЛО[1,2-a][1,4]ДИАЗЕПИН-3-ОНА В КАЧЕСТВЕ ПРОТИВОГРИБКОВОГО СРЕДСТВА В ОТНОШЕНИИ ДРОЖЖЕВЫХ ГРИБОВ |
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