BR112022005148A2 - Sistemas de injeção e métodos de uso dos mesmos - Google Patents

Sistemas de injeção e métodos de uso dos mesmos

Info

Publication number
BR112022005148A2
BR112022005148A2 BR112022005148A BR112022005148A BR112022005148A2 BR 112022005148 A2 BR112022005148 A2 BR 112022005148A2 BR 112022005148 A BR112022005148 A BR 112022005148A BR 112022005148 A BR112022005148 A BR 112022005148A BR 112022005148 A2 BR112022005148 A2 BR 112022005148A2
Authority
BR
Brazil
Prior art keywords
sealing element
injection
puncture
sealing
syringe barrel
Prior art date
Application number
BR112022005148A
Other languages
English (en)
Inventor
Chitnis Girish
Karp Jeff
Ahn Edward
Laulicht Bryan
Original Assignee
Meiragtx Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meiragtx Therapeutics Inc filed Critical Meiragtx Therapeutics Inc
Publication of BR112022005148A2 publication Critical patent/BR112022005148A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31501—Means for blocking or restricting the movement of the rod or piston
    • A61M5/31505—Integral with the syringe barrel, i.e. connected to the barrel so as to make up a single complete piece or unit
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
    • A61M5/321—Means for protection against accidental injuries by used needles
    • A61M5/322—Retractable needles, i.e. disconnected from and withdrawn into the syringe barrel by the piston
    • A61M5/3221—Constructional features thereof, e.g. to improve manipulation or functioning
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/329—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles characterised by features of the needle shaft
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/46—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for controlling depth of insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/50—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for preventing re-use, or for indicating if defective, used, tampered with or unsterile
    • A61M5/5013—Means for blocking the piston or the fluid passageway to prevent illegal refilling of a syringe
    • A61M5/502—Means for blocking the piston or the fluid passageway to prevent illegal refilling of a syringe for blocking the piston
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A61M2005/31516—Piston or piston-rod constructions, e.g. connection of piston with piston-rod reducing dead-space in the syringe barrel after delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
    • A61M5/321—Means for protection against accidental injuries by used needles
    • A61M5/322—Retractable needles, i.e. disconnected from and withdrawn into the syringe barrel by the piston
    • A61M5/3221—Constructional features thereof, e.g. to improve manipulation or functioning
    • A61M2005/323—Connection between plunger distal end and needle hub proximal end, e.g. stud protruding from the plunger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/50—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for preventing re-use, or for indicating if defective, used, tampered with or unsterile
    • A61M5/5013—Means for blocking the piston or the fluid passageway to prevent illegal refilling of a syringe
    • A61M5/502—Means for blocking the piston or the fluid passageway to prevent illegal refilling of a syringe for blocking the piston
    • A61M2005/5026—Means for blocking the piston or the fluid passageway to prevent illegal refilling of a syringe for blocking the piston allowing single filling of syringe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/50—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for preventing re-use, or for indicating if defective, used, tampered with or unsterile
    • A61M5/5013—Means for blocking the piston or the fluid passageway to prevent illegal refilling of a syringe
    • A61M5/502—Means for blocking the piston or the fluid passageway to prevent illegal refilling of a syringe for blocking the piston
    • A61M2005/5033—Means for blocking the piston or the fluid passageway to prevent illegal refilling of a syringe for blocking the piston by use of an intermediate blocking member positioned between the syringe barrel and the piston rod to prevent retraction of the latter, e.g. toothed clip placed on the piston rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/06—Head
    • A61M2210/0612—Eyes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Environmental & Geological Engineering (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

SISTEMAS DE INJEÇÃO E MÉTODOS DE USO DOS MESMOS. Um sistema de injeção compreendendo um cilindro de seringa; um primeiro elemento de vedação e um segundo elemento de vedação disposto de forma móvel no cilindro de seringa; uma câmara de injeção entre eles; um elemento de punção que se estende do primeiro elemento de vedação para fornecer um agente de injeção da câmara de injeção para um espaço biológico, em que um ou mais do cilindro de seringa, o primeiro ou o segundo elemento de vedação são configurados para impedir o movimento proximal do primeiro elemento de vedação após um local pré-selecionado, enquanto permite que o segundo elemento de vedação entre em contato com o primeiro elemento de vedação, o sistema é configurado de modo que, quando uma força é aplicada no segundo elemento de vedação em uma direção distal, em resposta a uma primeira força oposta, o elemento de punção avança e em resposta a uma segunda força oposta, o elemento de punção permanece estacionário e o agente de injeção é transportado através do elemento de punção.
BR112022005148A 2019-09-20 2020-09-20 Sistemas de injeção e métodos de uso dos mesmos BR112022005148A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962903406P 2019-09-20 2019-09-20
US202063052518P 2020-07-16 2020-07-16
PCT/US2020/051702 WO2021055906A1 (en) 2019-09-20 2020-09-20 Injection systems and methods of their use

Publications (1)

Publication Number Publication Date
BR112022005148A2 true BR112022005148A2 (pt) 2023-02-23

Family

ID=74884238

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022005148A BR112022005148A2 (pt) 2019-09-20 2020-09-20 Sistemas de injeção e métodos de uso dos mesmos

Country Status (11)

Country Link
US (1) US20220379044A1 (pt)
EP (1) EP4031214A4 (pt)
JP (1) JP2022548401A (pt)
KR (1) KR20220083712A (pt)
CN (1) CN114728132A (pt)
AU (1) AU2020349562A1 (pt)
BR (1) BR112022005148A2 (pt)
CA (1) CA3151700A1 (pt)
IL (1) IL291492A (pt)
MX (1) MX2022003405A (pt)
WO (1) WO2021055906A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2023001866A (es) * 2020-08-13 2023-07-06 Meiragtx Uk Ii Ltd Sistema de inyeccion motorizada y metodos de uso.
EP4249015A1 (en) * 2022-03-25 2023-09-27 Stada Arzneimittel Ag Method for preparing a sterilised drug delivery device
CN115323001A (zh) * 2022-07-28 2022-11-11 深圳先进技术研究院 一种靶向视网膜的基因递送系统及其应用

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3266680D1 (en) * 1981-07-29 1985-11-07 Duphar Int Res Hypodermic syringe
US5106372A (en) * 1991-05-03 1992-04-21 Sherwood Medical Company Single use syringe
US5938637A (en) * 1997-03-14 1999-08-17 Path Single-use medicine delivery unit for needleless hypodermic injector
DE19936294A1 (de) * 1999-08-02 2001-02-15 Hans Mueller Spritze
JP4141156B2 (ja) * 2002-03-15 2008-08-27 日本ベクトン・ディッキンソン株式会社 プランジャ後退制限機構付きプレフィルドシリンジ
IL160891A0 (en) * 2004-03-16 2004-08-31 Auto-mix needle
DE202004011516U1 (de) * 2004-07-22 2005-12-08 Schwarzbich, Jörg Spritze
FR2884721A1 (fr) * 2005-04-20 2006-10-27 Becton Dickinson France Soc Pa Ensemble d'injection et dispositif d'assistance a l'injection
WO2009089409A2 (en) * 2008-01-10 2009-07-16 Bausch & Lomb Incorporated Intravitreal injection system having coaxial cannulae and use thereof
KR101702674B1 (ko) * 2008-11-26 2017-02-06 백톤 디킨슨 앤드 컴퍼니 일회용 자동 불능식 주사기
WO2010091132A1 (en) * 2009-02-04 2010-08-12 Mallinckrodt Inc. Hand-actuated syringe with vacuum chamber for auto refill
JP5619037B2 (ja) * 2009-03-06 2014-11-05 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 後退可能な針を備えたシリンジ用のシール部材
IN2012DN00344A (pt) * 2009-07-10 2015-05-08 Becton Dickinson Co
US8992482B2 (en) * 2010-03-12 2015-03-31 Control Medical Technology, Llc Syringe with flow control valves and associated methods
TWI775096B (zh) * 2012-05-15 2022-08-21 澳大利亞商艾佛蘭屈澳洲私營有限公司 使用腺相關病毒(aav)sflt-1治療老年性黃斑部退化(amd)
WO2014160613A1 (en) * 2013-03-29 2014-10-02 Silk Road Medical, Inc, Systems and methods for aspirating from a body lumen
CA3121759C (en) * 2013-05-03 2024-01-02 Clearside Biomedical, Inc. Apparatus and methods for ocular injection
WO2016060925A1 (en) * 2014-10-16 2016-04-21 Incept, Llc Ocular gels or hydrogels and microinjectors
US10850044B2 (en) * 2015-02-10 2020-12-01 Dali Medical Devices Ltd. Safe auto-needle device
EP3554582A4 (en) * 2016-12-16 2020-06-24 The Brigham and Women's Hospital, Inc. SYSTEM AND METHOD FOR RESISTANCE-DEPENDENT SELF-CONTROLLED MEDICAL PENETRATION
CN107866196B (zh) * 2017-12-14 2023-09-12 江苏宝卫士生物科技有限公司 一种连体供给装置及其方法

Also Published As

Publication number Publication date
CA3151700A1 (en) 2021-03-25
CN114728132A (zh) 2022-07-08
US20220379044A1 (en) 2022-12-01
IL291492A (en) 2022-05-01
AU2020349562A1 (en) 2022-05-12
WO2021055906A1 (en) 2021-03-25
JP2022548401A (ja) 2022-11-18
KR20220083712A (ko) 2022-06-20
EP4031214A1 (en) 2022-07-27
EP4031214A4 (en) 2023-11-08
MX2022003405A (es) 2022-08-22

Similar Documents

Publication Publication Date Title
BR112022005148A2 (pt) Sistemas de injeção e métodos de uso dos mesmos
BRPI0614087B8 (pt) seringa de uso único com sistema de redução de impulso
BR112018010677A8 (pt) sistema de seringa e conector
BR112018075483A2 (pt) conjunto de acionamento para sistema de distribuição de fármacos
AR104869A1 (es) Indicador audible
BR112019023985A2 (pt) sistema de autocorreção e componentes e métodos relacionados
BR112016016290A2 (pt) Composições farmacêuticas de insulina de ação rápida, conjunto de infusão, sistema de conjunto de infusão e usos de análogos monoméricos ou diméricos de insulina
BR112019003083A2 (pt) conjuntos de catéteres com válvula e métodos relacionados
BR112015021716A2 (pt) seringa com múltiplos compartimentos
ECSP18081954A (es) Detección de infección microbiana en heridas
BR112018077021A2 (pt) terapias de combinação
BR112017025748A2 (pt) autoinjetor e método de montagem
BR112018075437A2 (pt) conjunto espaçador para sistema de administração de fármaco
BR112015021446A2 (pt) métodos cirúrgicos empregando composições de peptídeo amfifílico purificado
BR112018008550A2 (pt) sistema e método para engate de êmbolo de seringa em um injetor
BR112016002646A2 (pt) dispositivos e métodos de entrega de fármaco de múltiplas unidades
BR112015029339A2 (pt) pistão para utilizar uma seringa com rácio dimensional específico de uma estrutura selante
MX2020003785A (es) Disposicion de esterilizacion para dispositivo de administracion de farmaco.
BR112018002342A2 (pt) polímeros furtivos intrinsecamente desordenados e geneticamente modificados para entrega e métodos para uso dos mesmos
BR112019003770A2 (pt) formulação líquida que contém toxina botulínica e agente de estabilização, e método de preparação para a mesma
BR112019002267A2 (pt) sistema de injeção de implante/medicamento baseado em alojamento de segurança
BR112016012364A8 (pt) mecanismo de acionamento de bomba de fármaco
BR112015017717A2 (pt) mecanismo de acionamento de bomba de fármaco
BR112016025045A2 (pt) sistema de distribuição de fármaco e método de distribuição de um composto biologicamente ativo
BR112018002520A2 (pt) Agonistas de tlr4 e composições dos mesmos e seuuso no tratamento de câncer