AU2013261718B2 - Pyrazole derivatives and their use as LPAR5 antagonists - Google Patents
Pyrazole derivatives and their use as LPAR5 antagonists Download PDFInfo
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- AU2013261718B2 AU2013261718B2 AU2013261718A AU2013261718A AU2013261718B2 AU 2013261718 B2 AU2013261718 B2 AU 2013261718B2 AU 2013261718 A AU2013261718 A AU 2013261718A AU 2013261718 A AU2013261718 A AU 2013261718A AU 2013261718 B2 AU2013261718 B2 AU 2013261718B2
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- alkyl
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- cycloalkyl
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- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
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- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
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- Organic Chemistry (AREA)
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- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12305552.7 | 2012-05-18 | ||
| EP12305552 | 2012-05-18 | ||
| PCT/EP2013/060171 WO2013171317A1 (en) | 2012-05-18 | 2013-05-16 | Pyrazole derivatives and their use as lpar5 antagonists |
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| AU2013261718A1 AU2013261718A1 (en) | 2014-12-18 |
| AU2013261718B2 true AU2013261718B2 (en) | 2017-10-19 |
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| CN (1) | CN104302625B (https=) |
| AU (1) | AU2013261718B2 (https=) |
| BR (1) | BR112014028406A2 (https=) |
| CA (1) | CA2871542A1 (https=) |
| CY (1) | CY1118618T1 (https=) |
| DK (1) | DK2882715T3 (https=) |
| ES (1) | ES2612205T3 (https=) |
| HR (1) | HRP20170098T1 (https=) |
| HU (1) | HUE032890T2 (https=) |
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| SG (1) | SG11201407210SA (https=) |
| SI (1) | SI2882715T1 (https=) |
| WO (1) | WO2013171317A1 (https=) |
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| EP2850062B1 (en) | 2012-05-18 | 2017-07-19 | Sanofi | Pyridine derivatives and their use in the treatment of conditions associated with pathological thrombus formation |
| BR112017026535B1 (pt) | 2015-06-12 | 2023-12-19 | Vettore, LLC | Composto e composição farmacêutica |
| WO2018111904A1 (en) | 2016-12-12 | 2018-06-21 | Vettore, LLC | Heterocyclic inhibitors of mct4 |
| PL4038052T3 (pl) | 2019-10-02 | 2024-08-26 | Domain Therapeutics | Antagoniści receptora ep4 prostaglandyny e2 (pge2) |
| WO2024092205A1 (en) * | 2022-10-27 | 2024-05-02 | The Trustees Of Indiana University | Inhibition of ship1 as a therapeutic strategy for the treatment of alzheimer's disease |
| CN119930520B (zh) * | 2023-11-03 | 2026-03-06 | 中国药科大学 | N-芳基吡唑类化合物及其药物组合物和应用 |
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| EP2118066A1 (en) | 2007-02-09 | 2009-11-18 | Takeda Pharmaceutical Company Limited | Fused ring compounds as partial agonists of ppar-gamma |
| WO2009080227A2 (en) | 2007-12-26 | 2009-07-02 | Sanofi-Aventis | Pyrazole-carboxamide derivatives as p2y12 antagonists |
| JP5509100B2 (ja) | 2008-03-07 | 2014-06-04 | アジェンデ・キミケ・リウニテ・アンジェリニ・フランチェスコ・ア・チ・エレ・ア・エフェ・ソシエタ・ペル・アチオニ | 新規な１−ベンジル−３−ヒドロキシメチルインダゾール誘導体及びそのＭＣＰ−１，ＣＸ３ＣＲ１及びｐ４０の発現に基づく疾病の治療への使用 |
| EA019711B1 (ru) * | 2008-03-07 | 2014-05-30 | Ацьенде Кимике Рьюните Анджелини Франческо A.K.P.A.Ф. С.П.А. | ПРОИЗВОДНЫЕ 1-БЕНЗИЛ-3-ГИДРОКСИМЕТИЛИНДАЗОЛА, СОДЕРЖАЩАЯ ИХ ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ И ИХ ПРИМЕНЕНИЕ ПРИ ЛЕЧЕНИИ ЗАБОЛЕВАНИЙ, ОБУСЛОВЛЕННЫХ ЭКСПРЕССИЕЙ МСР-1, СХ3CR1 ИЛИ р40 |
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| EP2850062B1 (en) | 2012-05-18 | 2017-07-19 | Sanofi | Pyridine derivatives and their use in the treatment of conditions associated with pathological thrombus formation |
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2013
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- 2013-05-16 PL PL13723151T patent/PL2882715T3/pl unknown
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- 2013-05-16 CN CN201380025967.9A patent/CN104302625B/zh not_active Expired - Fee Related
- 2013-05-16 CA CA2871542A patent/CA2871542A1/en not_active Abandoned
- 2013-05-16 JP JP2015512072A patent/JP6257596B2/ja not_active Expired - Fee Related
- 2013-05-16 BR BR112014028406A patent/BR112014028406A2/pt not_active Application Discontinuation
- 2013-05-16 HR HRP20170098TT patent/HRP20170098T1/hr unknown
- 2013-05-16 AU AU2013261718A patent/AU2013261718B2/en not_active Ceased
- 2013-05-16 PT PT137231510T patent/PT2882715T/pt unknown
- 2013-05-16 MX MX2014014011A patent/MX347615B/es active IP Right Grant
- 2013-05-16 EP EP13723151.0A patent/EP2882715B1/en not_active Not-in-force
- 2013-05-16 SG SG11201407210SA patent/SG11201407210SA/en unknown
- 2013-05-16 SI SI201330499A patent/SI2882715T1/sl unknown
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- 2013-05-16 ES ES13723151.0T patent/ES2612205T3/es active Active
- 2013-05-16 RU RU2014151360A patent/RU2645344C2/ru not_active IP Right Cessation
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2014
- 2014-10-20 IL IL235221A patent/IL235221A/en active IP Right Grant
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2017
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Non-Patent Citations (6)
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| CAS Registry Accession Number: RN 1279828-94-2, Date Entered: 14/04/2011 * |
| CAS Registry Accession Number: RN 1279830-96-4, Date Entered: 14/04/2011 * |
| CAS Registry Accession Number: RN 1279831-82-1, Date Entered: 14/04/2011 * |
| CAS Registry Accession Number: RN 1279842-08-8, Date Entered: 14/04/2011 * |
| CAS Registry Accession Number: RN 1279845-01-0, Date Entered: 14/04/2011 * |
| CAS Registry Accession Number: RN 1279877-48-3, Date Entered: 24/04/2011 * |
Also Published As
| Publication number | Publication date |
|---|---|
| SI2882715T1 (sl) | 2017-03-31 |
| EP2882715A1 (en) | 2015-06-17 |
| SG11201407210SA (en) | 2014-12-30 |
| US9346762B2 (en) | 2016-05-24 |
| JP6257596B2 (ja) | 2018-01-10 |
| DK2882715T3 (en) | 2017-02-13 |
| CA2871542A1 (en) | 2013-11-21 |
| AU2013261718A1 (en) | 2014-12-18 |
| KR20150010973A (ko) | 2015-01-29 |
| RU2014151360A (ru) | 2016-07-10 |
| CN104302625B (zh) | 2017-04-19 |
| US20150141477A1 (en) | 2015-05-21 |
| CN104302625A (zh) | 2015-01-21 |
| PL2882715T3 (pl) | 2017-04-28 |
| CY1118618T1 (el) | 2017-07-12 |
| MX2014014011A (es) | 2015-02-12 |
| HUE032890T2 (hu) | 2017-11-28 |
| IL235221A (en) | 2016-06-30 |
| BR112014028406A2 (pt) | 2017-06-27 |
| WO2013171317A1 (en) | 2013-11-21 |
| JP2015517514A (ja) | 2015-06-22 |
| ES2612205T3 (es) | 2017-05-12 |
| RU2645344C2 (ru) | 2018-02-21 |
| LT2882715T (lt) | 2017-02-10 |
| PT2882715T (pt) | 2016-12-30 |
| EP2882715B1 (en) | 2016-11-09 |
| HRP20170098T1 (hr) | 2017-03-24 |
| MX347615B (es) | 2017-05-04 |
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