CN104395336B - 以计算方式优化的h5n1和h1n1流感病毒的广泛反应性抗原 - Google Patents
以计算方式优化的h5n1和h1n1流感病毒的广泛反应性抗原 Download PDFInfo
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- CN104395336B CN104395336B CN201380027311.0A CN201380027311A CN104395336B CN 104395336 B CN104395336 B CN 104395336B CN 201380027311 A CN201380027311 A CN 201380027311A CN 104395336 B CN104395336 B CN 104395336B
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
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- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
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- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1018—Orthomyxoviridae, e.g. influenza virus
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/08—RNA viruses
- G01N2333/11—Orthomyxoviridae, e.g. influenza virus
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
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- Chemical & Material Sciences (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
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- Pharmacology & Pharmacy (AREA)
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- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
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- Physics & Mathematics (AREA)
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- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261617815P | 2012-03-30 | 2012-03-30 | |
| US61/617,815 | 2012-03-30 | ||
| PCT/US2013/030530 WO2013148164A1 (en) | 2012-03-30 | 2013-03-12 | Computationally optimized broadly reactive antigens for h5n1 and h1n1 influenza viruses |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104395336A CN104395336A (zh) | 2015-03-04 |
| CN104395336B true CN104395336B (zh) | 2018-01-23 |
Family
ID=49261015
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380027311.0A Expired - Fee Related CN104395336B (zh) | 2012-03-30 | 2013-03-12 | 以计算方式优化的h5n1和h1n1流感病毒的广泛反应性抗原 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US9212207B2 (enExample) |
| EP (1) | EP2831094B1 (enExample) |
| JP (1) | JP2015513902A (enExample) |
| KR (1) | KR20150004800A (enExample) |
| CN (1) | CN104395336B (enExample) |
| AU (1) | AU2013240365B2 (enExample) |
| BR (1) | BR112014023900A2 (enExample) |
| CA (1) | CA2868330A1 (enExample) |
| HK (1) | HK1203522A1 (enExample) |
| IN (1) | IN2014DN07399A (enExample) |
| MX (1) | MX345150B (enExample) |
| MY (1) | MY166953A (enExample) |
| RU (2) | RU2639551C2 (enExample) |
| SG (1) | SG11201406153XA (enExample) |
| WO (1) | WO2013148164A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2011302360B2 (en) * | 2010-09-14 | 2015-01-29 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Computationally optimized broadly reactive antigens for influenza |
| JP6113155B2 (ja) | 2011-06-20 | 2017-04-12 | ユニバーシティ オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション | 計算で最適化した広い反応性を示すh1n1インフルエンザの抗原 |
| SG11201503989PA (en) * | 2012-11-27 | 2015-06-29 | Univ Pittsburgh | Computationally optimized broadly reactive antigens for h1n1 influenza |
| US20140286981A1 (en) * | 2013-03-14 | 2014-09-25 | Wisconsin Alumni Research Foundation | Broadly reactive mosaic peptide for influenza vaccine |
| CN107847579A (zh) * | 2014-12-19 | 2018-03-27 | 俄勒冈健康与科学大学 | 人和禽h5n1流感的计算优化的广泛反应性抗原的协同共同给药 |
| AU2015364253B2 (en) | 2014-12-19 | 2020-01-23 | Oregon Health & Science University | Synergistic co-administration of computationally optimized broadly reactive antigens for H1N1 influenza |
| CA2987939A1 (en) | 2015-06-02 | 2016-12-08 | Sanofi Pasteur Inc. | Engineered influenza antigenic polypeptides and immunogenic compositions thereof |
| CA2986701A1 (en) * | 2015-06-09 | 2016-12-15 | Sanofi Pasteur, Inc. | Methods of optimizing nucleotide sequences encoding engineered influenza proteins |
| US20200237898A1 (en) * | 2015-09-21 | 2020-07-30 | Oregon Health & Science University | Vaccines intelligently produced by epitope recombination (viper) for influenza |
| EP3464328A1 (en) * | 2016-06-02 | 2019-04-10 | Sanofi Pasteur Inc. | Engineered influenza antigenic polypeptides and immunogenic compositions thereof |
| KR102731582B1 (ko) | 2016-06-03 | 2024-11-15 | 사노피 파스퇴르 인코포레이티드 | 조작된 인플루엔자 헤마글루티닌 폴리펩티드의 변형 |
| CN112153981B (zh) * | 2018-03-28 | 2025-01-21 | 圣诺菲·帕斯图尔公司 | 产生包含神经氨酸酶的广泛保护性疫苗组合物的方法 |
| EP3774884B1 (en) * | 2018-03-28 | 2023-12-06 | Sanofi Pasteur Inc. | Methods of generating broadly protective vaccine compositions comprising hemagglutinin |
| EP3773703A1 (en) | 2018-04-03 | 2021-02-17 | Sanofi | Antigenic influenza-ferritin polypeptides |
| JP2021519596A (ja) | 2018-04-03 | 2021-08-12 | サノフイSanofi | フェリチンタンパク質 |
| CN113260378B (zh) | 2018-11-06 | 2024-06-07 | 勃林格殷格翰动物保健有限公司 | 针对禽流感病毒h5亚型的免疫原性组合物 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012036993A1 (en) * | 2010-09-14 | 2012-03-22 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Computationally optimized broadly reactive antigens for influenza |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1294892B1 (en) | 2000-06-23 | 2007-10-17 | Wyeth Holdings Corporation | Assembly of wild-type and chimeric influenza virus-like particles (vlps) |
| US20050181459A1 (en) | 2002-06-11 | 2005-08-18 | Matthew Baker | Method for mapping and eliminating T cell epitopes |
| US8592197B2 (en) | 2003-07-11 | 2013-11-26 | Novavax, Inc. | Functional influenza virus-like particles (VLPs) |
| CN101163714A (zh) | 2005-02-24 | 2008-04-16 | 马萨诸塞大学 | 流感病毒核酸、多肽及其用途 |
| MX2008000890A (es) | 2005-07-19 | 2008-03-18 | Dow Global Technologies Inc | Vacunas de influenza (flu) recombinantes. |
| WO2007072214A2 (en) | 2005-12-19 | 2007-06-28 | Novartis Vaccines And Diagnostics Srl | Methods of clustering gene and protein sequences |
| US20080045472A1 (en) | 2006-03-31 | 2008-02-21 | Council Of Scientific And Industrial Research Bharat Biotech | Targets for human micro rnas in avian influenza virus (h5n1) genome |
| MY170607A (en) | 2006-09-07 | 2019-08-20 | Crucell Holland Bv | Human binding molecules capable of neutralizing influenza virus h5n1 and uses thereof |
| WO2008091657A1 (en) * | 2007-01-23 | 2008-07-31 | Academia Sinica | Flu vaccines and methods of use thereof |
| EP2185195A2 (en) | 2007-08-16 | 2010-05-19 | Tripep Ab | Immunogen platform |
| AU2008331673B2 (en) | 2007-11-12 | 2014-12-11 | The Trustees Of The University Of Pennsylvania | Novel vaccines against multiple subtypes of influenza virus |
| KR101956910B1 (ko) | 2008-01-21 | 2019-03-12 | 메디카고 인코포레이티드 | 헤마글루티닌을 발현하는 트랜스제닉 식물에서 생산된 재조합 인플루엔자 바이러스-유사 입자(VLPs) |
| US7981428B2 (en) * | 2008-01-23 | 2011-07-19 | Academia Sinica | Flu vaccines and methods of use thereof |
| WO2010036970A2 (en) | 2008-09-25 | 2010-04-01 | Fraunhofer Usa, Inc. | Influenza vaccines, antigens, compositions, and methods |
| US20110177122A1 (en) * | 2008-09-26 | 2011-07-21 | The United States Of America, As Represented By The Secretary, Dept. Of Health & Human Services | Dna prime/activated vaccine boost immunization to influenza virus |
| JP5797636B2 (ja) | 2009-04-03 | 2015-10-21 | メリアル リミテッド | ニューカッスル病ウイルスをベクターとするトリワクチン |
| US8298820B2 (en) | 2010-01-26 | 2012-10-30 | The Trustees Of The University Of Pennsylvania | Influenza nucleic acid molecules and vaccines made therefrom |
| JP6113155B2 (ja) * | 2011-06-20 | 2017-04-12 | ユニバーシティ オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション | 計算で最適化した広い反応性を示すh1n1インフルエンザの抗原 |
| RU2018113521A (ru) | 2012-02-07 | 2019-03-04 | Юниверсити Оф Питтсбург - Оф Зе Коммонвэлс Систем Оф Хайе Эдьюкейшн | Рекомбинантный полипептид гемагглютинин (ha) вируса гриппа для вызова иммунного ответа в отношении вирусов гриппа h2n2 или b |
| EP3305806B1 (en) | 2012-02-13 | 2020-08-26 | University of Pittsburgh - Of the Commonwealth System of Higher Education | Computationally optimized broadly reactive antigens for human and avian h5n1 influenza |
| SG11201503989PA (en) | 2012-11-27 | 2015-06-29 | Univ Pittsburgh | Computationally optimized broadly reactive antigens for h1n1 influenza |
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2013
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- 2013-03-12 BR BR112014023900-2A patent/BR112014023900A2/pt not_active IP Right Cessation
- 2013-03-12 HK HK15104016.5A patent/HK1203522A1/xx unknown
- 2013-03-12 WO PCT/US2013/030530 patent/WO2013148164A1/en not_active Ceased
- 2013-03-12 RU RU2017141447A patent/RU2017141447A/ru not_active Application Discontinuation
- 2013-03-12 IN IN7399DEN2014 patent/IN2014DN07399A/en unknown
- 2013-03-12 US US14/388,726 patent/US9212207B2/en active Active
- 2013-03-12 SG SG11201406153XA patent/SG11201406153XA/en unknown
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- 2013-03-12 CN CN201380027311.0A patent/CN104395336B/zh not_active Expired - Fee Related
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- 2013-03-12 MX MX2014011387A patent/MX345150B/es active IP Right Grant
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2015
- 2015-11-12 US US14/939,279 patent/US9555095B2/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012036993A1 (en) * | 2010-09-14 | 2012-03-22 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Computationally optimized broadly reactive antigens for influenza |
Non-Patent Citations (2)
| Title |
|---|
| Protection against Divergent Influenza H1N1 Virus by a Centralized Influenza Hemagglutinin;Eric A. Weaver et al;《PLoS ONE》;20110301;第6卷(第3期);e18314 * |
| 登录号ABD62843;D. Spiro et al;《GenBank数据库》;20071024;氨基酸序列 * |
Also Published As
| Publication number | Publication date |
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| JP2015513902A (ja) | 2015-05-18 |
| BR112014023900A2 (pt) | 2020-11-24 |
| CA2868330A1 (en) | 2013-10-03 |
| AU2013240365A1 (en) | 2014-10-23 |
| US9212207B2 (en) | 2015-12-15 |
| MX345150B (es) | 2017-01-18 |
| RU2017141447A (ru) | 2019-02-13 |
| AU2013240365B2 (en) | 2017-03-30 |
| US20150017196A1 (en) | 2015-01-15 |
| EP2831094A1 (en) | 2015-02-04 |
| RU2014142785A (ru) | 2016-05-20 |
| RU2639551C2 (ru) | 2017-12-21 |
| US9555095B2 (en) | 2017-01-31 |
| MY166953A (en) | 2018-07-25 |
| HK1203522A1 (en) | 2015-10-30 |
| IN2014DN07399A (enExample) | 2015-04-24 |
| WO2013148164A1 (en) | 2013-10-03 |
| EP2831094A4 (en) | 2015-10-14 |
| EP2831094B1 (en) | 2018-06-13 |
| SG11201406153XA (en) | 2014-10-30 |
| MX2014011387A (es) | 2014-10-14 |
| KR20150004800A (ko) | 2015-01-13 |
| US20160279226A1 (en) | 2016-09-29 |
| CN104395336A (zh) | 2015-03-04 |
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