MX359825B - Compuesto pirazol y su uso farmaceutico. - Google Patents

Compuesto pirazol y su uso farmaceutico.

Info

Publication number
MX359825B
MX359825B MX2014002552A MX2014002552A MX359825B MX 359825 B MX359825 B MX 359825B MX 2014002552 A MX2014002552 A MX 2014002552A MX 2014002552 A MX2014002552 A MX 2014002552A MX 359825 B MX359825 B MX 359825B
Authority
MX
Mexico
Prior art keywords
medical purposes
pyrazole compound
formula
pyrazole
compound
Prior art date
Application number
MX2014002552A
Other languages
English (en)
Spanish (es)
Other versions
MX2014002552A (es
Inventor
Hiroshi Ueno
Kazuyuki Sugimoto
Kazuhito Ueyama
Yosuke Ogoshi
Dai Motoda
Tomoya Miura
Toshihiko Iwayama
Koichi Suzawa
Hironobu Nagamori
Akihiko Takahashi
Original Assignee
Japan Tobacco Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Tobacco Inc filed Critical Japan Tobacco Inc
Publication of MX2014002552A publication Critical patent/MX2014002552A/es
Publication of MX359825B publication Critical patent/MX359825B/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • A61K31/41551,2-Diazoles non condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41781,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10Laxatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
MX2014002552A 2011-08-31 2012-08-30 Compuesto pirazol y su uso farmaceutico. MX359825B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2011188121 2011-08-31
US201161573433P 2011-09-06 2011-09-06
PCT/JP2012/072066 WO2013031922A1 (ja) 2011-08-31 2012-08-30 ピラゾール化合物及びその医薬用途

Publications (2)

Publication Number Publication Date
MX2014002552A MX2014002552A (es) 2014-04-25
MX359825B true MX359825B (es) 2018-10-10

Family

ID=47756400

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014002552A MX359825B (es) 2011-08-31 2012-08-30 Compuesto pirazol y su uso farmaceutico.

Country Status (28)

Country Link
US (5) US8846746B2 (enExample)
EP (4) EP3199533B1 (enExample)
JP (6) JP6091811B2 (enExample)
KR (1) KR101989203B1 (enExample)
CN (1) CN103917535B (enExample)
AR (2) AR087701A1 (enExample)
AU (1) AU2012302723B2 (enExample)
BR (1) BR112014004651B1 (enExample)
CA (1) CA2845127C (enExample)
CL (1) CL2014000490A1 (enExample)
CO (1) CO6890098A2 (enExample)
CY (1) CY1121631T1 (enExample)
DK (1) DK3199533T3 (enExample)
HK (1) HK1202290A1 (enExample)
IL (1) IL230763A (enExample)
MX (1) MX359825B (enExample)
MY (1) MY172422A (enExample)
PE (1) PE20142343A1 (enExample)
PH (1) PH12014500444A1 (enExample)
PL (1) PL3199533T3 (enExample)
RS (1) RS58870B1 (enExample)
RU (1) RU2617678C2 (enExample)
SG (1) SG11201400244YA (enExample)
SI (1) SI3199533T1 (enExample)
SM (1) SMT201900292T1 (enExample)
TW (1) TWI549949B (enExample)
WO (1) WO2013031922A1 (enExample)
ZA (1) ZA201401071B (enExample)

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UA117092C2 (uk) 2011-09-06 2018-06-25 Байєр Інтеллектуал Проперті Гмбх Амінозаміщені імідазопіридазини
RU2602739C2 (ru) 2012-05-07 2016-11-20 Киссеи Фармасьютикал Ко., Лтд. Производное пиразола и его применение в медицинских целях
WO2014076162A1 (en) 2012-11-19 2014-05-22 Bayer Pharma Aktiengesellschaft Aminoimidazopyridazines
EP2952206B1 (en) * 2013-02-04 2018-10-24 Taisho Pharmaceutical Co., Ltd. Prophylactic or therapeutic drug for constipation
CN105358173B (zh) * 2013-05-08 2022-09-02 休斯敦系统大学 靶向癌症治疗的egfr-sglt1相互作用
CN105294703B (zh) * 2015-10-23 2018-01-23 西安近代化学研究所 3,7,10‑三氧代‑2,4,6,8,9,11‑六氮杂[3,3,3]螺桨烷的合成方法
JP2019526547A (ja) 2016-08-11 2019-09-19 バイエル・クロップサイエンス・アクチェンゲゼルシャフト 置換されているピラゾリニル誘導体、それらを製造する方法、並びに、除草剤及び/又は植物成長調節剤としてのそれらの使用
CN109563048B (zh) 2016-08-15 2022-05-06 拜耳农作物科学股份公司 用于制备3-氨基-1-(2,6-二取代的苯基)吡唑的方法
TWI805699B (zh) * 2018-03-01 2023-06-21 日商日本煙草產業股份有限公司 甲基內醯胺環化合物及其用途
AU2019249560B2 (en) 2018-04-04 2023-10-05 Japan Tobacco Inc. Heteroaryl-substituted pyrazole compound and medicinal use thereof
CA3151909A1 (en) * 2019-09-04 2021-03-11 Japan Tobacco Inc. Therapeutic or prophylactic method for diabetes using combination medicine
JP7760370B2 (ja) * 2019-09-04 2025-10-27 日本たばこ産業株式会社 慢性腎臓病の治療又は予防方法
MX2022011490A (es) * 2020-03-19 2022-10-07 Japan Tobacco Inc Tratamiento o metodo de prevencion de falla cardiaca cronica.

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Also Published As

Publication number Publication date
JP2018115216A (ja) 2018-07-26
HK1202290A1 (en) 2015-09-25
CY1121631T1 (el) 2020-07-31
PE20142343A1 (es) 2015-01-29
BR112014004651A2 (pt) 2017-03-28
US20130085132A1 (en) 2013-04-04
EP4656638A2 (en) 2025-12-03
CA2845127C (en) 2020-03-10
EP2784074A4 (en) 2015-06-03
JP2025039641A (ja) 2025-03-21
EP3199533A1 (en) 2017-08-02
RU2014112048A (ru) 2015-10-10
MY172422A (en) 2019-11-25
US20150183763A1 (en) 2015-07-02
WO2013031922A1 (ja) 2013-03-07
NZ620977A (en) 2016-02-26
DK3199533T3 (da) 2019-05-20
US8846746B2 (en) 2014-09-30
EP3199533B1 (en) 2019-02-27
AU2012302723A1 (en) 2014-02-27
SG11201400244YA (en) 2014-10-30
KR20140062048A (ko) 2014-05-22
AR087701A1 (es) 2014-04-09
ZA201401071B (en) 2016-10-26
KR101989203B1 (ko) 2019-06-13
JP2013063968A (ja) 2013-04-11
CN103917535B (zh) 2015-06-24
EP3524599A1 (en) 2019-08-14
JP2017082005A (ja) 2017-05-18
JP6091811B2 (ja) 2017-03-08
US20180346449A1 (en) 2018-12-06
CN103917535A (zh) 2014-07-09
JP2023087032A (ja) 2023-06-22
JP2020125348A (ja) 2020-08-20
BR112014004651B1 (pt) 2021-08-31
PL3199533T3 (pl) 2019-09-30
IL230763A0 (en) 2014-03-31
US20230348438A1 (en) 2023-11-02
MX2014002552A (es) 2014-04-25
CO6890098A2 (es) 2014-03-10
AU2012302723B2 (en) 2016-08-11
TWI549949B (zh) 2016-09-21
SI3199533T1 (sl) 2019-06-28
CA2845127A1 (en) 2013-03-07
IL230763A (en) 2016-10-31
EP2784074A1 (en) 2014-10-01
CL2014000490A1 (es) 2014-08-22
PH12014500444A1 (en) 2017-04-07
RS58870B1 (sr) 2019-08-30
US20200317644A1 (en) 2020-10-08
RU2617678C2 (ru) 2017-04-26
AR123441A2 (es) 2022-11-30
TW201321372A (zh) 2013-06-01
SMT201900292T1 (it) 2019-07-11

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