RU2702356C2 - Композиция для чрескожного всасывания - Google Patents

Композиция для чрескожного всасывания Download PDF

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Publication number
RU2702356C2
RU2702356C2 RU2018110617A RU2018110617A RU2702356C2 RU 2702356 C2 RU2702356 C2 RU 2702356C2 RU 2018110617 A RU2018110617 A RU 2018110617A RU 2018110617 A RU2018110617 A RU 2018110617A RU 2702356 C2 RU2702356 C2 RU 2702356C2
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RU
Russia
Prior art keywords
tizanidine
sorbic acid
salt
drug
acid
Prior art date
Application number
RU2018110617A
Other languages
English (en)
Russian (ru)
Other versions
RU2018110617A (ru
RU2018110617A3 (https=
Inventor
Ясуси МИВА
Хидетоси ХАМАМОТО
Наоя АКАДЗАВА
Original Assignee
Медрэкс Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Медрэкс Ко., Лтд. filed Critical Медрэкс Ко., Лтд.
Publication of RU2018110617A publication Critical patent/RU2018110617A/ru
Publication of RU2018110617A3 publication Critical patent/RU2018110617A3/ru
Application granted granted Critical
Publication of RU2702356C2 publication Critical patent/RU2702356C2/ru

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Emergency Medicine (AREA)
  • Organic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RU2018110617A 2015-08-29 2016-08-29 Композиция для чрескожного всасывания RU2702356C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JPPCT/JP2015/074553 2015-08-29
PCT/JP2015/074553 WO2017037813A1 (ja) 2015-08-29 2015-08-29 塩基性薬物とソルビン酸とを含有する経皮吸収組成物
PCT/JP2016/075203 WO2017038767A1 (ja) 2015-08-29 2016-08-29 経皮吸収組成物

Publications (3)

Publication Number Publication Date
RU2018110617A RU2018110617A (ru) 2019-09-30
RU2018110617A3 RU2018110617A3 (https=) 2019-09-30
RU2702356C2 true RU2702356C2 (ru) 2019-10-08

Family

ID=58187853

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2018110617A RU2702356C2 (ru) 2015-08-29 2016-08-29 Композиция для чрескожного всасывания

Country Status (16)

Country Link
US (3) US9974858B2 (https=)
EP (1) EP3342423B1 (https=)
JP (2) JP6259117B2 (https=)
KR (1) KR20180039622A (https=)
CN (1) CN107427509B (https=)
BR (1) BR112018001387B8 (https=)
CO (1) CO2018001831A2 (https=)
ES (1) ES2864017T3 (https=)
MX (1) MX388148B (https=)
MY (1) MY189987A (https=)
PH (1) PH12018500271A1 (https=)
RU (1) RU2702356C2 (https=)
SG (1) SG11201800043UA (https=)
UA (1) UA123212C2 (https=)
WO (2) WO2017037813A1 (https=)
ZA (1) ZA201800296B (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107427509B (zh) 2015-08-29 2021-06-15 美德阿利克斯株式会社 含有碱性药物和山梨酸的经皮吸收组成物
US11559519B2 (en) 2018-01-31 2023-01-24 Medrx, Co., Ltd. Tizanidine therapy system
US11186585B2 (en) 2018-08-17 2021-11-30 Kappa-Pharma LLC Compositions and methods of enhancing opioid receptor engagement by opioid hexadienoates and optionally substituted hexadienoates
TWI772807B (zh) * 2019-05-27 2022-08-01 日商救急藥品工業股份有限公司 外用製劑
CA3149152A1 (en) * 2019-08-11 2021-02-18 Kappa-Pharma LLC Compositions and methods of enhancing opioid receptor engagement by opioid hexadienoates and optionally substituted hexadienoates
US12103639B2 (en) * 2021-06-03 2024-10-01 Sram, Llc Bicycle control system
CA3226214A1 (en) * 2021-08-30 2023-03-09 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system for the transdermal administration of guanfacine comprising guanfacine and a mono-carboxylic acid
US20240398765A1 (en) * 2021-10-15 2024-12-05 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system for the transdermal administration of tizanidine
CN116370439A (zh) * 2022-04-01 2023-07-04 江苏山信药业有限公司 一种伐尼克兰透皮贴剂及其制备方法和其应用

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61172830A (ja) * 1985-01-26 1986-08-04 Showa Denko Kk 皮膚外用剤組成物
WO2001007018A1 (fr) * 1999-07-27 2001-02-01 Hisamitsu Pharmaceutical Co., Inc. Bandes adhesives a usage externe
JP2007008871A (ja) * 2005-06-30 2007-01-18 Teikoku Seiyaku Co Ltd 経皮吸収促進組成物
CN101143127A (zh) * 2007-10-25 2008-03-19 复旦大学 一种酚妥拉明外用制剂及其制备方法
RU2334507C2 (ru) * 2004-03-19 2008-09-27 Макнейл Аб Средство для чрескожного введения никотина
JP2009529011A (ja) * 2006-03-06 2009-08-13 重▲慶▼医葯工▲業▼研究院有限責任公司 神経系疾患の予防又は治療のためのラサギリンの経皮吸収貼付剤、及びその調製方法
WO2011027786A1 (ja) * 2009-09-07 2011-03-10 ニプロパッチ株式会社 経皮吸収型製剤
JP2012158521A (ja) * 2009-04-17 2012-08-23 Kureha Corp 外用剤
JP2013528632A (ja) * 2010-06-18 2013-07-11 メルツ ファーマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディト ゲゼルシャフト アウフ アクティーン １−アミノ−アルキルシクロヘキサン誘導体の局所用途のためのゲル製剤

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040142024A1 (en) 1999-07-27 2004-07-22 Hisamitsu Pharmaceutical Co., Inc. Patch formulation for external use
AU2008327436B2 (en) * 2007-11-22 2013-09-05 Medrx Co., Ltd. External preparation composition comprising fatty acid-based ionic liquid as active ingredient
EP2255809B1 (en) * 2008-02-27 2017-08-23 Hisamitsu Pharmaceutical Co., Inc. Medicated patch
EP2311498A4 (en) 2008-08-05 2013-07-24 Medrx Co Ltd EXTERNAL PREPARATION COMPRISING A FATTY ACID SALT OR A BENZOIC ACID SALT OF A PHARMACOLOGICALLY ACTIVE BASIC COMPONENT, AND PROCESS FOR PRODUCTION THEREOF
HUE045479T2 (hu) * 2012-06-20 2019-12-30 Medrx Co Ltd Tapadó preparátum készítmény, amely elõállítható gyógyszerhatóanyag, szerves oldószer, lipofil kenõcsalap és por összekeverésével
JP2014125483A (ja) 2012-12-27 2014-07-07 Lion Corp 貼付剤
CN107427509B (zh) * 2015-08-29 2021-06-15 美德阿利克斯株式会社 含有碱性药物和山梨酸的经皮吸收组成物

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61172830A (ja) * 1985-01-26 1986-08-04 Showa Denko Kk 皮膚外用剤組成物
WO2001007018A1 (fr) * 1999-07-27 2001-02-01 Hisamitsu Pharmaceutical Co., Inc. Bandes adhesives a usage externe
RU2334507C2 (ru) * 2004-03-19 2008-09-27 Макнейл Аб Средство для чрескожного введения никотина
JP2007008871A (ja) * 2005-06-30 2007-01-18 Teikoku Seiyaku Co Ltd 経皮吸収促進組成物
JP2009529011A (ja) * 2006-03-06 2009-08-13 重▲慶▼医葯工▲業▼研究院有限責任公司 神経系疾患の予防又は治療のためのラサギリンの経皮吸収貼付剤、及びその調製方法
CN101143127A (zh) * 2007-10-25 2008-03-19 复旦大学 一种酚妥拉明外用制剂及其制备方法
JP2012158521A (ja) * 2009-04-17 2012-08-23 Kureha Corp 外用剤
WO2011027786A1 (ja) * 2009-09-07 2011-03-10 ニプロパッチ株式会社 経皮吸収型製剤
JP2013528632A (ja) * 2010-06-18 2013-07-11 メルツ ファーマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディト ゲゼルシャフト アウフ アクティーン １−アミノ−アルキルシクロヘキサン誘導体の局所用途のためのゲル製剤

Also Published As

Publication number Publication date
BR112018001387A2 (pt) 2018-09-11
SG11201800043UA (en) 2018-02-27
EP3342423B1 (en) 2021-03-10
US20180236082A1 (en) 2018-08-23
EP3342423A4 (en) 2018-07-25
PH12018500271A1 (en) 2018-08-13
BR112018001387B1 (pt) 2023-09-05
US20200171156A1 (en) 2020-06-04
ZA201800296B (en) 2019-04-24
US20170056502A1 (en) 2017-03-02
KR20180039622A (ko) 2018-04-18
JPWO2017038767A1 (ja) 2017-09-07
CN107427509A (zh) 2017-12-01
MX388148B (es) 2025-03-19
CO2018001831A2 (es) 2018-05-21
BR112018001387B8 (pt) 2024-03-05
ES2864017T3 (es) 2021-10-13
EP3342423A1 (en) 2018-07-04
WO2017038767A1 (ja) 2017-03-09
US9974858B2 (en) 2018-05-22
MY189987A (en) 2022-03-22
US10588973B2 (en) 2020-03-17
US11382978B2 (en) 2022-07-12
WO2017037813A1 (ja) 2017-03-09
UA123212C2 (uk) 2021-03-03
MX2018002015A (es) 2018-06-19
JP2017149782A (ja) 2017-08-31
RU2018110617A (ru) 2019-09-30
JP6259117B2 (ja) 2018-01-10
RU2018110617A3 (https=) 2019-09-30
CN107427509B (zh) 2021-06-15

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