RU2648999C2 - Способы повышения эффективности этапов очистки белка, находящихся ниже по потоку, с использованием мембранной ионообменной хроматографии - Google Patents
Способы повышения эффективности этапов очистки белка, находящихся ниже по потоку, с использованием мембранной ионообменной хроматографии Download PDFInfo
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
- B01D15/361—Ion-exchange
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/165—Extraction; Separation; Purification by chromatography mixed-mode chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
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- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
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- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Manufacture Of Macromolecular Shaped Articles (AREA)
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| US201161579285P | 2011-12-22 | 2011-12-22 | |
| US61/579,285 | 2011-12-22 | ||
| PCT/US2012/070373 WO2013096322A1 (en) | 2011-12-22 | 2012-12-18 | Ion exchange membrane chromatography |
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| RU2014130017A RU2014130017A (ru) | 2016-02-10 |
| RU2648999C2 true RU2648999C2 (ru) | 2018-03-29 |
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| RU2014130017A RU2648999C2 (ru) | 2011-12-22 | 2012-12-18 | Способы повышения эффективности этапов очистки белка, находящихся ниже по потоку, с использованием мембранной ионообменной хроматографии |
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| RU2782457C2 (ru) * | 2018-07-06 | 2022-10-27 | Бэджер Лайсенсинг Ллс | Обработка остаточных потоков от производства бисфенолов |
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| RU2648999C2 (ru) * | 2011-12-22 | 2018-03-29 | Дженентек, Инк. | Способы повышения эффективности этапов очистки белка, находящихся ниже по потоку, с использованием мембранной ионообменной хроматографии |
| WO2015088677A1 (en) | 2013-12-12 | 2015-06-18 | Emd Millipore Corporation | Protein separations using an acrylamide containing filter |
| CN106029682B (zh) * | 2013-12-27 | 2021-04-13 | 中外制药株式会社 | 等电点低的抗体的纯化方法 |
| CN104693303B (zh) * | 2015-02-28 | 2018-03-13 | 苏州金盟生物技术有限公司 | 一种蛋白制品中的核酸去除方法 |
| WO2017027861A1 (en) | 2015-08-13 | 2017-02-16 | Amgen Inc. | Charged depth filtration of antigen-binding proteins |
| GB201711481D0 (en) | 2017-07-17 | 2017-08-30 | Ucb Biopharma Sprl | Protein purification |
| EP3546475A1 (en) * | 2018-03-27 | 2019-10-02 | Sanofi | Full flow-through process for purifying recombinant proteins |
| US10792618B2 (en) | 2018-06-19 | 2020-10-06 | Sartorius Stedim Biotech Gmbh | Particle separation and/or purification of a fluid |
| KR102140531B1 (ko) * | 2018-08-07 | 2020-08-04 | (주)휴온스 | Gly-Tβ4의 제조방법 |
| GB201815405D0 (en) * | 2018-09-21 | 2018-11-07 | Fujifilm Mfg Europe Bv | Membranes suitable for detecting, filtering and/or purifying biomolecules |
| US12306152B2 (en) | 2018-12-21 | 2025-05-20 | Solventum Intellectual Properties Company | Method for testing a chromatography device used for ion exchange |
| AR119264A1 (es) * | 2019-06-05 | 2021-12-09 | Genentech Inc | Método para reutilización de cromatografía |
| MX2022009134A (es) * | 2020-01-24 | 2022-10-21 | Alkermes Pharma Ireland Ltd | Metodos de purificacion. |
| US11416468B2 (en) * | 2020-07-21 | 2022-08-16 | International Business Machines Corporation | Active-active system index management |
| CN116371011B (zh) * | 2023-05-26 | 2023-08-18 | 湖南杰萃生物技术有限公司 | 一种从桑叶中提取黄酮和生物碱的方法 |
| CN117866038B (zh) * | 2024-03-11 | 2024-05-28 | 北京百力格生物科技有限公司 | 纯化含有宿主核酸的带亲和标签的酸性蛋白的方法 |
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2022
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- 2024-03-01 US US18/593,665 patent/US20240247027A1/en active Pending
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| RU2145873C1 (ru) * | 1993-09-21 | 2000-02-27 | Хемосол Инк. | Способ очистки гемоглобина в коммерческом масштабе |
| WO2009135656A1 (en) * | 2008-05-06 | 2009-11-12 | Lonza Biologics Plc. | A method for the purification of antibodies using displacement chromatography |
| WO2010019148A1 (en) * | 2008-08-14 | 2010-02-18 | Genentech, Inc. | Methods for removing a contaminant using indigenous protein displacement ion exchange membrane chromatography |
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| RU2782457C2 (ru) * | 2018-07-06 | 2022-10-27 | Бэджер Лайсенсинг Ллс | Обработка остаточных потоков от производства бисфенолов |
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