RU2617678C2 - Пиразольное соединение и его применение в фармацевтике - Google Patents

Пиразольное соединение и его применение в фармацевтике Download PDF

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RU2617678C2
RU2617678C2 RU2014112048A RU2014112048A RU2617678C2 RU 2617678 C2 RU2617678 C2 RU 2617678C2 RU 2014112048 A RU2014112048 A RU 2014112048A RU 2014112048 A RU2014112048 A RU 2014112048A RU 2617678 C2 RU2617678 C2 RU 2617678C2
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group
compound
alkyl group
alkoxy
groups
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RU2014112048A
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RU2014112048A (ru
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Томоя МИУРА
Ёсукэ ОГОСИ
Кадзухито УЭЯМА
Дай МОТОДА
Тосихико ИВАЯМА
Койти СУДЗАВА
Хиронобу НАГАМОРИ
Хироси УЭНО
Акихико ТАКАХАСИ
Кадзуюки СУГИМОТО
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Джапан Тобакко Инк.
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
RU2014112048A 2011-08-31 2012-08-30 Пиразольное соединение и его применение в фармацевтике RU2617678C2 (ru)

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JP2011-188121 2011-08-31
JP2011188121 2011-08-31
US201161573433P 2011-09-06 2011-09-06
US61/573433 2011-09-06
PCT/JP2012/072066 WO2013031922A1 (ja) 2011-08-31 2012-08-30 ピラゾール化合物及びその医薬用途

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RU2014112048A RU2014112048A (ru) 2015-10-10
RU2617678C2 true RU2617678C2 (ru) 2017-04-26

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EP (4) EP3199533B1 (enExample)
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CN (1) CN103917535B (enExample)
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SI (1) SI3199533T1 (enExample)
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EP3497092A1 (de) 2016-08-11 2019-06-19 Bayer CropScience Aktiengesellschaft Substituierte pyrazolinylderivate, verfahren zu deren herstellung und ihre verwendung als herbizide und/oder pflanzenwachstumsregulatoren
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TWI805699B (zh) * 2018-03-01 2023-06-21 日商日本煙草產業股份有限公司 甲基內醯胺環化合物及其用途
TWI805727B (zh) * 2018-04-04 2023-06-21 日商日本煙草產業股份有限公司 經雜芳基取代之吡唑化合物及其醫藥用途
CN114585387B (zh) * 2019-09-04 2024-10-29 日本烟草产业株式会社 利用联用药物的糖尿病的治疗或预防方法
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RU2356906C2 (ru) * 2002-08-08 2009-05-27 Киссеи Фармасьютикал Ко., Лтд. Производные пиразола, лекарственные композиции, содержащие эти производные, их применение в медицине и промежуточные соединения для их получения
RU2370499C2 (ru) * 2004-06-11 2009-10-20 Санофи-Авентис Дойчланд Гмбх Новые фторгликозидные производные пиразолов, содержащее их лекарственное средство и их применение
US20090048256A1 (en) * 2005-10-21 2009-02-19 Yasunori Moritani Pyrazole Compounds Having Cannabinoid Receptor (CB1) Antagonizing Activity
JP2010222298A (ja) * 2009-03-24 2010-10-07 Shionogi & Co Ltd Ｎｐｙｙ５受容体拮抗作用を有するピロリドン誘導体

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JP2023087032A (ja) 2023-06-22
MX359825B (es) 2018-10-10
SG11201400244YA (en) 2014-10-30
SMT201900292T1 (it) 2019-07-11
BR112014004651A2 (pt) 2017-03-28
EP2784074A1 (en) 2014-10-01
CY1121631T1 (el) 2020-07-31
CN103917535B (zh) 2015-06-24
EP3199533B1 (en) 2019-02-27
PL3199533T3 (pl) 2019-09-30
TW201321372A (zh) 2013-06-01
IL230763A (en) 2016-10-31
CL2014000490A1 (es) 2014-08-22
NZ620977A (en) 2016-02-26
PE20142343A1 (es) 2015-01-29
CA2845127C (en) 2020-03-10
JP2020125348A (ja) 2020-08-20
IL230763A0 (en) 2014-03-31
ZA201401071B (en) 2016-10-26
US20130085132A1 (en) 2013-04-04
WO2013031922A1 (ja) 2013-03-07
KR101989203B1 (ko) 2019-06-13
JP6091811B2 (ja) 2017-03-08
AR123441A2 (es) 2022-11-30
HK1202290A1 (en) 2015-09-25
CO6890098A2 (es) 2014-03-10
EP2784074A4 (en) 2015-06-03
US20180346449A1 (en) 2018-12-06
KR20140062048A (ko) 2014-05-22
AR087701A1 (es) 2014-04-09
JP2025039641A (ja) 2025-03-21
JP2017082005A (ja) 2017-05-18
JP2018115216A (ja) 2018-07-26
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CA2845127A1 (en) 2013-03-07
US8846746B2 (en) 2014-09-30
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DK3199533T3 (da) 2019-05-20
US20200317644A1 (en) 2020-10-08
RU2014112048A (ru) 2015-10-10
MY172422A (en) 2019-11-25
TWI549949B (zh) 2016-09-21
EP3524599A1 (en) 2019-08-14
AU2012302723A1 (en) 2014-02-27
PH12014500444A1 (en) 2017-04-07
RS58870B1 (sr) 2019-08-30
AU2012302723B2 (en) 2016-08-11
MX2014002552A (es) 2014-04-25
JP2013063968A (ja) 2013-04-11
BR112014004651B1 (pt) 2021-08-31
CN103917535A (zh) 2014-07-09
US20150183763A1 (en) 2015-07-02
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EP4656638A2 (en) 2025-12-03
SI3199533T1 (sl) 2019-06-28

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