RU2645344C2 - Производные пиразола и их применение в качестве lpar5 антагонистов - Google Patents
Производные пиразола и их применение в качестве lpar5 антагонистов Download PDFInfo
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- RU2645344C2 RU2645344C2 RU2014151360A RU2014151360A RU2645344C2 RU 2645344 C2 RU2645344 C2 RU 2645344C2 RU 2014151360 A RU2014151360 A RU 2014151360A RU 2014151360 A RU2014151360 A RU 2014151360A RU 2645344 C2 RU2645344 C2 RU 2645344C2
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- Prior art keywords
- alkyl
- group
- methyl
- pyrazol
- substituted
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Classifications
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P37/00—Drugs for immunological or allergic disorders
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12305552.7 | 2012-05-18 | ||
| EP12305552 | 2012-05-18 | ||
| PCT/EP2013/060171 WO2013171317A1 (en) | 2012-05-18 | 2013-05-16 | Pyrazole derivatives and their use as lpar5 antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2014151360A RU2014151360A (ru) | 2016-07-10 |
| RU2645344C2 true RU2645344C2 (ru) | 2018-02-21 |
Family
ID=48446368
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2014151360A RU2645344C2 (ru) | 2012-05-18 | 2013-05-16 | Производные пиразола и их применение в качестве lpar5 антагонистов |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US9346762B2 (https=) |
| EP (1) | EP2882715B1 (https=) |
| JP (1) | JP6257596B2 (https=) |
| KR (1) | KR20150010973A (https=) |
| CN (1) | CN104302625B (https=) |
| AU (1) | AU2013261718B2 (https=) |
| BR (1) | BR112014028406A2 (https=) |
| CA (1) | CA2871542A1 (https=) |
| CY (1) | CY1118618T1 (https=) |
| DK (1) | DK2882715T3 (https=) |
| ES (1) | ES2612205T3 (https=) |
| HR (1) | HRP20170098T1 (https=) |
| HU (1) | HUE032890T2 (https=) |
| IL (1) | IL235221A (https=) |
| LT (1) | LT2882715T (https=) |
| MX (1) | MX347615B (https=) |
| PL (1) | PL2882715T3 (https=) |
| PT (1) | PT2882715T (https=) |
| RU (1) | RU2645344C2 (https=) |
| SG (1) | SG11201407210SA (https=) |
| SI (1) | SI2882715T1 (https=) |
| WO (1) | WO2013171317A1 (https=) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| EP2850062B1 (en) | 2012-05-18 | 2017-07-19 | Sanofi | Pyridine derivatives and their use in the treatment of conditions associated with pathological thrombus formation |
| BR112017026535B1 (pt) | 2015-06-12 | 2023-12-19 | Vettore, LLC | Composto e composição farmacêutica |
| WO2018111904A1 (en) | 2016-12-12 | 2018-06-21 | Vettore, LLC | Heterocyclic inhibitors of mct4 |
| PL4038052T3 (pl) | 2019-10-02 | 2024-08-26 | Domain Therapeutics | Antagoniści receptora ep4 prostaglandyny e2 (pge2) |
| WO2024092205A1 (en) * | 2022-10-27 | 2024-05-02 | The Trustees Of Indiana University | Inhibition of ship1 as a therapeutic strategy for the treatment of alzheimer's disease |
| CN119930520B (zh) * | 2023-11-03 | 2026-03-06 | 中国药科大学 | N-芳基吡唑类化合物及其药物组合物和应用 |
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| JP5509100B2 (ja) | 2008-03-07 | 2014-06-04 | アジェンデ・キミケ・リウニテ・アンジェリニ・フランチェスコ・ア・チ・エレ・ア・エフェ・ソシエタ・ペル・アチオニ | 新規な１−ベンジル−３−ヒドロキシメチルインダゾール誘導体及びそのＭＣＰ−１，ＣＸ３ＣＲ１及びｐ４０の発現に基づく疾病の治療への使用 |
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| EP2850062B1 (en) | 2012-05-18 | 2017-07-19 | Sanofi | Pyridine derivatives and their use in the treatment of conditions associated with pathological thrombus formation |
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Also Published As
| Publication number | Publication date |
|---|---|
| SI2882715T1 (sl) | 2017-03-31 |
| EP2882715A1 (en) | 2015-06-17 |
| SG11201407210SA (en) | 2014-12-30 |
| US9346762B2 (en) | 2016-05-24 |
| JP6257596B2 (ja) | 2018-01-10 |
| DK2882715T3 (en) | 2017-02-13 |
| CA2871542A1 (en) | 2013-11-21 |
| AU2013261718A1 (en) | 2014-12-18 |
| KR20150010973A (ko) | 2015-01-29 |
| RU2014151360A (ru) | 2016-07-10 |
| CN104302625B (zh) | 2017-04-19 |
| US20150141477A1 (en) | 2015-05-21 |
| CN104302625A (zh) | 2015-01-21 |
| PL2882715T3 (pl) | 2017-04-28 |
| CY1118618T1 (el) | 2017-07-12 |
| MX2014014011A (es) | 2015-02-12 |
| HUE032890T2 (hu) | 2017-11-28 |
| IL235221A (en) | 2016-06-30 |
| BR112014028406A2 (pt) | 2017-06-27 |
| WO2013171317A1 (en) | 2013-11-21 |
| JP2015517514A (ja) | 2015-06-22 |
| ES2612205T3 (es) | 2017-05-12 |
| LT2882715T (lt) | 2017-02-10 |
| PT2882715T (pt) | 2016-12-30 |
| EP2882715B1 (en) | 2016-11-09 |
| HRP20170098T1 (hr) | 2017-03-24 |
| MX347615B (es) | 2017-05-04 |
| AU2013261718B2 (en) | 2017-10-19 |
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