JP2015513902A - 計算で最適化した広い反応性を示す、h5n1およびh1n1インフルエンザウイルスの抗原 - Google Patents
計算で最適化した広い反応性を示す、h5n1およびh1n1インフルエンザウイルスの抗原 Download PDFInfo
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- JP2015513902A JP2015513902A JP2015503258A JP2015503258A JP2015513902A JP 2015513902 A JP2015513902 A JP 2015513902A JP 2015503258 A JP2015503258 A JP 2015503258A JP 2015503258 A JP2015503258 A JP 2015503258A JP 2015513902 A JP2015513902 A JP 2015513902A
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- A—HUMAN NECESSITIES
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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- A—HUMAN NECESSITIES
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
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- A61K2039/55505—Inorganic adjuvants
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
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- C—CHEMISTRY; METALLURGY
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1018—Orthomyxoviridae, e.g. influenza virus
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/08—RNA viruses
- G01N2333/11—Orthomyxoviridae, e.g. influenza virus
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
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- Virology (AREA)
- General Health & Medical Sciences (AREA)
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- Medicinal Chemistry (AREA)
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- Pharmacology & Pharmacy (AREA)
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- Microbiology (AREA)
- Biophysics (AREA)
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- Mycology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261617815P | 2012-03-30 | 2012-03-30 | |
| US61/617,815 | 2012-03-30 | ||
| PCT/US2013/030530 WO2013148164A1 (en) | 2012-03-30 | 2013-03-12 | Computationally optimized broadly reactive antigens for h5n1 and h1n1 influenza viruses |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2015513902A true JP2015513902A (ja) | 2015-05-18 |
Family
ID=49261015
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015503258A Pending JP2015513902A (ja) | 2012-03-30 | 2013-03-12 | 計算で最適化した広い反応性を示す、h5n1およびh1n1インフルエンザウイルスの抗原 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US9212207B2 (enExample) |
| EP (1) | EP2831094B1 (enExample) |
| JP (1) | JP2015513902A (enExample) |
| KR (1) | KR20150004800A (enExample) |
| CN (1) | CN104395336B (enExample) |
| AU (1) | AU2013240365B2 (enExample) |
| BR (1) | BR112014023900A2 (enExample) |
| CA (1) | CA2868330A1 (enExample) |
| HK (1) | HK1203522A1 (enExample) |
| IN (1) | IN2014DN07399A (enExample) |
| MX (1) | MX345150B (enExample) |
| MY (1) | MY166953A (enExample) |
| RU (2) | RU2017141447A (enExample) |
| SG (1) | SG11201406153XA (enExample) |
| WO (1) | WO2013148164A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2021519085A (ja) * | 2018-03-28 | 2021-08-10 | サノフィ パスツール インコーポレイテッド | ノイラミニダーゼを含む広範に防御的なワクチン組成物を生成する方法 |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8883171B2 (en) * | 2010-09-14 | 2014-11-11 | University of Pittsburgh—of the Commonwealth System of Higher Education | Computationally optimized broadly reactive antigens for influenza |
| EP2721158B1 (en) | 2011-06-20 | 2017-05-03 | University of Pittsburgh - Of the Commonwealth System of Higher Education | Computationally optimized broadly reactive antigens for h1n1 influenza |
| MX2015005056A (es) * | 2012-11-27 | 2015-07-23 | Univ Pittsburgh | Antigenos ampliamente reactivos computacionalmente optimizados para influenza h1n1. |
| US20140286981A1 (en) | 2013-03-14 | 2014-09-25 | Wisconsin Alumni Research Foundation | Broadly reactive mosaic peptide for influenza vaccine |
| CA2970163A1 (en) * | 2014-12-19 | 2016-06-23 | Oregon Health & Science University | Synergistic co-administration of computationally optimized broadly reactive antigens for human and avian h5n1 influenza |
| WO2016100922A1 (en) * | 2014-12-19 | 2016-06-23 | Oregon Health & Science University | Synergistic co-administration of computationally optimized broadly reactive antigens for h1n1 influenza |
| US10584148B2 (en) * | 2015-06-02 | 2020-03-10 | Sanofi Pasteur Inc. | Engineered influenza antigenic polypeptides and immunogenic compositions thereof |
| CN108290932A (zh) * | 2015-06-09 | 2018-07-17 | 圣诺菲·帕斯图尔公司 | 优化编码工程改造的流感蛋白的核苷酸序列的方法 |
| US20200237898A1 (en) * | 2015-09-21 | 2020-07-30 | Oregon Health & Science University | Vaccines intelligently produced by epitope recombination (viper) for influenza |
| EP3464328A1 (en) * | 2016-06-02 | 2019-04-10 | Sanofi Pasteur Inc. | Engineered influenza antigenic polypeptides and immunogenic compositions thereof |
| US11116832B2 (en) | 2016-06-03 | 2021-09-14 | Sanofi Pasteur Inc. | Modification of engineered influenza hemagglutinin polypeptides |
| CN112189019B (zh) * | 2018-03-28 | 2024-10-25 | 圣诺菲·帕斯图尔公司 | 产生包含血凝素的广泛保护性疫苗组合物的方法 |
| CN112512565A (zh) | 2018-04-03 | 2021-03-16 | 赛诺菲 | 抗原性流感-铁蛋白多肽 |
| EP3773698A1 (en) | 2018-04-03 | 2021-02-17 | Sanofi | Ferritin proteins |
| JP7337921B2 (ja) * | 2018-11-06 | 2023-09-04 | ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハー | 鳥インフルエンザウイルスh5亜型に対する免疫原性組成物 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011506272A (ja) * | 2007-11-12 | 2011-03-03 | ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルバニア | インフルエンザウイルスの複数のサブタイプに対する新規ワクチン |
| WO2012036993A1 (en) * | 2010-09-14 | 2012-03-22 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Computationally optimized broadly reactive antigens for influenza |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE376059T1 (de) | 2000-06-23 | 2007-11-15 | Wyeth Corp | Assemblierung von wildtyp und chimären influenzavirus-ähnlichen partikeln (vlps) |
| US20050181459A1 (en) | 2002-06-11 | 2005-08-18 | Matthew Baker | Method for mapping and eliminating T cell epitopes |
| US8592197B2 (en) | 2003-07-11 | 2013-11-26 | Novavax, Inc. | Functional influenza virus-like particles (VLPs) |
| EP1851238A4 (en) | 2005-02-24 | 2008-12-31 | Univ Massachusetts | FLUID NUCLEIC ACIDS, POLYPEPTIDES AND USES THEREOF |
| WO2007011904A2 (en) | 2005-07-19 | 2007-01-25 | Dow Global Technologies Inc. | Recombinant flu vaccines |
| WO2007072214A2 (en) | 2005-12-19 | 2007-06-28 | Novartis Vaccines And Diagnostics Srl | Methods of clustering gene and protein sequences |
| US20080045472A1 (en) | 2006-03-31 | 2008-02-21 | Council Of Scientific And Industrial Research Bharat Biotech | Targets for human micro rnas in avian influenza virus (h5n1) genome |
| HRP20130163T1 (hr) | 2006-09-07 | 2013-03-31 | Crucell Holland B.V. | Ljudske molekule za vezanje koje mogu neutralizirati virus influence h5n1 i njihova uporaba |
| TWI403518B (zh) * | 2007-01-23 | 2013-08-01 | Academia Sinica | 一種流感疫苗及其使用方法 |
| US8071561B2 (en) | 2007-08-16 | 2011-12-06 | Chrontech Pharma Ab | Immunogen platform |
| SG187500A1 (en) | 2008-01-21 | 2013-02-28 | Medicago Inc | Recombinant influenza virus-like particles (vlps) produced in transgenic plants expressing hemagglutinin |
| US7981428B2 (en) * | 2008-01-23 | 2011-07-19 | Academia Sinica | Flu vaccines and methods of use thereof |
| WO2010036970A2 (en) | 2008-09-25 | 2010-04-01 | Fraunhofer Usa, Inc. | Influenza vaccines, antigens, compositions, and methods |
| WO2010036948A2 (en) | 2008-09-26 | 2010-04-01 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Dna prime/inactivated vaccine boost immunization to influenza virus |
| KR101715418B1 (ko) | 2009-04-03 | 2017-03-10 | 메리얼 인코포레이티드 | 뉴캐슬 질환 바이러스-벡터를 이용한 조류 백신 |
| US8298820B2 (en) | 2010-01-26 | 2012-10-30 | The Trustees Of The University Of Pennsylvania | Influenza nucleic acid molecules and vaccines made therefrom |
| EP2721158B1 (en) | 2011-06-20 | 2017-05-03 | University of Pittsburgh - Of the Commonwealth System of Higher Education | Computationally optimized broadly reactive antigens for h1n1 influenza |
| AU2013217166B2 (en) * | 2012-02-07 | 2017-04-06 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Computationally optimized broadly reactive antigens for H3N2, H2N2, and B influenza viruses |
| US9566327B2 (en) | 2012-02-13 | 2017-02-14 | University of Pittsburgh—of the Commonwealth System of Higher Education | Computationally optimized broadly reactive antigens for human and avian H5N1 influenza |
| MX2015005056A (es) | 2012-11-27 | 2015-07-23 | Univ Pittsburgh | Antigenos ampliamente reactivos computacionalmente optimizados para influenza h1n1. |
-
2013
- 2013-03-12 IN IN7399DEN2014 patent/IN2014DN07399A/en unknown
- 2013-03-12 RU RU2017141447A patent/RU2017141447A/ru not_active Application Discontinuation
- 2013-03-12 MY MYPI2014002785A patent/MY166953A/en unknown
- 2013-03-12 CA CA2868330A patent/CA2868330A1/en not_active Abandoned
- 2013-03-12 JP JP2015503258A patent/JP2015513902A/ja active Pending
- 2013-03-12 EP EP13769077.2A patent/EP2831094B1/en not_active Not-in-force
- 2013-03-12 MX MX2014011387A patent/MX345150B/es active IP Right Grant
- 2013-03-12 WO PCT/US2013/030530 patent/WO2013148164A1/en not_active Ceased
- 2013-03-12 US US14/388,726 patent/US9212207B2/en active Active
- 2013-03-12 BR BR112014023900-2A patent/BR112014023900A2/pt not_active IP Right Cessation
- 2013-03-12 AU AU2013240365A patent/AU2013240365B2/en not_active Ceased
- 2013-03-12 CN CN201380027311.0A patent/CN104395336B/zh not_active Expired - Fee Related
- 2013-03-12 HK HK15104016.5A patent/HK1203522A1/xx unknown
- 2013-03-12 KR KR1020147027594A patent/KR20150004800A/ko not_active Withdrawn
- 2013-03-12 SG SG11201406153XA patent/SG11201406153XA/en unknown
- 2013-03-12 RU RU2014142785A patent/RU2639551C2/ru not_active IP Right Cessation
-
2015
- 2015-11-12 US US14/939,279 patent/US9555095B2/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011506272A (ja) * | 2007-11-12 | 2011-03-03 | ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルバニア | インフルエンザウイルスの複数のサブタイプに対する新規ワクチン |
| WO2012036993A1 (en) * | 2010-09-14 | 2012-03-22 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Computationally optimized broadly reactive antigens for influenza |
Non-Patent Citations (1)
| Title |
|---|
| THE JOURNAL OF INFECTIOUS DISEASES, vol. 205, JPN6016045951, 23 March 2012 (2012-03-23), pages 1562 - 1570, ISSN: 0003646441 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2021519085A (ja) * | 2018-03-28 | 2021-08-10 | サノフィ パスツール インコーポレイテッド | ノイラミニダーゼを含む広範に防御的なワクチン組成物を生成する方法 |
| JP7329530B2 (ja) | 2018-03-28 | 2023-08-18 | サノフィ パスツール インコーポレイテッド | ノイラミニダーゼを含む広範に防御的なワクチン組成物を生成する方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| HK1203522A1 (en) | 2015-10-30 |
| EP2831094B1 (en) | 2018-06-13 |
| US20150017196A1 (en) | 2015-01-15 |
| EP2831094A1 (en) | 2015-02-04 |
| CN104395336A (zh) | 2015-03-04 |
| EP2831094A4 (en) | 2015-10-14 |
| MX345150B (es) | 2017-01-18 |
| WO2013148164A1 (en) | 2013-10-03 |
| RU2017141447A (ru) | 2019-02-13 |
| AU2013240365B2 (en) | 2017-03-30 |
| US9555095B2 (en) | 2017-01-31 |
| MY166953A (en) | 2018-07-25 |
| RU2014142785A (ru) | 2016-05-20 |
| BR112014023900A2 (pt) | 2020-11-24 |
| CN104395336B (zh) | 2018-01-23 |
| US20160279226A1 (en) | 2016-09-29 |
| US9212207B2 (en) | 2015-12-15 |
| AU2013240365A1 (en) | 2014-10-23 |
| SG11201406153XA (en) | 2014-10-30 |
| IN2014DN07399A (enExample) | 2015-04-24 |
| RU2639551C2 (ru) | 2017-12-21 |
| MX2014011387A (es) | 2014-10-14 |
| KR20150004800A (ko) | 2015-01-13 |
| CA2868330A1 (en) | 2013-10-03 |
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