RU2532330C2 - Фармацевтические композиции - Google Patents
Фармацевтические композиции Download PDFInfo
- Publication number
- RU2532330C2 RU2532330C2 RU2011146335/15A RU2011146335A RU2532330C2 RU 2532330 C2 RU2532330 C2 RU 2532330C2 RU 2011146335/15 A RU2011146335/15 A RU 2011146335/15A RU 2011146335 A RU2011146335 A RU 2011146335A RU 2532330 C2 RU2532330 C2 RU 2532330C2
- Authority
- RU
- Russia
- Prior art keywords
- compound
- formula
- diabetes mellitus
- insulin
- glimepiride
- Prior art date
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- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 57
- 206010012601 diabetes mellitus Diseases 0.000 claims abstract description 119
- 229960004346 glimepiride Drugs 0.000 claims abstract description 58
- WIGIZIANZCJQQY-RUCARUNLSA-N glimepiride Chemical compound O=C1C(CC)=C(C)CN1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)N[C@@H]2CC[C@@H](C)CC2)C=C1 WIGIZIANZCJQQY-RUCARUNLSA-N 0.000 claims abstract description 58
- 150000003839 salts Chemical class 0.000 claims abstract description 57
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical compound CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 claims abstract description 44
- 201000010099 disease Diseases 0.000 claims abstract description 36
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 36
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 34
- 208000002249 Diabetes Complications Diseases 0.000 claims abstract description 29
- 230000003914 insulin secretion Effects 0.000 claims abstract description 26
- WHSOLWOTCHFFBK-ZQGJOIPISA-N Luseogliflozin Chemical compound C1=CC(OCC)=CC=C1CC1=CC([C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)S2)O)=C(OC)C=C1C WHSOLWOTCHFFBK-ZQGJOIPISA-N 0.000 claims abstract description 8
- 238000000034 method Methods 0.000 claims description 42
- OETHQSJEHLVLGH-UHFFFAOYSA-N metformin hydrochloride Chemical compound Cl.CN(C)C(=N)N=C(N)N OETHQSJEHLVLGH-UHFFFAOYSA-N 0.000 claims description 29
- ZJJXGWJIGJFDTL-UHFFFAOYSA-N glipizide Chemical compound C1=NC(C)=CN=C1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)NC2CCCCC2)C=C1 ZJJXGWJIGJFDTL-UHFFFAOYSA-N 0.000 claims description 25
- 229960001381 glipizide Drugs 0.000 claims description 24
- 229960004329 metformin hydrochloride Drugs 0.000 claims description 24
- 229960004580 glibenclamide Drugs 0.000 claims description 22
- ZNNLBTZKUZBEKO-UHFFFAOYSA-N glyburide Chemical compound COC1=CC=C(Cl)C=C1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)NC2CCCCC2)C=C1 ZNNLBTZKUZBEKO-UHFFFAOYSA-N 0.000 claims description 22
- 230000002708 enhancing effect Effects 0.000 claims description 21
- 229960003105 metformin Drugs 0.000 claims description 18
- 208000032131 Diabetic Neuropathies Diseases 0.000 claims description 7
- 238000011282 treatment Methods 0.000 claims description 7
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims description 6
- 206010012689 Diabetic retinopathy Diseases 0.000 claims description 5
- 208000026106 cerebrovascular disease Diseases 0.000 claims description 5
- 208000029078 coronary artery disease Diseases 0.000 claims description 5
- 208000030613 peripheral artery disease Diseases 0.000 claims description 5
- 230000002265 prevention Effects 0.000 claims description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract description 126
- 239000008103 glucose Substances 0.000 abstract description 126
- 230000000694 effects Effects 0.000 abstract description 107
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- 239000003814 drug Substances 0.000 abstract description 54
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- 150000001875 compounds Chemical class 0.000 description 310
- 229940126062 Compound A Drugs 0.000 description 139
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 description 139
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 125
- 229960001031 glucose Drugs 0.000 description 125
- HYAFETHFCAUJAY-UHFFFAOYSA-N pioglitazone Chemical compound N1=CC(CC)=CC=C1CCOC(C=C1)=CC=C1CC1C(=O)NC(=O)S1 HYAFETHFCAUJAY-UHFFFAOYSA-N 0.000 description 68
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- SYOKIDBDQMKNDQ-XWTIBIIYSA-N vildagliptin Chemical compound C1C(O)(C2)CC(C3)CC1CC32NCC(=O)N1CCC[C@H]1C#N SYOKIDBDQMKNDQ-XWTIBIIYSA-N 0.000 description 20
- XUFXOAAUWZOOIT-SXARVLRPSA-N (2R,3R,4R,5S,6R)-5-[[(2R,3R,4R,5S,6R)-5-[[(2R,3R,4S,5S,6R)-3,4-dihydroxy-6-methyl-5-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)-1-cyclohex-2-enyl]amino]-2-oxanyl]oxy]-3,4-dihydroxy-6-(hydroxymethyl)-2-oxanyl]oxy]-6-(hydroxymethyl)oxane-2,3,4-triol Chemical compound O([C@H]1O[C@H](CO)[C@H]([C@@H]([C@H]1O)O)O[C@H]1O[C@@H]([C@H]([C@H](O)[C@H]1O)N[C@@H]1[C@@H]([C@@H](O)[C@H](O)C(CO)=C1)O)C)[C@@H]1[C@@H](CO)O[C@@H](O)[C@H](O)[C@H]1O XUFXOAAUWZOOIT-SXARVLRPSA-N 0.000 description 19
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- FZNCGRZWXLXZSZ-CIQUZCHMSA-N Voglibose Chemical group OCC(CO)N[C@H]1C[C@](O)(CO)[C@@H](O)[C@H](O)[C@H]1O FZNCGRZWXLXZSZ-CIQUZCHMSA-N 0.000 description 19
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Landscapes
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| JP2009100210 | 2009-04-16 | ||
| JP2009-100210 | 2009-04-16 | ||
| PCT/JP2010/057196 WO2010119990A1 (en) | 2009-04-16 | 2010-04-16 | Pharmaceutical compositions |
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| RU2014121260/15A Division RU2014121260A (ru) | 2009-04-16 | 2014-05-26 | Фармацевтические композиции |
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| RU2011146335A RU2011146335A (ru) | 2013-05-27 |
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| EP (3) | EP2419097B1 (https=) |
| JP (4) | JP5077786B2 (https=) |
| KR (2) | KR20120016051A (https=) |
| CN (7) | CN102395364A (https=) |
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| AU (1) | AU2010237748B2 (https=) |
| BR (1) | BRPI1012539A2 (https=) |
| CA (1) | CA2755392A1 (https=) |
| CY (2) | CY1114703T1 (https=) |
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| MX (1) | MX2011010901A (https=) |
| MY (3) | MY183793A (https=) |
| NZ (4) | NZ606888A (https=) |
| PH (3) | PH12015500235A1 (https=) |
| PL (2) | PL2601949T3 (https=) |
| PT (2) | PT2601949E (https=) |
| RS (2) | RS53056B (https=) |
| RU (2) | RU2532330C2 (https=) |
| SG (6) | SG2014015093A (https=) |
| SI (2) | SI2601949T1 (https=) |
| SM (1) | SMT201500015B (https=) |
| TW (3) | TW201103534A (https=) |
| UA (2) | UA111742C2 (https=) |
| WO (1) | WO2010119990A1 (https=) |
| ZA (1) | ZA201106727B (https=) |
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| RU2680527C1 (ru) * | 2015-02-27 | 2019-02-22 | Те Асан Фаундейшн | Композиции для предотвращения или лечения кальциноза клапана, содержащие dpp-4 ингибитор |
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| US7772191B2 (en) | 2005-05-10 | 2010-08-10 | Boehringer Ingelheim International Gmbh | Processes for preparing of glucopyranosyl-substituted benzyl-benzene derivatives and intermediates therein |
| AP2011005795A0 (en) | 2009-02-13 | 2011-08-31 | Boehringer Ingelheim Int | SGLT-2 inhibitor for treating type 1 diabetes mellitus, type 2 diabetes mellitus, impaired glucose tolerance or hyperglycemia. |
| JP5758900B2 (ja) | 2009-09-30 | 2015-08-05 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | グルコピラノシル置換ベンジルベンゼン誘導体の調製方法 |
| UY32919A (es) | 2009-10-02 | 2011-04-29 | Boehringer Ingelheim Int | Composición farmacéutica, forma de dosificación farmacéutica, procedimiento para su preparación, mé todos para su tratamiento y sus usos |
| US20120283169A1 (en) * | 2010-11-08 | 2012-11-08 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
| TR201101809A1 (tr) * | 2010-12-21 | 2012-07-23 | Sanovel İlaç Sanayi̇ Ve Ti̇caret Anoni̇m Şi̇rketi̇ | Vildagliptin ve glimepirid kombinasyonları. |
| US9192617B2 (en) | 2012-03-20 | 2015-11-24 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
| HK1202458A1 (en) | 2012-05-17 | 2015-10-02 | Vtv治疗有限责任公司 | Glucokinase activator compositions for the treatment of diabetes |
| US9320727B2 (en) * | 2012-08-30 | 2016-04-26 | Taisho Pharmaceutical Co., Ltd | Combinations of SGLT 2 inhibitors and antihypertensive drugs |
| HRP20190101T1 (hr) | 2013-04-05 | 2019-03-08 | Boehringer Ingelheim International Gmbh | Terapeutske uporabe empagliflozina |
| US20140303097A1 (en) | 2013-04-05 | 2014-10-09 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
| CA2812519A1 (en) | 2013-04-05 | 2014-10-05 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
| US11813275B2 (en) | 2013-04-05 | 2023-11-14 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
| FI4000608T3 (fi) | 2013-04-18 | 2026-01-21 | Boehringer Ingelheim Int | Farmaseuttinen koostumus, menetelmä hoitamiseksi ja sen käyttöjä |
| TW201636015A (zh) * | 2013-07-05 | 2016-10-16 | 卡地拉保健有限公司 | 協同性組成物 |
| CN105963280B (zh) * | 2016-06-30 | 2018-11-06 | 合肥华方医药科技有限公司 | 一种伏格列波糖口腔速溶膜及其制备方法 |
| BR112019005930A2 (pt) | 2016-10-19 | 2019-06-11 | Boehringer Ingelheim Int | combinações compreendendo um inibidor de ssao/vap-1 e um inibidor de sglt2, e usos das mesmas |
| KR20250097990A (ko) | 2016-11-10 | 2025-06-30 | 베링거 인겔하임 인터내셔날 게엠베하 | 약제학적 조성물, 치료 방법 및 이의 용도 |
| US11439689B2 (en) * | 2016-11-14 | 2022-09-13 | Kaohsiung Medical University | Method for detecting whether glucose metabolism is abnormal, and prevention and treatment therefor |
| US20210113561A1 (en) | 2018-04-17 | 2021-04-22 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
| KR20190137343A (ko) | 2018-06-01 | 2019-12-11 | 김유찬 | 계량 인덕션 |
| CN112040945A (zh) | 2018-06-12 | 2020-12-04 | Vtv治疗有限责任公司 | 葡萄糖激酶激活剂与胰岛素或胰岛素类似物组合的治疗用途 |
| US12213970B2 (en) | 2018-10-29 | 2025-02-04 | Boehringer Ingelheim International Gmbh | Pyridinyl sulfonamide derivatives, pharmaceutical compositions and uses thereof |
| DK3873600T5 (da) | 2018-10-29 | 2024-03-18 | Boehringer Ingelheim Int | Pyridinylsulfonamidderivater, farmaceutiske sammensætninger og anvendelser deraf |
| US12391658B2 (en) | 2020-02-18 | 2025-08-19 | Vtv Therapeutics Llc | Sulfoxide and sulfone glucokinase activators and methods of use thereof |
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| DE4432757A1 (de) | 1994-09-14 | 1996-03-21 | Boehringer Mannheim Gmbh | Pharmazeutische Zubereitung enthaltend Metformin und Verfahren zu deren Herstellung |
| JP2003520759A (ja) | 1999-08-31 | 2003-07-08 | アンドルックス ファーマスーティカルズ インコーポレーテッド | 単位核を有する徐放性錠剤 |
| WO2002080936A1 (en) * | 2001-04-04 | 2002-10-17 | Ortho Mcneil Pharmaceutical, Inc. | Combination therapy comprising glucose reabsorption inhibitors and ppar modulators |
| WO2002083066A2 (en) * | 2001-04-11 | 2002-10-24 | Bristol-Myers Squibb Company | Amino acid complexes of c-aryl glucosides for treatment of diabetes and method |
| RU2434862C2 (ru) * | 2006-06-29 | 2011-11-27 | Тайсо Фармасьютикал Ко., Лтд. | С-фенил-1-тиоглюцитолы |
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| AU2007316613B2 (en) * | 2006-11-09 | 2013-11-28 | Boehringer Ingelheim International Gmbh | Combination therapy with SGLT-2 inhibitors and their pharmaceutical compositions |
| AU2007332476A1 (en) * | 2006-12-14 | 2008-06-19 | Taisho Pharmaceutical Co., Ltd. | 1-phenyl 1-thio-D-glucitol derivative |
| PE20090938A1 (es) | 2007-08-16 | 2009-08-08 | Boehringer Ingelheim Int | Composicion farmaceutica que comprende un derivado de benceno sustituido con glucopiranosilo |
| PE20090603A1 (es) | 2007-08-16 | 2009-06-11 | Boehringer Ingelheim Int | Composicion farmaceutica que comprende un inhibidor de sglt2 y un inhibidor de dpp iv |
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Cited By (1)
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|---|---|---|---|---|
| RU2680527C1 (ru) * | 2015-02-27 | 2019-02-22 | Те Асан Фаундейшн | Композиции для предотвращения или лечения кальциноза клапана, содержащие dpp-4 ингибитор |
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