RU2639551C2 - Оптимизированные с помощью вычислительных средств антигены с широким спектром реактивности для вирусов гриппа h5n1 и h1n1 - Google Patents

Оптимизированные с помощью вычислительных средств антигены с широким спектром реактивности для вирусов гриппа h5n1 и h1n1 Download PDF

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RU2639551C2
RU2639551C2 RU2014142785A RU2014142785A RU2639551C2 RU 2639551 C2 RU2639551 C2 RU 2639551C2 RU 2014142785 A RU2014142785 A RU 2014142785A RU 2014142785 A RU2014142785 A RU 2014142785A RU 2639551 C2 RU2639551 C2 RU 2639551C2
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influenza virus
virus
vlp
protein
polypeptide
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RU2014142785A
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RU2014142785A (ru
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Тед М. РОСС
Кори Дж. КРЕВАР
Дональд М. КАРТЕР
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Юниверсити Оф Питтсбург - Оф Зе Коммонвэлс Систем Оф Хайе Эдьюкейшн
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A—HUMAN NECESSITIES
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    • A61K2039/55511—Organic adjuvants
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    • A—HUMAN NECESSITIES
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1018—Orthomyxoviridae, e.g. influenza virus
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
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    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
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    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12Q2600/00—Oligonucleotides characterized by their use
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    • G01N2333/08—RNA viruses
    • G01N2333/11—Orthomyxoviridae, e.g. influenza virus
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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RU2014142785A 2012-03-30 2013-03-12 Оптимизированные с помощью вычислительных средств антигены с широким спектром реактивности для вирусов гриппа h5n1 и h1n1 RU2639551C2 (ru)

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US201261617815P 2012-03-30 2012-03-30
US61/617,815 2012-03-30
PCT/US2013/030530 WO2013148164A1 (en) 2012-03-30 2013-03-12 Computationally optimized broadly reactive antigens for h5n1 and h1n1 influenza viruses

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RU2017141447A Division RU2017141447A (ru) 2012-03-30 2013-03-12 Рекомбинантные полипептиды гемагглютинина (ha) вируса гриппа, композиции, содержащие их, и способы вызова иммунного ответа в отношении вируса гриппа h1n1

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RU2014142785A RU2014142785A (ru) 2016-05-20
RU2639551C2 true RU2639551C2 (ru) 2017-12-21

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RU2014142785A RU2639551C2 (ru) 2012-03-30 2013-03-12 Оптимизированные с помощью вычислительных средств антигены с широким спектром реактивности для вирусов гриппа h5n1 и h1n1

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WO2012036993A1 (en) * 2010-09-14 2012-03-22 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Computationally optimized broadly reactive antigens for influenza
RU2612900C2 (ru) 2011-06-20 2017-03-13 Юниверсити Оф Питтсбург - Оф Зе Коммонвэлс Систем Оф Хайе Эдьюкейшн Антигены вируса гриппа h1n1 с широким спектром активности, оптимизированные с применением вычислительных средств
KR20150089005A (ko) * 2012-11-27 2015-08-04 유니버시티 오브 피츠버그 - 오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 H1n1에 대한 계산적으로 최적화되고 넓은 반응성의 항원
US20140286981A1 (en) * 2013-03-14 2014-09-25 Wisconsin Alumni Research Foundation Broadly reactive mosaic peptide for influenza vaccine
CN107530417A (zh) 2014-12-19 2018-01-02 俄勒冈健康与科学大学 H1n1流感的计算优化的广泛反应性抗原的协同共同给药
US10548965B2 (en) * 2014-12-19 2020-02-04 Oregon Health & Science University Synergistic co-administration of computationally optimized broadly reactive antigens for human and avian H5N1 influenza
WO2016196846A2 (en) * 2015-06-02 2016-12-08 Sanofi Pasteur Inc. Engineered influenza antigenic polypeptides and immunogenic compositions thereof
US10927151B2 (en) * 2015-06-09 2021-02-23 Sanofi Pasteur Inc. Methods of optimizing nucleotide sequences encoding engineered influenza proteins
WO2017053413A1 (en) * 2015-09-21 2017-03-30 Oregon Health & Science University Vaccines intelligently produced by epitope recombination (viper) for influenza
AU2017272344B2 (en) 2016-06-02 2022-03-03 Sanofi Pasteur Inc. Engineered influenza antigenic polypeptides and immunogenic compositions thereof
EP3464327A1 (en) * 2016-06-03 2019-04-10 Sanofi Pasteur Inc. Modification of engineered influenza hemagglutinin polypeptides
EP3773709A4 (en) * 2018-03-28 2021-12-29 Sanofi Pasteur Inc. Methods of generating broadly protective vaccine compositions comprising neuraminidase
CN112189019B (zh) * 2018-03-28 2024-10-25 圣诺菲·帕斯图尔公司 产生包含血凝素的广泛保护性疫苗组合物的方法
EP3773703A1 (en) 2018-04-03 2021-02-17 Sanofi Antigenic influenza-ferritin polypeptides
CN112512564A (zh) 2018-04-03 2021-03-16 赛诺菲 铁蛋白蛋白
MX2021005257A (es) 2018-11-06 2021-06-18 Boehringer Ingelheim Vetmedica Gmbh Composicion inmunogenica contra el subtipo h5 del virus de la influenza aviar.

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KR20150089005A (ko) 2012-11-27 2015-08-04 유니버시티 오브 피츠버그 - 오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 H1n1에 대한 계산적으로 최적화되고 넓은 반응성의 항원

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RU97121580A (ru) * 1995-05-26 1999-10-27 Эм Джи-Пи эм Си, Л.Л.Си. Способ получения гемагглютининовых поливалентных вакцин против гриппа
US20090060949A1 (en) * 2007-01-23 2009-03-05 Ho David D Flu vaccines and methods of use thereof
US7981428B2 (en) * 2008-01-23 2011-07-19 Academia Sinica Flu vaccines and methods of use thereof
WO2010036948A2 (en) * 2008-09-26 2010-04-01 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Dna prime/inactivated vaccine boost immunization to influenza virus

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US20160279226A1 (en) 2016-09-29
MY166953A (en) 2018-07-25
US9212207B2 (en) 2015-12-15
KR20150004800A (ko) 2015-01-13
AU2013240365B2 (en) 2017-03-30
WO2013148164A1 (en) 2013-10-03
HK1203522A1 (en) 2015-10-30
JP2015513902A (ja) 2015-05-18
AU2013240365A1 (en) 2014-10-23
CA2868330A1 (en) 2013-10-03
SG11201406153XA (en) 2014-10-30
MX2014011387A (es) 2014-10-14
US9555095B2 (en) 2017-01-31
EP2831094A4 (en) 2015-10-14
CN104395336B (zh) 2018-01-23
RU2017141447A (ru) 2019-02-13
RU2014142785A (ru) 2016-05-20
EP2831094A1 (en) 2015-02-04
BR112014023900A2 (pt) 2020-11-24
EP2831094B1 (en) 2018-06-13
CN104395336A (zh) 2015-03-04
US20150017196A1 (en) 2015-01-15
IN2014DN07399A (enExample) 2015-04-24
MX345150B (es) 2017-01-18

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