RU2709742C2 - Гуманизированные антитела к ox40 и способы их применения - Google Patents

Гуманизированные антитела к ox40 и способы их применения Download PDF

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RU2709742C2
RU2709742C2 RU2017115662A RU2017115662A RU2709742C2 RU 2709742 C2 RU2709742 C2 RU 2709742C2 RU 2017115662 A RU2017115662 A RU 2017115662A RU 2017115662 A RU2017115662 A RU 2017115662A RU 2709742 C2 RU2709742 C2 RU 2709742C2
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antibody
seq
cells
fragment
human
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RU2017115662A3 (cg-RX-API-DMAC7.html
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Скотт А. ХАММОНД
Майкл ОБЕРСТ
Цюнь ДУ
Мелисса ДАМШРОДЕР
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МЕДИММЬЮН, ЭлЭлСи
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    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • AHUMAN NECESSITIES
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    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • C07K2317/00Immunoglobulins specific features
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    • C07K2317/00Immunoglobulins specific features
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    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732Antibody-dependent cellular cytotoxicity [ADCC]
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    • C07K2317/734Complement-dependent cytotoxicity [CDC]
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    • C07K2317/00Immunoglobulins specific features
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    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plant Pathology (AREA)
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
RU2017115662A 2014-10-10 2015-10-07 Гуманизированные антитела к ox40 и способы их применения RU2709742C2 (ru)

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US201462062431P 2014-10-10 2014-10-10
US62/062,431 2014-10-10
PCT/US2015/054490 WO2016057667A1 (en) 2014-10-10 2015-10-07 Humanized anti-ox40 antibodies and uses thereof

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RU2017115662A RU2017115662A (ru) 2018-11-13
RU2017115662A3 RU2017115662A3 (cg-RX-API-DMAC7.html) 2019-05-20
RU2709742C2 true RU2709742C2 (ru) 2019-12-19

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EP (1) EP3204422B1 (cg-RX-API-DMAC7.html)
JP (2) JP6794348B2 (cg-RX-API-DMAC7.html)
KR (1) KR20170064550A (cg-RX-API-DMAC7.html)
CN (1) CN107074953A (cg-RX-API-DMAC7.html)
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CL (1) CL2017000885A1 (cg-RX-API-DMAC7.html)
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IL (1) IL251537A0 (cg-RX-API-DMAC7.html)
MX (1) MX2017004715A (cg-RX-API-DMAC7.html)
RU (1) RU2709742C2 (cg-RX-API-DMAC7.html)
SG (1) SG11201702826XA (cg-RX-API-DMAC7.html)
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Cited By (1)

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RU2826983C2 (ru) * 2020-09-10 2024-09-19 Обласов Михаил Викторович Способ лечения covid-19 с помощью применения агонистов рецептора ox40 (cd134)

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