RU2710491C2 - Устройство для инъекции лекарственного средства в глазную ткань и способ инъекции лекарственного средства в глазную ткань - Google Patents
Устройство для инъекции лекарственного средства в глазную ткань и способ инъекции лекарственного средства в глазную ткань Download PDFInfo
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- RU2710491C2 RU2710491C2 RU2017101660A RU2017101660A RU2710491C2 RU 2710491 C2 RU2710491 C2 RU 2710491C2 RU 2017101660 A RU2017101660 A RU 2017101660A RU 2017101660 A RU2017101660 A RU 2017101660A RU 2710491 C2 RU2710491 C2 RU 2710491C2
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- distal end
- puncture element
- needle
- needle connector
- target tissue
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| US62/035,682 | 2014-08-11 | ||
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| US20070202186A1 (en) | 2006-02-22 | 2007-08-30 | Iscience Interventional Corporation | Apparatus and formulations for suprachoroidal drug delivery |
| US20120271272A1 (en) | 2010-10-15 | 2012-10-25 | Iscience Interventional Corporation | Device for ocular access |
| EP2916827B1 (en) | 2012-11-08 | 2020-06-10 | Clearside Biomedical Inc. | Methods for the treatment of ocular disease in human subjects |
| SG10201702674PA (en) | 2013-05-03 | 2017-06-29 | Clearside Biomedical Inc | Apparatus and methods for ocular injection |
| EP3003454B1 (en) | 2013-06-03 | 2020-01-08 | Clearside Biomedical, Inc. | Apparatus for drug delivery using multiple reservoirs |
| WO2015126694A1 (en) | 2014-02-12 | 2015-08-27 | Ethicon Endo-Surgery, Inc. | Method and apparatus for suprachoroidal administration of therapeutic agent |
| US9949874B2 (en) | 2014-06-06 | 2018-04-24 | Janssen Biotech, Inc. | Therapeutic agent delivery device with convergent lumen |
| US9925088B2 (en) | 2014-06-06 | 2018-03-27 | Janssen Biotech, Inc. | Sub-retinal tangential needle catheter guide and introducer |
| RU2710491C2 (ru) | 2014-06-20 | 2019-12-26 | Клиасайд Байомедикал, Инк. | Устройство для инъекции лекарственного средства в глазную ткань и способ инъекции лекарственного средства в глазную ткань |
| US10219936B2 (en) | 2014-09-11 | 2019-03-05 | Orbit Biomedical Limited | Therapeutic agent delivery device with advanceable cannula and needle |
| US10258502B2 (en) | 2014-09-18 | 2019-04-16 | Orbit Biomedical Limited | Therapeutic agent delivery device |
| US20180296816A1 (en) * | 2015-01-29 | 2018-10-18 | KIWI Platform Inc. Co., Ltd. | Transdermal microneedle unit and transdermal microneedle drug delivery device having the same |
| US10390707B2 (en) * | 2015-05-11 | 2019-08-27 | Samsung Electronics Co., Ltd | Needle for biosensor and bio sensor including the same |
| US10828830B2 (en) * | 2015-12-30 | 2020-11-10 | Revotek Co., Ltd | Bioprinter |
| WO2017120600A1 (en) * | 2016-01-08 | 2017-07-13 | Clearside Biomedical, Inc. | Compositions and methods of treating wet age-related macular degeneration |
| WO2017139375A1 (en) | 2016-02-10 | 2017-08-17 | Clearside Biomedical, Inc. | Ocular injection kit, packaging, and methods of use |
| US10478553B2 (en) | 2016-03-09 | 2019-11-19 | Orbit Biomedical Limited | Apparatus for subretinal administration of therapeutic agent via a curved needle |
| CA3062845A1 (en) | 2016-05-02 | 2017-11-09 | Clearside Biomedical, Inc. | Systems and methods for ocular drug delivery |
| US10806629B2 (en) | 2016-06-17 | 2020-10-20 | Gyroscope Therapeutics Limited | Injection device for subretinal delivery of therapeutic agent |
| US11000410B2 (en) | 2016-06-17 | 2021-05-11 | Gyroscope Therapeutics Limited | Guide apparatus for tangential entry into suprachoroidal space |
| US10646374B2 (en) | 2016-06-17 | 2020-05-12 | Orbit Biomedical Limited | Apparatus and method to form entry bleb for subretinal delivery of therapeutic agent |
| EP3487586A4 (en) * | 2016-07-20 | 2020-03-04 | Emory University | FORMULAS FOR THE SUPRACHOROIDAL SPACE OF AN EYE AND METHOD |
| WO2018015488A1 (en) | 2016-07-20 | 2018-01-25 | Ecole Polytechnique Federale De Lausanne (Epfl) | Device for controlled puncturing of an object |
| EP3496680B1 (en) | 2016-08-12 | 2024-10-02 | Clearside Biomedical, Inc. | Device for adjusting the insertion depth of a needle for medicament delivery |
| IL247684A0 (en) | 2016-09-07 | 2017-01-31 | Waismed Ltd | Tube for use in intraosseous injections |
| US11273072B2 (en) | 2017-01-13 | 2022-03-15 | Gyroscope Therapeutics Limited | Suprachoroidal injection device |
| KR20190122806A (ko) * | 2017-03-13 | 2019-10-30 | 장피트 | 조합 치료요법용 약학 조성물 |
| US11076984B2 (en) | 2017-03-13 | 2021-08-03 | Gyroscope Therapeutics Limited | Method of performing subretinal drainage and agent delivery |
| IL251684B (en) * | 2017-04-09 | 2019-01-31 | Tel Hashomer Medical Res Infrastructure & Services Ltd | Device and method for creating a channel in soft tissue |
| SG11201909566QA (en) * | 2017-04-14 | 2019-11-28 | Nal Pharmaceutical Group Ltd | Pre-filled syringe containing moxifloxacin |
| WO2018204515A1 (en) | 2017-05-02 | 2018-11-08 | Georgia Tech Research Corporation | Targeted drug delivery methods using a microneedle |
| AU2018284223A1 (en) * | 2017-06-13 | 2020-01-16 | Irenix Medical, Inc. | Active agent delivery devices and methods for using the same |
| GB2582521B (en) | 2017-11-14 | 2022-07-13 | Cook Biotech Inc | Preserved tissue products and related methods |
| GB2583231B (en) * | 2017-11-14 | 2023-07-19 | Cook Biotech Inc | Sterilized tissue products and related methods |
| US12485233B2 (en) * | 2018-04-19 | 2025-12-02 | Everads Therapy Ltd. | Device for injecting a substance into an interlayer of a body tissue or organ |
| US20210307963A1 (en) * | 2018-08-24 | 2021-10-07 | Irenix Medical, Inc. | Active Agent Delivery Devices and Methods for Using the Same |
| WO2020214799A1 (en) * | 2019-04-16 | 2020-10-22 | Clearside Biomedical, Inc. | Injectable triamcinolone formulations |
| CN109999279B (zh) * | 2019-05-05 | 2021-04-20 | 河南省中医院(河南中医药大学第二附属医院) | 一种麻醉科用进针装置 |
| CN118718181A (zh) | 2019-06-05 | 2024-10-01 | 里珍纳龙药品有限公司 | 用于精确剂量递送的装置及方法 |
| CN119279913A (zh) | 2019-06-14 | 2025-01-10 | 安特雷克公司 | 支架 |
| EP4031214B1 (en) | 2019-09-20 | 2026-02-18 | MeiraGTx Ocular UK Limited | Injection systems |
| US12453656B2 (en) | 2020-05-20 | 2025-10-28 | Iantrek, Inc. | System for shaping and implanting biologic intraocular stent for increased aqueous outflow and lowering of intraocular pressure |
| CA3183402A1 (en) | 2020-05-20 | 2021-11-25 | Iantrek, Inc. | System for shaping and implanting biologic intraocular stent for increased aqueous outflow and lowering of intraocular pressure |
| WO2021252962A1 (en) * | 2020-06-11 | 2021-12-16 | Aquavit Pharmaceuticals, Inc, | Methods and compositions for delivering bioactive compositions to ocular tissue using microneedle devices |
| US12440373B2 (en) * | 2020-06-11 | 2025-10-14 | AesculaTech, Inc. | Device for controlled injection across a variety of material properties |
| CA3188860A1 (en) * | 2020-08-12 | 2022-02-17 | Bryan Grygus | Systems and methods for drug delivery to ocular tissue |
| WO2022236778A1 (en) * | 2021-05-13 | 2022-11-17 | Beijing Sightnovo Medical Technology Co., Ltd | Medical penetration device and system |
| CN115337140B (zh) * | 2021-05-13 | 2025-01-10 | 中国医学科学院北京协和医院 | 眼部植入器具总成 |
| CN115337139B (zh) * | 2021-05-13 | 2025-02-25 | 中国医学科学院北京协和医院 | 眼部穿刺装置和眼部植入器具总成 |
| EP4346720A4 (en) | 2021-05-28 | 2025-01-01 | Sight Sciences, Inc. | INTRAOCULAR DEVICES, SYSTEMS AND METHODS |
| FR3128364B1 (fr) * | 2021-10-26 | 2024-06-28 | Hopital Fond Adolphe De Rothschild | Dispositif a succion oculaire |
| WO2023074892A1 (ja) * | 2021-10-29 | 2023-05-04 | ニプロ株式会社 | 医療用中空針及び医療用中空針の製造方法 |
| USD1037439S1 (en) | 2022-01-17 | 2024-07-30 | EyePoint Pharamaceuticals, Inc. | Ocular injector |
| WO2024112747A1 (en) | 2022-11-23 | 2024-05-30 | Iantrek, Inc. | Devices and systems for cutting, loading, and delivering biologic intraocular implants for increased aqueous outflow and lowering of intraocular pressure |
| CN120659593A (zh) * | 2022-11-28 | 2025-09-16 | 美国商业眼科医疗器械公司 | 用于治疗眼睛的病症的生物可侵蚀眼部植入物 |
| USD1120314S1 (en) | 2022-11-30 | 2026-03-24 | Regeneron Pharmaceuticals, Inc. | Dose delivery device |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU14351U1 (ru) * | 2000-02-15 | 2000-07-20 | Государственное учреждение Межотраслевой научно-технический комплекс "Микрохирургия глаза" | Игла-направитель для пункции ретробульбарного пространства |
| US20060089607A1 (en) * | 2004-10-22 | 2006-04-27 | Medical Instrument Development Laboratories, Inc. | Ophthalmic cannula insertion tool and method |
| US20100010452A1 (en) * | 2007-01-09 | 2010-01-14 | Fovea Pharmaceuticals | Apparatus for intra-ocular injection |
| US20120265149A1 (en) * | 2010-03-31 | 2012-10-18 | Ocuject, Llc | Device and method for intraocular drug delivery |
Family Cites Families (311)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2187259A (en) * | 1936-07-11 | 1940-01-16 | George E Barnhart | Hypodermic needle |
| US2841145A (en) | 1956-05-07 | 1958-07-01 | John A Epps | Syringe |
| US2939459A (en) | 1957-01-11 | 1960-06-07 | Jorge A Lazarte | Tandem syringe |
| US3376999A (en) | 1967-05-31 | 1968-04-09 | Gen Dynamics Corp | Packaging, mixing and dispensing apparatus |
| US3788320A (en) | 1972-02-25 | 1974-01-29 | Kendall & Co | Spinal needle |
| US4383530A (en) | 1981-06-05 | 1983-05-17 | John Bruno | Hypodermic needle and method of making needles |
| US4377897A (en) | 1981-08-04 | 1983-03-29 | Ocular Associates | Ophthalmic needle and method for manufacturing the same |
| JPS5875563A (ja) | 1981-10-30 | 1983-05-07 | テルモ株式会社 | 留置カテ−テル用接続具 |
| JPS60501696A (ja) | 1983-06-28 | 1985-10-11 | シユテリメ−ト ゲゼルシヤフト フユ−ル メデイツイ−ニツシエンベダルフ ミツト ベシユレンクテル ハフツング | 導入補助装置を有する医療装置 |
| NZ212899A (en) | 1984-07-31 | 1987-10-30 | Phillips Pty Ltd N J | Piston operated adjustable volume dose injector for animals |
| US4708147A (en) | 1985-02-25 | 1987-11-24 | Haaga John R | Universal biopsy needle |
| US4826871A (en) | 1985-03-13 | 1989-05-02 | Gressel Philip D | Topical ophthalmic compositions containing one or more retinoids |
| US4689040A (en) | 1985-04-29 | 1987-08-25 | Thompson Robert J | Tip for a phacoemulsification needle |
| US4689042A (en) | 1985-05-20 | 1987-08-25 | Survival Technology, Inc. | Automatic medicament ingredient mixing and injecting apparatus |
| US4826490A (en) | 1985-07-29 | 1989-05-02 | National Research Development Corporation | Safety device for hypodermic needle or the like |
| US4601708A (en) | 1985-09-09 | 1986-07-22 | Pavel Jordan | Automatic injection for syringe needle, and assembly |
| US4966773A (en) | 1986-11-25 | 1990-10-30 | Alcon Laboratories, Inc. | Topical ophthalmic compositions containing microfine retinoid particles |
| US4795432A (en) | 1987-02-19 | 1989-01-03 | Karczmer Claude M | Shield assembly for hypodermic injection devices |
| US4804371A (en) | 1987-05-06 | 1989-02-14 | Vaillancourt Vincent L | Post-injection needle sheath |
| EP0443630B1 (de) | 1987-07-10 | 1993-12-29 | B. Braun Melsungen AG | Kanüle |
| DE3802158A1 (de) | 1987-08-11 | 1989-02-23 | Hoechst Ag | Vorrichtung zur applikation von implantaten |
| US5547467A (en) | 1988-01-21 | 1996-08-20 | Massachusettes Institute Of Technology | Method for rapid temporal control of molecular transport across tissue |
| US5066276A (en) | 1988-06-21 | 1991-11-19 | Alcon Laboratories, Inc. | Method and apparatus for injecting viscous fluid into the eye to lift pre-retinal and post-retinal membrane with linear pressure control |
| DE68922619T2 (de) | 1988-09-23 | 1996-01-18 | Frank Hunter | Klinische messsonde. |
| US5817075A (en) | 1989-08-14 | 1998-10-06 | Photogenesis, Inc. | Method for preparation and transplantation of planar implants and surgical instrument therefor |
| US5015240A (en) | 1990-05-01 | 1991-05-14 | Ian Campbell Cree | Hypodermic needle shield |
| US5098389A (en) | 1990-06-28 | 1992-03-24 | Becton, Dickinson And Company | Hypodermic needle assembly |
| ES2023597A6 (es) * | 1990-11-05 | 1992-01-16 | Rodiera Olive Jose Javier | Aguja para uso medico, en especial para funcion lumbar y anestesia regional. |
| US5273530A (en) | 1990-11-14 | 1993-12-28 | The University Of Rochester | Intraretinal delivery and withdrawal instruments |
| EP0501034A1 (en) | 1991-01-30 | 1992-09-02 | CeramOptec GmbH | Illuminated leading probe device |
| US5181909A (en) | 1991-05-15 | 1993-01-26 | Mcfarlane Richard H | Ampule-container medical syringe and methods |
| GB9111049D0 (en) * | 1991-05-22 | 1991-07-17 | Parkin Adrian | Hypodermic needle |
| US5312361A (en) | 1991-09-13 | 1994-05-17 | Zadini Filiberto P | Automatic cannulation device |
| WO1993020784A1 (en) | 1992-04-10 | 1993-10-28 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University | A microneedle for injection of ocular blood vessels |
| US5295972A (en) | 1992-08-04 | 1994-03-22 | Metatech Corporation | Hypodermic syringe with protective cap |
| US5279564A (en) | 1992-09-11 | 1994-01-18 | Edward Weck Incorporated | Cannula retention device |
| US5300084A (en) | 1992-11-23 | 1994-04-05 | United States Surgical Corporation | Pneumoperitoneum needle |
| US5681825A (en) | 1993-03-15 | 1997-10-28 | Lindqvist; Bengt | Surgical method |
| US5354286A (en) | 1993-12-07 | 1994-10-11 | Survival Technology, Inc. | Injection device having polyparaxylylene coated container |
| US5397313A (en) | 1994-01-27 | 1995-03-14 | The Kendall Company | Low friction syringe |
| US5658256A (en) | 1994-08-22 | 1997-08-19 | Shields; Jack W. | Universal sharps shield |
| SE9402816D0 (sv) | 1994-08-24 | 1994-08-24 | Pharmacia Ab | Method and meams for drug administration |
| WO1996009838A1 (en) | 1994-09-28 | 1996-04-04 | Celtrix Pharmaceuticals, Inc. | METHOD OF TREATING MACULAR DEGENERATION USING TGF-$g(b) |
| US5792099A (en) | 1995-02-14 | 1998-08-11 | Decamp; Dennis | Syringe and cannula for insertion of viscoelastic material into an eye and method of using same |
| US5779668A (en) | 1995-03-29 | 1998-07-14 | Abbott Laboratories | Syringe barrel for lyophilization, reconstitution and administration |
| US5968022A (en) | 1995-04-28 | 1999-10-19 | Saito; Yoshikuni | Medical hollow needle and method of production |
| USD383049S (en) | 1995-06-30 | 1997-09-02 | Fiskars Inc. | Tool handle grip |
| US6280470B1 (en) | 1995-10-20 | 2001-08-28 | Gholam A. Peyman | Intrastromal corneal modification |
| US5788679A (en) | 1996-06-26 | 1998-08-04 | Gravlee, Jr.; Joseph F. | Phacoemulsification needle |
| US5911223A (en) | 1996-08-09 | 1999-06-15 | Massachusetts Institute Of Technology | Introduction of modifying agents into skin by electroporation |
| US6129710A (en) * | 1997-05-12 | 2000-10-10 | Spectrum Biotech Inc. | Needle cannula attachment device for a disposable syringe |
| EA199901013A1 (ru) | 1997-05-16 | 2000-06-26 | Амген Инк. | Гели пролонгированного действия |
| AUPO940697A0 (en) | 1997-09-23 | 1997-10-16 | Kaal, Joseph Hermes | Retractable syringe |
| EP1053041A4 (en) | 1998-01-12 | 2001-02-07 | Georgia Tech Res Inst | ASSESSMENT AND CONTROL OF ACOUSTIC EFFECTS ON TISSUE |
| US6309347B1 (en) | 1998-03-17 | 2001-10-30 | Fuji Photo Optical Co., Ltd. | Air and water supply system for endoscopes |
| US6391005B1 (en) | 1998-03-30 | 2002-05-21 | Agilent Technologies, Inc. | Apparatus and method for penetration with shaft having a sensor for sensing penetration depth |
| US6540725B1 (en) | 1998-06-04 | 2003-04-01 | Biosense Webster, Inc. | Injection catheter with controllably extendable injection needle |
| US6503231B1 (en) | 1998-06-10 | 2003-01-07 | Georgia Tech Research Corporation | Microneedle device for transport of molecules across tissue |
| US6936053B1 (en) | 1998-07-02 | 2005-08-30 | Jeffrey N. Weiss | Ocular implant needle |
| US6378526B1 (en) | 1998-08-03 | 2002-04-30 | Insite Vision, Incorporated | Methods of ophthalmic administration |
| US6309374B1 (en) | 1998-08-03 | 2001-10-30 | Insite Vision Incorporated | Injection apparatus and method of using same |
| FR2784034B1 (fr) | 1998-10-01 | 2000-12-15 | Marc Brunel | Dispositif d'injection a usage unique destine a etre pre-rempli |
| US6219575B1 (en) | 1998-10-23 | 2001-04-17 | Babak Nemati | Method and apparatus to enhance optical transparency of biological tissues |
| US6670321B1 (en) | 1998-12-30 | 2003-12-30 | The Children's Medical Center Corporation | Prevention and treatment for retinal ischemia and edema |
| US6773916B1 (en) | 1999-01-05 | 2004-08-10 | The Flinders University Of South Australia | Agents and methods for treatment and diagnosis of ocular disorders |
| US6319240B1 (en) | 1999-05-25 | 2001-11-20 | Iomed, Inc. | Methods and apparatus for ocular iontophoresis |
| US6611707B1 (en) | 1999-06-04 | 2003-08-26 | Georgia Tech Research Corporation | Microneedle drug delivery device |
| US6743211B1 (en) | 1999-11-23 | 2004-06-01 | Georgia Tech Research Corporation | Devices and methods for enhanced microneedle penetration of biological barriers |
| US6256533B1 (en) | 1999-06-09 | 2001-07-03 | The Procter & Gamble Company | Apparatus and method for using an intracutaneous microneedle array |
| FR2794650B1 (fr) | 1999-06-10 | 2001-09-14 | Marc Brunel | Dispositif d'injection a usage unique |
| FR2801795B1 (fr) | 1999-12-07 | 2002-07-05 | Plastef Investissements | Dispositif de support de securite pour une seringue et ensemble d'un tel dispositif et d'une seringue |
| KR100769224B1 (ko) | 1999-12-10 | 2007-10-22 | 아이싸이언스 인터벤셔날 코포레이션 | 안 질환의 치료방법 |
| US20010051798A1 (en) | 1999-12-28 | 2001-12-13 | Hochman Mark N. | Method of performing an injection using a bi-directional rotational insertion technique |
| JP4372310B2 (ja) | 2000-04-10 | 2009-11-25 | ニプロ株式会社 | 混注用アダプター |
| US6585690B1 (en) * | 2000-06-29 | 2003-07-01 | Becton Dickinson And Company | Hypodermic syringe with selectivity retractable needle |
| US6530904B1 (en) | 2000-08-15 | 2003-03-11 | Evan T. Edwards | Medical injector |
| JP4187922B2 (ja) * | 2000-09-14 | 2008-11-26 | テルモ株式会社 | 液体注入針および液体注入装置 |
| US20030060447A1 (en) | 2002-04-24 | 2003-03-27 | Mutlu Karakelle | Non-aspirating transitional viscoelastics for use in surgery |
| US9302903B2 (en) | 2000-12-14 | 2016-04-05 | Georgia Tech Research Corporation | Microneedle devices and production thereof |
| US6387078B1 (en) | 2000-12-21 | 2002-05-14 | Gillespie, Iii Richard D. | Automatic mixing and injecting apparatus |
| US20030171722A1 (en) | 2001-01-04 | 2003-09-11 | Michel Paques | Microsurgical injection and/or distending instruments and surgical method and apparatus utilizing same |
| JP4083425B2 (ja) * | 2001-01-25 | 2008-04-30 | テルモ株式会社 | 液体注入針および液体注入装置 |
| US7025774B2 (en) | 2001-06-12 | 2006-04-11 | Pelikan Technologies, Inc. | Tissue penetration device |
| US8337419B2 (en) | 2002-04-19 | 2012-12-25 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
| US20030073609A1 (en) | 2001-06-29 | 2003-04-17 | Pinkerton Thomas C. | Enhanced pharmacokinetic profile of intradermally delivered substances |
| US6749792B2 (en) | 2001-07-09 | 2004-06-15 | Lifescan, Inc. | Micro-needles and methods of manufacture and use thereof |
| MXPA04001505A (es) * | 2001-07-24 | 2004-05-31 | Artes Medical Usa Inc | Jeringa alargada. |
| WO2003024507A2 (en) | 2001-09-19 | 2003-03-27 | Biovalve Technologies, Inc. | Microneedles, microneedle arrays, and systems and methods relating to same |
| AU2002330083A1 (en) | 2001-09-21 | 2003-04-01 | Biovalve Technologies, Inc. | Gas pressure actuated microneedle arrays, and systems and methods relating to same |
| US7429258B2 (en) | 2001-10-26 | 2008-09-30 | Massachusetts Institute Of Technology | Microneedle transport device |
| US7569035B1 (en) | 2001-11-02 | 2009-08-04 | Meridian Medical Technologies, Inc. | Automatic injector with anti-coring needle |
| WO2003039634A1 (en) | 2001-11-09 | 2003-05-15 | Alza Corporation | Pneumatic powered autoinjector |
| DE50214560D1 (de) | 2001-11-22 | 2010-09-09 | Eduard Anton Haefliger | Vorrichtung und Verfahren zur Durchführung opthalmologischer Eingriffe |
| US7204823B2 (en) | 2001-12-19 | 2007-04-17 | Medtronic Minimed, Inc. | Medication delivery system and monitor |
| US20050033230A1 (en) | 2002-02-15 | 2005-02-10 | Alchas Paul G. | Prefillable intradermal delivery device with hidden needle and passive shielding |
| US7198606B2 (en) | 2002-04-19 | 2007-04-03 | Pelikan Technologies, Inc. | Method and apparatus for a multi-use body fluid sampling device with analyte sensing |
| WO2003097137A2 (en) | 2002-05-16 | 2003-11-27 | Scott Laboratories, Inc. | Drug container entry mechanisms and method |
| US6979316B1 (en) | 2002-05-23 | 2005-12-27 | Seedlings Life Science Ventures Llc | Apparatus and method for rapid auto-injection of medication |
| US6945952B2 (en) | 2002-06-25 | 2005-09-20 | Theraject, Inc. | Solid solution perforator for drug delivery and other applications |
| US7316676B2 (en) | 2002-08-20 | 2008-01-08 | Gholam A. Peyman | Treatment of retinal detachment |
| DE10242984B4 (de) | 2002-09-17 | 2010-09-23 | Sanatis Gmbh | Vorrichtung zum Herstellen von Gemischen aus zwei Komponenten |
| KR20050047118A (ko) | 2002-09-18 | 2005-05-19 | 알러간, 인코포레이티드 | 안과 임플란트의 수송을 위한 방법 및 장치 |
| EP1590034B1 (en) | 2002-10-07 | 2014-05-14 | Biovalve Technologies, Inc. | Microneedle array patch |
| US6883222B2 (en) | 2002-10-16 | 2005-04-26 | Bioject Inc. | Drug cartridge assembly and method of manufacture |
| JP2004196787A (ja) | 2002-12-04 | 2004-07-15 | Santen Pharmaceut Co Ltd | 結膜下デポによるドラッグデリバリーシステム |
| US8110209B2 (en) | 2002-12-20 | 2012-02-07 | Xeris Pharmaceuticals Inc. | Intracutaneous injection |
| CA2513705A1 (en) | 2003-01-21 | 2004-08-05 | Carmel Pharma Ab | A needle for penetrating a membrane |
| US20040199130A1 (en) | 2003-04-03 | 2004-10-07 | Chornenky Victor I. | Apparatus and method for treatment of macular degeneration |
| WO2005000382A2 (en) | 2003-06-04 | 2005-01-06 | Georgia Tech Research Corporation | Drilling microneedle device |
| US7914803B2 (en) | 2003-06-13 | 2011-03-29 | Alcon, Inc. | Ophthalmic compositions containing a synergistic combination of three polymers |
| DE10327119A1 (de) | 2003-06-13 | 2004-12-30 | Aventis Pharma Deutschland Gmbh | Kappe für Injektionsvorrichtungen |
| CA2529495C (en) | 2003-06-16 | 2013-02-05 | Solx, Inc. | Shunt for the treatment of glaucoma |
| PL1638468T3 (pl) | 2003-06-30 | 2008-01-31 | Alza Corp | Sposób powlekania mikrowystępów do przekłuwania skóry |
| USD499153S1 (en) | 2003-07-08 | 2004-11-30 | Test Rite International Company, Ltd | Handle for jump rope |
| US20050009910A1 (en) | 2003-07-10 | 2005-01-13 | Allergan, Inc. | Delivery of an active drug to the posterior part of the eye via subconjunctival or periocular delivery of a prodrug |
| CA2539023A1 (en) | 2003-09-23 | 2005-04-14 | Alcon Inc. | Triamcinolone acetonide and anecortave acetate formulations for injection |
| US20050101882A1 (en) | 2003-11-12 | 2005-05-12 | Leira Enrique C. | Safety pressure device for body fluid extraction |
| US20060141049A1 (en) | 2003-11-12 | 2006-06-29 | Allergan, Inc. | Triamcinolone compositions for intravitreal administration to treat ocular conditions |
| US20090148527A1 (en) | 2007-12-07 | 2009-06-11 | Robinson Michael R | Intraocular formulation |
| US20050101582A1 (en) | 2003-11-12 | 2005-05-12 | Allergan, Inc. | Compositions and methods for treating a posterior segment of an eye |
| KR20060130648A (ko) | 2004-01-12 | 2006-12-19 | 아이싸이언스 인터벤셔날 코포레이션 | 점성 물질용 인젝터 |
| DK1715827T3 (da) | 2004-01-23 | 2011-04-18 | Iscience Interventional Corp | Sammensat ophthalmisk mikrokanyle |
| US7678077B2 (en) | 2004-02-20 | 2010-03-16 | Boston Scientific Scimed, Inc. | Variable depth injection device and method |
| US7361168B2 (en) | 2004-04-21 | 2008-04-22 | Acclarent, Inc. | Implantable device and methods for delivering drugs and other substances to treat sinusitis and other disorders |
| US20080058704A1 (en) | 2004-04-29 | 2008-03-06 | Michael Hee | Apparatus and Method for Ocular Treatment |
| CN101052434A (zh) | 2004-04-29 | 2007-10-10 | I科学干预公司 | 用于治疗眼睛的装置和方法 |
| US20100173866A1 (en) | 2004-04-29 | 2010-07-08 | Iscience Interventional Corporation | Apparatus and method for ocular treatment |
| US8685435B2 (en) | 2004-04-30 | 2014-04-01 | Allergan, Inc. | Extended release biodegradable ocular implants |
| US20050244463A1 (en) | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Sustained release intraocular implants and methods for treating ocular vasculopathies |
| US20050244462A1 (en) | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Devices and methods for treating a mammalian eye |
| US20050244469A1 (en) | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Extended therapeutic effect ocular implant treatments |
| WO2006004595A2 (en) | 2004-05-28 | 2006-01-12 | Georgia Tech Research Corporation | Methods and devices for thermal treatment |
| US8323227B2 (en) | 2004-07-02 | 2012-12-04 | C. R. Bard, Inc. | Tip configurations for a multi-lumen catheter |
| CA2573668A1 (en) | 2004-07-12 | 2006-02-16 | Allergan, Inc. | Ophthalmic compositions and methods for treating ophthalmic conditions |
| US7615041B2 (en) | 2004-07-29 | 2009-11-10 | Boston Scientific Scimed, Inc. | Vial adaptor |
| US7503920B2 (en) | 2004-08-11 | 2009-03-17 | Tzony Siegal | Spinal surgery system and method |
| US7722669B2 (en) | 2004-08-13 | 2010-05-25 | Richard Foulkes | Method and insert for modifying eye color |
| US8114110B2 (en) | 2004-09-22 | 2012-02-14 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Transseptal puncture needle and needle assemblies |
| US7627938B2 (en) | 2004-10-15 | 2009-12-08 | Board Of Regents, The Univeristy Of Texas System | Tapered hollow metallic microneedle array assembly and method of making and using the same |
| US7097776B2 (en) | 2004-10-22 | 2006-08-29 | Hewlett-Packard Development Company, L.P. | Method of fabricating microneedles |
| US7648482B2 (en) | 2004-11-22 | 2010-01-19 | Intelliject, Inc. | Devices, systems, and methods for medicament delivery |
| JP2008520397A (ja) | 2004-11-23 | 2008-06-19 | エドワード・ケイ・ジュニアー・ウォング | 眼及び眼の周囲組織の温度制御及び治療のための医療装置 |
| US20060173418A1 (en) | 2004-12-13 | 2006-08-03 | Arrow International, Inc. | Loss of resistance syringe |
| US20060169664A1 (en) | 2004-12-28 | 2006-08-03 | Holopack International Corp. | Vial for filling a syringe |
| US7803142B2 (en) | 2005-02-02 | 2010-09-28 | Summit Access Llc | Microtaper needle and method of use |
| TW200640443A (en) | 2005-02-23 | 2006-12-01 | Alcon Inc | Methods for treating ocular angiogenesis, retinal edema, retinal ischemia, and diabetic retinopathy using selective RTK inhibitors |
| US20060233858A1 (en) | 2005-03-08 | 2006-10-19 | Allergan, Inc. | Systems and methods providing targeted intraocular drug delivery |
| KR20080018858A (ko) | 2005-03-11 | 2008-02-28 | 알콘, 인코퍼레이티드 | 녹내장 치료용 플리즐 관련 단백질―1의 RNAⅰ-중재저해 |
| US8003124B2 (en) | 2005-04-08 | 2011-08-23 | Surmodics, Inc. | Sustained release implants and methods for subretinal delivery of bioactive agents to treat or prevent retinal disease |
| US7722581B2 (en) | 2005-04-11 | 2010-05-25 | Gholam A. Peyman | Crystalline lens drug delivery |
| US7645264B2 (en) | 2005-04-11 | 2010-01-12 | Becton, Dickinson And Company | Injection device with secondary reservoir |
| KR100976281B1 (ko) | 2005-04-26 | 2010-08-16 | 바이오레이즈 테크놀로지, 인크. | 안구 치료 장치 |
| US20060259008A1 (en) | 2005-04-27 | 2006-11-16 | Allergan, Inc. | Apparatus and methods useful for intravitreal injection of drugs |
| WO2006128034A1 (en) | 2005-05-25 | 2006-11-30 | Georgia Tech Research Corporation | Microneedles and methods for microinfusion |
| EP1893130A4 (en) | 2005-06-17 | 2015-08-26 | Georgia Tech Res Inst | COATED MICROSTRUCTURES AND METHOD FOR THE PRODUCTION THEREOF |
| US20070082841A1 (en) | 2005-09-27 | 2007-04-12 | Aciont, Inc. | Ocular administration of immunosuppressive agents |
| US20070093877A1 (en) | 2005-10-26 | 2007-04-26 | Beecham Michael C | System for maintaining normal health of retinal cells and promoting regeneration of retinal cells |
| WO2007084582A2 (en) | 2006-01-17 | 2007-07-26 | Forsight Labs, Llc | Drug delivery treatment device |
| US20070202186A1 (en) | 2006-02-22 | 2007-08-30 | Iscience Interventional Corporation | Apparatus and formulations for suprachoroidal drug delivery |
| US7918814B2 (en) | 2006-05-02 | 2011-04-05 | Georgia Tech Research Corporation | Method for drug delivery to ocular tissue using microneedle |
| US8197435B2 (en) | 2006-05-02 | 2012-06-12 | Emory University | Methods and devices for drug delivery to ocular tissue using microneedle |
| US20070270768A1 (en) | 2006-05-17 | 2007-11-22 | Bruno Dacquay | Mechanical Linkage Mechanism For Ophthalmic Injection Device |
| US20070270745A1 (en) | 2006-05-18 | 2007-11-22 | Camran Nezhat | Vacuum actuated tissue lifting device |
| USD598543S1 (en) | 2006-06-13 | 2009-08-18 | Angiomed Gmbh & Co. Medizintechnik Kg | Handle for a medical delivery device |
| US8668676B2 (en) | 2006-06-19 | 2014-03-11 | Allergan, Inc. | Apparatus and methods for implanting particulate ocular implants |
| US8802128B2 (en) | 2006-06-23 | 2014-08-12 | Allergan, Inc. | Steroid-containing sustained release intraocular implants and related methods |
| US8974511B2 (en) | 2010-11-15 | 2015-03-10 | Aquesys, Inc. | Methods for treating closed angle glaucoma |
| US8852137B2 (en) | 2010-11-15 | 2014-10-07 | Aquesys, Inc. | Methods for implanting a soft gel shunt in the suprachoroidal space |
| US8663303B2 (en) | 2010-11-15 | 2014-03-04 | Aquesys, Inc. | Methods for deploying an intraocular shunt from a deployment device and into an eye |
| US9039761B2 (en) | 2006-08-04 | 2015-05-26 | Allergan, Inc. | Ocular implant delivery assemblies with distal caps |
| US20080058717A1 (en) | 2006-09-04 | 2008-03-06 | Spector David M | Oral cavity liquid delivery system including pre-angled needle guidance assembly and method for using the same |
| US7998108B2 (en) * | 2006-09-12 | 2011-08-16 | Psivida Us, Inc. | Injector apparatus and method of use |
| US20080097346A1 (en) | 2006-09-19 | 2008-04-24 | Alcon, Inc. | Trocar cannula |
| US20080097390A1 (en) | 2006-09-27 | 2008-04-24 | Alcon Manufacturing, Ltd. | Spring actuated delivery system |
| US7849334B2 (en) | 2006-09-29 | 2010-12-07 | Intel Coporation | Transitioning a computing platform to a low power system state |
| WO2008061043A2 (en) | 2006-11-10 | 2008-05-22 | Glaukos Corporation | Uveoscleral shunt and methods for implanting same |
| US8969415B2 (en) | 2006-12-01 | 2015-03-03 | Allergan, Inc. | Intraocular drug delivery systems |
| CA2670990A1 (en) | 2006-12-01 | 2008-06-12 | Allergan, Inc. | Method for determining optimum intraocular locations for drug delivery systems |
| RU2344767C2 (ru) | 2006-12-18 | 2009-01-27 | Наталья Александровна Уракова | Способ внутриартериальной инъекции по а.л. уракову |
| US20080177239A1 (en) | 2007-01-18 | 2008-07-24 | Yong Li | Trocar cannula system |
| DE102007018696A1 (de) | 2007-04-18 | 2008-10-23 | Sanofi-Aventis Deutschland Gmbh | Injektionsvorrichtung zur Abgabe eines Medikaments |
| USD590690S1 (en) | 2007-05-24 | 2009-04-21 | Domino S.P.A. | Handlebar hand grip |
| US20090030381A1 (en) | 2007-07-23 | 2009-01-29 | Lind Casey J | Arced Hypodermic Needle |
| US20110202012A1 (en) | 2007-08-16 | 2011-08-18 | Bartlett Edwin C | Smart Injection Syring Systems Providing Real-Time User Feedback of Correct Needle Position |
| CN102670352A (zh) | 2007-09-07 | 2012-09-19 | Qlt股份有限公司 | 用于泪腺植入物的插入和抽出工具 |
| CA2639322C (en) | 2007-09-07 | 2016-11-08 | Becton, Dickinson And Company | Pen needle hub having increased contact area |
| US20090076463A1 (en) | 2007-09-17 | 2009-03-19 | Jurg Attinger | Trocar Cannula |
| US20090081277A1 (en) | 2007-09-21 | 2009-03-26 | Allergan, Inc. | Pharmaceutical formulations and methods for treating ocular conditions |
| US8602959B1 (en) | 2010-05-21 | 2013-12-10 | Robert Park | Methods and devices for delivery of radiation to the posterior portion of the eye |
| JP2009183441A (ja) | 2008-02-06 | 2009-08-20 | Ken Kondo | 静脈留置針組立体 |
| US20100152646A1 (en) | 2008-02-29 | 2010-06-17 | Reshma Girijavallabhan | Intravitreal injection device and method |
| EP2262506B1 (en) | 2008-03-11 | 2014-05-07 | Alcon Research, Ltd. | Low viscosity, highly flocculated triamcinolone acetonide suspensions for intravitreal injection |
| US20090259180A1 (en) | 2008-04-11 | 2009-10-15 | Jong Soo Choi | Injection method using injector with length-adjustable needle and injection apparatus using the same |
| US20090287161A1 (en) | 2008-05-15 | 2009-11-19 | Allergan, Inc | Metered, multiple dose/aliquot syringe |
| US20090312782A1 (en) | 2008-06-13 | 2009-12-17 | Maxwell Choongwon Park | Method and apparatus for repairing tendons |
| US9022940B2 (en) | 2008-07-18 | 2015-05-05 | Joseph H. Meier | Handheld imaging devices and related methods |
| US8821870B2 (en) | 2008-07-18 | 2014-09-02 | Allergan, Inc. | Method for treating atrophic age related macular degeneration |
| EP2346551B1 (en) | 2008-08-30 | 2020-12-16 | Sanofi-Aventis Deutschland GmbH | Cartridge and needle system therefor |
| US8221353B2 (en) * | 2008-10-21 | 2012-07-17 | KMG Pharma, Inc | Intravitreal injection device and system |
| US7678078B1 (en) | 2008-10-21 | 2010-03-16 | KMG Pharma LLC | Intravitreal injection device, system and method |
| WO2010054660A1 (en) | 2008-11-11 | 2010-05-20 | Herlev Hospital | Double cannula system for anaesthetic needle |
| JP5520962B2 (ja) | 2008-12-05 | 2014-06-11 | イバンティス インコーポレイテッド | 眼内インプラントを眼球内に送出するための装置 |
| WO2010067319A2 (en) | 2008-12-09 | 2010-06-17 | Nanopass Technologies Ltd. | Device for injecting fluid isolated from microneedle hub with dead-space-reducing insert |
| US8545554B2 (en) | 2009-01-16 | 2013-10-01 | Allergan, Inc. | Intraocular injector |
| US8425473B2 (en) | 2009-01-23 | 2013-04-23 | Iscience Interventional Corporation | Subretinal access device |
| ES2378012B1 (es) | 2009-01-29 | 2013-02-12 | Innova Salud Desarrollos Sanitarios S.L. | Dispositivo para la administración de productos inyectables con caudal controlado. |
| EP2395930A4 (en) | 2009-02-10 | 2013-04-10 | Psivida Inc | EYE TROWART ASSEMBLY |
| US8057483B2 (en) | 2009-02-14 | 2011-11-15 | Ocular Transplantation Llc | Subretinal implantation instrument |
| WO2010100104A1 (en) | 2009-03-02 | 2010-09-10 | Sanofi-Aventis Deutschland Gmbh | Medication delivery device with foldable finger pad |
| US8617121B2 (en) | 2009-03-05 | 2013-12-31 | Sanofi-Aventis Deutschland Gmbh | Drug delivery device |
| DK2403569T3 (da) | 2009-03-05 | 2014-07-21 | Sanofi Aventis Deutschland | Lægemiddelafgivelsesanordning med tilbagetrækkelig nål |
| US9216255B2 (en) | 2009-03-05 | 2015-12-22 | Sanofi-Aventis Deutschland Gmbh | Needle assembly |
| DK2403568T3 (en) | 2009-03-05 | 2015-03-23 | Sanofi Aventis Deutschland | Needle device |
| JP5586633B2 (ja) | 2009-03-06 | 2014-09-10 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 後退可能な針を備えた薬物送達デバイス |
| US8287494B2 (en) | 2009-03-23 | 2012-10-16 | Colin Ma | Intravitreal injection devices and methods of injecting a substance into the vitreous chamber of the eye |
| SE0900371A1 (sv) | 2009-03-24 | 2010-09-25 | Istvan Bartha | Anordning för distribution av flytande läkemedel |
| JP4505561B1 (ja) * | 2009-03-30 | 2010-07-21 | 篤志 今津 | 圧力式穿刺注射器 |
| WO2010119392A1 (en) | 2009-04-15 | 2010-10-21 | Koninklijke Philips Electronics N.V. | Needle with integrated fibers in the cutting facets of the bevel |
| US20120130207A1 (en) | 2009-04-29 | 2012-05-24 | Janisys Limited | micro-needle device and apparatus and a method for applying a micro-needle element to a site on the skin of a subject |
| CN102458509B (zh) | 2009-05-15 | 2015-04-22 | I科学干预公司 | 用于视网膜下导管插入的装置 |
| JP5752683B2 (ja) | 2009-06-25 | 2015-07-22 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 薬剤の共送達のためのカニューレアセンブリ |
| RU2428956C2 (ru) | 2009-07-13 | 2011-09-20 | Александр Дмитриевич Ромащенко | Способ лечения атрофии зрительного нерва посредством трансплантации аутологичных стволовых клеток |
| US8535333B2 (en) | 2009-07-29 | 2013-09-17 | Transcend Medical, Inc. | Ocular implant applier and methods of use |
| CA2770558A1 (en) | 2009-08-12 | 2011-02-17 | Sanofi-Aventis Deutschland Gmbh | Cap for a portable medical delivery device and such a medical delivery device |
| WO2011023738A1 (en) | 2009-08-28 | 2011-03-03 | Sanofi-Aventis Deutschland Gmbh | Assembly kit for preparing of a pre-filled syringe |
| WO2011034627A2 (en) | 2009-09-21 | 2011-03-24 | Harvard Bioscience, Inc. | Methods and apparatus for introducing cells at a tissue site |
| WO2011057065A1 (en) | 2009-11-06 | 2011-05-12 | The Uab Research Foundation | Apparatuses and methods for delivering substances to the inner eye |
| AU2010317659B2 (en) | 2009-11-11 | 2014-01-23 | Unitract Syringe Pty Ltd | Clinical syringe |
| MX361556B (es) | 2009-12-22 | 2018-12-10 | Unitract Syringe Pty Ltd | Jeringa retráctil con eficiencia de suministro mejorada y sistema de bloqueo. |
| US8529492B2 (en) | 2009-12-23 | 2013-09-10 | Trascend Medical, Inc. | Drug delivery devices and methods |
| CA2786366A1 (en) * | 2010-01-05 | 2011-07-14 | Allergan, Inc. | Syringe comprising two plungers with locking means |
| WO2011109388A2 (en) | 2010-03-01 | 2011-09-09 | Medical Instrument Development Laboratories, Inc. | Cannula for intraocular surgery |
| EP2364740A1 (en) | 2010-03-09 | 2011-09-14 | Sanofi-Aventis Deutschland GmbH | Arrangement for transferring a translation of a drive means to a plunger |
| US9408746B2 (en) | 2010-03-31 | 2016-08-09 | Ocuject, Llc | Device and method for intraocular drug delivery |
| US8652118B2 (en) | 2010-04-08 | 2014-02-18 | Kmg Pharma, Llc | Sub-mucosal agent delivery, apparatus, system and method |
| US8574217B2 (en) | 2010-04-08 | 2013-11-05 | Kmg Pharma, Llc | Sub-mucosal agent delivery method for the eye |
| US8430862B2 (en) | 2010-04-08 | 2013-04-30 | KMG Pharma LLC | Subconjunctival agent delivery apparatus, system and method |
| US8632589B2 (en) | 2010-05-04 | 2014-01-21 | Abbott Medical Optics Inc. | IOL insertion system with semi-automatic trailing haptic configuration management |
| TWI556807B (zh) | 2010-05-04 | 2016-11-11 | Unitract Syringe Pty Ltd | Syringe syringe adapter and syringe assembly |
| US8932258B2 (en) | 2010-05-14 | 2015-01-13 | C. R. Bard, Inc. | Catheter placement device and method |
| US8545430B2 (en) | 2010-06-09 | 2013-10-01 | Transcend Medical, Inc. | Expandable ocular devices |
| US9987435B2 (en) | 2010-06-10 | 2018-06-05 | Anthony J. Colantonio | Apparatus and method for safely inserting an introducer needle into epidural space |
| AU2011271518A1 (en) | 2010-07-02 | 2012-12-13 | Alcon Research, Ltd. | Compounds for the treatment of posterior segment disorders and diseases |
| KR101180032B1 (ko) | 2010-07-12 | 2012-09-05 | 인싸이토(주) | 외형 조절이 가능한 중공형 마이크로니들의 제조방법 |
| TW201216948A (en) | 2010-07-19 | 2012-05-01 | Sanofi Aventis Deutschland | Medicament cartridges with non-standard dimensions |
| AU2011308629A1 (en) | 2010-09-30 | 2013-05-23 | Evonik Corporation | Drug delivery blade and methods for delivering a drug depot to a target site |
| US8864740B2 (en) | 2010-10-01 | 2014-10-21 | Sanofi-Aventis Deutschland Gmbh | Needle assembly with release mechanism |
| EP2438939A1 (en) | 2010-10-08 | 2012-04-11 | Sanofi-Aventis Deutschland GmbH | Arrangement for coupling a plunger to either a syringe or a stopper |
| US20120271272A1 (en) | 2010-10-15 | 2012-10-25 | Iscience Interventional Corporation | Device for ocular access |
| US20120101475A1 (en) | 2010-10-21 | 2012-04-26 | Meridian Medical Technologies, Inc. | High Efficiency Auto-Injector |
| EP2632516A1 (en) | 2010-10-25 | 2013-09-04 | Sanofi-Aventis Deutschland GmbH | Device for controlling a penetration depth of injection needle |
| EP2446866A1 (en) | 2010-11-02 | 2012-05-02 | Fovea Pharmaceuticals | Apparatus for injection into an eye |
| CA2816806A1 (en) | 2010-11-03 | 2012-05-10 | Sanofi-Aventis Deutschland Gmbh | Needle cannula containing medicament |
| US9241701B2 (en) | 2010-11-11 | 2016-01-26 | Depuy Mitek, Inc. | Cannula system and method for partial thickness rotator cuff repair |
| JP5704389B2 (ja) | 2010-11-29 | 2015-04-22 | ニプロ株式会社 | 医療用中空針および医療用中空針の製造方法 |
| US8608710B2 (en) * | 2010-12-09 | 2013-12-17 | Becton Dickinson & Company | Pen needle assembly with different gauge needle cannulas |
| US9968337B2 (en) | 2010-12-20 | 2018-05-15 | Cook Medical Technologies Llc | Coring tissue biopsy needle and method of use |
| USD667111S1 (en) | 2011-03-17 | 2012-09-11 | Surgical Innovations Limited | Handle for surgical instrument |
| EP2500002A1 (en) | 2011-03-17 | 2012-09-19 | Sanofi-Aventis Deutschland GmbH | Apparatus for intraocular injection |
| WO2012135109A1 (en) * | 2011-03-25 | 2012-10-04 | The Curators Of The University Of Missouri | Intravitreal injection device |
| EP2510911A1 (en) | 2011-04-13 | 2012-10-17 | Sanofi-Aventis Deutschland GmbH | Apparatus for intraocular injection |
| EP2510902A1 (en) | 2011-04-15 | 2012-10-17 | Sanofi-Aventis Deutschland GmbH | Intraocular injection device |
| EP2514461A1 (en) | 2011-04-20 | 2012-10-24 | Sanofi-Aventis Deutschland GmbH | Needle assembly for a medical device |
| EP2522318A1 (en) | 2011-05-12 | 2012-11-14 | Sanofi-Aventis Deutschland GmbH | Guide device for intraocular injection |
| EP2540261A1 (en) | 2011-06-30 | 2013-01-02 | Sanofi-Aventis Deutschland GmbH | Intraocular medicament delivery device |
| WO2013022772A1 (en) | 2011-08-05 | 2013-02-14 | Unitract Syringe Pty Ltd | Cannula with controlled depth of insertion |
| CA2845891A1 (en) | 2011-09-13 | 2013-03-21 | Sanofi-Aventis Deutschland Gmbh | Injection device |
| EP2574355A1 (en) | 2011-09-27 | 2013-04-03 | Sanofi-Aventis Deutschland GmbH | Package for a medicament delivery device |
| EP2578190A1 (en) | 2011-10-07 | 2013-04-10 | Sanofi-Aventis Deutschland GmbH | Intraocular injection device |
| EP2578189A1 (en) | 2011-10-07 | 2013-04-10 | Sanofi-Aventis Deutschland GmbH | Apparatus for intraocular injection |
| EP2578191A1 (en) | 2011-10-07 | 2013-04-10 | Sanofi-Aventis Deutschland GmbH | Apparatus for intraocular injection |
| EP2578260A1 (en) | 2011-10-07 | 2013-04-10 | Sanofi-Aventis Deutschland GmbH | Apparatus for intraocular injection |
| EP2586407A1 (en) | 2011-10-31 | 2013-05-01 | Sanofi-Aventis Deutschland GmbH | Aid device for intraocular injection |
| EP2596826A1 (en) | 2011-11-24 | 2013-05-29 | Sanofi-Aventis Deutschland GmbH | Safety syringe |
| EP2601990A1 (en) | 2011-12-08 | 2013-06-12 | Sanofi-Aventis Deutschland GmbH | Syringe carrier |
| EP2601992A1 (en) | 2011-12-08 | 2013-06-12 | Sanofi-Aventis Deutschland GmbH | Syringe carrier |
| EP2601988A1 (en) | 2011-12-08 | 2013-06-12 | Sanofi-Aventis Deutschland GmbH | Syringe carrier |
| US9345839B2 (en) | 2011-12-08 | 2016-05-24 | Unitract Syringe Pty Ltd | Accurate dose control mechanisms and drug delivery syringes |
| BR112014012522A2 (pt) | 2011-12-15 | 2017-06-06 | Sanofi Aventis Deutschland | método para encher um reservatório, reservatório e conjunto para encher um reservatório |
| EP2609952B1 (en) | 2011-12-30 | 2015-01-14 | Q-Med AB | Bruiseless cannula |
| AU344164S (en) | 2012-02-02 | 2012-09-04 | Terumo Corp | Safety device for indwelling needle |
| EP2626096A1 (en) | 2012-02-10 | 2013-08-14 | Sanofi-Aventis Deutschland GmbH | Medicament delivery device with needle assembly removal mechanism |
| KR20140127896A (ko) | 2012-02-23 | 2014-11-04 | 유니트랙트 시린지 피티와이 엘티디 | 치료적 임플란트의 표적화 전달용 디바이스 |
| USD672506S1 (en) | 2012-02-28 | 2012-12-11 | Idea Village Products, Inc. | Exfoliating device |
| US20150013835A1 (en) | 2012-02-29 | 2015-01-15 | Sanofi-Aventis Deutschland Gmbh | Extraction device for a single extraction of a medicament from a container |
| CN104470559B (zh) | 2012-03-12 | 2018-02-06 | 尤尼特拉克特注射器控股有限公司 | 用于无菌流体路径组件的填充匣及包含填充匣的药物输送装置 |
| EP2641629A1 (en) | 2012-03-22 | 2013-09-25 | Sanofi-Aventis Deutschland GmbH | Medical injection device with injection site pain reduction device |
| US9421129B2 (en) * | 2012-04-02 | 2016-08-23 | Ocuject, Llc | Intraocular delivery devices and methods therefor |
| US9833523B2 (en) | 2012-04-24 | 2017-12-05 | The Ohio State University | Pharmacokinetic determination of intravitreal agents |
| US9849252B2 (en) * | 2012-05-04 | 2017-12-26 | Sofia Eleni Armes | Electromechanical manipulating device for medical needle and syringe with sensory biofeedback and pain suppression capability |
| US9956341B2 (en) | 2012-07-03 | 2018-05-01 | Milestone Scientific, Inc. | Drug infusion with pressure sensing and non-continuous flow for identification of and injection into fluid-filled anatomic spaces |
| US10201655B2 (en) | 2012-08-13 | 2019-02-12 | The Brigham And Women's Hospital, Inc. | Methods and devices for inserting a needle |
| EP2887982B1 (en) * | 2012-08-27 | 2022-11-23 | Clearside Biomedical, Inc. | Apparatus for drug delivery using microneedles |
| USD715125S1 (en) | 2012-10-08 | 2014-10-14 | The Ames Companies, Inc. | Grip |
| EP2916827B1 (en) | 2012-11-08 | 2020-06-10 | Clearside Biomedical Inc. | Methods for the treatment of ocular disease in human subjects |
| USD740098S1 (en) | 2013-03-19 | 2015-10-06 | Tong Yah Electronic Technology Co., Ltd. | Vehicular handle |
| US9987163B2 (en) | 2013-04-16 | 2018-06-05 | Novartis Ag | Device for dispensing intraocular substances |
| SG10201702674PA (en) | 2013-05-03 | 2017-06-29 | Clearside Biomedical Inc | Apparatus and methods for ocular injection |
| EP3003454B1 (en) | 2013-06-03 | 2020-01-08 | Clearside Biomedical, Inc. | Apparatus for drug delivery using multiple reservoirs |
| WO2015015467A1 (en) | 2013-08-02 | 2015-02-05 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | A device for delivery of compositions to the eye |
| AU2014305922A1 (en) | 2013-08-07 | 2016-02-25 | Unitract Syringe Pty Ltd | Luer connection adapters for retractable needle syringes |
| US9925343B2 (en) | 2013-08-07 | 2018-03-27 | Unitract Syringe Pty Ltd | Luer connection adapters for syringes |
| USD718602S1 (en) | 2013-09-09 | 2014-12-02 | Midwest Tool And Cutlery Company | Hand grip for hand tools |
| USD713958S1 (en) | 2013-12-05 | 2014-09-23 | Becton, Dickinson And Company | Pen needle outer cover |
| WO2015095772A2 (en) | 2013-12-20 | 2015-06-25 | Emory University | Formulations and methods for targeted ocular delivery of therapeutic agents |
| USD726908S1 (en) | 2014-02-06 | 2015-04-14 | St. Jude Medical, Cardiology Division, Inc. | Catheter handle |
| KR102511477B1 (ko) | 2014-06-17 | 2023-03-16 | 클리어사이드 바이오메디컬, 인코포레이드 | 안구 후부 질환을 치료하기 위한 방법 및 디바이스 |
| RU2710491C2 (ru) | 2014-06-20 | 2019-12-26 | Клиасайд Байомедикал, Инк. | Устройство для инъекции лекарственного средства в глазную ткань и способ инъекции лекарственного средства в глазную ткань |
| KR20170060074A (ko) | 2014-09-19 | 2017-05-31 | 옥슬러 리미티드 | 안과용 전달 장치 |
| EP3193829B1 (en) | 2014-09-19 | 2021-12-08 | Oxular Limited | Ophthalmic drug compositions |
| USD750223S1 (en) | 2014-10-14 | 2016-02-23 | Clearside Biomedical, Inc. | Medical injector for ocular injection |
-
2015
- 2015-06-19 RU RU2017101660A patent/RU2710491C2/ru active
- 2015-06-19 EP EP15810459.6A patent/EP3157598A4/en not_active Withdrawn
- 2015-06-19 CN CN201580039277.8A patent/CN106794321A/zh active Pending
- 2015-06-19 CA CA2952958A patent/CA2952958A1/en not_active Abandoned
- 2015-06-19 MX MX2016017028A patent/MX2016017028A/es unknown
- 2015-06-19 JP JP2016574090A patent/JP2017524419A/ja active Pending
- 2015-06-19 WO PCT/US2015/036715 patent/WO2015196085A2/en not_active Ceased
-
2016
- 2016-12-19 US US15/383,582 patent/US9956114B2/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU14351U1 (ru) * | 2000-02-15 | 2000-07-20 | Государственное учреждение Межотраслевой научно-технический комплекс "Микрохирургия глаза" | Игла-направитель для пункции ретробульбарного пространства |
| US20060089607A1 (en) * | 2004-10-22 | 2006-04-27 | Medical Instrument Development Laboratories, Inc. | Ophthalmic cannula insertion tool and method |
| US20100010452A1 (en) * | 2007-01-09 | 2010-01-14 | Fovea Pharmaceuticals | Apparatus for intra-ocular injection |
| US20120265149A1 (en) * | 2010-03-31 | 2012-10-18 | Ocuject, Llc | Device and method for intraocular drug delivery |
Also Published As
| Publication number | Publication date |
|---|---|
| RU2017101660A3 (https=) | 2019-03-05 |
| JP2017524419A (ja) | 2017-08-31 |
| US9956114B2 (en) | 2018-05-01 |
| WO2015196085A2 (en) | 2015-12-23 |
| RU2017101660A (ru) | 2018-07-20 |
| CA2952958A1 (en) | 2015-12-23 |
| WO2015196085A3 (en) | 2016-03-17 |
| EP3157598A2 (en) | 2017-04-26 |
| US20170095369A1 (en) | 2017-04-06 |
| MX2016017028A (es) | 2017-08-07 |
| EP3157598A4 (en) | 2018-05-16 |
| CN106794321A (zh) | 2017-05-31 |
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