AR123441A2 - Compuesto de pirazol - Google Patents
Compuesto de pirazolInfo
- Publication number
- AR123441A2 AR123441A2 ARP210102479A ARP210102479A AR123441A2 AR 123441 A2 AR123441 A2 AR 123441A2 AR P210102479 A ARP210102479 A AR P210102479A AR P210102479 A ARP210102479 A AR P210102479A AR 123441 A2 AR123441 A2 AR 123441A2
- Authority
- AR
- Argentina
- Prior art keywords
- group
- saturated heterocycle
- alkyl
- membered
- represented
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Reivindicación 1: Un compuesto o una de sus sales farmacéuticamente aceptables representado por la fórmula general [1], caracterizado porque Anillo Cy es (1) arilo C₆₋₁₀, (2) cicloalquilo C₃₋₈ o (3) cicloalquenilo C₃₋₈, n1 es 0, 1, 2, 3, ó 4, R¹ᵃ está representado (1) un átomo de halógeno, (2) hidroxi, (3) carboxi, (4) un grupo alquilo C₁₋₆, (5) un grupo alquenilo C₂₋₈, (6) un grupo alquinilo C₂₋₈, (7) un grupo alcoxi C₁₋₆, (8) un grupo cicloalquilo C₃₋₆, (9) un grupo haloalquilo C₁₋₆, (10) un grupo hidroxialquilo C₁₋₆, (11) un grupo alcoxi C₁₋₆alquilo C₁₋₆, (12) un grupo haloalcoxi C₁₋₆alquilo C₁₋₆ (13) un grupo alquil C₁₋₆sulfonilalquilo C₁₋₆, (14) un grupo haloalquil C₁₋₆sulfonilalquilo C₁₋₆, (15) un grupo halodialquil C₁₋₆aminoalquilo C₁₋₆, (16) un grupo cicloalquil C₃₋₆alquinilo C₂₋₆, (17) un grupo haloalcoxi C₁₋₆, (18) un grupo carboxialcoxi C₁₋₆, (19) un grupo alquil C₁₋₆sulfanilo, (20) un grupo alquilsulfonilo C₁₋₆, (21) un grupo haloalquilsulfonilo C₁₋₆, (22) un grupo alquil C₁₋₈carbonilo, (23) un grupo alquil C₁₋₆oxicarbonilo, (24) un grupo representado por la fórmula [2], donde R⁵ es (a) un átomo de hidrógeno o (b) un grupo alquilo C₁₋₆, y R⁶ es (a) un grupo alquilo C₁₋₆ o (b) un grupo haloalquilo C₁₋₆, (25) un grupo alquilo C₆₋₁₀ de heterociclo saturado (el heterociclo saturado es un heterociclo saturado de 4 miembros a 6 miembros que tiene 1 a 2 heteroátomos seleccionados de nitrógeno, oxígeno, y azufre), o (26) un grupo oxialquilo C₁₋₆ de un heterociclo saturado (el heterociclo saturado es un heterociclo saturado de 4 miembros a 6 miembros que tiene 1 a 2 heteroátomos seleccionados de nitrógeno, oxígeno, y azufre), con la condición de que cuando n1 es 2, 3, ó 4, R¹ᵃ puede ser igual o diferente, R²ᵃ es (1) un grupo hidroxialquilo C₁₋₈, (2) un grupo cicloalquilo C₃₋₈alquilo C₁₋₆, (3) un grupo aril C₆₋₁₀, alquilo C₁₋₆, (4) un grupo alquilo C₆₋₁₀ de heterociclo saturado (el heterociclo saturado es un heterociclo saturado de 4 miembros a 6 miembros que tiene 1 a 2 heteroátomos seleccionados de nitrógeno, oxígeno, y azufre), (5) un grupo cicloalquilo C₃₋₈, (6) un grupo haloalquilo C₁₋₆, (7) un grupo alcoxi C₁₋₆alquilo C₁₋₆, (8) un grupo halocicloalquilo C₃₋₈, (9) un grupo arilo C₆₋₁₀ (el grupo arilo C₆₋₁₀ está opcionalmente sustituido con 1 a 4 sustituyentes seleccionados de (a) un átomo de halógeno, (b) hidroxi, (c) un grupo alquilo C₁₋₆, (d) un grupo alquenilo C₂₋₈, (e) un grupo alquinilo C₂₋₆, (f) un grupo alcoxi C₁₋₆, (g) un grupo haloalquilo C₁₋₆, (h) un grupo alcoxi C₁₋₆alquilo C₁₋₆, (i) un grupo haloalcoxi C₁₋₆, (j) un grupo hidroxialcoxi C₁₋₆, (k) un grupo alcoxi C₁₋₆alcoxi C₁₋₆, (l) un grupo carboxialcoxi C₁₋₆, (m) un grupo aril C₁₋₆alcoxi C₁₋₆, (n) un grupo alquil C₁₋₆sulfanilalcoxi C₁₋₆, (o) un grupo alquil C₁₋₆sulfonilalcoxi C₁₋₆, (p) un grupo aril C₆₋₁₀alcoxi C₁₋₆alcoxi C₁₋₆, (q) un grupo alcoxi C₁₋₆ del heterociclo saturado (el heterociclo saturado es un heterociclo saturado de 4 miembros a 6 miembros que tiene 1 a 2 heteroátomos seleccionados de nitrógeno, oxígeno, y azufre, y está opcionalmente sustituido con 1 a 2 grupos alquilo C₁₋₆), (r) un grupo heterociclo oxi saturado (el heterociclo saturado es un heterociclo saturado de 4 miembros a 6 miembros que tiene 1 a 2 heteroátomos seleccionados de nitrógeno, oxígeno, y azufre, (s) un grupo cicloalquil C₃₋₈oxi, (t) un grupo alcoxi C₁₋₆carboniloxi, y (u) un grupo alquilsulfonilo C₁₋₆), o (10) un grupo heterociclo saturado (el heterociclo saturado es un heterociclo saturado de 4 miembros a 6 miembros que tiene 1 a 2 heteroátomos seleccionados de nitrógeno, oxígeno, y azufre, y está opcionalmente sustituido con 1 a 4 grupos alquilo C₁₋₆), Anillo Cyᵃ es un grupo seleccionado de (1) un grupo representado por la fórmula [3], donde m2 es 1, 2 ó 3, m3 es 1, 2 ó 3, n3 es 1 ó 2, (2) un grupo representado por la fórmula [4], donde m4 es 0, 1, 2 ó 3, m5 es 0, 1 ó 2, siempre que la suma de m4 y m5 sea 1 o más, (3) un grupo representado por la fórmula [5], donde m4 es 0, 1, 2 ó 3, m5 es 0, 1 ó 2, siempre que la suma de m4 y m5 sea 1 o más, (4) un grupo representado por la fórmula [6], donde m6 es 0, 1 ó 2, m7 es 0, 1 ó 2, siempre que la suma de m6 y m7 es 1 o más, (5) un grupo representado por la fórmula [7], donde m6 es 0, 1 ó 2, m7 es 0, 1 ó 2, siempre que la suma de m6 y m7 es 1 o más, (6) un grupo representado por la fórmula [7], donde m8 es 1 ó 2, m9 es 1 ó 2, y (7) un grupo representado por la fórmula [9], donde m8 es 1 ó 2, m9 es 1 ó 2, n2 es 0, 1, 2, 3, ó 4, R³ᵃ es (1) hidroxi, (2) un grupo alquilo C₁₋₆ o (3) un grupo hidroxialquilo C₁₋₆, con la condición de que cuando n2 sea 2, 3, ó 4, R³ᵃ puede ser igual o diferente, R³ᵇ es (1) hidroxi, (2) un grupo alquilo C₁₋₆ (que puede formar un grupo cicloalquilo C₃₋₆ junto con el carbono al que está unido y el carbono adyacente a este) o (3) un grupo hidroxialquilo C₁₋₆, o (4) cuando dos R³ᵇ se unen al mismo carbono, forman un grupo cicloalquilo C₃₋₆ junto con el carbono al que están unidos, siempre que cuando n2 sea 2, 3 ó 4, cada R³ᵇ puede ser igual o diferente, y R⁴ᵇ es (1) un átomo de hidrógeno, (2) un grupo alquilo C₁₋₆, (3) un grupo carboxialquilo C₁₋₆, (4) un grupo haloalquilo C₁₋₆ o (5) un grupo alcoxi C₁₋₆alquilo C₁₋₆.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2011188121 | 2011-08-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR123441A2 true AR123441A2 (es) | 2022-11-30 |
Family
ID=47756400
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP120103173A AR087701A1 (es) | 2011-08-31 | 2012-08-28 | Derivados de pirazol con actividad inhibidora de sglt1 |
ARP210102479A AR123441A2 (es) | 2011-08-31 | 2021-09-06 | Compuesto de pirazol |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP120103173A AR087701A1 (es) | 2011-08-31 | 2012-08-28 | Derivados de pirazol con actividad inhibidora de sglt1 |
Country Status (26)
Country | Link |
---|---|
US (5) | US8846746B2 (es) |
EP (3) | EP2784074A4 (es) |
JP (5) | JP6091811B2 (es) |
KR (1) | KR101989203B1 (es) |
CN (1) | CN103917535B (es) |
AR (2) | AR087701A1 (es) |
AU (1) | AU2012302723B2 (es) |
BR (1) | BR112014004651B1 (es) |
CA (1) | CA2845127C (es) |
CL (1) | CL2014000490A1 (es) |
CO (1) | CO6890098A2 (es) |
CY (1) | CY1121631T1 (es) |
DK (1) | DK3199533T3 (es) |
HK (1) | HK1202290A1 (es) |
IL (1) | IL230763A (es) |
MX (1) | MX359825B (es) |
MY (1) | MY172422A (es) |
PE (1) | PE20142343A1 (es) |
PL (1) | PL3199533T3 (es) |
RS (1) | RS58870B1 (es) |
RU (1) | RU2617678C2 (es) |
SG (1) | SG11201400244YA (es) |
SI (1) | SI3199533T1 (es) |
TW (1) | TWI549949B (es) |
WO (1) | WO2013031922A1 (es) |
ZA (1) | ZA201401071B (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR087701A1 (es) * | 2011-08-31 | 2014-04-09 | Japan Tobacco Inc | Derivados de pirazol con actividad inhibidora de sglt1 |
UA117092C2 (uk) | 2011-09-06 | 2018-06-25 | Байєр Інтеллектуал Проперті Гмбх | Амінозаміщені імідазопіридазини |
WO2013168671A1 (ja) | 2012-05-07 | 2013-11-14 | キッセイ薬品工業株式会社 | ピラゾール誘導体及びその医薬用途 |
CA2891644A1 (en) | 2012-11-19 | 2014-05-22 | Bayer Pharma Aktiengesellschaft | Aminoimidazopyridazines |
JP5807767B2 (ja) * | 2013-02-04 | 2015-11-10 | 大正製薬株式会社 | 便秘症の予防又は治療薬 |
JP6309080B2 (ja) | 2013-05-08 | 2018-04-18 | ザ ユニバーシティ オブ ヒューストン システム | がん治療のためのegfr−sglt1相互作用の標的化 |
CN105294703B (zh) * | 2015-10-23 | 2018-01-23 | 西安近代化学研究所 | 3,7,10‑三氧代‑2,4,6,8,9,11‑六氮杂[3,3,3]螺桨烷的合成方法 |
WO2018029104A1 (de) | 2016-08-11 | 2018-02-15 | Bayer Cropscience Aktiengesellschaft | Substituierte pyrazolinylderivate, verfahren zu deren herstellung und ihre verwendung als herbizide und/oder pflanzenwachstumsregulatoren |
MX2019001813A (es) | 2016-08-15 | 2019-05-20 | Bayer Cropscience Ag | Procedimiento para la preparacion de pyrazoles de 3-amino-1-(2,6-disustituido-fenilo). |
TWI805699B (zh) * | 2018-03-01 | 2023-06-21 | 日商日本煙草產業股份有限公司 | 甲基內醯胺環化合物及其用途 |
CA3089092A1 (en) * | 2018-04-04 | 2019-10-10 | Japan Tobacco Inc. | Pyrazole compounds substituted with heteroaryl and pharmaceutical use thereof |
CA3151909A1 (en) | 2019-09-04 | 2021-03-11 | Japan Tobacco Inc. | Therapeutic or prophylactic method for diabetes using combination medicine |
CA3152939A1 (en) * | 2019-09-04 | 2021-03-11 | Japan Tobacco Inc. | Chronic kidney disease treatment or prevention method |
CN115209919A (zh) * | 2020-03-19 | 2022-10-18 | 日本烟草产业株式会社 | 慢性心衰的治疗或预防方法 |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2713225B1 (fr) | 1993-12-02 | 1996-03-01 | Sanofi Sa | N-pipéridino-3-pyrazolecarboxamide substitué. |
FR2692575B1 (fr) | 1992-06-23 | 1995-06-30 | Sanofi Elf | Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant. |
CA2383555C (en) * | 1999-08-12 | 2009-02-17 | Paolo Pevarello | 3(5)-amino-pyrazole derivatives, process for their preparation and their use as antitumor agents |
US6387900B1 (en) * | 1999-08-12 | 2002-05-14 | Pharmacia & Upjohn S.P.A. | 3(5)-ureido-pyrazole derivatives process for their preparation and their use as antitumor agents |
US8084467B2 (en) * | 1999-10-18 | 2011-12-27 | University Of Connecticut | Pyrazole derivatives as cannabinoid receptor antagonists |
US7375087B2 (en) * | 2002-08-08 | 2008-05-20 | Kissei Pharmaceutical Co., Ltd. | Pyrazole derivative, medicinal composition containing the same, medicinal use thereof, and intermediate for production thereof |
JP2004137245A (ja) * | 2002-08-23 | 2004-05-13 | Kissei Pharmaceut Co Ltd | ピラゾール誘導体、それを含有する医薬組成物、その医薬用途及びその製造中間体 |
US7247628B2 (en) | 2002-12-12 | 2007-07-24 | Pfizer, Inc. | Cannabinoid receptor ligands and uses thereof |
DE102004028241B4 (de) | 2004-06-11 | 2007-09-13 | Sanofi-Aventis Deutschland Gmbh | Neue Fluorglykosidderivate von Pyrazolen, diese Verbindungen enthaltende Arzneimittel und Herstellung dieser Arzneimittel |
AR051446A1 (es) * | 2004-09-23 | 2007-01-17 | Bristol Myers Squibb Co | Glucosidos de c-arilo como inhibidores selectivos de transportadores de glucosa (sglt2) |
AU2005308575A1 (en) | 2004-11-23 | 2006-06-01 | Warner-Lambert Company Llc | 7-(2h-pyrazol-3-yl)-3, 5-dihyroxy-heptanoic acid derivatives as HMG Co-A reductase inhibitors for the treatment of lipidemia |
WO2007034279A2 (en) * | 2005-09-19 | 2007-03-29 | Pfizer Products Inc. | C3a antagonists and pharmaceutical compositions thereof |
JP5069894B2 (ja) * | 2005-10-21 | 2012-11-07 | 田辺三菱製薬株式会社 | ピラゾール化合物 |
TWI378922B (en) * | 2005-10-21 | 2012-12-11 | Mitsubishi Tanabe Pharma Corp | A pyrazole compound |
EP1951678A1 (en) | 2005-10-21 | 2008-08-06 | Mitsubishi Tanabe Pharma Corporation | Pyrazole compounds having cannabinoid receptor (cb1) antagonizing activity |
US20070117858A1 (en) | 2005-11-23 | 2007-05-24 | Mingde Xia | Substituted 5-heteroaryl-1-phenyl-pyrazole cannabinoid modulators |
JP2010505957A (ja) * | 2006-10-10 | 2010-02-25 | アムゲン インコーポレイティッド | 糖尿病に対して使用されるn−アリールピラゾール化合物 |
JP4994295B2 (ja) * | 2007-04-20 | 2012-08-08 | 田辺三菱製薬株式会社 | 医薬組成物 |
WO2010048149A2 (en) | 2008-10-20 | 2010-04-29 | Kalypsys, Inc. | Heterocyclic modulators of gpr119 for treatment of disease |
JP2010222298A (ja) * | 2009-03-24 | 2010-10-07 | Shionogi & Co Ltd | Npyy5受容体拮抗作用を有するピロリドン誘導体 |
US8278302B2 (en) * | 2009-04-08 | 2012-10-02 | Boehringer Ingelheim International Gmbh | Substituted piperidines as CCR3 antagonists |
US8163704B2 (en) * | 2009-10-20 | 2012-04-24 | Novartis Ag | Glycoside derivatives and uses thereof |
RU2017144535A (ru) | 2010-03-30 | 2019-02-18 | Версеон Корпорейшн | Мультизамещенные ароматические соединения в качестве ингибиторов тромбина |
EP2594555B1 (en) | 2010-07-02 | 2018-03-07 | ASKA Pharmaceutical Co., Ltd. | HETEROCYCLIC COMPOUND, AND p27 KIP1 DEGRADATION INHIBITOR |
CA2818903C (en) | 2010-12-14 | 2021-03-23 | Electrophoretics Limited | 5-(1,3-benzoxazol-2-yl)-4-(pyridin-4-yl)pyrimidin-2-amine and its use as a casein kinase 1delta inhibitor |
AR087701A1 (es) * | 2011-08-31 | 2014-04-09 | Japan Tobacco Inc | Derivados de pirazol con actividad inhibidora de sglt1 |
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