RU2586306C2 - Состав с микросферами для длительного непрерывного высвобождения рисперидона - Google Patents

Состав с микросферами для длительного непрерывного высвобождения рисперидона Download PDF

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RU2586306C2
RU2586306C2 RU2013147949/15A RU2013147949A RU2586306C2 RU 2586306 C2 RU2586306 C2 RU 2586306C2 RU 2013147949/15 A RU2013147949/15 A RU 2013147949/15A RU 2013147949 A RU2013147949 A RU 2013147949A RU 2586306 C2 RU2586306 C2 RU 2586306C2
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Prior art keywords
glycolide
pharmaceutical composition
terminated
polylactide glycolide
risperidone
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RU2013147949/15A
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English (en)
Russian (ru)
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RU2013147949A (ru
Inventor
Каоксианг СУН
Ронгцаи ЛИАНГ
Килин ВАНГ
Вениан ВАНГ
Ванхуи ЛИУ
Йоуксин ЛИ
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Шандонг Люие Фармацеутикал Ко., Лтд
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Application filed by Шандонг Люие Фармацеутикал Ко., Лтд filed Critical Шандонг Люие Фармацеутикал Ко., Лтд
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
RU2013147949/15A 2011-04-25 2012-04-10 Состав с микросферами для длительного непрерывного высвобождения рисперидона RU2586306C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201110102840.5 2011-04-25
CN201110102840 2011-04-25
PCT/CN2012/000473 WO2012146052A1 (en) 2011-04-25 2012-04-10 Risperidone sustained release microsphere composition

Publications (2)

Publication Number Publication Date
RU2013147949A RU2013147949A (ru) 2015-05-27
RU2586306C2 true RU2586306C2 (ru) 2016-06-10

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Country Link
US (5) US9446135B2 (enExample)
EP (4) EP3566696B1 (enExample)
JP (2) JP5728128B2 (enExample)
KR (2) KR101932207B1 (enExample)
CN (2) CN103338752B (enExample)
AU (1) AU2012248038B2 (enExample)
BR (1) BR112013027235B1 (enExample)
CA (1) CA2832663C (enExample)
ES (4) ES2607497T3 (enExample)
HU (4) HUE032310T2 (enExample)
PL (4) PL3199146T3 (enExample)
PT (3) PT2701687T (enExample)
RU (1) RU2586306C2 (enExample)
WO (1) WO2012146052A1 (enExample)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL3199146T3 (pl) 2011-04-25 2020-03-31 Shan Dong Luye Pharmaceutical Co., Ltd. Kompozycja mikrosfery rysperydonu o przedłużonym uwalnianiu
CN103990114B (zh) * 2014-05-06 2016-05-18 浙江圣兆药物科技股份有限公司 一种艾塞那肽缓释微球组合物
JP2016102093A (ja) * 2014-11-28 2016-06-02 ニプロ株式会社 塩基性の求核化合物を含有するマイクロカプセルの製造方法
US20190029969A1 (en) * 2015-09-07 2019-01-31 Nipro Corporation Risperidone-containing microcapsule, method for preparing same and release control method
CN105560192A (zh) * 2016-01-07 2016-05-11 万全万特制药江苏有限公司 一种棕榈酸帕利哌酮长效微球注射液的制备方法
WO2018015915A1 (en) 2016-07-22 2018-01-25 Cadila Healthcare Limited A parenteral controlled release composition of an atypical antipsychotic agent
CN106390102A (zh) * 2016-11-30 2017-02-15 郑州仁宏医药科技有限公司 一种治疗精神分裂症的西药组合物
CN106727589A (zh) * 2017-01-24 2017-05-31 广州帝奇医药技术有限公司 帕利哌酮及其衍生物的缓释组合物与该缓释组合物的制备方法
CN106822043A (zh) * 2017-01-24 2017-06-13 广州帝奇医药技术有限公司 利培酮缓释组合物及其制备方法
CN116270486A (zh) * 2017-01-24 2023-06-23 广州帝奇医药技术有限公司 水难溶或微溶性药物缓释组合物及其制备方法
CN106822042A (zh) * 2017-01-24 2017-06-13 广州帝奇医药技术有限公司 一种利培酮缓释组合物及其制备方法
CN106963746A (zh) * 2017-03-17 2017-07-21 广州帝奇医药技术有限公司 一种水难溶/微溶性药物缓释组合物
CN107349175A (zh) * 2017-06-06 2017-11-17 浙江理工大学 一种负载脂肪褐变剂的微针贴片及其制备方法
CN107049985B (zh) * 2017-06-07 2020-06-19 广州帝奇医药技术有限公司 一种抗帕金森病药物的长效缓释制剂及其制备方法
CN107213136B (zh) * 2017-06-07 2021-06-01 广州帝奇医药技术有限公司 一种长效缓释药物制剂及其制备方法
CN107412188A (zh) * 2017-09-06 2017-12-01 广州中医药大学 阿塞那平微球及其制备方法和其注射剂
CN112545995B (zh) * 2018-05-16 2024-02-23 珠海市丽珠微球科技有限公司 一种阿立哌唑缓释微球及其制备方法
CN108635339B (zh) * 2018-08-06 2021-07-06 深圳市泛谷药业股份有限公司 一种利培酮植入剂及其制备方法
GR1009870B (el) * 2019-07-09 2020-11-12 Φαρματεν Α.Β.Ε.Ε. Φαρμακευτικο σκευασμα που περιλαμβανει ενα ατυπο αντιψυχωσικο φαρμακο και μεθοδος παρασκευης αυτου
WO2021134623A1 (zh) * 2019-12-31 2021-07-08 广州帝奇医药技术有限公司 一种叔胺药物组合物及其产业化批量制备方法
CA3222421A1 (en) * 2021-06-23 2022-12-29 Peptron, Inc. Sustained release formulation composition comprising semaglutide or pharmaceutically acceptable salt thereof
CN115006354A (zh) * 2022-06-16 2022-09-06 北京阳光诺和药物研究股份有限公司 一种利培酮-共混plga缓释微球及其制备方法
AU2023352588A1 (en) * 2022-09-26 2025-04-03 The Methodist Hospital Microparticle formulations for intravenous therapy and methods for their manufacture and use
CN118831056A (zh) * 2023-04-11 2024-10-25 珠海市华海康医药科技有限责任公司 一种注射用非奈利酮缓释微球及其制备方法
CN119606887A (zh) * 2023-11-09 2025-03-14 武汉人福创新药物研发中心有限公司 一种药物缓释微球组合物及其制备方法和应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101292960A (zh) * 2006-04-29 2008-10-29 中国人民解放军军事医学科学院毒物药物研究所 含利培酮的缓释微球及其制备方法
RU2355385C2 (ru) * 2002-11-06 2009-05-20 Алза Корпорейшн Композиции пролонгированного действия с контролируемым высвобождением
CN101653422A (zh) * 2008-08-20 2010-02-24 山东绿叶制药有限公司 利培酮缓释微球、其制备方法和用途

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE52535B1 (en) 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
PT669128E (pt) * 1992-11-17 2000-06-30 Yoshitomi Pharmaceutical Micro-esfera de libertacao sustentada contendo antipsicoticos e processo para produzir a mesma
AU694147B2 (en) 1993-11-19 1998-07-16 Alkermes, Inc. Microencapsulated 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
US6558702B2 (en) * 2001-04-13 2003-05-06 Alkermes Controlled Therapeutics, Inc. Method of modifying the release profile of sustained release compositions
EP1615924A1 (en) 2003-04-22 2006-01-18 Synthon B.V. Water soluble salts of risperidone
WO2005110369A2 (en) * 2004-04-30 2005-11-24 American Pharmaceutical Partners, Inc. Sustained-release microspheres and methods of making and using same
EP1661560B1 (en) * 2004-11-22 2008-11-05 Hisamitsu Pharmaceutical Co., Inc. Transdermal patch comprising a melting point lowering agent
EP1968549B1 (en) 2005-12-22 2014-05-14 Novartis AG Sustained release formulation comprising octreotide and two or more polylactide-co-glycolide polymers
PE20090387A1 (es) 2007-05-24 2009-04-28 Novartis Ag Formulacion de pasireotida
CA2687979C (en) 2007-05-25 2017-07-04 Tolmar Therapeutics, Inc. Sustained delivery formulations of risperidone compounds
JP5222550B2 (ja) * 2007-12-27 2013-06-26 財團法人工業技術研究院 徐放性組成物およびその製造方法
CN101584652B (zh) 2009-06-19 2012-06-20 上海医药集团股份有限公司 利培酮缓释凝胶注射剂及其制备方法
UA111162C2 (uk) 2010-08-04 2016-04-11 Флекшен Терап'Ютікс, Інк. Ін'єкційна композиція ацетоніду триамцинолону для лікування болю
PL3199146T3 (pl) 2011-04-25 2020-03-31 Shan Dong Luye Pharmaceutical Co., Ltd. Kompozycja mikrosfery rysperydonu o przedłużonym uwalnianiu

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2355385C2 (ru) * 2002-11-06 2009-05-20 Алза Корпорейшн Композиции пролонгированного действия с контролируемым высвобождением
CN101292960A (zh) * 2006-04-29 2008-10-29 中国人民解放军军事医学科学院毒物药物研究所 含利培酮的缓释微球及其制备方法
CN101653422A (zh) * 2008-08-20 2010-02-24 山东绿叶制药有限公司 利培酮缓释微球、其制备方法和用途

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US20190343840A1 (en) 2019-11-14
EP3772354C0 (en) 2023-11-01
AU2012248038B2 (en) 2015-11-12
KR101932207B1 (ko) 2018-12-24
EP3566696B1 (en) 2020-10-07
JP5728128B2 (ja) 2015-06-03
US20160331752A1 (en) 2016-11-17
EP3566696A1 (en) 2019-11-13
BR112013027235B1 (pt) 2021-11-16
WO2012146052A1 (en) 2012-11-01
US20140050799A1 (en) 2014-02-20
RU2013147949A (ru) 2015-05-27
PL3566696T3 (pl) 2021-04-19
CN104127385A (zh) 2014-11-05
PL3772354T3 (pl) 2024-04-02
ES2607497T3 (es) 2017-03-31
EP3199146A1 (en) 2017-08-02
EP3772354A1 (en) 2021-02-10
KR101539313B1 (ko) 2015-07-24
PT3199146T (pt) 2019-10-25
HUE046004T2 (hu) 2020-01-28
US9532991B2 (en) 2017-01-03
PL3199146T3 (pl) 2020-03-31
EP2701687A1 (en) 2014-03-05
US11110094B2 (en) 2021-09-07
PT3566696T (pt) 2021-01-11
ES2749864T3 (es) 2020-03-24
US10406161B2 (en) 2019-09-10
AU2012248038A1 (en) 2013-10-24
JP2015143259A (ja) 2015-08-06
CN103338752B (zh) 2014-10-29
PL2701687T3 (pl) 2017-03-31
US20170056407A1 (en) 2017-03-02
ES2968917T3 (es) 2024-05-14
CN103338752A (zh) 2013-10-02
HUE032310T2 (hu) 2017-09-28
ES2855349T3 (es) 2021-09-23
US10098882B2 (en) 2018-10-16
BR112013027235A2 (pt) 2016-12-27
CA2832663C (en) 2016-02-09
JP2014512396A (ja) 2014-05-22
EP3772354B1 (en) 2023-11-01
CN104127385B (zh) 2017-08-04
CA2832663A1 (en) 2012-11-01
EP2701687B1 (en) 2016-09-21
EP3199146B1 (en) 2019-07-17
JP6072121B2 (ja) 2017-02-01
HUE066287T2 (hu) 2024-07-28
US9446135B2 (en) 2016-09-20
HK1185560A1 (en) 2014-02-21
KR20150050598A (ko) 2015-05-08
US20190022098A1 (en) 2019-01-24
KR20140026481A (ko) 2014-03-05
EP2701687A4 (en) 2014-12-17
PT2701687T (pt) 2016-12-20
HUE052864T2 (hu) 2021-05-28

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